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Conserved domains on  [gi|489511062|ref|WP_003415914|]
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MULTISPECIES: 1-acyl-sn-glycerol-3-phosphate acyltransferase [Mycobacterium]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 11415180)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid; 1-acyl-sn-glycerol-3-phosphate acyltransferase, for example, converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position by utilizing either acyl-CoA or acyl-ACP as the fatty acyl donor;

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0008654|GO:0016746
PubMed:  18718904|18931347
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 55-286 1.25e-28

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 109.33  E-value: 1.25e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062  55 LVVMPLPGRTRVQRIYCRLVLRLFGVRITVSGSP-VRNLRGVLVVSGHVSWLDVFCIGSVLPG--SFVARADMFTGRTIG 131
Cdd:COG0204    4 LFLLLRRFRYRLVRLWARLLLRLLGVRVRVEGLEnLPADGPVLIVANHQSWLDILLLLAALPRpvRFVAKKELFKIPLLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062 132 IVARILKIIPIERASLRRLPGVVDTIARRLRAGQTVVAFPEGT-TWCGRPGDdagrpaaragagcshrgcgaFYPAMFQA 210
Cdd:COG0204   84 WLLRALGAIPVDRSKRRAALRALRQAVEALKAGESLVIFPEGTrSPDGRLLP--------------------FKTGAARL 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062 211 AIDAGRPVQPLRLTYHHvdgtvstapafvgddtlvRSVCRLLTVRRTLAWVRV----ESLQLPGTDRRNLARRCQSAVLA 286
Cdd:COG0204  144 ALEAGVPIVPVAIDGTE------------------RALPKGFLPRPGKVTVRIgppiDPSDLEGEDRRELAERLRAAIEA 205
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 55-286 1.25e-28

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 109.33  E-value: 1.25e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062  55 LVVMPLPGRTRVQRIYCRLVLRLFGVRITVSGSP-VRNLRGVLVVSGHVSWLDVFCIGSVLPG--SFVARADMFTGRTIG 131
Cdd:COG0204    4 LFLLLRRFRYRLVRLWARLLLRLLGVRVRVEGLEnLPADGPVLIVANHQSWLDILLLLAALPRpvRFVAKKELFKIPLLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062 132 IVARILKIIPIERASLRRLPGVVDTIARRLRAGQTVVAFPEGT-TWCGRPGDdagrpaaragagcshrgcgaFYPAMFQA 210
Cdd:COG0204   84 WLLRALGAIPVDRSKRRAALRALRQAVEALKAGESLVIFPEGTrSPDGRLLP--------------------FKTGAARL 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062 211 AIDAGRPVQPLRLTYHHvdgtvstapafvgddtlvRSVCRLLTVRRTLAWVRV----ESLQLPGTDRRNLARRCQSAVLA 286
Cdd:COG0204  144 ALEAGVPIVPVAIDGTE------------------RALPKGFLPRPGKVTVRIgppiDPSDLEGEDRRELAERLRAAIEA 205
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 71-227 1.18e-25

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 100.42  E-value: 1.18e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062  71 CRLVLRLFGVRITVSGS-PVRNLRGVLVVSGHVSWLDVFCIGSVLPG--SFVARADMFTGRTIGIVARILKIIPIERASL 147
Cdd:cd07989    1 LRLLLRLLGVRVRVEGLeNLPPKGPVIIVANHQSYLDPLVLGAALPRpiRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062 148 RRLPGVVDTIARRLRAGQTVVAFPEGTTWcgRPGDDagrpaaragagcshrgcGAFYPAMFQAAIDAGRPVQPLRLTYHH 227
Cdd:cd07989   81 RSAREALREAIEALKEGESVVIFPEGTRS--RDGEL-----------------LPFKSGAFRLAKEAGVPIVPVAISGTW 141
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 81-223 1.81e-23

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 93.11  E-value: 1.81e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062   81 RITVSGS-PVRNLRGVLVVSGHVSWLDVFCIGSVLPGS-----FVARADMFTGRTIGIVARILKIIPIERASLRRLPGVV 154
Cdd:pfam01553   1 RIEVHGLeNLPRGGPAIVVANHQSYLDVLLLSLALYKRgrplvFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489511062  155 DTIARRLRAGQTVVAFPEGTTWCGrpgddagrpaaragagcshRGCGAFYPAMFQAAIDAGRPVQPLRL 223
Cdd:pfam01553  81 EYLVELLREGKLVVIFPEGTRSRE-------------------GELLPFKKGAFRLAIEAGVPIVPVAI 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 95-226 2.82e-19

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 81.63  E-value: 2.82e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062    95 VLVVSGHVSWLDVFCIGSVLP-----GSFVARADMFTGRTIGIVARILKIIPIERASLRRLPGVVDTIARRLRAGQTVVA 169
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPrklgrVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLKEGEWLLI 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 489511062   170 FPEGTTWCgrpgddagrpaaragagcsHRGCGAFYPAMFQAAIDAGRPVQPLRLTYH 226
Cdd:smart00563  81 FPEGTRSR-------------------PGKLLPFKKGAARLALEAGVPIVPVAIRGT 118
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 79-223 8.40e-14

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 66.99  E-value: 8.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062   79 GVRITVSGS---PVRNlrGVLVVSGHVSWLDVFCIGSVLPG--SFVARADMFTGRTIGIVARILKIIPIERASLRRLPGV 153
Cdd:TIGR00530   1 GLKVEVVGPenlPAKS--PVLVVANHQSNLDPLTLSAAFPPpiVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATA 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062  154 VDTIARRLRAGQTVVAFPEGTTWCGrpgddagrpaaragagcshRGCGAFYPAMFQAAIDAGRPVQPLRL 223
Cdd:TIGR00530  79 LKAAIEVLKQGRSIGVFPEGTRSRG-------------------RDILPFKKGAFHIAIKAGVPILPVVL 129
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 72-174 7.10e-08

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 53.77  E-value: 7.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062   72 RLVLRLF---GVRITVSGspVRNL---RGVLVVSGHVSWLDVFCIGSVLPGS--FVARADMFTGRTIGIVARILKIIPIE 143
Cdd:PRK08633  416 RFLLLLLmhtRYRLRVEG--RENIpakGGALLLGNHVSWIDWALLQAASPRPirFVMERSIYEKWYLKWFFKLFGVIPIS 493

                          90       100       110
                  ....*....|....*....|....*....|.
gi 489511062  144 RASLRRLpgvVDTIARRLRAGQTVVAFPEGT 174
Cdd:PRK08633  494 SGGSKES---LEFIRKALDDGEVVCIFPEGA 521
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 55-286 1.25e-28

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 109.33  E-value: 1.25e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062  55 LVVMPLPGRTRVQRIYCRLVLRLFGVRITVSGSP-VRNLRGVLVVSGHVSWLDVFCIGSVLPG--SFVARADMFTGRTIG 131
Cdd:COG0204    4 LFLLLRRFRYRLVRLWARLLLRLLGVRVRVEGLEnLPADGPVLIVANHQSWLDILLLLAALPRpvRFVAKKELFKIPLLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062 132 IVARILKIIPIERASLRRLPGVVDTIARRLRAGQTVVAFPEGT-TWCGRPGDdagrpaaragagcshrgcgaFYPAMFQA 210
Cdd:COG0204   84 WLLRALGAIPVDRSKRRAALRALRQAVEALKAGESLVIFPEGTrSPDGRLLP--------------------FKTGAARL 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062 211 AIDAGRPVQPLRLTYHHvdgtvstapafvgddtlvRSVCRLLTVRRTLAWVRV----ESLQLPGTDRRNLARRCQSAVLA 286
Cdd:COG0204  144 ALEAGVPIVPVAIDGTE------------------RALPKGFLPRPGKVTVRIgppiDPSDLEGEDRRELAERLRAAIEA 205
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 71-227 1.18e-25

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 100.42  E-value: 1.18e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062  71 CRLVLRLFGVRITVSGS-PVRNLRGVLVVSGHVSWLDVFCIGSVLPG--SFVARADMFTGRTIGIVARILKIIPIERASL 147
Cdd:cd07989    1 LRLLLRLLGVRVRVEGLeNLPPKGPVIIVANHQSYLDPLVLGAALPRpiRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062 148 RRLPGVVDTIARRLRAGQTVVAFPEGTTWcgRPGDDagrpaaragagcshrgcGAFYPAMFQAAIDAGRPVQPLRLTYHH 227
Cdd:cd07989   81 RSAREALREAIEALKEGESVVIFPEGTRS--RDGEL-----------------LPFKSGAFRLAKEAGVPIVPVAISGTW 141
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 81-223 1.81e-23

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 93.11  E-value: 1.81e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062   81 RITVSGS-PVRNLRGVLVVSGHVSWLDVFCIGSVLPGS-----FVARADMFTGRTIGIVARILKIIPIERASLRRLPGVV 154
Cdd:pfam01553   1 RIEVHGLeNLPRGGPAIVVANHQSYLDVLLLSLALYKRgrplvFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489511062  155 DTIARRLRAGQTVVAFPEGTTWCGrpgddagrpaaragagcshRGCGAFYPAMFQAAIDAGRPVQPLRL 223
Cdd:pfam01553  81 EYLVELLREGKLVVIFPEGTRSRE-------------------GELLPFKKGAFRLAIEAGVPIVPVAI 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 95-226 2.82e-19

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 81.63  E-value: 2.82e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062    95 VLVVSGHVSWLDVFCIGSVLP-----GSFVARADMFTGRTIGIVARILKIIPIERASLRRLPGVVDTIARRLRAGQTVVA 169
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPrklgrVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLKEGEWLLI 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 489511062   170 FPEGTTWCgrpgddagrpaaragagcsHRGCGAFYPAMFQAAIDAGRPVQPLRLTYH 226
Cdd:smart00563  81 FPEGTRSR-------------------PGKLLPFKKGAARLALEAGVPIVPVAIRGT 118
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 71-226 4.95e-15

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 72.25  E-value: 4.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062  71 CRLVLRLFG-VRITVSGSPVRNLRGVLVVSGHVSWLDVFCIGSVLPGSFVARADMFTGRTIGIVARILKIIPIERASLRR 149
Cdd:cd07991    1 ARVLLFAFGfYVIKVHGKPDPPEAPRIIVANHTSFIDPLILFSDLFPSIVAKKELGKLPFIGTILRALGCIFVDRSEPKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062 150 LPGVVDTIARRLRAGQ--TVVAFPEGTTWCGRpgddagrpaaragagcshrgcgafYPAMFQA-AIDAGRPVQPLRLTYH 226
Cdd:cd07991   81 RKKVVEEIKERATDPNwpPILIFPEGTTTNGK------------------------ALIMFKKgAFEPGVPVQPVAIRYP 136
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 79-223 8.40e-14

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 66.99  E-value: 8.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062   79 GVRITVSGS---PVRNlrGVLVVSGHVSWLDVFCIGSVLPG--SFVARADMFTGRTIGIVARILKIIPIERASLRRLPGV 153
Cdd:TIGR00530   1 GLKVEVVGPenlPAKS--PVLVVANHQSNLDPLTLSAAFPPpiVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATA 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062  154 VDTIARRLRAGQTVVAFPEGTTWCGrpgddagrpaaragagcshRGCGAFYPAMFQAAIDAGRPVQPLRL 223
Cdd:TIGR00530  79 LKAAIEVLKQGRSIGVFPEGTRSRG-------------------RDILPFKKGAFHIAIKAGVPILPVVL 129
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 68-175 5.17e-09

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 54.96  E-value: 5.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062  68 RIYCRLVLRLFGVRITVSG-SPVRNLRGVLVVSGHV-SWLDVFCIGSVL--PGSFVARADMFTGRTIGIVARILKIIPIE 143
Cdd:cd07992    2 RLLSRVILRIYFRRITVVGrENVPKDGPVIFLGNHPnALIDPLLLAATLrrPVRFLAKADLFKNPLIGWLLESFGAIPVY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 489511062 144 RAS-LRRLPG-------VVDTIARRLRAGQTVVAFPEGTT 175
Cdd:cd07992   82 RPKdLARGGIgkisnaaVFDAVGEALKAGGAIGIFPEGGS 121
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 72-174 7.10e-08

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 53.77  E-value: 7.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062   72 RLVLRLF---GVRITVSGspVRNL---RGVLVVSGHVSWLDVFCIGSVLPGS--FVARADMFTGRTIGIVARILKIIPIE 143
Cdd:PRK08633  416 RFLLLLLmhtRYRLRVEG--RENIpakGGALLLGNHVSWIDWALLQAASPRPirFVMERSIYEKWYLKWFFKLFGVIPIS 493

                          90       100       110
                  ....*....|....*....|....*....|.
gi 489511062  144 RASLRRLpgvVDTIARRLRAGQTVVAFPEGT 174
Cdd:PRK08633  494 SGGSKES---LEFIRKALDDGEVVCIFPEGA 521
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 72-175 4.47e-05

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 43.56  E-value: 4.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062  72 RLVLRLFGVRITVSGSPVRNL---RGVLVVSGHVSWLDvFCIGSVLPGSFVARADMFTGRTIGIVA----RILKIIPIER 144
Cdd:cd06551    2 RYLLLNFFGFVRLEVKGPPPPpggGPVLFVSNHSSWWD-GLILFLLLERGLRRDVYGLMDEELLERypffTRLGAFSVDR 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 489511062 145 ASLRRLPGVVDTIARRLRA-GQTVVAFPEGTT 175
Cdd:cd06551   81 DSPRSAAKSLKYVARLLSKpGSVVWIFPEGTR 112
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 77-174 5.69e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 40.30  E-value: 5.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511062  77 LFGVRITVSGSPVRNLRG-VLVVSGHVSWLDVFCIGSVLpgsfvARADMFtGRT-------------IGIVARILKIIPI 142
Cdd:cd07990    7 LSGVKVVVYGDEPKLPKErALIISNHRSEVDWLVLWMLA-----DRFGRL-GRLkivlkdslkypplGGWGWQLGEFIFL 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 489511062 143 ER---ASLRRLPGVVDTIARRLRAGQTVVaFPEGT 174
Cdd:cd07990   81 KRkweKDEKTIKRQLKRLKDSPEPFWLLI-FPEGT 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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