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Conserved domains on  [gi|489501377|ref|WP_003406276|]
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MULTISPECIES: lytic transglycosylase domain-containing protein [Mycobacterium]

Protein Classification

lytic transglycosylase domain-containing protein( domain architecture ID 12989787)

lytic transglycosylase domain-containing protein similar to lytic transglycosylase which catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc)

PubMed:  9723170|7479697|8765311

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 135-272 2.44e-21

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


:

Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 88.13  E-value: 2.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489501377 135 CGVSWNLLAGIGRIESMhanggatdargtaiqpiYGPtldgtlpgneiiiqssvGNRVTYARAMGPMQFLPGTWARYATD 214
Cdd:cd13399    1 YGVPPGILAAILGVESG-----------------FGP-----------------NAGGSPAGAQGIAQFMPSTWKAYGVD 46

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489501377 215 GDDDGVADPQNLFDSTLAAARYLCSGG--LNLRDPAQVMAALLRYNNSM-PYAQNVLGWAA 272
Cdd:cd13399   47 GNGDGKADPFNPEDAIASAANYLCRHGwdLNAFLGEDNFLALAAYNAGPgAYANAVLELAA 107
 
Name Accession Description Interval E-value
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 135-272 2.44e-21

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 88.13  E-value: 2.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489501377 135 CGVSWNLLAGIGRIESMhanggatdargtaiqpiYGPtldgtlpgneiiiqssvGNRVTYARAMGPMQFLPGTWARYATD 214
Cdd:cd13399    1 YGVPPGILAAILGVESG-----------------FGP-----------------NAGGSPAGAQGIAQFMPSTWKAYGVD 46

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489501377 215 GDDDGVADPQNLFDSTLAAARYLCSGG--LNLRDPAQVMAALLRYNNSM-PYAQNVLGWAA 272
Cdd:cd13399   47 GNGDGKADPFNPEDAIASAANYLCRHGwdLNAFLGEDNFLALAAYNAGPgAYANAVLELAA 107
SLT_2 pfam13406
Transglycosylase SLT domain; This family is related to the SLT domain pfam01464.
 194-237 1.15e-06

Transglycosylase SLT domain; This family is related to the SLT domain pfam01464.


Pssm-ID: 404311 [Multi-domain]  Cd Length: 292  Bit Score: 49.86  E-value: 1.15e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 489501377  194 YARAMGPMQFLPGTWARYATDGDDDGVADpqnLFDS---TLA-AARYL 237
Cdd:pfam13406 152 WAGAMGQTQFMPSSYLAYAVDFDGDGRRD---LWNSppdALAsVANYL 196
MltB COG2951
Membrane-bound lytic murein transglycosylase B [Cell wall/membrane/envelope biogenesis];
194-237 3.49e-06

Membrane-bound lytic murein transglycosylase B [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442193 [Multi-domain]  Cd Length: 326  Bit Score: 48.62  E-value: 3.49e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 489501377 194 YARAMGPMQFLPGTWARYATDGDDDGVADpqnLFDST---LA-AARYL 237
Cdd:COG2951  178 WAGAMGQTQFMPSSYLRYAVDFDGDGRRD---LWNSPpdaLAsTANYL 222
 
Name Accession Description Interval E-value
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 135-272 2.44e-21

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 88.13  E-value: 2.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489501377 135 CGVSWNLLAGIGRIESMhanggatdargtaiqpiYGPtldgtlpgneiiiqssvGNRVTYARAMGPMQFLPGTWARYATD 214
Cdd:cd13399    1 YGVPPGILAAILGVESG-----------------FGP-----------------NAGGSPAGAQGIAQFMPSTWKAYGVD 46

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489501377 215 GDDDGVADPQNLFDSTLAAARYLCSGG--LNLRDPAQVMAALLRYNNSM-PYAQNVLGWAA 272
Cdd:cd13399   47 GNGDGKADPFNPEDAIASAANYLCRHGwdLNAFLGEDNFLALAAYNAGPgAYANAVLELAA 107
SLT_2 pfam13406
Transglycosylase SLT domain; This family is related to the SLT domain pfam01464.
 194-237 1.15e-06

Transglycosylase SLT domain; This family is related to the SLT domain pfam01464.


Pssm-ID: 404311 [Multi-domain]  Cd Length: 292  Bit Score: 49.86  E-value: 1.15e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 489501377  194 YARAMGPMQFLPGTWARYATDGDDDGVADpqnLFDS---TLA-AARYL 237
Cdd:pfam13406 152 WAGAMGQTQFMPSSYLAYAVDFDGDGRRD---LWNSppdALAsVANYL 196
MltB COG2951
Membrane-bound lytic murein transglycosylase B [Cell wall/membrane/envelope biogenesis];
194-237 3.49e-06

Membrane-bound lytic murein transglycosylase B [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442193 [Multi-domain]  Cd Length: 326  Bit Score: 48.62  E-value: 3.49e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 489501377 194 YARAMGPMQFLPGTWARYATDGDDDGVADpqnLFDST---LA-AARYL 237
Cdd:COG2951  178 WAGAMGQTQFMPSSYLRYAVDFDGDGRRD---LWNSPpdaLAsTANYL 222
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 197-258 1.16e-03

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 38.35  E-value: 1.16e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489501377 197 AMGPMQFLPGTWARYAtdgdDDGVADPQNLFDSTLAAARYLCsgGLNLRDPAQVMAALLRYN 258
Cdd:cd00254   24 ARGLMQLMPGTARDLG----RRGVDDLFDPEENIRAGARYLR--ELLDRFGGDLELALAAYN 79
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 15-258 1.40e-03

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 39.98  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489501377  15 AVRRGACRLTRAPAFGVAAIAPLVFASAVGGAAPVFPGRTAPVHAVITPVAAVAASGIDLSGPVVIAMKRPPTSFRVAVA 94
Cdd:COG0741    1 AAAAAAAAAALALAASAAAALALALLAAAAAAAALAAAAAALAAAAAAAAGAAAAAASAAAGGPALAAALAAADALAAFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489501377  95 TISAPPPPMIVNSPGALGIPamalSAYRNAelkMAAAAPGCGVSWNLLAGIGRIESmhanGGATDARgtaiqpiygptld 174
Cdd:COG0741   81 AIAALAAELLALAALLLRRP----LPYLPL---IEEAAKKYGVDPALVLALIRQES----AFNPNAV------------- 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489501377 175 gtlpgneiiiqSSVGnrvtyarAMGPMQFLPGTWARYATDGDDDgvADPQNLFD---STLAAARYLcsGGLNLRDPAQVM 251
Cdd:COG0741  137 -----------SPAG-------ARGLMQLMPATARRLGLKLGLG--PSPDDLFDpetNIRAGAAYL--RELLDRFDGDLV 194


                 ....*..
gi 489501377 252 AALLRYN 258
Cdd:COG0741  195 LALAAYN 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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