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Conserved domains on  [gi|489505319|ref|WP_003410200|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Mycobacterium]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-88 1.85e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 91.10  E-value: 1.85e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489505319   1 MSTYRSPDRA---WQALADGTRRAIVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGTRRVYQLDPTG 77
Cdd:COG0640    1 MSETKELEELaelFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEA 80

                         90
                 ....*....|.
gi 489505319  78 LAALRTDLDRF 88
Cdd:COG0640   81 LAELLEWLLEL 91
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-88 1.85e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 91.10  E-value: 1.85e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489505319   1 MSTYRSPDRA---WQALADGTRRAIVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGTRRVYQLDPTG 77
Cdd:COG0640    1 MSETKELEELaelFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEA 80

                         90
                 ....*....|.
gi 489505319  78 LAALRTDLDRF 88
Cdd:COG0640   81 LAELLEWLLEL 91
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 8-81 8.44e-24

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 86.36  E-value: 8.44e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489505319   8 DRAWQALADGTRRAIVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGTRRVYQLDPTGLAAL 81
Cdd:NF033788   2 AELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAEL 75
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-75 2.76e-18

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 72.33  E-value: 2.76e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489505319  12 QALADGTRRAIVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGTRRVYQLDP 75
Cdd:cd00090    2 KALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
22-86 4.43e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 71.47  E-value: 4.43e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489505319    22 IVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGTRRVYQLDPTGLAALRTDLD 86
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 10-76 9.43e-18

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 70.90  E-value: 9.43e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489505319  10 AWQALADGTRRAIVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGTRRVYQLDPT 76
Cdd:NF033789   1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTT 67
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 16-60 1.14e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 57.07  E-value: 1.14e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 489505319   16 DGTRRAIVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLV 60
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 14-75 7.79e-06

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 41.34  E-value: 7.79e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489505319  14 LADGTRRAIVERL-AHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGTRRVYQLDP 75
Cdd:PRK10141  13 LSDETRLGIVLLLrESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSP 75
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-88 1.85e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 91.10  E-value: 1.85e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489505319   1 MSTYRSPDRA---WQALADGTRRAIVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGTRRVYQLDPTG 77
Cdd:COG0640    1 MSETKELEELaelFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEA 80

                         90
                 ....*....|.
gi 489505319  78 LAALRTDLDRF 88
Cdd:COG0640   81 LAELLEWLLEL 91
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 8-81 8.44e-24

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 86.36  E-value: 8.44e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489505319   8 DRAWQALADGTRRAIVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGTRRVYQLDPTGLAAL 81
Cdd:NF033788   2 AELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAEL 75
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-75 2.76e-18

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 72.33  E-value: 2.76e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489505319  12 QALADGTRRAIVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGTRRVYQLDP 75
Cdd:cd00090    2 KALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
22-86 4.43e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 71.47  E-value: 4.43e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489505319    22 IVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGTRRVYQLDPTGLAALRTDLD 86
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 10-76 9.43e-18

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 70.90  E-value: 9.43e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489505319  10 AWQALADGTRRAIVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGTRRVYQLDPT 76
Cdd:NF033789   1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTT 67
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
1-75 4.13e-16

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 67.75  E-value: 4.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489505319   1 MSTYRSPDRAWQALADGTRRAIVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAG-----TRRVYQLDP 75
Cdd:COG1777    1 MSDDEDLDRLLDALGNPTRRRILALLSEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREGredgrARKYYRLSA 80
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 16-60 1.14e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 57.07  E-value: 1.14e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 489505319   16 DGTRRAIVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLV 60
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
12-60 2.10e-09

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 50.34  E-value: 2.10e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 489505319  12 QALADGTRRAIVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLV 60
Cdd:COG4189   14 KALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLI 62
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 12-60 3.23e-08

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 46.38  E-value: 3.23e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 489505319   12 QALADGTRRAIVERLA-HGPLAVGELARDLPVSRPAVSQHLKVLKTARLV 60
Cdd:pfam12840   5 EALADPTRLRILRALVgDEPLTASELARRLDISRNTLSYHLRKLEEAGLV 54
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
6-81 1.97e-07

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 46.84  E-value: 1.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489505319   6 SPDRAWQALADGTRRAIVERL-AHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGT-----RRVYQLDPTGLA 79
Cdd:COG2345    2 TDTPALAALADPTRRRILELLkRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETERRgrgrpAKLYRLTEAGRA 81


                 ..
gi 489505319  80 AL 81
Cdd:COG2345   82 RF 83
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
13-75 1.27e-06

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 44.10  E-value: 1.27e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489505319  13 ALADGTRRAIVERLA-HGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGTRRVYQLDP 75
Cdd:COG3398   93 YLRRETPRRILLYLLeNPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNP 156
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 14-75 7.79e-06

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 41.34  E-value: 7.79e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489505319  14 LADGTRRAIVERL-AHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGTRRVYQLDP 75
Cdd:PRK10141  13 LSDETRLGIVLLLrESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSP 75
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
19-82 2.12e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 38.72  E-value: 2.12e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489505319  19 RRAIVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCdrpaGTRRVYQLDPTGLAALR 82
Cdd:COG4742   18 RKNILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLIE----RDDGEYELTTLGRLVVE 77
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
26-101 1.59e-03

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 35.68  E-value: 1.59e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489505319  26 LAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRP-AGTRRVY-QLDPTGLAALRTDLDRFWTRALTGYAQLID 101
Cdd:COG1510   38 LSDEPLTADELAEELGVSKSSVSTALRELEDWGLVRRVRkPGDRKDYfRAEKDVWELFRRVFRERLRREIDPTLELLR 115
BirA COG1654
Biotin operon repressor [Transcription];
18-55 3.29e-03

Biotin operon repressor [Transcription];


Pssm-ID: 441260 [Multi-domain]  Cd Length: 324  Bit Score: 35.35  E-value: 3.29e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 489505319  18 TRRAIVERLAHGPLAVGE-LARDLPVSRPAVSQHLKVLK 55
Cdd:COG1654    5 TRLKLLRLLADGEFHSGEeLAEELGVSRAAVWKHIKALR 43
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 27-69 6.23e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 32.56  E-value: 6.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 489505319   27 AHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGTRR 69
Cdd:pfam12802  16 RNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADR 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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