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Conserved domains on  [gi|489511812|ref|WP_003416661|]
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IclR family transcriptional regulator [Clostridioides difficile]

Protein Classification

IclR family transcriptional regulator( domain architecture ID 11444403)

IclR family transcriptional regulator functions as an activator or repressor of genes involved in primary and secondary metabolism, virulence, quorum sensing, and sporulation

CATH:  1.10.10.10|3.30.450.40
Gene Ontology:  GO:0003677|GO:0006355|GO:0003700
PubMed:  16472303|16597823

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
5-255 5.82e-72

DNA-binding transcriptional regulator, IclR family [Transcription];


:

Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 220.46  E-value: 5.82e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812   5 INALDRALDIILLLYHEKREMGITEISKAMGVYKSTVHRTLVTLENKGFVIQNAENGKYWLGINLYAIGMVVGEKMSLTE 84
Cdd:COG1414    5 VQSLERALAILEALAEAGGGLSLSELARRLGLPKSTVHRLLATLEEEGYVERDPEGGRYRLGPRLLELGSAALRRLDLRR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812  85 IVKPYTKKLNQEFNEVVNVSILEERaqdspRSIIIHKEYGSnQLLSVNPSVGSSSECYCSAVGKCLMAF--NDSIDfEKY 162
Cdd:COG1414   85 LARPVLEELAEETGETVHLAVLDGD-----EVVYVARVEGP-RPVRVSSRVGSRLPLHATASGKALLAFlpEEELE-ALL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812 163 RKTPIHKYTEHTIDNWDDMMLFLAKIKEQGYAIDDEELEHGLTCIGAPILDKNNKAIAAISLSGPTIRMREGDFEYKIKR 242
Cdd:COG1414  158 ARAGLPRFTPNTITDPAALRAELAEIRERGYAVDDGELEPGVRAVAAPVFDADGRVVAALSVSGPSSRLTEERLEELAPA 237

                        250
                 ....*....|...
gi 489511812 243 VIETAKSISELFR 255
Cdd:COG1414  238 LRAAAREISRALG 250
 
Name Accession Description Interval E-value
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
5-255 5.82e-72

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 220.46  E-value: 5.82e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812   5 INALDRALDIILLLYHEKREMGITEISKAMGVYKSTVHRTLVTLENKGFVIQNAENGKYWLGINLYAIGMVVGEKMSLTE 84
Cdd:COG1414    5 VQSLERALAILEALAEAGGGLSLSELARRLGLPKSTVHRLLATLEEEGYVERDPEGGRYRLGPRLLELGSAALRRLDLRR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812  85 IVKPYTKKLNQEFNEVVNVSILEERaqdspRSIIIHKEYGSnQLLSVNPSVGSSSECYCSAVGKCLMAF--NDSIDfEKY 162
Cdd:COG1414   85 LARPVLEELAEETGETVHLAVLDGD-----EVVYVARVEGP-RPVRVSSRVGSRLPLHATASGKALLAFlpEEELE-ALL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812 163 RKTPIHKYTEHTIDNWDDMMLFLAKIKEQGYAIDDEELEHGLTCIGAPILDKNNKAIAAISLSGPTIRMREGDFEYKIKR 242
Cdd:COG1414  158 ARAGLPRFTPNTITDPAALRAELAEIRERGYAVDDGELEPGVRAVAAPVFDADGRVVAALSVSGPSSRLTEERLEELAPA 237

                        250
                 ....*....|...
gi 489511812 243 VIETAKSISELFR 255
Cdd:COG1414  238 LRAAAREISRALG 250
PRK15090 PRK15090
DNA-binding transcriptional regulator KdgR; Provisional
 21-252 1.57e-46

DNA-binding transcriptional regulator KdgR; Provisional


Pssm-ID: 185046 [Multi-domain]  Cd Length: 257  Bit Score: 155.56  E-value: 1.57e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812  21 EKREMGITEISKAMGVYKSTVHRTLVTLENKGFVIQNAENGKYWLGINLYAIGMVVGEKMSLTEIVKPYTKKLNQEFNEV 100
Cdd:PRK15090  25 EEREIGITELSQRVMMSKSTVYRFLQTMKTLGYVAQEGESEKYSLTLKLFELGAKALQNVDLIRSADIQMREISRLTKET 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812 101 VNVSILEERaqdsprSII-IHK---EYGsnqlLSVNPSVGSSSECYCSAVGKCLMAFNDSIDFEK-YRKTPIHKYTEHTI 175
Cdd:PRK15090 105 IHLGALDED------SIVyIHKidsMYN----LRMYSRIGRRNPLYSTAIGKVLLAWRDRDEVREiLSGVEFKRSTEKTI 174

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489511812 176 DNWDDMMLFLAKIKEQGYAIDDEELEHGLTCIGAPILDKNNKAIAAISLSGPTIRMREGDFEYKIKRVIETAKSISE 252
Cdd:PRK15090 175 TSTEALLPVLDQVREQGYGEDNEEQEEGLRCIAVPVFDRFGVVIAGLSISFPTLRFSEERKQEYVAMLHTAARKISE 251
IclR pfam01614
Bacterial transcriptional regulator; This family of bacterial transcriptional regulators ...
 134-251 4.40e-35

Bacterial transcriptional regulator; This family of bacterial transcriptional regulators includes the glycerol operon regulatory protein and acetate operon repressor both of which are members of the iclR family. These proteins have a Helix-Turn-Helix motif at the N-terminus. However this family covers the C-terminal region that binds to regulatory substrates including Glyoxylate, allantoin/ate, indole, aromatic hydrocarbons, sugar acids, succinic semialdehyde, benzoate derivatives, ascorbic acid, glycerol-3-phosphate, glyceraldehyde-3-phosphate and pyruvate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426346 [Multi-domain]  Cd Length: 128  Bit Score: 122.01  E-value: 4.40e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812  134 SVGSSSECYCSAVGKCLMAFNDSIDFEKYRK-TPIHKYTEHTIDNWDDMMLFLAKIKEQGYAIDDEELEHGLTCIGAPIL 212
Cdd:pfam01614   8 AIGRRLPLHATAIGKALLAWLDEEELEAYLErYELKRLTPNTITDPEALLEELAQIREQGYAVDREEHELGVRCIAAPIF 87

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 489511812  213 DKNNKAIAAISLSGPTIRMREGDFEYKIKRVIETAKSIS 251
Cdd:pfam01614  88 DASGDVVAAISVSGPTSRLTEEELDYLLALLREAARKIS 126
pcaR_pcaU TIGR02431
beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Member of this ...
 3-254 1.12e-33

beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Member of this family are IclR-type transcriptional regulators with similar DNA binding sites, able to bind at least three different metabolites related to protocatechuate metabolism. Beta-ketoadipate is the inducer for PcaR, p-hydroxybenzoate for PobR, and protocatechuate for PcaU. [Regulatory functions, DNA interactions]


Pssm-ID: 131484 [Multi-domain]  Cd Length: 248  Bit Score: 121.98  E-value: 1.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812    3 EIINALDRALDIILLLYHEKREMGITEISKAMGVYKSTVHRTLVTLENKGFVIQNaeNGKYWLGINLYAIGMVVGEKMSL 82
Cdd:TIGR02431   3 DFVASLARGLAVIEAFGAERPRLTLTDVAEATGLTRAAARRFLLTLVELGYVTSD--GRLFWLTPRVLRLGYAYLSSAPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812   83 TEIVKPYTKKLNQEFNEVVNVSILEEraQDsprsIIIHKEYGSNQLLSVNPSVGSSSECYCSAVGKCLMAFNDSIDFEKY 162
Cdd:TIGR02431  81 PKVAQPLLERLSAQTHESCSVAVLDG--DE----IVYVARSPTHRIMSVGLSVGTRLPAYCTSMGRVLLAGLDDEELDEY 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812  163 -RKTPIHKYTEHTIDNWDDMMLFLAKIKEQGYAIDDEELEHGLTCIGAPILDKNNKAIAAISLSGPTIRMREGDFeykIK 241
Cdd:TIGR02431 155 lARSTLQALTPRTITDRDALLAELLAVRAQGYALVDQELELGLRSIAVPIRNARGQVVAALNVSTHAARTTPEEL---VE 231

                         250
                  ....*....|....*..
gi 489511812  242 RVI----ETAKSISELF 254
Cdd:TIGR02431 232 RILplllEAARELRQLL 248
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
5-94 4.03e-26

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 97.66  E-value: 4.03e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812     5 INALDRALDIILLLYHEKREMGITEISKAMGVYKSTVHRTLVTLENKGFVIQNAENGKYWLGINLYAIGMVVGEKMSLTE 84
Cdd:smart00346   1 IQSLERGLAVLRALAEEPGGLTLAELAERLGLSKSTAHRLLNTLQELGYVEQDGQNGRYRLGPKVLELGQSYLSSLDLRE 80

                           90
                   ....*....|
gi 489511812    85 IVKPYTKKLN 94
Cdd:smart00346  81 VAKPVLEELS 90
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-68 1.68e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 39.20  E-value: 1.68e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489511812  12 LDIILLLYheKREMGITEISKAMGVYKSTVHRTLVTLENKGFVIQNAENGKYWLGIN 68
Cdd:cd00090   10 LRILRLLL--EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLT 64
 
Name Accession Description Interval E-value
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
5-255 5.82e-72

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 220.46  E-value: 5.82e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812   5 INALDRALDIILLLYHEKREMGITEISKAMGVYKSTVHRTLVTLENKGFVIQNAENGKYWLGINLYAIGMVVGEKMSLTE 84
Cdd:COG1414    5 VQSLERALAILEALAEAGGGLSLSELARRLGLPKSTVHRLLATLEEEGYVERDPEGGRYRLGPRLLELGSAALRRLDLRR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812  85 IVKPYTKKLNQEFNEVVNVSILEERaqdspRSIIIHKEYGSnQLLSVNPSVGSSSECYCSAVGKCLMAF--NDSIDfEKY 162
Cdd:COG1414   85 LARPVLEELAEETGETVHLAVLDGD-----EVVYVARVEGP-RPVRVSSRVGSRLPLHATASGKALLAFlpEEELE-ALL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812 163 RKTPIHKYTEHTIDNWDDMMLFLAKIKEQGYAIDDEELEHGLTCIGAPILDKNNKAIAAISLSGPTIRMREGDFEYKIKR 242
Cdd:COG1414  158 ARAGLPRFTPNTITDPAALRAELAEIRERGYAVDDGELEPGVRAVAAPVFDADGRVVAALSVSGPSSRLTEERLEELAPA 237

                        250
                 ....*....|...
gi 489511812 243 VIETAKSISELFR 255
Cdd:COG1414  238 LRAAAREISRALG 250
PRK15090 PRK15090
DNA-binding transcriptional regulator KdgR; Provisional
 21-252 1.57e-46

DNA-binding transcriptional regulator KdgR; Provisional


Pssm-ID: 185046 [Multi-domain]  Cd Length: 257  Bit Score: 155.56  E-value: 1.57e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812  21 EKREMGITEISKAMGVYKSTVHRTLVTLENKGFVIQNAENGKYWLGINLYAIGMVVGEKMSLTEIVKPYTKKLNQEFNEV 100
Cdd:PRK15090  25 EEREIGITELSQRVMMSKSTVYRFLQTMKTLGYVAQEGESEKYSLTLKLFELGAKALQNVDLIRSADIQMREISRLTKET 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812 101 VNVSILEERaqdsprSII-IHK---EYGsnqlLSVNPSVGSSSECYCSAVGKCLMAFNDSIDFEK-YRKTPIHKYTEHTI 175
Cdd:PRK15090 105 IHLGALDED------SIVyIHKidsMYN----LRMYSRIGRRNPLYSTAIGKVLLAWRDRDEVREiLSGVEFKRSTEKTI 174

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489511812 176 DNWDDMMLFLAKIKEQGYAIDDEELEHGLTCIGAPILDKNNKAIAAISLSGPTIRMREGDFEYKIKRVIETAKSISE 252
Cdd:PRK15090 175 TSTEALLPVLDQVREQGYGEDNEEQEEGLRCIAVPVFDRFGVVIAGLSISFPTLRFSEERKQEYVAMLHTAARKISE 251
IclR pfam01614
Bacterial transcriptional regulator; This family of bacterial transcriptional regulators ...
 134-251 4.40e-35

Bacterial transcriptional regulator; This family of bacterial transcriptional regulators includes the glycerol operon regulatory protein and acetate operon repressor both of which are members of the iclR family. These proteins have a Helix-Turn-Helix motif at the N-terminus. However this family covers the C-terminal region that binds to regulatory substrates including Glyoxylate, allantoin/ate, indole, aromatic hydrocarbons, sugar acids, succinic semialdehyde, benzoate derivatives, ascorbic acid, glycerol-3-phosphate, glyceraldehyde-3-phosphate and pyruvate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426346 [Multi-domain]  Cd Length: 128  Bit Score: 122.01  E-value: 4.40e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812  134 SVGSSSECYCSAVGKCLMAFNDSIDFEKYRK-TPIHKYTEHTIDNWDDMMLFLAKIKEQGYAIDDEELEHGLTCIGAPIL 212
Cdd:pfam01614   8 AIGRRLPLHATAIGKALLAWLDEEELEAYLErYELKRLTPNTITDPEALLEELAQIREQGYAVDREEHELGVRCIAAPIF 87

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 489511812  213 DKNNKAIAAISLSGPTIRMREGDFEYKIKRVIETAKSIS 251
Cdd:pfam01614  88 DASGDVVAAISVSGPTSRLTEEELDYLLALLREAARKIS 126
PRK11569 PRK11569
glyoxylate bypass operon transcriptional repressor IclR;
5-251 3.92e-34

glyoxylate bypass operon transcriptional repressor IclR;


Pssm-ID: 183206 [Multi-domain]  Cd Length: 274  Bit Score: 124.15  E-value: 3.92e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812   5 INALDRALDIILLLYHEKREMGITEISKAMGVYKSTVHRTLVTLENKGFVIQNAENGKYWLGINLYAIGMVVGEKMSLTE 84
Cdd:PRK11569  24 VQSLTRGLKLLEWIAESNGSVALTELAQQAGLPNSTTHRLLTTMQQQGFVRQVGELGHWAIGAHAFIVGSSFLQSRNLLA 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812  85 IVKPYTKKLNQEFNEVVNVSILEeraQDSPRSIIIhKEYGSNQLLSVNPSVGSSSECYCSAVGKCLMA-FNDSIDFEKYR 163
Cdd:PRK11569 104 IVHPILRNLMEDSGETVNLAVLD---QSDHQAIII-DQVQCTALMRMSAPIGGKLPMHASGAGKAFLAqLSEEQVTKLLH 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812 164 KTPIHKYTEHTIDNWDDMMLFLAKIKEQGYAIDDEELEHGLTCIGAPILDKNNKAIAAISLSGPTIRMREGDFEYKIKRV 243
Cdd:PRK11569 180 RKGLHAYTHATLVSPVHLKEDLAQTRKRGYSFDDEEHALGLRCVAACIFDEHREPFAAISISGPISRITDDRVTELGAMV 259


                 ....*...
gi 489511812 244 IETAKSIS 251
Cdd:PRK11569 260 IKAAKEVT 267
pcaR_pcaU TIGR02431
beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Member of this ...
 3-254 1.12e-33

beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Member of this family are IclR-type transcriptional regulators with similar DNA binding sites, able to bind at least three different metabolites related to protocatechuate metabolism. Beta-ketoadipate is the inducer for PcaR, p-hydroxybenzoate for PobR, and protocatechuate for PcaU. [Regulatory functions, DNA interactions]


Pssm-ID: 131484 [Multi-domain]  Cd Length: 248  Bit Score: 121.98  E-value: 1.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812    3 EIINALDRALDIILLLYHEKREMGITEISKAMGVYKSTVHRTLVTLENKGFVIQNaeNGKYWLGINLYAIGMVVGEKMSL 82
Cdd:TIGR02431   3 DFVASLARGLAVIEAFGAERPRLTLTDVAEATGLTRAAARRFLLTLVELGYVTSD--GRLFWLTPRVLRLGYAYLSSAPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812   83 TEIVKPYTKKLNQEFNEVVNVSILEEraQDsprsIIIHKEYGSNQLLSVNPSVGSSSECYCSAVGKCLMAFNDSIDFEKY 162
Cdd:TIGR02431  81 PKVAQPLLERLSAQTHESCSVAVLDG--DE----IVYVARSPTHRIMSVGLSVGTRLPAYCTSMGRVLLAGLDDEELDEY 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812  163 -RKTPIHKYTEHTIDNWDDMMLFLAKIKEQGYAIDDEELEHGLTCIGAPILDKNNKAIAAISLSGPTIRMREGDFeykIK 241
Cdd:TIGR02431 155 lARSTLQALTPRTITDRDALLAELLAVRAQGYALVDQELELGLRSIAVPIRNARGQVVAALNVSTHAARTTPEEL---VE 231

                         250
                  ....*....|....*..
gi 489511812  242 RVI----ETAKSISELF 254
Cdd:TIGR02431 232 RILplllEAARELRQLL 248
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
5-94 4.03e-26

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 97.66  E-value: 4.03e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812     5 INALDRALDIILLLYHEKREMGITEISKAMGVYKSTVHRTLVTLENKGFVIQNAENGKYWLGINLYAIGMVVGEKMSLTE 84
Cdd:smart00346   1 IQSLERGLAVLRALAEEPGGLTLAELAERLGLSKSTAHRLLNTLQELGYVEQDGQNGRYRLGPKVLELGQSYLSSLDLRE 80

                           90
                   ....*....|
gi 489511812    85 IVKPYTKKLN 94
Cdd:smart00346  81 VAKPVLEELS 90
PRK10163 PRK10163
HTH-type transcriptional repressor AllR;
7-251 2.73e-23

HTH-type transcriptional repressor AllR;


Pssm-ID: 182279 [Multi-domain]  Cd Length: 271  Bit Score: 95.08  E-value: 2.73e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812   7 ALDRALDIILLLYHEKREMGITEISKAMGVYKSTVHRTLVTLENKGFVIQNAENGKYWLGINLYAIGMVVGEKMSLTEIV 86
Cdd:PRK10163  23 ALERGIAILQYLEKSGGSSSVSDISLNLDLPLSTTFRLLKVLQAADFVYQDSQLGWWHIGLGVFNVGAAYIHNRDVLSVA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812  87 KPYTKKLNQEFNEVVNVSIleeraQDSPRSIIIHKEYGSNQLLSVNPsVGSSSECYCSAVGKCLM---AFNDSIDFekYR 163
Cdd:PRK10163 103 GPFMRRLMLLSGETVNVAI-----RNGNEAVLIGQLECKSMVRMCAP-LGSRLPLHASGAGKALLyplAEEELMSI--IL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812 164 KTPIHKYTEHTIDNWDDMMLFLAKIKEQGYAIDDEELEHGLTCIGAPILDKNNKAIAAISLSGPTIRMREGDFEYKIKRV 243
Cdd:PRK10163 175 QTGLQQFTPTTLVDMPTLLKDLEQARELGYTVDKEEHVVGLNCIASAIYDDVGSVVAAISISGPSSRLTEDRFVSQGELV 254


                 ....*...
gi 489511812 244 IETAKSIS 251
Cdd:PRK10163 255 RDTARDIS 262
HTH_IclR pfam09339
IclR helix-turn-helix domain;
7-57 3.87e-12

IclR helix-turn-helix domain;


Pssm-ID: 430539 [Multi-domain]  Cd Length: 52  Bit Score: 59.34  E-value: 3.87e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 489511812    7 ALDRALDIILLLYHEKREMGITEISKAMGVYKSTVHRTLVTLENKGFVIQN 57
Cdd:pfam09339   1 SLDRALAILDALAEAPGPLTLTEIARRTGLPKSTAHRLLQTLVELGYVEQD 51
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
1-63 1.96e-05

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 43.03  E-value: 1.96e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489511812   1 MGEIINALDRALDIILLLYHEKREMGITEISKAMGVYKSTVHRTLVTLENKGFVI---QNAENGKY 63
Cdd:COG3355   19 LECVYGLSETDAEVYLILLENGEPLTVEELAEALDRSRSTVYRSLQKLLEAGLVErekRNLEGGGY 84
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
3-80 1.46e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 42.19  E-value: 1.46e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489511812   3 EIINALDRALDIILLLYheKREMGITEISKAMGVYKSTVHRTLVTLENKGFVIQnaENGKYwlgiNLYAIGMVVGEKM 80
Cdd:COG4742   10 DFLFLSEKRKNILLLLA--EGPKTRSELAESLDVSRSTILRQLKELEERGLIER--DDGEY----ELTTLGRLVVEEM 79
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-68 1.68e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 39.20  E-value: 1.68e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489511812  12 LDIILLLYheKREMGITEISKAMGVYKSTVHRTLVTLENKGFVIQNAENGKYWLGIN 68
Cdd:cd00090   10 LRILRLLL--EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLT 64
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
15-62 8.01e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 37.96  E-value: 8.01e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 489511812    15 ILLLYHEKREMGITEISKAMGVYKSTVHRTLVTLENKGFV--IQNAENGK 62
Cdd:smart00347  15 VLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVrrEPSPEDRR 64
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 15-62 1.36e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 35.99  E-value: 1.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 489511812   15 ILLLYHEKREMGITEISKAMGVYKSTVHRTLVTLENKGFV--IQNAENGK 62
Cdd:pfam01047   8 ILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIerSRSPEDRR 57
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 8-54 1.77e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 36.43  E-value: 1.77e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 489511812   8 LDRALDIILLLYHEKREMGITEISKAMGVYKSTVHRTLVTLENKGFV 54
Cdd:COG2512   14 LEDERRVLELLRENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLI 60
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
15-54 2.03e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 37.64  E-value: 2.03e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 489511812  15 ILLLYHEKREMGITEISKAMGVYKSTVHRTLVTLENKGFV 54
Cdd:COG1846   43 VLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLV 82
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
12-56 2.71e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 37.11  E-value: 2.71e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 489511812  12 LDIILLLYHEKREMGITEISKAMGVYKSTVHRTLVTLENKGFVIQ 56
Cdd:COG1321   12 LKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEY 56
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
12-62 4.60e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 35.71  E-value: 4.60e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489511812  12 LDIILLLYheKREMGITEISKAMGVYKSTVHRTLVTLENKGFVIQNAENGK 62
Cdd:COG4189   22 LRILRLLA--EEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKPGK 70
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
13-54 5.40e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.49  E-value: 5.40e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 489511812    13 DIILLLYHekREMGITEISKAMGVYKSTVHRTLVTLENKGFV 54
Cdd:smart00418   1 KILKLLAE--GELCVCELAEILGLSQSTVSHHLKKLREAGLV 40
YrhO COG1378
Sugar-specific transcriptional regulator TrmB [Transcription];
24-116 6.54e-03

Sugar-specific transcriptional regulator TrmB [Transcription];


Pssm-ID: 440988 [Multi-domain]  Cd Length: 238  Bit Score: 36.92  E-value: 6.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489511812  24 EMGITEISKAMGVYKSTVHRTLVTLENKGFVIQNAENGKYWlginlYAIgmvvgekmSLTEIVKPYTKKLNQEFNEVVNv 103
Cdd:COG1378   27 PATASELAKASGVPRSRVYDVLESLEEKGLVEVSEGRPKRY-----RAV--------PPEEALERLLEEREEELEELRE- 92

                         90
                 ....*....|...
gi 489511812 104 sILEERAQDSPRS 116
Cdd:COG1378   93 -ELEELYEELREP 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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