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Conserved domains on  [gi|489504433|ref|WP_003409317|]
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MULTISPECIES: NAD(P)/FAD-dependent oxidoreductase [Mycobacterium]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 11441299)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to sulfide:quinone oxidoreductase which catalyzes the oxidation of hydrogen sulfide using quinone as the electron acceptor

EC:  1.6.-.-
Gene Ontology:  GO:0003954|GO:0006116
PubMed:  15590775|28181562

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
14-415 1.46e-153

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


:

Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 441.11  E-value: 1.46e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  14 RHRVVIIGSGFGGLNAAKKLKR---ADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQrNVQVLLGNVT 90
Cdd:COG1252    1 MKRIVIVGGGFAGLEAARRLRKklgGDAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRRA-GVRFIQGEVT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  91 HIDLAGQCVVselLGHTYQTPYDSLIVAAGAGQSYFGNDHFAEFAPGMKSIDDALELRGRILSAFEQAERssdperrAKL 170
Cdd:COG1252   80 GIDPEARTVT---LADGRTLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERAER-------RRL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 171 LTFTVVGAGPTGVEMAGQIAELAEHTLKgaFRHIDSTKARVILLDAAPAVLPPMGAKLGQRAAARLQKLGVEIQLGAMVT 250
Cdd:COG1252  150 LTIVVVGGGPTGVELAGELAELLRKLLR--YPGIDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVT 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 251 DVDRNGITVKDSdgtvRRIESACKVWSAGVSASRLGRDLAeqsrVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAVE--- 327
Cdd:COG1252  228 EVDADGVTLEDG----EEIPADTVIWAAGVKAPPLLADLG----LPTDRRGRVLVDPTLQVPGHPNVFAIGDCAAVPdpd 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 328 --GVPGVAQGAIQGAKYVASTIKAELAGanpAEREPFQYFDKGSMATVSRFSAVAKIGPVEFSGFIAWLIWLVLHLAYLI 405
Cdd:COG1252  300 gkPVPKTAQAAVQQAKVLAKNIAALLRG---KPLKPFRYRDKGCLASLGRGAAVADVGGLKLSGFLAWLLKRAIHLYFLP 376

                        410
                 ....*....|
gi 489504433 406 GFKTKITTLL 415
Cdd:COG1252  377 GFRGRLRVLL 386
 
Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
14-415 1.46e-153

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 441.11  E-value: 1.46e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  14 RHRVVIIGSGFGGLNAAKKLKR---ADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQrNVQVLLGNVT 90
Cdd:COG1252    1 MKRIVIVGGGFAGLEAARRLRKklgGDAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRRA-GVRFIQGEVT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  91 HIDLAGQCVVselLGHTYQTPYDSLIVAAGAGQSYFGNDHFAEFAPGMKSIDDALELRGRILSAFEQAERssdperrAKL 170
Cdd:COG1252   80 GIDPEARTVT---LADGRTLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERAER-------RRL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 171 LTFTVVGAGPTGVEMAGQIAELAEHTLKgaFRHIDSTKARVILLDAAPAVLPPMGAKLGQRAAARLQKLGVEIQLGAMVT 250
Cdd:COG1252  150 LTIVVVGGGPTGVELAGELAELLRKLLR--YPGIDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVT 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 251 DVDRNGITVKDSdgtvRRIESACKVWSAGVSASRLGRDLAeqsrVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAVE--- 327
Cdd:COG1252  228 EVDADGVTLEDG----EEIPADTVIWAAGVKAPPLLADLG----LPTDRRGRVLVDPTLQVPGHPNVFAIGDCAAVPdpd 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 328 --GVPGVAQGAIQGAKYVASTIKAELAGanpAEREPFQYFDKGSMATVSRFSAVAKIGPVEFSGFIAWLIWLVLHLAYLI 405
Cdd:COG1252  300 gkPVPKTAQAAVQQAKVLAKNIAALLRG---KPLKPFRYRDKGCLASLGRGAAVADVGGLKLSGFLAWLLKRAIHLYFLP 376

                        410
                 ....*....|
gi 489504433 406 GFKTKITTLL 415
Cdd:COG1252  377 GFRGRLRVLL 386
PTZ00318 PTZ00318
NADH dehydrogenase-like protein; Provisional
 13-425 7.43e-67

NADH dehydrogenase-like protein; Provisional


Pssm-ID: 185553 [Multi-domain]  Cd Length: 424  Bit Score: 220.02  E-value: 7.43e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  13 RRHRVVIIGSGFGGLNAAKKLKRADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNvQVLLGNVTHI 92
Cdd:PTZ00318   9 KKPNVVVLGTGWAGAYFVRNLDPKKYNITVISPRNHMLFTPLLPQTTTGTLEFRSICEPVRPALAKLPN-RYLRAVVYDV 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  93 DLAGQ---CVVSELLGH----TYQTPYDSLIVAAGAGQSYFGNDHFAEFAPGMKSIDDALELRGRILSAFEQAER-SSDP 164
Cdd:PTZ00318  88 DFEEKrvkCGVVSKSNNanvnTFSVPYDKLVVAHGARPNTFNIPGVEERAFFLKEVNHARGIRKRIVQCIERASLpTTSV 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 165 ERRAKLLTFTVVGAGPTGVEMAGQIAELAEHTLKGAFRHIdSTKARVILLDAAPAVLPPMGAKLGQRAAARLQKLGVEIQ 244
Cdd:PTZ00318 168 EERKRLLHFVVVGGGPTGVEFAAELADFFRDDVRNLNPEL-VEECKVTVLEAGSEVLGSFDQALRKYGQRRLRRLGVDIR 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 245 LGAMVTDVDRNGITVKDSDgtvrRIESACKVWSAGVSASRLGRDLaeqsRVELDRAGRVQVLPDLSIPGYPNVFVVGDMA 324
Cdd:PTZ00318 247 TKTAVKEVLDKEVVLKDGE----VIPTGLVVWSTGVGPGPLTKQL----KVDKTSRGRISVDDHLRVKPIPNVFALGDCA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 325 AVEGV--PGVAQGAIQGAKYVASTIKAELAGANPAErePFQYFDKGSMATVSRFSAVAKIGPVEFSGFIAWLIWLVLHLA 402
Cdd:PTZ00318 319 ANEERplPTLAQVASQQGVYLAKEFNNELKGKPMSK--PFVYRSLGSLAYLGNYSAIVQLGAFDLSGFKALLFWRSAYLT 396

                        410       420
                 ....*....|....*....|...
gi 489504433 403 YLIGFKTKITTLLSWTVTFLSTR 425
Cdd:PTZ00318 397 ILGSWRSKLYVLVNWAGTAIFGR 419
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 15-340 1.49e-50

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 173.66  E-value: 1.49e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433   15 HRVVIIGSGFGGLNAAKKLKRADVDIKLI-ARTTHHLFQPLLYQVATGIISEGEIAP--------PTRVVLRKQRNVQVL 85
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIeDEGTCPYGGCVLSKALLGAAEAPEIASlwadlykrKEEVVKKLNNGIEVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433   86 LG-NVTHIDLAGQCVVSELL--GHTYQTPYDSLIVAAGAGQSYFGndhfaefAPGMKsiddalELRGRILSAFEQAERSS 162
Cdd:pfam07992  81 LGtEVVSIDPGAKKVVLEELvdGDGETITYDRLVIATGARPRLPP-------IPGVE------LNVGFLVRTLDSAEALR 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  163 DPERRAKLLtftVVGAGPTGVEMAGQIAELAehtlkgafrhidstkARVILLDAAPAVLPPMGAKLGQRAAARLQKLGVE 242
Cdd:pfam07992 148 LKLLPKRVV---VVGGGYIGVELAAALAKLG---------------KEVTLIEALDRLLRAFDEEISAALEKALEKNGVE 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  243 IQLGAMVTDVDRNGITVKDSDGTVRRIESACKVWSAGVSASrlgRDLAEQSRVELDRAGRVQVLPDLSIPgYPNVFVVGD 322
Cdd:pfam07992 210 VRLGTSVKEIIGDGDGVEVILKDGTEIDADLVVVAIGRRPN---TELLEAAGLELDERGGIVVDEYLRTS-VPGIYAAGD 285

                         330
                  ....*....|....*...
gi 489504433  323 MAAveGVPGVAQGAIQGA 340
Cdd:pfam07992 286 CRV--GGPELAQNAVAQG 301
 
Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
14-415 1.46e-153

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 441.11  E-value: 1.46e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  14 RHRVVIIGSGFGGLNAAKKLKR---ADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQrNVQVLLGNVT 90
Cdd:COG1252    1 MKRIVIVGGGFAGLEAARRLRKklgGDAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRRA-GVRFIQGEVT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  91 HIDLAGQCVVselLGHTYQTPYDSLIVAAGAGQSYFGNDHFAEFAPGMKSIDDALELRGRILSAFEQAERssdperrAKL 170
Cdd:COG1252   80 GIDPEARTVT---LADGRTLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERAER-------RRL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 171 LTFTVVGAGPTGVEMAGQIAELAEHTLKgaFRHIDSTKARVILLDAAPAVLPPMGAKLGQRAAARLQKLGVEIQLGAMVT 250
Cdd:COG1252  150 LTIVVVGGGPTGVELAGELAELLRKLLR--YPGIDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVT 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 251 DVDRNGITVKDSdgtvRRIESACKVWSAGVSASRLGRDLAeqsrVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAVE--- 327
Cdd:COG1252  228 EVDADGVTLEDG----EEIPADTVIWAAGVKAPPLLADLG----LPTDRRGRVLVDPTLQVPGHPNVFAIGDCAAVPdpd 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 328 --GVPGVAQGAIQGAKYVASTIKAELAGanpAEREPFQYFDKGSMATVSRFSAVAKIGPVEFSGFIAWLIWLVLHLAYLI 405
Cdd:COG1252  300 gkPVPKTAQAAVQQAKVLAKNIAALLRG---KPLKPFRYRDKGCLASLGRGAAVADVGGLKLSGFLAWLLKRAIHLYFLP 376

                        410
                 ....*....|
gi 489504433 406 GFKTKITTLL 415
Cdd:COG1252  377 GFRGRLRVLL 386
PTZ00318 PTZ00318
NADH dehydrogenase-like protein; Provisional
 13-425 7.43e-67

NADH dehydrogenase-like protein; Provisional


Pssm-ID: 185553 [Multi-domain]  Cd Length: 424  Bit Score: 220.02  E-value: 7.43e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  13 RRHRVVIIGSGFGGLNAAKKLKRADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNvQVLLGNVTHI 92
Cdd:PTZ00318   9 KKPNVVVLGTGWAGAYFVRNLDPKKYNITVISPRNHMLFTPLLPQTTTGTLEFRSICEPVRPALAKLPN-RYLRAVVYDV 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  93 DLAGQ---CVVSELLGH----TYQTPYDSLIVAAGAGQSYFGNDHFAEFAPGMKSIDDALELRGRILSAFEQAER-SSDP 164
Cdd:PTZ00318  88 DFEEKrvkCGVVSKSNNanvnTFSVPYDKLVVAHGARPNTFNIPGVEERAFFLKEVNHARGIRKRIVQCIERASLpTTSV 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 165 ERRAKLLTFTVVGAGPTGVEMAGQIAELAEHTLKGAFRHIdSTKARVILLDAAPAVLPPMGAKLGQRAAARLQKLGVEIQ 244
Cdd:PTZ00318 168 EERKRLLHFVVVGGGPTGVEFAAELADFFRDDVRNLNPEL-VEECKVTVLEAGSEVLGSFDQALRKYGQRRLRRLGVDIR 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 245 LGAMVTDVDRNGITVKDSDgtvrRIESACKVWSAGVSASRLGRDLaeqsRVELDRAGRVQVLPDLSIPGYPNVFVVGDMA 324
Cdd:PTZ00318 247 TKTAVKEVLDKEVVLKDGE----VIPTGLVVWSTGVGPGPLTKQL----KVDKTSRGRISVDDHLRVKPIPNVFALGDCA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 325 AVEGV--PGVAQGAIQGAKYVASTIKAELAGANPAErePFQYFDKGSMATVSRFSAVAKIGPVEFSGFIAWLIWLVLHLA 402
Cdd:PTZ00318 319 ANEERplPTLAQVASQQGVYLAKEFNNELKGKPMSK--PFVYRSLGSLAYLGNYSAIVQLGAFDLSGFKALLFWRSAYLT 396

                        410       420
                 ....*....|....*....|...
gi 489504433 403 YLIGFKTKITTLLSWTVTFLSTR 425
Cdd:PTZ00318 397 ILGSWRSKLYVLVNWAGTAIFGR 419
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 15-340 1.49e-50

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 173.66  E-value: 1.49e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433   15 HRVVIIGSGFGGLNAAKKLKRADVDIKLI-ARTTHHLFQPLLYQVATGIISEGEIAP--------PTRVVLRKQRNVQVL 85
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIeDEGTCPYGGCVLSKALLGAAEAPEIASlwadlykrKEEVVKKLNNGIEVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433   86 LG-NVTHIDLAGQCVVSELL--GHTYQTPYDSLIVAAGAGQSYFGndhfaefAPGMKsiddalELRGRILSAFEQAERSS 162
Cdd:pfam07992  81 LGtEVVSIDPGAKKVVLEELvdGDGETITYDRLVIATGARPRLPP-------IPGVE------LNVGFLVRTLDSAEALR 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  163 DPERRAKLLtftVVGAGPTGVEMAGQIAELAehtlkgafrhidstkARVILLDAAPAVLPPMGAKLGQRAAARLQKLGVE 242
Cdd:pfam07992 148 LKLLPKRVV---VVGGGYIGVELAAALAKLG---------------KEVTLIEALDRLLRAFDEEISAALEKALEKNGVE 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  243 IQLGAMVTDVDRNGITVKDSDGTVRRIESACKVWSAGVSASrlgRDLAEQSRVELDRAGRVQVLPDLSIPgYPNVFVVGD 322
Cdd:pfam07992 210 VRLGTSVKEIIGDGDGVEVILKDGTEIDADLVVVAIGRRPN---TELLEAAGLELDERGGIVVDEYLRTS-VPGIYAAGD 285

                         330
                  ....*....|....*...
gi 489504433  323 MAAveGVPGVAQGAIQGA 340
Cdd:pfam07992 286 CRV--GGPELAQNAVAQG 301
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 37-326 1.37e-22

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 97.96  E-value: 1.37e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  37 DVDIKLIARTTHHLFQP--LLYQVATGIISEGEIAPPTRVVLRKqRNVQVLLGN-VTHIDLAGQCV-VSEllGHTYqtPY 112
Cdd:COG0446    5 DAEITVIEKGPHHSYQPcgLPYYVGGGIKDPEDLLVRTPESFER-KGIDVRTGTeVTAIDPEAKTVtLRD--GETL--SY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 113 DSLIVAAGAGQSYF---GNDHfaEFAPGMKSIDDALELRGRIlsafeqaeRSSDPERraklltFTVVGAGPTGVEMAgqi 189
Cdd:COG0446   80 DKLVLATGARPRPPpipGLDL--PGVFTLRTLDDADALREAL--------KEFKGKR------AVVIGGGPIGLELA--- 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 190 AELAEHtlkgafrhidstKARVILLDAAPAVLPPMGAKLGQRAAARLQKLGVEIQLGAMVTDVD-RNGITVKDSDGtvRR 268
Cdd:COG0446  141 EALRKR------------GLKVTLVERAPRLLGVLDPEMAALLEEELREHGVELRLGETVVAIDgDDKVAVTLTDG--EE 206

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489504433 269 IESACKVWSAGVSASrlgRDLAEQSRVELDRAGRVQVLPDLSIpGYPNVFVVGDMAAV 326
Cdd:COG0446  207 IPADLVVVAPGVRPN---TELAKDAGLALGERGWIKVDETLQT-SDPDVYAAGDCAEV 260
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 174-347 2.76e-10

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 62.03  E-value: 2.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 174 TVVGAGPTGVEMAgqiaelaehtlkGAFRHIDStkaRVILLDAAPAVLPPMGAKLGQRAAARLQKLGVEIQLGAMVTDVD 253
Cdd:COG1249  172 VVIGGGYIGLEFA------------QIFARLGS---EVTLVERGDRLLPGEDPEISEALEKALEKEGIDILTGAKVTSVE 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 254 R--NGITVKDSDGTVRRIESACKV-WSAGVSA--SRLGrdlAEQSRVELDRAGRVQVLPDLSIpGYPNVFVVGDMAaveG 328
Cdd:COG1249  237 KtgDGVTVTLEDGGGEEAVEADKVlVATGRRPntDGLG---LEAAGVELDERGGIKVDEYLRT-SVPGIYAIGDVT---G 309

                        170
                 ....*....|....*....
gi 489504433 329 VPGVAQGAIQGAKYVASTI 347
Cdd:COG1249  310 GPQLAHVASAEGRVAAENI 328
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
17-328 4.91e-09

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 58.00  E-value: 4.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  17 VVIIGSGFGGLNAAKKLKRADVD--IKLIARTT---------HHLFQplLYQVATGII--SEGEIApptrvvlrKQRNVq 83
Cdd:PRK04965   5 IVIIGSGFAARQLVKNIRKQDAHipITLITADSgdeynkpdlSHVFS--QGQRADDLTrqSAGEFA--------EQFNL- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  84 VLLGN--VTHIDLAGQCVVSEllGHTYqtPYDSLIVAAGAgqsyfgndhfAEFAPGMKSidDALELRGRILSAFEQAErs 161
Cdd:PRK04965  74 RLFPHtwVTDIDAEAQVVKSQ--GNQW--QYDKLVLATGA----------SAFVPPIPG--RELMLTLNSQQEYRAAE-- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 162 sDPERRAKllTFTVVGAGPTGVEMAGQIAelaehtlkgafrhidSTKARVILLDAA----PAVLPP-MGAKLGQraaaRL 236
Cdd:PRK04965 136 -TQLRDAQ--RVLVVGGGLIGTELAMDLC---------------RAGKAVTLVDNAasllASLMPPeVSSRLQH----RL 193

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 237 QKLGVEIQLGAMVTDVDRN--GITVKDSDGtvRRIESACKVWSAGVSASrlgRDLAEQSRVELDRAgrVQVLPDLSIPGy 314
Cdd:PRK04965 194 TEMGVHLLLKSQLQGLEKTdsGIRATLDSG--RSIEVDAVIAAAGLRPN---TALARRAGLAVNRG--IVVDSYLQTSA- 265

                        330
                 ....*....|....
gi 489504433 315 PNVFVVGDMAAVEG 328
Cdd:PRK04965 266 PDIYALGDCAEING 279
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
15-337 1.79e-08

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 55.90  E-value: 1.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  15 HRVVIIGSGFGGLNAAKKLKRADVDIKLI--------ARTTHHLFQPLlyqvatGI---ISEGEIAppTRvvLRKQ---R 80
Cdd:COG0492    1 YDVVIIGAGPAGLTAAIYAARAGLKTLVIeggepggqLATTKEIENYP------GFpegISGPELA--ER--LREQaerF 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  81 NVQVLLGNVTHIDLAGQCVVSELL-GHTYQTpyDSLIVAAGAGQSYfgndhfaefaPGMKSIDdalELRGRILSAFEQAE 159
Cdd:COG0492   71 GAEILLEEVTSVDKDDGPFRVTTDdGTEYEA--KAVIIATGAGPRK----------LGLPGEE---EFEGRGVSYCATCD 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 160 RssdPERRAKllTFTVVGAGPTGVEMAGQIAELAEH-TL---KGAFRHIDSTKARvilLDAAPavlppmgaklgqraaar 235
Cdd:COG0492  136 G---FFFRGK--DVVVVGGGDSALEEALYLTKFASKvTLihrRDELRASKILVER---LRANP----------------- 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 236 lqklGVEIQLGAMVTDVDRN----GITVKDSD-GTVRRIEsACKVWSAGVSASRLgrDLAEQSRVELDRAGRVQVLPDL- 309
Cdd:COG0492  191 ----KIEVLWNTEVTEIEGDgrveGVTLKNVKtGEEKELE-VDGVFVAIGLKPNT--ELLKGLGLELDEDGYIVVDEDMe 263

                        330       340       350
                 ....*....|....*....|....*....|..
gi 489504433 310 -SIPGypnVFVVGDMA--AVEGVP-GVAQGAI 337
Cdd:COG0492  264 tSVPG---VFAAGDVRdyKYRQAAtAAGEGAI 292
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 175-260 8.74e-08

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 49.51  E-value: 8.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  175 VVGAGPTGVEMAGQIAELAehtlkgafrhidstkARVILLDAAPAVLPPMGAKLGQRAAARLQKLGVEIQLGAMVTDVDR 254
Cdd:pfam00070   4 VVGGGYIGLELAGALARLG---------------SKVTVVERRDRLLPGFDPEIAKILQEKLEKNGIEFLLNTTVEAIEG 68


                  ....*.
gi 489504433  255 NGITVK 260
Cdd:pfam00070  69 NGDGVV 74
PRK13512 PRK13512
coenzyme A disulfide reductase; Provisional
 16-347 3.91e-05

coenzyme A disulfide reductase; Provisional


Pssm-ID: 184103 [Multi-domain]  Cd Length: 438  Bit Score: 45.93  E-value: 3.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  16 RVVIIGSGFGGLNAAKKLKRADVDIKLIA----RTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNVQV-LLGNVT 90
Cdd:PRK13512   3 KIIVVGAVAGGATCASQIRRLDKESDIIIfekdRDMSFANCALPYYIGEVVEDRKYALAYTPEKFYDRKQITVkTYHEVI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  91 HIDLAGQCVvsELLGH----TYQTPYDSLIVAAGAGQSYFGNDHFAEFApgMKSIDDAlelrgrilSAFEQAERSSDPER 166
Cdd:PRK13512  83 AINDERQTV--TVLNRktneQFEESYDKLILSPGASANSLGFESDITFT--LRNLEDT--------DAIDQFIKANQVDK 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 167 RaklltfTVVGAGPTGVEMAGQIAElaehtlkgafRHIDSTkarviLLDAAPAVLPPMGAKLGQRAAARLQKLGVEIQLG 246
Cdd:PRK13512 151 A------LVVGAGYISLEVLENLYE----------RGLHPT-----LIHRSDKINKLMDADMNQPILDELDKREIPYRLN 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 247 AMVTDVDRNGITVK--DSDGTVRRIEsackvwsaGVsASRLGRDLAEQSRVELDRAGRVQVlPDLSIPGYPNVFVVGDMA 324
Cdd:PRK13512 210 EEIDAINGNEVTFKsgKVEHYDMIIE--------GV-GTHPNSKFIESSNIKLDDKGFIPV-NDKFETNVPNIYAIGDII 279

                        330       340       350
                 ....*....|....*....|....*....|.
gi 489504433 325 AV--------EGVPgVAQGAIQGAKYVASTI 347
Cdd:PRK13512 280 TShyrhvdlpASVP-LAWGAHRAASIVAEQI 309
PRK07251 PRK07251
FAD-containing oxidoreductase;
175-322 2.03e-04

FAD-containing oxidoreductase;


Pssm-ID: 180907 [Multi-domain]  Cd Length: 438  Bit Score: 43.58  E-value: 2.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 175 VVGAGPTGVEMAGQIAELAehtlkgafrhidstkARVILLDAAPAVLPPMGAKLGQRAAARLQKLGVEIQLGAMVTDVDR 254
Cdd:PRK07251 162 IIGGGNIGLEFAGLYNKLG---------------SKVTVLDAASTILPREEPSVAALAKQYMEEDGITFLLNAHTTEVKN 226

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 255 NG--ITVKDSDGTVRrieSACKVWSAGVSASRLGRDLaEQSRVELDRAGRVQVlPDLSIPGYPNVFVVGD 322
Cdd:PRK07251 227 DGdqVLVVTEDETYR---FDALLYATGRKPNTEPLGL-ENTDIELTERGAIKV-DDYCQTSVPGVFAVGD 291
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 136-322 2.04e-04

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 43.63  E-value: 2.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 136 PGMKSIDDAlelrgRILS---AFEQAERssdPERraklltFTVVGAGPTGVEMAgqiaeLAEHTLkGafrhidstkARVI 212
Cdd:PRK06292 146 PGVWLILGD-----RLLTsddAFELDKL---PKS------LAVIGGGVIGLELG-----QALSRL-G---------VKVT 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 213 LLDAAPAVLPPMGAKLGQRAAARLQKlGVEIQLGAMVTDVDRNG---ITVKDSDGTVRRIEsACKVWSAgvsasrLGR-- 287
Cdd:PRK06292 197 VFERGDRILPLEDPEVSKQAQKILSK-EFKIKLGAKVTSVEKSGdekVEELEKGGKTETIE-ADYVLVA------TGRrp 268

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 489504433 288 ---DLA-EQSRVELDRAGRVQVLPDL--SIpgyPNVFVVGD 322
Cdd:PRK06292 269 ntdGLGlENTGIELDERGRPVVDEHTqtSV---PGIYAAGD 306
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 9-43 3.40e-04

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 42.93  E-value: 3.40e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 489504433   9 AQPPRRHRVVIIGSGFGGLNAAKKLKRADVDIKLI 43
Cdd:COG2072    1 TAATEHVDVVVIGAGQAGLAAAYHLRRAGIDFVVL 35
PRK06327 PRK06327
dihydrolipoamide dehydrogenase; Validated
 175-322 8.74e-04

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235779 [Multi-domain]  Cd Length: 475  Bit Score: 41.45  E-value: 8.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433 175 VVGAGPTGVEMAGQIAELAehtlkgafrhidstkARVILLDAAPAVLPPMGAKLGQRAAARLQKLGVEIQLGAMVTDV-- 252
Cdd:PRK06327 188 VIGAGVIGLELGSVWRRLG---------------AEVTILEALPAFLAAADEQVAKEAAKAFTKQGLDIHLGVKIGEIkt 252

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489504433 253 DRNGITVK--DSDGTVRRIESACKVWSAGVSASRLGRdLAEQSRVELDRAGRVQVLPDLSIpGYPNVFVVGD 322
Cdd:PRK06327 253 GGKGVSVAytDADGEAQTLEVDKLIVSIGRVPNTDGL-GLEAVGLKLDERGFIPVDDHCRT-NVPNVYAIGD 322
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 16-120 1.37e-03

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 40.56  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489504433  16 RVVIIGSGFGGLNAAKKLKRADVDIKLIARtTHHLFQPLLYQVATGIISEgeiapptrvvLRKqRNVQVLLG-NVTHIDL 94
Cdd:COG0446  126 RAVVIGGGPIGLELAEALRKRGLKVTLVER-APRLLGVLDPEMAALLEEE----------LRE-HGVELRLGeTVVAIDG 193

                         90       100
                 ....*....|....*....|....*.
gi 489504433  95 AGQCVVSELLGHTYqtPYDSLIVAAG 120
Cdd:COG0446  194 DDKVAVTLTDGEEI--PADLVVVAPG 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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