NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|489514680|ref|WP_003419517|]
View 

MULTISPECIES: type III pantothenate kinase [Mycobacterium]

Protein Classification

type III pantothenate kinase( domain architecture ID 10014195)

type III pantothenate kinase catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis

CATH:  3.30.420.40
EC:  2.7.1.33
Gene Ontology:  GO:0005524|GO:0016310|GO:0004594|GO:0046872|GO:0015937
PubMed:  16905099|8800467|7781919
SCOP:  3000092

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK13318 PRK13318
type III pantothenate kinase;
1-264 4.71e-122

type III pantothenate kinase;


:

Pssm-ID: 237347 [Multi-domain]  Cd Length: 258  Bit Score: 348.67  E-value: 4.71e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680   1 MLLAIDVRNTHTVVGLLSGmkehAKVVQQWRIRTESEVTADELALTIDGLIGEDS---ERLTGTAALSTVPSVLHEVRIM 77
Cdd:PRK13318   1 MLLAIDVGNTNTVFGLYEG----GKLVAHWRISTDSRRTADEYGVWLKQLLGLSGldpEDITGIIISSVVPSVMHSLERM 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680  78 LDQYWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQ 157
Cdd:PRK13318  77 CRKYFNIEPLVVVGPGVKTGINIKVDNPKEVGADRIVNAVAAYELYGGPLIVVDFGTATTFDVVSAKGEYLGGVIAPGIN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680 158 VSSDAAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDvsgfsVDHDVAIVATGHTAPLLLPE 237
Cdd:PRK13318 157 ISADALFQRAAKLPRVEITKPDSVIGKNTVEAMQSGIYYGYVGLVEGIVKRIKEE-----LGKDPKVIATGGLAPLFAEE 231

                        250       260
                 ....*....|....*....|....*..
gi 489514680 238 LHTVDHYDQHLTLQGLRLVFERNLEVQ 264
Cdd:PRK13318 232 SDTIDIVDPDLTLKGLRLIYERNKELQ 258
 
Name Accession Description Interval E-value
PRK13318 PRK13318
type III pantothenate kinase;
1-264 4.71e-122

type III pantothenate kinase;


Pssm-ID: 237347 [Multi-domain]  Cd Length: 258  Bit Score: 348.67  E-value: 4.71e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680   1 MLLAIDVRNTHTVVGLLSGmkehAKVVQQWRIRTESEVTADELALTIDGLIGEDS---ERLTGTAALSTVPSVLHEVRIM 77
Cdd:PRK13318   1 MLLAIDVGNTNTVFGLYEG----GKLVAHWRISTDSRRTADEYGVWLKQLLGLSGldpEDITGIIISSVVPSVMHSLERM 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680  78 LDQYWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQ 157
Cdd:PRK13318  77 CRKYFNIEPLVVVGPGVKTGINIKVDNPKEVGADRIVNAVAAYELYGGPLIVVDFGTATTFDVVSAKGEYLGGVIAPGIN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680 158 VSSDAAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDvsgfsVDHDVAIVATGHTAPLLLPE 237
Cdd:PRK13318 157 ISADALFQRAAKLPRVEITKPDSVIGKNTVEAMQSGIYYGYVGLVEGIVKRIKEE-----LGKDPKVIATGGLAPLFAEE 231

                        250       260
                 ....*....|....*....|....*..
gi 489514680 238 LHTVDHYDQHLTLQGLRLVFERNLEVQ 264
Cdd:PRK13318 232 SDTIDIVDPDLTLKGLRLIYERNKELQ 258
baf TIGR00671
pantothenate kinase, type III; This model describes a family of proteins found in a single ...
 2-258 4.98e-98

pantothenate kinase, type III; This model describes a family of proteins found in a single copy in at least ten different early completed bacterial genomes. The only characterized member of the family is Bvg accessory factor (Baf), a protein required, in addition to the regulatory operon bvgAS, for heterologous transcription of the Bordetella pertussis toxin operon (ptx) in E. coli. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273210 [Multi-domain]  Cd Length: 243  Bit Score: 287.06  E-value: 4.98e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680    2 LLAIDVRNTHTVVGLLSgmkeHAKVVQQWRIRTESEVTADELALTIDGLIGEDserLTGTAALSTVPSVLHEVRIMLDQY 81
Cdd:TIGR00671   1 LLLIDVGNTRIVFALNS----GNKVYQFWRLATNLMKTYDEHSEFLKELFGKS---LNKAFISSVVPELTEAVRNMIPKI 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680   82 WPSVPHVlIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSD 161
Cdd:TIGR00671  74 KNIKPEI-FFPLVYDGLPNLYKSPKELGIDRVANALAAIKFYGFNVVVVDAGTALTIDLVDQEGKFLGGAIAPGLGISLH 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680  162 AAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSgfsvdHDVAIVATGHtAPLLLPELHTV 241
Cdd:TIGR00671 153 ALKDRAAALPKFEIARPDEVLGKSTREAVQSGAVYGVLGLIQGLLKDWKKYFK-----RKFAVVITGG-DGKYLSAFLPF 226

                         250
                  ....*....|....*..
gi 489514680  242 DHYDQHLTLQGLRLVFE 258
Cdd:TIGR00671 227 SIYDPHLTVEGMRNLLR 243
CoaX COG1521
Pantothenate kinase type III [Coenzyme transport and metabolism];
1-260 1.03e-87

Pantothenate kinase type III [Coenzyme transport and metabolism];


Pssm-ID: 441130 [Multi-domain]  Cd Length: 250  Bit Score: 261.25  E-value: 1.03e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680   1 MLLAIDVRNTHTVVGLLSGmkehAKVVQQWRIRTESEvTADELALTIDGLIGEDSERLTGTAALSTVPSVLHEVRIMLDQ 80
Cdd:COG1521    1 MLLAIDIGNTRIKWGLFDG----GELLASWRLATDRR-TADELAELLRQLLAALLPDIEGVIISSVVPPLTEALEELLRK 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680  81 YWPSVPHVlIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSS 160
Cdd:COG1521   76 YFGVPPLV-VGPGVKTGLKNAYDNPEELGADRIANAVAARELYGGPLLVVDFGTATTFDVVDADGEYLGGAIAPGLGLSL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680 161 DAAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSgfsvdHDVAIVATGHTAPLLLPELHT 240
Cdd:COG1521  155 EALHQRTAKLPLVELEKPPSVIGKNTVEAIQSGVVYGYAGLIEGLIERIKEELG-----EDPKVIATGGDAPLLAPELKT 229

                        250       260
                 ....*....|....*....|
gi 489514680 241 VDHYDQHLTLQGLRLVFERN 260
Cdd:COG1521  230 IDIVDPDLVLEGLRLIYERN 249
Pan_kinase pfam03309
Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of ...
 2-208 7.56e-70

Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of pantothenate (Pan), the first step in the universal pathway of CoA biosynthesis.


Pssm-ID: 460881 [Multi-domain]  Cd Length: 205  Bit Score: 213.96  E-value: 7.56e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680    2 LLAIDVRNTHTVVGLLSGmkehAKVVQQWRIRTESEVTADELALTIDGLIGEDSERLTGTAALSTV-PSVLHEVRIMLDQ 80
Cdd:pfam03309   1 LLAIDIGNTNIKWGLFDG----DKLVAHWRISTDARRTADELGVLLRSLLRLAGIDPIDGVIISSVvPPLNAALERACLK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680   81 YWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRF-RKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVS 159
Cdd:pfam03309  77 YFKIEPLVVGAPGIKTGLRNRYDNPKELGADRWVNAVAARELYpGKPLIVVDFGTATTFDAVSADGEYLGGAIAPGIGLS 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 489514680  160 SDAAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGR 208
Cdd:pfam03309 157 LDALAQGTAKLPRVEITRPGSVIGKNTVEAIQSGILYGYAGLVEGIIRR 205
ASKHA_NBD_PanK-III cd24015
nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar ...
 3-256 2.23e-67

nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar proteins; PanK (EC 2.7.1.33), also called pantothenic acid kinase, is the first enzyme in the Coenzyme A (CoA) biosynthetic pathway. It catalyzes the phosphorylation of pantothenate (vitamin B5) to form 4'-phosphopantothenate at the expense of a molecule of adenosine triphosphate (ATP), which is the rate-limiting step in CoA biosynthesis. It cannot utilize a phosphoryl donor other than ATP. Three distinct types of PanK have been identified, PanK-I, PanK-II and PanK-III. The model corresponds to PanK-III that belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466865 [Multi-domain]  Cd Length: 241  Bit Score: 209.04  E-value: 2.23e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680   3 LAIDVRNTHTVVGLLsgmkEHAKVVQQWRIRTESEVTADELALTIDGLIGEDserLTGTAALSTVPSVLHEVRIMLDQYW 82
Cdd:cd24015    1 LVIDIGNTNIKLGLF----DGGELVKIWRLSTDKELTEDELLLLLAGIELED---ISGVVISSVVPSLTEVLEEALKKYF 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680  83 PSVPHVlIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDA 162
Cdd:cd24015   74 GISPLV-VGPGLKLGVKIAYDNPKELGADRLANAVAAAKLYGRPVIVVDFGTATTIDLVDAEGEFLGGAIAPGIELSLKA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680 163 AAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSGfsvdhDVAIVATGHTAPLLLPELHTVD 242
Cdd:cd24015  153 LHQRTAKLPSVELIKPKKVIGKNTEEAIQSGVFYGYAGLIEGIIERLKKELGG-----DAKVILTGGDAKLVAPYLEPID 227

                        250
                 ....*....|....
gi 489514680 243 HYDQHLTLQGLRLV 256
Cdd:cd24015  228 IYDPDLTLKGLKLI 241
 
Name Accession Description Interval E-value
PRK13318 PRK13318
type III pantothenate kinase;
1-264 4.71e-122

type III pantothenate kinase;


Pssm-ID: 237347 [Multi-domain]  Cd Length: 258  Bit Score: 348.67  E-value: 4.71e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680   1 MLLAIDVRNTHTVVGLLSGmkehAKVVQQWRIRTESEVTADELALTIDGLIGEDS---ERLTGTAALSTVPSVLHEVRIM 77
Cdd:PRK13318   1 MLLAIDVGNTNTVFGLYEG----GKLVAHWRISTDSRRTADEYGVWLKQLLGLSGldpEDITGIIISSVVPSVMHSLERM 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680  78 LDQYWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQ 157
Cdd:PRK13318  77 CRKYFNIEPLVVVGPGVKTGINIKVDNPKEVGADRIVNAVAAYELYGGPLIVVDFGTATTFDVVSAKGEYLGGVIAPGIN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680 158 VSSDAAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDvsgfsVDHDVAIVATGHTAPLLLPE 237
Cdd:PRK13318 157 ISADALFQRAAKLPRVEITKPDSVIGKNTVEAMQSGIYYGYVGLVEGIVKRIKEE-----LGKDPKVIATGGLAPLFAEE 231

                        250       260
                 ....*....|....*....|....*..
gi 489514680 238 LHTVDHYDQHLTLQGLRLVFERNLEVQ 264
Cdd:PRK13318 232 SDTIDIVDPDLTLKGLRLIYERNKELQ 258
baf TIGR00671
pantothenate kinase, type III; This model describes a family of proteins found in a single ...
 2-258 4.98e-98

pantothenate kinase, type III; This model describes a family of proteins found in a single copy in at least ten different early completed bacterial genomes. The only characterized member of the family is Bvg accessory factor (Baf), a protein required, in addition to the regulatory operon bvgAS, for heterologous transcription of the Bordetella pertussis toxin operon (ptx) in E. coli. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273210 [Multi-domain]  Cd Length: 243  Bit Score: 287.06  E-value: 4.98e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680    2 LLAIDVRNTHTVVGLLSgmkeHAKVVQQWRIRTESEVTADELALTIDGLIGEDserLTGTAALSTVPSVLHEVRIMLDQY 81
Cdd:TIGR00671   1 LLLIDVGNTRIVFALNS----GNKVYQFWRLATNLMKTYDEHSEFLKELFGKS---LNKAFISSVVPELTEAVRNMIPKI 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680   82 WPSVPHVlIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSD 161
Cdd:TIGR00671  74 KNIKPEI-FFPLVYDGLPNLYKSPKELGIDRVANALAAIKFYGFNVVVVDAGTALTIDLVDQEGKFLGGAIAPGLGISLH 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680  162 AAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSgfsvdHDVAIVATGHtAPLLLPELHTV 241
Cdd:TIGR00671 153 ALKDRAAALPKFEIARPDEVLGKSTREAVQSGAVYGVLGLIQGLLKDWKKYFK-----RKFAVVITGG-DGKYLSAFLPF 226

                         250
                  ....*....|....*..
gi 489514680  242 DHYDQHLTLQGLRLVFE 258
Cdd:TIGR00671 227 SIYDPHLTVEGMRNLLR 243
CoaX COG1521
Pantothenate kinase type III [Coenzyme transport and metabolism];
1-260 1.03e-87

Pantothenate kinase type III [Coenzyme transport and metabolism];


Pssm-ID: 441130 [Multi-domain]  Cd Length: 250  Bit Score: 261.25  E-value: 1.03e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680   1 MLLAIDVRNTHTVVGLLSGmkehAKVVQQWRIRTESEvTADELALTIDGLIGEDSERLTGTAALSTVPSVLHEVRIMLDQ 80
Cdd:COG1521    1 MLLAIDIGNTRIKWGLFDG----GELLASWRLATDRR-TADELAELLRQLLAALLPDIEGVIISSVVPPLTEALEELLRK 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680  81 YWPSVPHVlIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSS 160
Cdd:COG1521   76 YFGVPPLV-VGPGVKTGLKNAYDNPEELGADRIANAVAARELYGGPLLVVDFGTATTFDVVDADGEYLGGAIAPGLGLSL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680 161 DAAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSgfsvdHDVAIVATGHTAPLLLPELHT 240
Cdd:COG1521  155 EALHQRTAKLPLVELEKPPSVIGKNTVEAIQSGVVYGYAGLIEGLIERIKEELG-----EDPKVIATGGDAPLLAPELKT 229

                        250       260
                 ....*....|....*....|
gi 489514680 241 VDHYDQHLTLQGLRLVFERN 260
Cdd:COG1521  230 IDIVDPDLVLEGLRLIYERN 249
PRK13321 PRK13321
type III pantothenate kinase;
1-262 5.69e-73

type III pantothenate kinase;


Pssm-ID: 237349 [Multi-domain]  Cd Length: 256  Bit Score: 223.98  E-value: 5.69e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680   1 MLLAIDVRNTHTVVGLLsgmkEHAKVVQQWRIRTESEVTADELALTIDGLIGE---DSERLTGTAALSTVPSVLHEVRIM 77
Cdd:PRK13321   1 MLLLIDVGNTNIKLGVF----DGDRLLRSFRLPTDKSRTSDELGILLLSLFRHaglDPEDIRAVVISSVVPPLNYSLESA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680  78 LDQYWPSVPHVlIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRFR-KAAIVVDFGSSICVDVVSAKGEFLGGAIAPGV 156
Cdd:PRK13321  77 CKRYFGIKPLF-VGPGIKTGLKIRYDNPREVGADRIVNAVAARRLYPdRNLIVVDFGTATTFDCVSGKGEYLGGAICPGI 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680 157 QVSSDAAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSGfsvdhDVAIVATGHTAPLLLP 236
Cdd:PRK13321 156 LISMEALSQKTAKLPRVEIAKPPSAIGKSTVSSIQSGLYYGYAGLVEGIVARIKAELGG-----PPRVIATGGFASLIAK 230

                        250       260
                 ....*....|....*....|....*.
gi 489514680 237 ELHTVDHYDQHLTLQGLRLVFERNLE 262
Cdd:PRK13321 231 ESRCFDHVDPDLLLEGLRILYQMNRA 256
Pan_kinase pfam03309
Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of ...
 2-208 7.56e-70

Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of pantothenate (Pan), the first step in the universal pathway of CoA biosynthesis.


Pssm-ID: 460881 [Multi-domain]  Cd Length: 205  Bit Score: 213.96  E-value: 7.56e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680    2 LLAIDVRNTHTVVGLLSGmkehAKVVQQWRIRTESEVTADELALTIDGLIGEDSERLTGTAALSTV-PSVLHEVRIMLDQ 80
Cdd:pfam03309   1 LLAIDIGNTNIKWGLFDG----DKLVAHWRISTDARRTADELGVLLRSLLRLAGIDPIDGVIISSVvPPLNAALERACLK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680   81 YWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRF-RKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVS 159
Cdd:pfam03309  77 YFKIEPLVVGAPGIKTGLRNRYDNPKELGADRWVNAVAARELYpGKPLIVVDFGTATTFDAVSADGEYLGGAIAPGIGLS 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 489514680  160 SDAAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGR 208
Cdd:pfam03309 157 LDALAQGTAKLPRVEITRPGSVIGKNTVEAIQSGILYGYAGLVEGIIRR 205
ASKHA_NBD_PanK-III cd24015
nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar ...
 3-256 2.23e-67

nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar proteins; PanK (EC 2.7.1.33), also called pantothenic acid kinase, is the first enzyme in the Coenzyme A (CoA) biosynthetic pathway. It catalyzes the phosphorylation of pantothenate (vitamin B5) to form 4'-phosphopantothenate at the expense of a molecule of adenosine triphosphate (ATP), which is the rate-limiting step in CoA biosynthesis. It cannot utilize a phosphoryl donor other than ATP. Three distinct types of PanK have been identified, PanK-I, PanK-II and PanK-III. The model corresponds to PanK-III that belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466865 [Multi-domain]  Cd Length: 241  Bit Score: 209.04  E-value: 2.23e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680   3 LAIDVRNTHTVVGLLsgmkEHAKVVQQWRIRTESEVTADELALTIDGLIGEDserLTGTAALSTVPSVLHEVRIMLDQYW 82
Cdd:cd24015    1 LVIDIGNTNIKLGLF----DGGELVKIWRLSTDKELTEDELLLLLAGIELED---ISGVVISSVVPSLTEVLEEALKKYF 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680  83 PSVPHVlIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDA 162
Cdd:cd24015   74 GISPLV-VGPGLKLGVKIAYDNPKELGADRLANAVAAAKLYGRPVIVVDFGTATTIDLVDAEGEFLGGAIAPGIELSLKA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680 163 AAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSGfsvdhDVAIVATGHTAPLLLPELHTVD 242
Cdd:cd24015  153 LHQRTAKLPSVELIKPKKVIGKNTEEAIQSGVFYGYAGLIEGIIERLKKELGG-----DAKVILTGGDAKLVAPYLEPID 227

                        250
                 ....*....|....
gi 489514680 243 HYDQHLTLQGLRLV 256
Cdd:cd24015  228 IYDPDLTLKGLKLI 241
PRK13320 PRK13320
type III pantothenate kinase;
1-260 1.72e-28

type III pantothenate kinase;


Pssm-ID: 237348 [Multi-domain]  Cd Length: 244  Bit Score: 108.80  E-value: 1.72e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680   1 MLLAIDVRNTHTVVGLLSGmkEHAKVVQQwrirteseVTADELALTIDGLIGEDSErlTGTAALSTVPSVLHEVRIMLDQ 80
Cdd:PRK13320   3 MNLVIDIGNTTTKLAVFEG--DELLEVFV--------VSTEGVEESLEKLLAKYPA--IRDAIVSSVVPLAEEAFSALLK 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680  81 YWPSVphVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRF-RKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVS 159
Cdd:PRK13320  71 LLFAV--LELDSETPLPFRNDYDTPETLGADRLALCAGARYLFpGKNVLAIDAGTAITYDVLDSEGVYLGGLISPGLEMR 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680 160 SDAAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSgfsvdhDVAIVATGHTAPLLLPELH 239
Cdd:PRK13320 149 FKALHEFTARLPLVTIEGPIPLIGRSTEECIRSGVVWGCVAEIEGLIEAYKSKLP------ELLVILTGGDAPFLASRLK 222

                        250       260
                 ....*....|....*....|.
gi 489514680 240 TVDHYDQHLTLQGLRLVFERN 260
Cdd:PRK13320 223 NTIFADEHAVLKGLNRILEYN 243
PRK13324 PRK13324
type III pantothenate kinase;
1-260 4.51e-17

type III pantothenate kinase;


Pssm-ID: 106284 [Multi-domain]  Cd Length: 258  Bit Score: 78.51  E-value: 4.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680   1 MLLAIDVRNTHTVVGLLSGmkehAKVVQQWRIRTES-EVTADELALTIDGLIGEDS---ERLTGTAALSTVPSVLHEVRI 76
Cdd:PRK13324   1 MLLVMDMGNSHIHIGVFDG----DRIVSQIRYATSSvDSTSDQMGVFLRQALRENSvdlGKIDGCGISSVVPHLNYSLGS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680  77 MLDQYWPSVPHVLIEPgvRTGIPLLVDNPKEVGADRIVNCLAAY-DRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPG 155
Cdd:PRK13324  77 AVIKYFNIKPFFISMD--TTDLDMSAVEAHQVGADRIASCISAIaDHPNKDLLIIDLGTATTFDLVTKDKKYLSGSIMPG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680 156 VQVSSDAAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSGfsvdhDVAIVATGHTAPLLL 235
Cdd:PRK13324 155 VKLSLNALCQGASQLSSVTIVKPEVAIGYDTKTNIRSGLYYGHLGALKELKRRSVEEFGS-----PVYTIATGGFAGLFK 229

                        250       260
                 ....*....|....*....|....*
gi 489514680 236 PElHTVDHYDQHLTLQGLRLVFERN 260
Cdd:PRK13324 230 EE-DIFNEISPDLILRGIRIAFLEN 253
PRK13329 PRK13329
pantothenate kinase; Reviewed
 1-256 1.06e-13

pantothenate kinase; Reviewed


Pssm-ID: 183979 [Multi-domain]  Cd Length: 249  Bit Score: 68.87  E-value: 1.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680   1 MLLAIDVRNTHtvvgLLSGMKEHAKVVQQWRIRtesevtADELALTIDGLIGEDSERLTGTAAL--STV--PSVLHEVRI 76
Cdd:PRK13329   2 TFLAIDVGNTR----LKWGLYDAAQPGAALLAH------GAEFLAEIDRLAEGAWAGLPAPARVlgCNVagDAVARRVAE 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680  77 MLDQyWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGV 156
Cdd:PRK13329  72 QLEL-WDVAPRWVVASAAECGVRNGYDHPARLGADRWVALIGARHGPARPCLVVMVGTAVTVDALDADGEFLGGLILPGH 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680 157 QVSSDAAAARSAAlrrveLARPRSVVG---KNTVECMQAGAVFGFAGLVDGLVGRIREdvsgfSVDHDVAIVATGHTAPL 233
Cdd:PRK13329 151 GLMLRALESGTAG-----LHVPTGEVRefpTNTSDALTSGGTQAIAGAVERMFRHLAQ-----HCGAEPECLLTGGAAWK 220

                        250       260
                 ....*....|....*....|...
gi 489514680 234 LLPELHTVDHYDQHLTLQGLRLV 256
Cdd:PRK13329 221 LAPSLTVPFELVDNLVLDGLLVI 243
PRK13322 PRK13322
pantothenate kinase; Reviewed
 30-258 8.05e-12

pantothenate kinase; Reviewed


Pssm-ID: 237350 [Multi-domain]  Cd Length: 246  Bit Score: 63.43  E-value: 8.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680  30 WRIrteseVTADELALTIDGLIGEDSERLTGTAALSTVP-------SVL-----HEVRIMLDQYWpSVPHVLIEP----- 92
Cdd:PRK13322  14 WRV-----IDNGGQIIEHGAHLDSPAELLLGLANLASLAptrcrivSVLseeetARLVAILEKRL-GIPVVFAKVaaela 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680  93 GVRTGipllVDNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAAAARSAALRR 172
Cdd:PRK13322  88 GVRNG----YEDPEQLGIDRWLALLGAFHLAKNACLVIDCGTAVTIDLVDADGQHLGGYICPGLYLMRDALRTHTRRIRY 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680 173 VELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSGfsvdhDVAIVATGHTAPLLLPELhTVDHYDQHLTLQG 252
Cdd:PRK13322 164 DDGTADSLSPGRNTVDAVERGCLLMLRGFIESQLEQARELWGP-----DFEIFLTGGDAPLLADHL-PQARVVPDLVFVG 237


                 ....*.
gi 489514680 253 LRLVFE 258
Cdd:PRK13322 238 LAQYCP 243
PRK13331 PRK13331
pantothenate kinase; Reviewed
 82-254 7.25e-09

pantothenate kinase; Reviewed


Pssm-ID: 237353 [Multi-domain]  Cd Length: 251  Bit Score: 55.05  E-value: 7.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680  82 WPSVPHV-LIEpgvRTGIPLLVDNPKeVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSS 160
Cdd:PRK13331  73 WQTYPNVrLIT---LDDIPLNNLYPT-LGIDRALALWGAGQTYGFPCLVIDAGTALTFTGVDSDRTLVGGAILPGLGLQL 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680 161 DAAAARSAALRRVEL-ARPRSVVGKNTVECMQAGAVFGFAGlvdGLVGRIREDVSGFSvdhDVAIVATGHTAPLLL---- 235
Cdd:PRK13331 149 RSLADKTAALPQVELpPPLPPRWATNTQEAIQSGVIYTILA---GLRDFIEDWLSLFP---DGKIVLTGGDGELLHnylq 222

                        170       180
                 ....*....|....*....|..
gi 489514680 236 ---PELHTVDHYDQHLTLQGLR 254
Cdd:PRK13331 223 dldPELAQRLRVDPNLIFWGIA 244
PRK13328 PRK13328
type III pantothenate kinase;
78-256 8.02e-09

type III pantothenate kinase;


Pssm-ID: 237352 [Multi-domain]  Cd Length: 255  Bit Score: 55.02  E-value: 8.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680  78 LDQYWPSVPHVLIEP-----GVRTGIPllvdNPKEVGADRIVNCLAAYDRFRKAA-IVVDFGSSICVDVVSAKGEFLGGA 151
Cdd:PRK13328  69 LAARWPGLPVTWVRSraaqcGVRNGYR----EPAQLGSDRWAGLIGARAAFPGEHlLIATFGTATTLDALRADGRFAGGL 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680 152 IAPGVQVSSDAAAA------RSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSGfsvdhDVAIV 225
Cdd:PRK13328 145 ILPGLALMMRALARhtaqlpTLDVDAASAAAGAVAPFADDTPDAISAGCLAAQAGLIERAWRDLAARWQA-----PVRLV 219

                        170       180       190
                 ....*....|....*....|....*....|.
gi 489514680 226 ATGHTAPLLLPELHTVDHYDQHLTLQGLRLV 256
Cdd:PRK13328 220 LSGGAADAVAPALTVPHTRHDNLVLLGLALI 250
PRK13326 PRK13326
type III pantothenate kinase;
108-256 5.31e-06

type III pantothenate kinase;


Pssm-ID: 237351  Cd Length: 262  Bit Score: 46.70  E-value: 5.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680 108 VGADRIVNCLAAYDRFR-KAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAAAARSAALRRVELARPRSVVGKNT 186
Cdd:PRK13326 108 LGSDVFANLVGAIEYYNiNDALVVDLGTACTIFAVSRQDGILGGLINGGPFTNLNALLDNAYLLKDFNLSVPKNLLGLST 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514680 187 VECMQAGAVFGFAGLVDGLVGRIREDvsgfsVDHDVAIVATGHTAPLLLPELHTVDHYDQHLTLQGLRLV 256
Cdd:PRK13326 188 SDSVNSGVIYQYKYLIEGVYHDLKRN-----YDREFNLIITGGNSNLILPLISVDFIFNLYLTLEGIRIL 252
PRK13333 PRK13333
type III pantothenate kinase;
106-157 6.31e-06

type III pantothenate kinase;


Pssm-ID: 183981 [Multi-domain]  Cd Length: 206  Bit Score: 45.69  E-value: 6.31e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489514680 106 KEVGADRIVNCLAAYDrfrkaAIVVDFGSSICVDVVSaKGEFLGGAIAPGVQ 157
Cdd:PRK13333  70 QGLGIDRIAACYAIED-----GVVVDAGSAITVDIMS-NGIHLGGFILPGIA 115
PRK13325 PRK13325
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/type III pantothenate kinase;
104-158 1.40e-05

bifunctional biotin--[acetyl-CoA-carboxylase] ligase/type III pantothenate kinase;


Pssm-ID: 183976 [Multi-domain]  Cd Length: 592  Bit Score: 45.86  E-value: 1.40e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489514680 104 NPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQV 158
Cdd:PRK13325 428 HPEEHGSDRWFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGFHL 482
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH