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Conserved domains on  [gi|489514873|ref|WP_003419710|]
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MULTISPECIES: phage holin family protein [Mycobacterium]

Protein Classification

phage holin family protein( domain architecture ID 10538267)

phage holin family protein may function in the transport of murein hydrolases (endolysins) across the cytoplasmic membrane to the cell wall where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis

Gene Ontology:  GO:0016020|GO:0005886
PubMed:  7669346

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Phage_holin_3_6 pfam07332
Putative Actinobacterial Holin-X, holin superfamily III; Phage_holin_3_6 is a family of small ...
 35-145 8.47e-28

Putative Actinobacterial Holin-X, holin superfamily III; Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.


:

Pssm-ID: 462148  Cd Length: 113  Bit Score: 99.92  E-value: 8.47e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514873   35 IKDATTQMSTLVRAEVELARAEITRDVKKGLTGSVFFISSLVVGFYSTFFFFFFVAELLDTWIWRWVAFLLVFAIMVVVT 114
Cdd:pfam07332   1 VRDLTAQLSTLVRTELELAKAELAEEAKRAGKGAGLLGAAGVLALFGLLFLLAALALALALVLPLWLAALIVAAVLLVVA 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 489514873  115 AVLALLGFLKVRRIRG-PRQTIASVKETRTAL 145
Cdd:pfam07332  81 GVLALVGRKRLKRASPlPERTIEELKEDVEAL 112
 
Name Accession Description Interval E-value
Phage_holin_3_6 pfam07332
Putative Actinobacterial Holin-X, holin superfamily III; Phage_holin_3_6 is a family of small ...
 35-145 8.47e-28

Putative Actinobacterial Holin-X, holin superfamily III; Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.


Pssm-ID: 462148  Cd Length: 113  Bit Score: 99.92  E-value: 8.47e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514873   35 IKDATTQMSTLVRAEVELARAEITRDVKKGLTGSVFFISSLVVGFYSTFFFFFFVAELLDTWIWRWVAFLLVFAIMVVVT 114
Cdd:pfam07332   1 VRDLTAQLSTLVRTELELAKAELAEEAKRAGKGAGLLGAAGVLALFGLLFLLAALALALALVLPLWLAALIVAAVLLVVA 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 489514873  115 AVLALLGFLKVRRIRG-PRQTIASVKETRTAL 145
Cdd:pfam07332  81 GVLALVGRKRLKRASPlPERTIEELKEDVEAL 112
CvpA COG1286
Colicin V production accessory protein CvpA, regulator of purF expression and biofilm ...
 62-123 3.27e-03

Colicin V production accessory protein CvpA, regulator of purF expression and biofilm formation [Nucleotide transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440897 [Multi-domain]  Cd Length: 161  Bit Score: 36.31  E-value: 3.27e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489514873  62 KKGLTGSVFFISSLVVGFYSTFFFFFFVAELLDTWIW-----RWVAFLLVFAIMVVVTAVLA-LLGFL 123
Cdd:COG1286   21 RRGFVREVLSLAGWIAAFFVALRFYPPLAPLLTLYIPdpalrNAVAFALLFIVVLIVGSLLGsLLSKL 88
 
Name Accession Description Interval E-value
Phage_holin_3_6 pfam07332
Putative Actinobacterial Holin-X, holin superfamily III; Phage_holin_3_6 is a family of small ...
 35-145 8.47e-28

Putative Actinobacterial Holin-X, holin superfamily III; Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.


Pssm-ID: 462148  Cd Length: 113  Bit Score: 99.92  E-value: 8.47e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489514873   35 IKDATTQMSTLVRAEVELARAEITRDVKKGLTGSVFFISSLVVGFYSTFFFFFFVAELLDTWIWRWVAFLLVFAIMVVVT 114
Cdd:pfam07332   1 VRDLTAQLSTLVRTELELAKAELAEEAKRAGKGAGLLGAAGVLALFGLLFLLAALALALALVLPLWLAALIVAAVLLVVA 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 489514873  115 AVLALLGFLKVRRIRG-PRQTIASVKETRTAL 145
Cdd:pfam07332  81 GVLALVGRKRLKRASPlPERTIEELKEDVEAL 112
CvpA COG1286
Colicin V production accessory protein CvpA, regulator of purF expression and biofilm ...
 62-123 3.27e-03

Colicin V production accessory protein CvpA, regulator of purF expression and biofilm formation [Nucleotide transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440897 [Multi-domain]  Cd Length: 161  Bit Score: 36.31  E-value: 3.27e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489514873  62 KKGLTGSVFFISSLVVGFYSTFFFFFFVAELLDTWIW-----RWVAFLLVFAIMVVVTAVLA-LLGFL 123
Cdd:COG1286   21 RRGFVREVLSLAGWIAAFFVALRFYPPLAPLLTLYIPdpalrNAVAFALLFIVVLIVGSLLGsLLSKL 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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