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Conserved domains on  [gi|489514295|ref|WP_003419132|]
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MULTISPECIES: acyl carrier protein [Bacteria]

Protein Classification

acyl carrier protein( domain architecture ID 10011594)

acyl carrier protein may function as a carrier of the growing fatty acid chain in fatty acid biosynthesis or as the carrier of activated (amino) acid groups in polyketide synthases and non-ribosomal peptide synthases

CATH:  1.10.1200.10
Gene Ontology:  GO:0009245|GO:0000035|GO:0006633|GO:0000036
PubMed:  20662770|18059524|30543875|30787330
SCOP:  4000857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 1-74 4.58e-25

acyl carrier protein; Provisional


:

Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 88.30  E-value: 4.58e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489514295  1 MFNKVVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGDIVKYIEANK 74
Cdd:PRK00982  4 IFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQ 77
 
Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 1-74 4.58e-25

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 88.30  E-value: 4.58e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489514295  1 MFNKVVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGDIVKYIEANK 74
Cdd:PRK00982  4 IFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQ 77
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-74 4.97e-22

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 80.67  E-value: 4.97e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489514295  1 MFNKVVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGDIVKYIEANK 74
Cdd:COG0236   6 LEERLAEIIAEVLGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKL 79
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 2-74 2.10e-19

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 73.97  E-value: 2.10e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489514295   2 FNKVVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGDIVKYIEANK 74
Cdd:TIGR00517  5 FEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEENQ 77
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 3-65 3.28e-11

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 52.57  E-value: 3.28e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489514295   3 NKVVEIIIEQLGVEDKEITMETSLMkDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGD 65
Cdd:pfam00550  1 ERLRELLAEVLGVPAEEIDPDTDLF-DLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 5-72 8.90e-07

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 41.85  E-value: 8.90e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489514295    5 VVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGDIVKYIEA 72
Cdd:smart00823 17 VREQVAAVLGHAAAEAIDPDRPFRDLGLDSLMAVELRNRLEAATGLRLPATLVFDHPTPAALAEHLAA 84
 
Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 1-74 4.58e-25

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 88.30  E-value: 4.58e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489514295  1 MFNKVVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGDIVKYIEANK 74
Cdd:PRK00982  4 IFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQ 77
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-74 4.97e-22

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 80.67  E-value: 4.97e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489514295  1 MFNKVVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGDIVKYIEANK 74
Cdd:COG0236   6 LEERLAEIIAEVLGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKL 79
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 2-74 7.68e-20

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 77.05  E-value: 7.68e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489514295   2 FNKVVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGDIVKYIEANK 74
Cdd:PTZ00171  72 LTRVKKVVKNFEKVDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDAIDYIEQNN 144
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 2-74 2.10e-19

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 73.97  E-value: 2.10e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489514295   2 FNKVVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGDIVKYIEANK 74
Cdd:TIGR00517  5 FEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEENQ 77
acpP CHL00124
acyl carrier protein; Validated
 2-74 5.28e-17

acyl carrier protein; Validated


Pssm-ID: 177047 [Multi-domain]  Cd Length: 82  Bit Score: 68.12  E-value: 5.28e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489514295  2 FNKVVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGDIVKYIEANK 74
Cdd:CHL00124  7 FEKVQSIVAEQLGIEKSEVTLDANFTRDLGADSLDVVELVMAIEEKFDIEIPDEDAEKISTLQEAVDFISQKI 79
PRK12449 PRK12449
acyl carrier protein; Provisional
 1-70 3.11e-13

acyl carrier protein; Provisional


Pssm-ID: 183533 [Multi-domain]  Cd Length: 80  Bit Score: 58.18  E-value: 3.11e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514295  1 MFNKVVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGDIVKYI 70
Cdd:PRK12449  6 IFERLINLIQKQRSYLSLAITEQTHLKDDLAVDSIELVEFIINVEDEFHIAIPDEDVEDMVSMGDLLDYL 75
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 3-65 3.28e-11

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 52.57  E-value: 3.28e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489514295   3 NKVVEIIIEQLGVEDKEITMETSLMkDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGD 65
Cdd:pfam00550  1 ERLRELLAEVLGVPAEEIDPDTDLF-DLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
PRK06508 PRK06508
acyl carrier protein; Provisional
 2-53 1.57e-07

acyl carrier protein; Provisional


Pssm-ID: 180597  Cd Length: 93  Bit Score: 44.04  E-value: 1.57e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 489514295  2 FNKVVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMALEDEFGIEIP 53
Cdd:PRK06508  5 FDKVADIIAETSDIPRDTITPESHTIDDLGIDSLDFLDIVFAIDKAFGIKLP 56
PRK08172 PRK08172
acyl carrier protein;
4-71 5.79e-07

acyl carrier protein;


Pssm-ID: 181266  Cd Length: 82  Bit Score: 42.57  E-value: 5.79e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489514295  4 KVVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGDIVKYIE 71
Cdd:PRK08172  8 RVKKVITSCIAVDVDSINGQTHLVEDLYADSLDLIDIVFGLSEEFDISCNENDLPDMTTFADICRVVK 75
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 5-72 8.90e-07

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 41.85  E-value: 8.90e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489514295    5 VVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGDIVKYIEA 72
Cdd:smart00823 17 VREQVAAVLGHAAAEAIDPDRPFRDLGLDSLMAVELRNRLEAATGLRLPATLVFDHPTPAALAEHLAA 84
PRK05350 PRK05350
acyl carrier protein; Provisional
 2-72 1.36e-05

acyl carrier protein; Provisional


Pssm-ID: 180033  Cd Length: 82  Bit Score: 38.82  E-value: 1.36e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489514295  2 FNKVVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGDIVKYIEA 72
Cdd:PRK05350  8 LERLRAILVELFEIDPEDITPEANLYEDLDLDSIDAVDLVVHLQKLTGKKIKPEEFKSVRTVQDVVDAVER 78
PRK09184 PRK09184
acyl carrier protein; Provisional
 3-74 3.77e-05

acyl carrier protein; Provisional


Pssm-ID: 181682  Cd Length: 89  Bit Score: 38.11  E-value: 3.77e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489514295  3 NKVVEIIIEQLGVED---KEITMETSLMKD-LEADSLDAVEIIMALEDEFGIEIPDTEAEN---FKSIGDIVKYIEANK 74
Cdd:PRK09184  9 RELAELIVEELNLEDvqpESIDADAPLYGEgLGLDSIDILEIALVISKRYGFQLRSDNPDNqriFASLRALAAYVAAHR 87
PRK07081 PRK07081
acyl carrier protein; Provisional
 34-72 2.67e-04

acyl carrier protein; Provisional


Pssm-ID: 180828  Cd Length: 83  Bit Score: 35.70  E-value: 2.67e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 489514295 34 SLDAVEIIMALEDEFGIEIPDT--EAENFKSIGDIVKYIEA 72
Cdd:PRK07081 35 SLATVQLMLAIEDAFDIEIPDEmlNRKLFASIDALAGAVTQ 75
PRK05828 PRK05828
acyl carrier protein; Validated
 27-71 3.55e-03

acyl carrier protein; Validated


Pssm-ID: 180278  Cd Length: 84  Bit Score: 32.92  E-value: 3.55e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 489514295 27 MKDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGDIVKYIE 71
Cdd:PRK05828 32 YRELKIDSLDMFSIIVSLESEFNIEFSDEKLMKLKNLADLILEVK 76
PRK07117 PRK07117
acyl carrier protein; Validated
 27-67 9.98e-03

acyl carrier protein; Validated


Pssm-ID: 180851 [Multi-domain]  Cd Length: 79  Bit Score: 31.60  E-value: 9.98e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 489514295 27 MKDLEADSLDAVEIIMALEDEFGIEIPDTEAENFKSIGDIV 67
Cdd:PRK07117 32 LVDLGANSMDRAEIVIMTLESLSLKIPLVEFAGAKNIGELA 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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