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Conserved domains on  [gi|489506252|ref|WP_003411127|]
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MULTISPECIES: antitoxin ParD2 [Mycobacterium]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Unstab_antitox super family cl09921
Putative addiction module component; This entry defines several short bacterial proteins, ...
12-69 5.62e-12

Putative addiction module component; This entry defines several short bacterial proteins, typically about 75 amino acids long, which are always found as part of a pair (at least) of small genes. The other protein in the pair always belongs to a family of plasmid stabilization proteins (IPR007712). It is likely that this protein and its partner comprise some form of addiction module - a pair of genes consisting of a stable toxin and an unstable antitoxin which mediate programmed cell death - although these gene-pairs are usually found on the bacterial main chromosome.


The actual alignment was detected with superfamily member TIGR02574:

Pssm-ID: 471951  Cd Length: 63  Bit Score: 54.71  E-value: 5.62e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489506252  12 DALSRDEQIELVEHINGNLA-EGMHI--SEANQALIEARANDTDDAHW--STIDDFDKRIRAR 69
Cdd:TIGR02574  1 LALSPDERIQLVEDIWDSIAaEAKHLilTEAQKAELDRRLADYKADPSkaSPWEEVRARIRKR 63
 
Name Accession Description Interval E-value
stabl_TIGR02574 TIGR02574
putative addiction module component, TIGR02574 family; Members of this family are bacterial ...
12-69 5.62e-12

putative addiction module component, TIGR02574 family; Members of this family are bacterial proteins, typically are about 75 amino acids long, always found as part of a pair (at least) of two small genes. The other in the pair always belongs to a subfamily of the larger family pfam05016 (although not necessarily scoring above the designated cutoff), which contains plasmid stabilization proteins. It is likely that this protein and its pfam05016 member partner comprise some form of addiction module, although these gene pairs usually are found on the bacterial main chromosome. [Mobile and extrachromosomal element functions, Other]


Pssm-ID: 131625  Cd Length: 63  Bit Score: 54.71  E-value: 5.62e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489506252  12 DALSRDEQIELVEHINGNLA-EGMHI--SEANQALIEARANDTDDAHW--STIDDFDKRIRAR 69
Cdd:TIGR02574  1 LALSPDERIQLVEDIWDSIAaEAKHLilTEAQKAELDRRLADYKADPSkaSPWEEVRARIRKR 63
 
Name Accession Description Interval E-value
stabl_TIGR02574 TIGR02574
putative addiction module component, TIGR02574 family; Members of this family are bacterial ...
12-69 5.62e-12

putative addiction module component, TIGR02574 family; Members of this family are bacterial proteins, typically are about 75 amino acids long, always found as part of a pair (at least) of two small genes. The other in the pair always belongs to a subfamily of the larger family pfam05016 (although not necessarily scoring above the designated cutoff), which contains plasmid stabilization proteins. It is likely that this protein and its pfam05016 member partner comprise some form of addiction module, although these gene pairs usually are found on the bacterial main chromosome. [Mobile and extrachromosomal element functions, Other]


Pssm-ID: 131625  Cd Length: 63  Bit Score: 54.71  E-value: 5.62e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489506252  12 DALSRDEQIELVEHINGNLA-EGMHI--SEANQALIEARANDTDDAHW--STIDDFDKRIRAR 69
Cdd:TIGR02574  1 LALSPDERIQLVEDIWDSIAaEAKHLilTEAQKAELDRRLADYKADPSkaSPWEEVRARIRKR 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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