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Conserved domains on  [gi|489502550|ref|WP_003407443|]
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MULTISPECIES: glucose-6-phosphate dehydrogenase [Mycobacterium]

Protein Classification

glucose-6-phosphate dehydrogenase( domain architecture ID 11481539)

glucose-6-phosphate dehydrogenase (NADP(+)) catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone

CATH:  3.40.50.720
EC:  1.1.1.49
Gene Ontology:  GO:0004345|GO:0050661|GO:0006006
PubMed:  39259139|24720642
SCOP:  4000091

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 20-514 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


:

Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 899.88  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  20 KRLPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWD 99
Cdd:PRK05722   1 MRLPRTAEPCDLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFARTPFDEEVWE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 100 RLAEGFRFVPGTFDDDDAFAQLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQGdrWSRVVIEKPFG 179
Cdd:PRK05722  81 RFLSRLYYVSGDVTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAAGLNEGGG--WRRVVIEKPFG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 180 HDLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIG 259
Cdd:PRK05722 159 HDLASARELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 260 AARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRLAEP--LDQTTSRGQYAAGWQGGEKVVGLLDEEGFAED 337
Cdd:PRK05722 239 ALRDMVQNHLLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPedVKENTVRGQYTAGWIGGKPVPGYREEEGVNPD 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 338 STTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATmTDELGTNAMVIRVQPDEGVTLRFGSK 417
Cdd:PRK05722 319 STTETFVALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEES-AEELGPNKLVIRIQPDEGISLRFNAK 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 418 VPGTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAA-HGTPDAYEAGTWG 496
Cdd:PRK05722 398 VPGEGMELRPVKLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEAdGGPPPPYPAGTWG 477

                        490
                 ....*....|....*...
gi 489502550 497 PESSLEMLRRTGREWRRP 514
Cdd:PRK05722 478 PEAADALLARDGRSWREP 495
 
Name Accession Description Interval E-value
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 20-514 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 899.88  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  20 KRLPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWD 99
Cdd:PRK05722   1 MRLPRTAEPCDLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFARTPFDEEVWE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 100 RLAEGFRFVPGTFDDDDAFAQLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQGdrWSRVVIEKPFG 179
Cdd:PRK05722  81 RFLSRLYYVSGDVTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAAGLNEGGG--WRRVVIEKPFG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 180 HDLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIG 259
Cdd:PRK05722 159 HDLASARELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 260 AARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRLAEP--LDQTTSRGQYAAGWQGGEKVVGLLDEEGFAED 337
Cdd:PRK05722 239 ALRDMVQNHLLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPedVKENTVRGQYTAGWIGGKPVPGYREEEGVNPD 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 338 STTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATmTDELGTNAMVIRVQPDEGVTLRFGSK 417
Cdd:PRK05722 319 STTETFVALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEES-AEELGPNKLVIRIQPDEGISLRFNAK 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 418 VPGTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAA-HGTPDAYEAGTWG 496
Cdd:PRK05722 398 VPGEGMELRPVKLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEAdGGPPPPYPAGTWG 477

                        490
                 ....*....|....*...
gi 489502550 497 PESSLEMLRRTGREWRRP 514
Cdd:PRK05722 478 PEAADALLARDGRSWREP 495
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 22-514 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 857.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  22 LPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWDRL 101
Cdd:COG0364    3 QMRPAEPCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFSRKPFDEEVWERF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 102 AEGFRFVPGTFDDDDAFAQLAETLEKLDAERgTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQGdrWSRVVIEKPFGHD 181
Cdd:COG0364   83 LERLHYVSGDFTDPEGYERLKELLEELDEER-TPGNRVFYLATPPSLFGPICENLGAAGLATEGG--WRRVVIEKPFGHD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 182 LASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAA 261
Cdd:COG0364  160 LASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 262 RDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRL--AEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDST 339
Cdd:COG0364  240 RDMVQNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPitPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDST 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 340 TETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMtDELGTNAMVIRVQPDEGVTLRFGSKVP 419
Cdd:COG0364  320 TETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETA-EELPPNRLVIRIQPDEGISLRFNAKVP 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 420 GTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAAHGT-PDAYEAGTWGPE 498
Cdd:COG0364  399 GLGMRLRPVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEpPPPYPAGSWGPE 478

                        490
                 ....*....|....*.
gi 489502550 499 SSLEMLRRTGREWRRP 514
Cdd:COG0364  479 AADALLARDGRSWREP 494
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 27-514 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 815.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550   27 GPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQnWDRLAEGFR 106
Cdd:TIGR00871   1 DPCILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREAIIKFETDEIDEQ-WDEFAQRLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  107 FVPGTFDDDDAFAQLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQGdrWSRVVIEKPFGHDLASAR 186
Cdd:TIGR00871  80 YVSGDVDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGK--WSRVVVEKPFGHDLASAQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  187 ELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQ 266
Cdd:TIGR00871 158 ELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  267 NHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTTETFAAI 346
Cdd:TIGR00871 238 NHLLQLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDDNNTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAAL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  347 TLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNAMVIRVQPDEGVTLRFGSKVPGTAMEVR 426
Cdd:TIGR00871 318 KLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERDANPRNALVIRIQPDEGVYLKFNAKKPGLNFETR 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  427 DVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAAHGTP--DAYEAGTWGPESSLEML 504
Cdd:TIGR00871 398 PVKLDFSYASRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGPspPNYPAGSWGPKEADELI 477

                         490
                  ....*....|
gi 489502550  505 RRTGREWRRP 514
Cdd:TIGR00871 478 RKDGRSWRKP 487
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
217-512 5.46e-174

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 491.57  E-value: 5.46e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  217 LALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKV 296
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  297 LSATRLAEP--LDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTE 374
Cdd:pfam02781  81 LRSLRPITPedVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  375 IALVFRRAPHLPFDAtmTDELGTNAMVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVL 454
Cdd:pfam02781 161 IRIQFKDVPHNLFRD--PGTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGERIPEAYERLLLDVM 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 489502550  455 LGEPSLFPVNAEVELAWEILDPALEHWAAHGtPDAYEAGTWGPESSLEMLRRTGREWR 512
Cdd:pfam02781 239 RGDQTLFVRSDEVEAAWRIVDPILEAWDEEK-PPPYPAGSWGPKAADELLARDGRKWR 295
 
Name Accession Description Interval E-value
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 20-514 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 899.88  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  20 KRLPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWD 99
Cdd:PRK05722   1 MRLPRTAEPCDLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFARTPFDEEVWE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 100 RLAEGFRFVPGTFDDDDAFAQLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQGdrWSRVVIEKPFG 179
Cdd:PRK05722  81 RFLSRLYYVSGDVTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAAGLNEGGG--WRRVVIEKPFG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 180 HDLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIG 259
Cdd:PRK05722 159 HDLASARELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 260 AARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRLAEP--LDQTTSRGQYAAGWQGGEKVVGLLDEEGFAED 337
Cdd:PRK05722 239 ALRDMVQNHLLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPedVKENTVRGQYTAGWIGGKPVPGYREEEGVNPD 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 338 STTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATmTDELGTNAMVIRVQPDEGVTLRFGSK 417
Cdd:PRK05722 319 STTETFVALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEES-AEELGPNKLVIRIQPDEGISLRFNAK 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 418 VPGTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAA-HGTPDAYEAGTWG 496
Cdd:PRK05722 398 VPGEGMELRPVKLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEAdGGPPPPYPAGTWG 477

                        490
                 ....*....|....*...
gi 489502550 497 PESSLEMLRRTGREWRRP 514
Cdd:PRK05722 478 PEAADALLARDGRSWREP 495
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 22-514 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 857.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  22 LPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWDRL 101
Cdd:COG0364    3 QMRPAEPCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFSRKPFDEEVWERF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 102 AEGFRFVPGTFDDDDAFAQLAETLEKLDAERgTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQGdrWSRVVIEKPFGHD 181
Cdd:COG0364   83 LERLHYVSGDFTDPEGYERLKELLEELDEER-TPGNRVFYLATPPSLFGPICENLGAAGLATEGG--WRRVVIEKPFGHD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 182 LASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAA 261
Cdd:COG0364  160 LASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 262 RDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRL--AEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDST 339
Cdd:COG0364  240 RDMVQNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPitPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDST 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 340 TETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMtDELGTNAMVIRVQPDEGVTLRFGSKVP 419
Cdd:COG0364  320 TETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETA-EELPPNRLVIRIQPDEGISLRFNAKVP 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 420 GTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAAHGT-PDAYEAGTWGPE 498
Cdd:COG0364  399 GLGMRLRPVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEpPPPYPAGSWGPE 478

                        490
                 ....*....|....*.
gi 489502550 499 SSLEMLRRTGREWRRP 514
Cdd:COG0364  479 AADALLARDGRSWREP 494
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 27-514 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 815.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550   27 GPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQnWDRLAEGFR 106
Cdd:TIGR00871   1 DPCILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREAIIKFETDEIDEQ-WDEFAQRLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  107 FVPGTFDDDDAFAQLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQGdrWSRVVIEKPFGHDLASAR 186
Cdd:TIGR00871  80 YVSGDVDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGK--WSRVVVEKPFGHDLASAQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  187 ELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQ 266
Cdd:TIGR00871 158 ELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  267 NHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTTETFAAI 346
Cdd:TIGR00871 238 NHLLQLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDDNNTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAAL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  347 TLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNAMVIRVQPDEGVTLRFGSKVPGTAMEVR 426
Cdd:TIGR00871 318 KLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERDANPRNALVIRIQPDEGVYLKFNAKKPGLNFETR 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  427 DVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAAHGTP--DAYEAGTWGPESSLEML 504
Cdd:TIGR00871 398 PVKLDFSYASRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGPspPNYPAGSWGPKEADELI 477

                         490
                  ....*....|
gi 489502550  505 RRTGREWRRP 514
Cdd:TIGR00871 478 RKDGRSWRKP 487
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
21-514 0e+00

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 680.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  21 RLPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWDR 100
Cdd:PRK12853   1 ADTAPAPPCTLVIFGATGDLARRKLLPALYRLARAGLLPEDLRIIGVGRDDWSDEQWRARVRESLRAFGADGFDDAVWDR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 101 LAEGFRFVPGTFDDDDAFAQLAETLekldaerGTGGNHAFYLAIPPKSFPVVCEQLHKSGLArpqgDRWSRVVIEKPFGH 180
Cdd:PRK12853  81 LAARLSYVQGDVTDPADYARLAEAL-------GPGGNPVFYLAVPPSLFAPVVENLGAAGLL----PEGRRVVLEKPFGH 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 181 DLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGA 260
Cdd:PRK12853 150 DLASARALNATLAKVFDEDQIYRIDHFLGKETVQNLLALRFANALLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGA 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 261 ARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTT 340
Cdd:PRK12853 230 LRDMVQNHLLQLLALVAMEPPASFDADAVRDEKAKVLRAIRPLDPDDVHTVRGQYTAGTVGGEPVPGYREEPGVDPDSRT 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 341 ETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDElgTNAMVIRVQPDEGVTLRFGSKVPG 420
Cdd:PRK12853 310 ETFVALKLEIDNWRWAGVPFYLRTGKRLAERRTEIVITFKPVPHALFRGTGVEP--PNRLVIRLQPDEGISLELNVKRPG 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 421 TAMEVRDVNMDFSYGSafAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAAHGTP-DAYEAGTWGPES 499
Cdd:PRK12853 388 PGMRLRPVELDADYAD--DERPLEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDAWAADPVPpHEYPAGSWGPAA 465

                        490
                 ....*....|....*
gi 489502550 500 SLEMLRRTGREWRRP 514
Cdd:PRK12853 466 ADALLARDGRGWREP 480
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
217-512 5.46e-174

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 491.57  E-value: 5.46e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  217 LALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKV 296
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  297 LSATRLAEP--LDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTE 374
Cdd:pfam02781  81 LRSLRPITPedVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  375 IALVFRRAPHLPFDAtmTDELGTNAMVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVL 454
Cdd:pfam02781 161 IRIQFKDVPHNLFRD--PGTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGERIPEAYERLLLDVM 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 489502550  455 LGEPSLFPVNAEVELAWEILDPALEHWAAHGtPDAYEAGTWGPESSLEMLRRTGREWR 512
Cdd:pfam02781 239 RGDQTLFVRSDEVEAAWRIVDPILEAWDEEK-PPPYPAGSWGPKAADELLARDGRKWR 295
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 26-514 1.62e-173

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 497.64  E-value: 1.62e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  26 AGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWDRLAEGF 105
Cdd:PRK12854   9 APPTVFVLFGATGDLAKRKLLPGLFHLARAGLLPPDWRIVGTGRGDVSAEAFREHARDALDEFGARKLDDGEWARFAKRL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 106 RFVPGTFDDDDAFAqLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPqgdrwSRVVIEKPFGHDLASA 185
Cdd:PRK12854  89 RYVPGGFLSAGPGA-LAAAVAAARAELGGDARLVHYLAVPPSAFLDVTRALGEAGLAEG-----SRVVMEKPFGTDLASA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 186 RELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVI 265
Cdd:PRK12854 163 EALNAAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNREFIDHVQIDVPETLGVDTRAAFYDATGAYRDMV 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 266 QNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRlaePLDQTTS-RGQYAagwqggekvvGLLDEEGFAEDSTTETFA 344
Cdd:PRK12854 243 VTHLFQVLAFVAMEPPTALEPDAISEEKNKVFRSMR---PLDPAEVvRGQYS----------GYRDEPGVAPDSTTETFV 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 345 AITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNAMVIRVQPDEGVTLRFGSKVPGTAME 424
Cdd:PRK12854 310 ALKVWIDNWRWAGVPFYLRTGKRMAEGQRIISIAFREPPYSMFPAGSVGAQGPDHLTFDLADNSKVSLSFYGKRPGPGMR 389

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 425 VRDVNMDFSYGS-AFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAAhgtPDAYEAGTWGPESSLEM 503
Cdd:PRK12854 390 LDKLSLQFSLKDtGPKGDVLEAYERLILDALRGDHTLFTTADGIESLWEVSQPLLEDPPP---VKPYAPGSWGPNAIHQL 466

                        490
                 ....*....|....*..
gi 489502550 504 LRRTG------REWRRP 514
Cdd:PRK12854 467 AAPDAwrlpfeREWREL 483
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 32-508 4.46e-149

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 437.64  E-value: 4.46e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  32 VIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDfgqvvyNAVQEHCRTPF-RQQNWDRLAEGF----R 106
Cdd:PTZ00309  58 IVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSDVE------RWKKETLARFFkRLDDRECHLEQFlkhiS 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 107 FVPGTFDDDDAFAQLAETLEKL-DAERG--TGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQgdrWSRVVIEKPFGHDLA 183
Cdd:PTZ00309 132 YISGSYDEDEDFKRLNKLIERMeEAFQGpeKGGNRLFYLALPPSVFASVCEGIHRGCMSKNG---WVRVIVEKPFGRDLE 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 184 SARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARD 263
Cdd:PTZ00309 209 SSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRD 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 264 VIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLsatRLAEPLD-QTTSRGQYAAgwQGGEKVVGLLDEEGFAEDSTTET 342
Cdd:PTZ00309 289 VMQNHLLQILALLAMEKPVSLSAEDIRDEKVKVL---KCIEPIKmEECVLGQYTA--SADGSIPGYLEDEGVPKDSTTPT 363

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 343 FAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPH-LPFDATMTdelgTNAMVIRVQPDEGVTLRFGSKVPGT 421
Cdd:PTZ00309 364 FAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEfRPSGDDTQ----RNELVIRAQPSEAMYLKITAKVPGL 439

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 422 AMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALeHWAAHG--TPDAYEAGTWGPES 499
Cdd:PTZ00309 440 SNDLHQTELDLTYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLL-HQIDRGevKPEPYPFGSRGPKE 518


                 ....*....
gi 489502550 500 SLEMLRRTG 508
Cdd:PTZ00309 519 ADELIKKNG 527
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 16-508 3.66e-123

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 369.44  E-value: 3.66e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  16 DKRDKRLPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPP-TFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPfr 94
Cdd:PLN02539   5 FVKEYEKVVETGCLSIIVLGASGDLAKKKTFPALFNLYRQGFLPPdEVHIFGYARSKITDEELRDRIRGYLKDEKNAP-- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  95 QQNWDRLAEGFRFVPGTFDDDDAFAQLAETLEKLDAERGTG---GNHAFYLAIPPKSFPVVCEQLHKSGLArpQGDRWSR 171
Cdd:PLN02539  83 AEAVSKFLQLIKYVSGAYDSEEGFRRLDKEISEHEISKNSAegsSRRLFYLALPPSVYPPVCKMIKKCCMN--KSGLWTR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 172 VVIEKPFGHDLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGR 251
Cdd:PLN02539 161 IVVEKPFGKDLESAEELSSQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLPLWNRDNIANVQIVFREDFGTEGR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 252 AGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLsatRLAEPL-DQTTSRGQYAagwqggekvvGLLD 330
Cdd:PLN02539 241 GGYFDEYGIIRDIIQNHLLQVLCLVAMEKPVSLKPEHIRDEKVKVL---QSVEPIkDEEVVLGQYE----------GYRD 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 331 EEGFAEDSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHlpfDATMTDELGTNAMVIRVQPDEGV 410
Cdd:PLN02539 308 DPTVPDDSNTPTFASVVLRINNERWEGVPFILKAGKALDSRKAEIRVQFKDVPG---DIFKCQKQGRNEFVIRLQPSEAM 384

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 411 TLRFGSKVPGTAMEVRDVNMDFSYGSAFAEDS-PEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAAHG-TPD 488
Cdd:PLN02539 385 YMKLTVKQPGLEMSTVQSELDLSYGQRYQDVViPEAYERLILDTIRGDQQHFVRRDELKAAWEIFTPLLHRIDAGKvKPI 464

                        490       500
                 ....*....|....*....|
gi 489502550 489 AYEAGTWGPESSLEMLRRTG 508
Cdd:PLN02539 465 PYKQGSRGPAEADELLEKAG 484
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 31-497 4.04e-115

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 351.62  E-value: 4.04e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  31 MVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQehCRTPFRQQNWDRLAEGFR---F 107
Cdd:PLN02640  91 ITVVGASGDLAKKKIFPALFALFYEDWLPENFTVFGYARTKLTDEELRDMISSTLT--CRIDQRENCGDKMDQFLKrcfY 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 108 VPGTFDDDDAFAQLAETLEklDAERGTGGNHAFYLAIPPKSFP--VVCEQLHKSGLarpqgDRWSRVVIEKPFGHDLASA 185
Cdd:PLN02640 169 HSGQYDSEEDFAELNKKLK--EKEAGKLSNRLFYLSIPPNIFVdvVRCASLRASSE-----NGWTRVIVEKPFGRDSESS 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 186 RELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVI 265
Cdd:PLN02640 242 GELTRCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDNYGIIRDIM 321

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 266 QNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRlaePLD-QTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTTETFA 344
Cdd:PLN02640 322 QNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMK---PLQlEDVIVGQYKGHSKGGKSYPAYTDDPTVPKHSLTPTFA 398

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 345 AITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDEL--GTNAMVIRVQPDEGVTLRFGSKVPGTA 422
Cdd:PLN02640 399 AAALFINNARWDGVPFLMKAGKALHTRRAEIRVQFRHVPGNLYKRNFGTDLdkATNELVLRVQPDEAIYLKINNKVPGLG 478

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489502550 423 MEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAAHG-TPDAYEAGTWGP 497
Cdd:PLN02640 479 MRLDRSDLNLLYRARYPREIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKiIPELYPYGSRGP 554
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 31-511 5.49e-115

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 352.36  E-value: 5.49e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  31 MVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQehCRTPFRQQNWDRLAEGFR---F 107
Cdd:PLN02333 120 ITVVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAELRNMVSKTLT--CRIDKRENCGEKMEEFLKrcfY 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 108 VPGTFDDDDAFAQLAETLEklDAERGTGGNHAFYLAIPPKSF--PVVCEQLHKSglarpQGDRWSRVVIEKPFGHDLASA 185
Cdd:PLN02333 198 HSGQYDSQEHFAELDKKLK--EHEGGRVSNRLFYLSIPPNIFvdAVKCASSSAS-----SVNGWTRVIVEKPFGRDSESS 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 186 RELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVI 265
Cdd:PLN02333 271 AALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDIM 350

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 266 QNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRlaePLD-QTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTTETFA 344
Cdd:PLN02333 351 QNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMR---PIQlEDVVIGQYKSHTKGGVTYPAYTDDKTVPKGSLTPTFA 427

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 345 AITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAP-HLPFDATMTD-ELGTNAMVIRVQPDEGVTLRFGSKVPGTA 422
Cdd:PLN02333 428 AAALFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRHVPgNLYNRNFGTDlDQATNELVIRVQPDEAIYLKINNKVPGLG 507

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550 423 MEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPAL-EHWAAHGTPDAYEAGTWGPESSL 501
Cdd:PLN02333 508 MRLDRSNLNLLYAARYSKEIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLkELEEKKIIPEYYPYGSRGPVGAH 587

                        490
                 ....*....|
gi 489502550 502 EMLRRTGREW 511
Cdd:PLN02333 588 YLAARYKVRW 597
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
32-215 1.07e-96

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 290.09  E-value: 1.07e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550   32 VIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHcrTPFRQQNWDRLAEGFRFVPGT 111
Cdd:pfam00479   1 VIFGATGDLAKRKLFPALYNLYRDGLLPEGFRIIGVARRDLSDEEFRERVREALKEF--KELDEEKWDRFLERLHYVSGD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502550  112 FDDDDAFAQLAETLEKLdaERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQGdrWSRVVIEKPFGHDLASARELNKA 191
Cdd:pfam00479  79 FDDPESYEKLKERLEEH--EDETRGNRLFYLAVPPSLFGPIAENLGRAGLSEEGG--WRRVVIEKPFGHDLESARELNDQ 154

                         170       180
                  ....*....|....*....|....
gi 489502550  192 VNAVFPEEAVFRIDHYLGKETVQN 215
Cdd:pfam00479 155 LAKVFKEEQIYRIDHYLGKETVQN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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