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Conserved domains on  [gi|489518605|ref|WP_003423413|]
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acetate--CoA ligase family protein [Clostridioides difficile]

Protein Classification

acetate--CoA ligase family protein( domain architecture ID 11437147)

acetate--CoA ligase family protein similar to ADP-forming acetate--CoA ligase that catalyzes the formation of acetate and ATP from acetyl-CoA by using ADP and phosphate

CATH:  3.30.1490.20
EC:  6.2.1.-
Gene Ontology:  GO:0043758|GO:0005524|GO:0046872
PubMed:  15491124|15316652
SCOP:  3000003

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PatZN COG1042
Acyl-CoA synthetase (NDP forming) [Energy production and conversion];
2-696 0e+00

Acyl-CoA synthetase (NDP forming) [Energy production and conversion];


:

Pssm-ID: 440664 [Multi-domain]  Cd Length: 708  Bit Score: 581.31  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605   2 SLEKLIRPKSIAIVGVTDKLG-FGRSAALSIVKSKDTDRVYYVNPKREELFGRKCYKTIQEVPEIVDCVVVCTPRNVVPS 80
Cdd:COG1042    5 SLDALFRPRSVAVIGASDRPGkVGGRVLRNLLEGGFKGKIYPVNPKYDEVLGLPCYPSVADLPEPPDLAVIAVPAETVPD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605  81 VLKDSAELGTKAAVVYASGFAEEGtEEGTDLENQLIEISNTYDMKILGPNCMGLLNCIDKVNLWAGGskwdLDTKKPGIG 160
Cdd:COG1042   85 VVEECGEKGVKAAVVISAGFAETG-EEGAALEQELLEIARRYGMRLLGPNCLGLINPATGLNATFAP----VPPLPGNIA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 161 IVGQSGFITAEIVssDYFN-----ISYGFSTGNGNIVTLEDAVDFLVDDNYASVIAIYLEGLKNPQKFIDALkRAAQKRK 235
Cdd:COG1042  160 LVSQSGALGTAIL--DWAAargigFSHFVSLGNEADVDFADLLDYLADDPDTRVILLYLEGIRDGRRFLSAA-RAAARGK 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 236 PVIILKSGRSEKGAISAASHTGNLAGSSKAFESIFEKYGVISVENLEQFMCLAQAFSVldGNLPTNSNFAAINFSGGENT 315
Cdd:COG1042  237 PVVVLKSGRSEAGARAAASHTGALAGSDAVYDAAFRRAGVIRVDDLEELFDAAEALAR--QPPPRGRRLAIVTNSGGPGV 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 316 ICADLAEENGVELAEISSETKEEMKKYLPGFATPKNPLD----ATTALFHEkdmivgLLHTFEKDSSVG-----FTMVGA 386
Cdd:COG1042  315 LAADALEDLGLELAELSEETQAALRAVLPPFASVGNPVDitgdADPERYAA------ALEALLADPNVDavlviLTPTAM 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 387 nirdeenEMHETLCQAVSEAReQGLKKPVFAVpTLEGNRYLDYRNRLEYNQVPIMSSVGTTFTCFNKMAKF--------- 457
Cdd:COG1042  389 -------TDPEEVAEALIEAA-KGSGKPVLAS-WMGGDSVAEARRLLREAGIPTFRTPERAVRALAALVRYrrnqerlme 459

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 458 ------IDYDYSKRTLEFKAVKKRESNnvvALSELDSKIEMKKYGVPVPGQGNAKSIDELDEILKYIKYPVVLKINSSEI 531
Cdd:COG1042  460 tpasedFDPDRERARAIIEAALAEGRG---VLTEAEAKALLAAYGIPVVPTRLARSAEEAVAAAEEIGYPVVLKIVSPDI 536

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 532 LHKSDVGGVKIGIKNRDEAVDAYNEILTNVKKAKPDANIDGILVQEMVESGIEIIIGITNDDQFGPMLLVGLGGVFVEVF 611
Cdd:COG1042  537 LHKSDVGGVRLNLRDAEAVRAAFEEILARVRAARPDARIDGVLVQPMVPGGVELIVGVKRDPVFGPVIMFGLGGIFVEVL 616

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 612 KDTTLYPLPINHDEAIMMLKKLKSFKLLNGYRGSEPCDIDALADMMVKLGKYAYENKdEVKEIDLNPVFVYPkgKGVCAV 691
Cdd:COG1042  617 KDVALRLPPLNEALAREMIRELRAAKLLRGYRGRPPADLDALADVLVRLSQLAADLP-EILELDINPLLVVP--EGVVAV 693


                 ....*
gi 489518605 692 DALIV 696
Cdd:COG1042  694 DARIR 698
 
Name Accession Description Interval E-value
PatZN COG1042
Acyl-CoA synthetase (NDP forming) [Energy production and conversion];
2-696 0e+00

Acyl-CoA synthetase (NDP forming) [Energy production and conversion];


Pssm-ID: 440664 [Multi-domain]  Cd Length: 708  Bit Score: 581.31  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605   2 SLEKLIRPKSIAIVGVTDKLG-FGRSAALSIVKSKDTDRVYYVNPKREELFGRKCYKTIQEVPEIVDCVVVCTPRNVVPS 80
Cdd:COG1042    5 SLDALFRPRSVAVIGASDRPGkVGGRVLRNLLEGGFKGKIYPVNPKYDEVLGLPCYPSVADLPEPPDLAVIAVPAETVPD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605  81 VLKDSAELGTKAAVVYASGFAEEGtEEGTDLENQLIEISNTYDMKILGPNCMGLLNCIDKVNLWAGGskwdLDTKKPGIG 160
Cdd:COG1042   85 VVEECGEKGVKAAVVISAGFAETG-EEGAALEQELLEIARRYGMRLLGPNCLGLINPATGLNATFAP----VPPLPGNIA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 161 IVGQSGFITAEIVssDYFN-----ISYGFSTGNGNIVTLEDAVDFLVDDNYASVIAIYLEGLKNPQKFIDALkRAAQKRK 235
Cdd:COG1042  160 LVSQSGALGTAIL--DWAAargigFSHFVSLGNEADVDFADLLDYLADDPDTRVILLYLEGIRDGRRFLSAA-RAAARGK 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 236 PVIILKSGRSEKGAISAASHTGNLAGSSKAFESIFEKYGVISVENLEQFMCLAQAFSVldGNLPTNSNFAAINFSGGENT 315
Cdd:COG1042  237 PVVVLKSGRSEAGARAAASHTGALAGSDAVYDAAFRRAGVIRVDDLEELFDAAEALAR--QPPPRGRRLAIVTNSGGPGV 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 316 ICADLAEENGVELAEISSETKEEMKKYLPGFATPKNPLD----ATTALFHEkdmivgLLHTFEKDSSVG-----FTMVGA 386
Cdd:COG1042  315 LAADALEDLGLELAELSEETQAALRAVLPPFASVGNPVDitgdADPERYAA------ALEALLADPNVDavlviLTPTAM 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 387 nirdeenEMHETLCQAVSEAReQGLKKPVFAVpTLEGNRYLDYRNRLEYNQVPIMSSVGTTFTCFNKMAKF--------- 457
Cdd:COG1042  389 -------TDPEEVAEALIEAA-KGSGKPVLAS-WMGGDSVAEARRLLREAGIPTFRTPERAVRALAALVRYrrnqerlme 459

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 458 ------IDYDYSKRTLEFKAVKKRESNnvvALSELDSKIEMKKYGVPVPGQGNAKSIDELDEILKYIKYPVVLKINSSEI 531
Cdd:COG1042  460 tpasedFDPDRERARAIIEAALAEGRG---VLTEAEAKALLAAYGIPVVPTRLARSAEEAVAAAEEIGYPVVLKIVSPDI 536

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 532 LHKSDVGGVKIGIKNRDEAVDAYNEILTNVKKAKPDANIDGILVQEMVESGIEIIIGITNDDQFGPMLLVGLGGVFVEVF 611
Cdd:COG1042  537 LHKSDVGGVRLNLRDAEAVRAAFEEILARVRAARPDARIDGVLVQPMVPGGVELIVGVKRDPVFGPVIMFGLGGIFVEVL 616

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 612 KDTTLYPLPINHDEAIMMLKKLKSFKLLNGYRGSEPCDIDALADMMVKLGKYAYENKdEVKEIDLNPVFVYPkgKGVCAV 691
Cdd:COG1042  617 KDVALRLPPLNEALAREMIRELRAAKLLRGYRGRPPADLDALADVLVRLSQLAADLP-EILELDINPLLVVP--EGVVAV 693


                 ....*
gi 489518605 692 DALIV 696
Cdd:COG1042  694 DARIR 698
AcCoA-syn-alpha TIGR02717
acetyl coenzyme A synthetase (ADP forming), alpha domain; Although technically reversible, it ...
 3-415 2.29e-96

acetyl coenzyme A synthetase (ADP forming), alpha domain; Although technically reversible, it is believed that this group of ADP-dependent acetyl-CoA synthetases (ACS) act in the direction of acetate and ATP production in the organisms in which it has been characterized. In most species this protein exists as a fused alpha-beta domain polypeptide. In Pyrococcus and related species, however the domains exist as separate polypeptides. This model represents the alpha (N-terminal) domain. In Pyrococcus and related species there appears to have been the development of a paralogous family such that four other proteins are close relatives. In reference, one of these (along with its beta-domain partner) was characterized as ACS-II showing specificity for phenylacetyl-CoA. This model has been constructed to exclude these non-ACS-I paralogs. This may result in new, authentic ACS-I sequences falling below the trusted cutoff.


Pssm-ID: 131764 [Multi-domain]  Cd Length: 447  Bit Score: 304.62  E-value: 2.29e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605    3 LEKLIRPKSIAIVGVTDKLG-FGRSAALSIVKSKDTDRVYYVNPKREELFGRKCYKTIQEVPEIVDCVVVCTPRNVVPSV 81
Cdd:TIGR02717   1 LEHLFNPKSVAVIGASRDPGkVGYAIMKNLIEGGYKGKIYPVNPKAGEILGVKAYPSVLEIPDPVDLAVIVVPAKYVPQV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605   82 LKDSAELGTKAAVVYASGFAEEGtEEGTDLENQLIEISNTYDMKILGPNCMGLLNCIDKVNLWAGGSkwdlDTKKPGIGI 161
Cdd:TIGR02717  81 VEECGEKGVKGAVVITAGFKEVG-EEGAELEQELVEIARKYGMRLLGPNCLGIINTHIKLNATFAPT----MPKKGGIAF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605  162 VGQSG-FITA--EIVSSDYFNISYGFSTGNGNIVTLEDAVDFLVDDNYASVIAIYLEGLKNPQKFIDALKRAAqKRKPVI 238
Cdd:TIGR02717 156 ISQSGaLLTAllDWAEKNGVGFSYFVSLGNKADIDESDLLEYLADDPDTKVILLYLEGIKDGRKFLKTAREIS-KKKPIV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605  239 ILKSGRSEKGAISAASHTGNLAGSSKAFESIFEKYGVISVENLEQFMCLAQAFSVLdgNLPTNSNFAAINFSGGENTICA 318
Cdd:TIGR02717 235 VLKSGTSEAGAKAASSHTGALAGSDEAYDAAFKQAGVIRADSIEELFDLARLLSNQ--PLPKGNRVAIITNAGGPGVIAT 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605  319 DLAEENGVELAEISSETKEEMKKYLPGFATPKNPLD----ATTALFhekdmiVGLLHTFEKDSSVGFTMV----GANIRD 390
Cdd:TIGR02717 313 DACEENGLELAELSEATKNKLRNILPPEASIKNPVDvlgdATPERY------AKALKTVAEDENVDGVVVvltpTAMTDP 386

                         410       420
                  ....*....|....*....|....*
gi 489518605  391 EEnemhetLCQAVSEAREQGLKKPV 415
Cdd:TIGR02717 387 EE------VAKGIIEGAKKSNEKPV 405
ATP-grasp_5 pfam13549
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ...
 483-696 4.15e-64

ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 463918 [Multi-domain]  Cd Length: 221  Bit Score: 211.95  E-value: 4.15e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605  483 LSELDSKIEMKKYGVPVPGQGNAKSIDELDEILKYIKYPVVLKINSSEILHKSDVGGVKIGIKNRDEAVDAYNEILTNVK 562
Cdd:pfam13549  10 LTEPEAKALLAAYGIPVVPTRLARSPEEAVAAAEEIGYPVVLKIVSPDILHKSDVGGVRLNLRSAEAVRAAYEEILERVR 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605  563 KAKPDANIDGILVQEMVESGIEIIIGITNDDQFGPMLLVGLGGVFVEVFKDTTLYPLPINHDEAIMMLKKLKSFKLLNGY 642
Cdd:pfam13549  90 RYRPDARIEGVLVQPMAPGGRELIVGVTRDPQFGPVIMFGLGGIAVEVLKDVAFRLPPLNMTLAREMIRRTRAYKLLKGY 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 489518605  643 RGSEPCDIDALADMMVKLGKYAYENKdEVKEIDLNPVFVYPkgKGVCAVDALIV 696
Cdd:pfam13549 170 RGEPPADLDALEDVLVRVSQLVIDFP-EIRELDINPLLADE--DGVVALDARIR 220
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 8-100 7.24e-15

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 70.62  E-value: 7.24e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605     8 RPKSIAIVGVTDKLGfgrSAALSIVKSKDTD------RVY--YVNPKREELfgrKCYKTIQEVPE--IVDCVVVCTPRNV 77
Cdd:smart00881   4 PNTSVAVVGASGNLG---SFGLAVMRNLLEYgtkfvgGVYpgKVGPKVDGV---PVYDSVAEAPEetGVDVAVIFVPAEA 77

                           90       100
                   ....*....|....*....|...
gi 489518605    78 VPSVLKDSAELGTKAAVVYASGF 100
Cdd:smart00881  78 APDAIDEAIEAGIKGIVVITEGI 100
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 496-556 1.27e-04

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 45.15  E-value: 1.27e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489518605 496 GVPVPGQGNAKSIDELDEILKYIKYPVVLKinsseilhKSDvG----GVKIGIKNRDEAVDAYNE 556
Cdd:PRK14016 226 GVPVPEGRVVTSAEDAWEAAEEIGYPVVVK--------PLD-GnhgrGVTVNITTREEIEAAYAV 281
 
Name Accession Description Interval E-value
PatZN COG1042
Acyl-CoA synthetase (NDP forming) [Energy production and conversion];
2-696 0e+00

Acyl-CoA synthetase (NDP forming) [Energy production and conversion];


Pssm-ID: 440664 [Multi-domain]  Cd Length: 708  Bit Score: 581.31  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605   2 SLEKLIRPKSIAIVGVTDKLG-FGRSAALSIVKSKDTDRVYYVNPKREELFGRKCYKTIQEVPEIVDCVVVCTPRNVVPS 80
Cdd:COG1042    5 SLDALFRPRSVAVIGASDRPGkVGGRVLRNLLEGGFKGKIYPVNPKYDEVLGLPCYPSVADLPEPPDLAVIAVPAETVPD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605  81 VLKDSAELGTKAAVVYASGFAEEGtEEGTDLENQLIEISNTYDMKILGPNCMGLLNCIDKVNLWAGGskwdLDTKKPGIG 160
Cdd:COG1042   85 VVEECGEKGVKAAVVISAGFAETG-EEGAALEQELLEIARRYGMRLLGPNCLGLINPATGLNATFAP----VPPLPGNIA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 161 IVGQSGFITAEIVssDYFN-----ISYGFSTGNGNIVTLEDAVDFLVDDNYASVIAIYLEGLKNPQKFIDALkRAAQKRK 235
Cdd:COG1042  160 LVSQSGALGTAIL--DWAAargigFSHFVSLGNEADVDFADLLDYLADDPDTRVILLYLEGIRDGRRFLSAA-RAAARGK 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 236 PVIILKSGRSEKGAISAASHTGNLAGSSKAFESIFEKYGVISVENLEQFMCLAQAFSVldGNLPTNSNFAAINFSGGENT 315
Cdd:COG1042  237 PVVVLKSGRSEAGARAAASHTGALAGSDAVYDAAFRRAGVIRVDDLEELFDAAEALAR--QPPPRGRRLAIVTNSGGPGV 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 316 ICADLAEENGVELAEISSETKEEMKKYLPGFATPKNPLD----ATTALFHEkdmivgLLHTFEKDSSVG-----FTMVGA 386
Cdd:COG1042  315 LAADALEDLGLELAELSEETQAALRAVLPPFASVGNPVDitgdADPERYAA------ALEALLADPNVDavlviLTPTAM 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 387 nirdeenEMHETLCQAVSEAReQGLKKPVFAVpTLEGNRYLDYRNRLEYNQVPIMSSVGTTFTCFNKMAKF--------- 457
Cdd:COG1042  389 -------TDPEEVAEALIEAA-KGSGKPVLAS-WMGGDSVAEARRLLREAGIPTFRTPERAVRALAALVRYrrnqerlme 459

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 458 ------IDYDYSKRTLEFKAVKKRESNnvvALSELDSKIEMKKYGVPVPGQGNAKSIDELDEILKYIKYPVVLKINSSEI 531
Cdd:COG1042  460 tpasedFDPDRERARAIIEAALAEGRG---VLTEAEAKALLAAYGIPVVPTRLARSAEEAVAAAEEIGYPVVLKIVSPDI 536

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 532 LHKSDVGGVKIGIKNRDEAVDAYNEILTNVKKAKPDANIDGILVQEMVESGIEIIIGITNDDQFGPMLLVGLGGVFVEVF 611
Cdd:COG1042  537 LHKSDVGGVRLNLRDAEAVRAAFEEILARVRAARPDARIDGVLVQPMVPGGVELIVGVKRDPVFGPVIMFGLGGIFVEVL 616

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 612 KDTTLYPLPINHDEAIMMLKKLKSFKLLNGYRGSEPCDIDALADMMVKLGKYAYENKdEVKEIDLNPVFVYPkgKGVCAV 691
Cdd:COG1042  617 KDVALRLPPLNEALAREMIRELRAAKLLRGYRGRPPADLDALADVLVRLSQLAADLP-EILELDINPLLVVP--EGVVAV 693


                 ....*
gi 489518605 692 DALIV 696
Cdd:COG1042  694 DARIR 698
AcCoA-syn-alpha TIGR02717
acetyl coenzyme A synthetase (ADP forming), alpha domain; Although technically reversible, it ...
 3-415 2.29e-96

acetyl coenzyme A synthetase (ADP forming), alpha domain; Although technically reversible, it is believed that this group of ADP-dependent acetyl-CoA synthetases (ACS) act in the direction of acetate and ATP production in the organisms in which it has been characterized. In most species this protein exists as a fused alpha-beta domain polypeptide. In Pyrococcus and related species, however the domains exist as separate polypeptides. This model represents the alpha (N-terminal) domain. In Pyrococcus and related species there appears to have been the development of a paralogous family such that four other proteins are close relatives. In reference, one of these (along with its beta-domain partner) was characterized as ACS-II showing specificity for phenylacetyl-CoA. This model has been constructed to exclude these non-ACS-I paralogs. This may result in new, authentic ACS-I sequences falling below the trusted cutoff.


Pssm-ID: 131764 [Multi-domain]  Cd Length: 447  Bit Score: 304.62  E-value: 2.29e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605    3 LEKLIRPKSIAIVGVTDKLG-FGRSAALSIVKSKDTDRVYYVNPKREELFGRKCYKTIQEVPEIVDCVVVCTPRNVVPSV 81
Cdd:TIGR02717   1 LEHLFNPKSVAVIGASRDPGkVGYAIMKNLIEGGYKGKIYPVNPKAGEILGVKAYPSVLEIPDPVDLAVIVVPAKYVPQV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605   82 LKDSAELGTKAAVVYASGFAEEGtEEGTDLENQLIEISNTYDMKILGPNCMGLLNCIDKVNLWAGGSkwdlDTKKPGIGI 161
Cdd:TIGR02717  81 VEECGEKGVKGAVVITAGFKEVG-EEGAELEQELVEIARKYGMRLLGPNCLGIINTHIKLNATFAPT----MPKKGGIAF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605  162 VGQSG-FITA--EIVSSDYFNISYGFSTGNGNIVTLEDAVDFLVDDNYASVIAIYLEGLKNPQKFIDALKRAAqKRKPVI 238
Cdd:TIGR02717 156 ISQSGaLLTAllDWAEKNGVGFSYFVSLGNKADIDESDLLEYLADDPDTKVILLYLEGIKDGRKFLKTAREIS-KKKPIV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605  239 ILKSGRSEKGAISAASHTGNLAGSSKAFESIFEKYGVISVENLEQFMCLAQAFSVLdgNLPTNSNFAAINFSGGENTICA 318
Cdd:TIGR02717 235 VLKSGTSEAGAKAASSHTGALAGSDEAYDAAFKQAGVIRADSIEELFDLARLLSNQ--PLPKGNRVAIITNAGGPGVIAT 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605  319 DLAEENGVELAEISSETKEEMKKYLPGFATPKNPLD----ATTALFhekdmiVGLLHTFEKDSSVGFTMV----GANIRD 390
Cdd:TIGR02717 313 DACEENGLELAELSEATKNKLRNILPPEASIKNPVDvlgdATPERY------AKALKTVAEDENVDGVVVvltpTAMTDP 386

                         410       420
                  ....*....|....*....|....*
gi 489518605  391 EEnemhetLCQAVSEAREQGLKKPV 415
Cdd:TIGR02717 387 EE------VAKGIIEGAKKSNEKPV 405
ATP-grasp_5 pfam13549
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ...
 483-696 4.15e-64

ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 463918 [Multi-domain]  Cd Length: 221  Bit Score: 211.95  E-value: 4.15e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605  483 LSELDSKIEMKKYGVPVPGQGNAKSIDELDEILKYIKYPVVLKINSSEILHKSDVGGVKIGIKNRDEAVDAYNEILTNVK 562
Cdd:pfam13549  10 LTEPEAKALLAAYGIPVVPTRLARSPEEAVAAAEEIGYPVVLKIVSPDILHKSDVGGVRLNLRSAEAVRAAYEEILERVR 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605  563 KAKPDANIDGILVQEMVESGIEIIIGITNDDQFGPMLLVGLGGVFVEVFKDTTLYPLPINHDEAIMMLKKLKSFKLLNGY 642
Cdd:pfam13549  90 RYRPDARIEGVLVQPMAPGGRELIVGVTRDPQFGPVIMFGLGGIAVEVLKDVAFRLPPLNMTLAREMIRRTRAYKLLKGY 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 489518605  643 RGSEPCDIDALADMMVKLGKYAYENKdEVKEIDLNPVFVYPkgKGVCAVDALIV 696
Cdd:pfam13549 170 RGEPPADLDALEDVLVRVSQLVIDFP-EIRELDINPLLADE--DGVVALDARIR 220
Succ_CoA_lig pfam13607
Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from ...
 158-291 1.53e-44

Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from Succinyl-CoA ligase alpha subunit and other related enzymes. A conserved histidine is involved in phosphoryl transfer.


Pssm-ID: 433345 [Multi-domain]  Cd Length: 138  Bit Score: 156.09  E-value: 1.53e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605  158 GIGIVGQSGFITAEIVS---SDYFNISYGFSTGNGNIVTLEDAVDFLVDDNYASVIAIYLEGLKNPQKFIDALKRAAQkR 234
Cdd:pfam13607   3 NIALVSQSGALGAALLDwarSRGIGFSKFVSLGNEADVDFADLLEYLADDPETRVILLYLEGIRDGRRFLRAARRAAR-R 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 489518605  235 KPVIILKSGRSEKGAISAASHTGNLAGSSKAFESIFEKYGVISVENLEQFMCLAQAF 291
Cdd:pfam13607  82 KPVVVLKAGRSEAGARAAASHTGALAGSDAVYDAAFRQAGVIRVDDLEELFDAAEAL 138
CoA_binding_2 pfam13380
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 10-136 9.07e-21

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 433162 [Multi-domain]  Cd Length: 116  Bit Score: 87.98  E-value: 9.07e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605   10 KSIAIVGVTDKLG-FGRsAALSIVKSKDTdRVYYVNPKREELFGRKCYKTIQEVPEIVDCVVVCTPRNVVPSVLKDSAEL 88
Cdd:pfam13380   1 KTIAVVGASPNPGrPGY-KVARYLLEHGY-PVIPVNPKAKEILGEPVYPSLADPPEPVDLVDVFRPPEAVPEIVEEALAL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 489518605   89 GTKAAVVYASGFAEEgteegtdlenqLIEISNTYDMKILGPNCMGLLN 136
Cdd:pfam13380  79 GAKAVWLQPGIENEE-----------AAAIARAAGIRVVGDRCLGVEH 115
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 8-100 7.24e-15

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 70.62  E-value: 7.24e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605     8 RPKSIAIVGVTDKLGfgrSAALSIVKSKDTD------RVY--YVNPKREELfgrKCYKTIQEVPE--IVDCVVVCTPRNV 77
Cdd:smart00881   4 PNTSVAVVGASGNLG---SFGLAVMRNLLEYgtkfvgGVYpgKVGPKVDGV---PVYDSVAEAPEetGVDVAVIFVPAEA 77

                           90       100
                   ....*....|....*....|...
gi 489518605    78 VPSVLKDSAELGTKAAVVYASGF 100
Cdd:smart00881  78 APDAIDEAIEAGIKGIVVITEGI 100
YccU COG1832
Predicted CoA-binding protein [General function prediction only];
6-92 3.49e-11

Predicted CoA-binding protein [General function prediction only];


Pssm-ID: 441437 [Multi-domain]  Cd Length: 138  Bit Score: 61.30  E-value: 3.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605   6 LIRPKSIAIVGVTDK--------------LGFgrsaalsivkskdtdRVYYVNPKREELFGRKCYKTIQEVPEIVDCVVV 71
Cdd:COG1832   13 LKSAKTIAVVGLSPNperpsyyvakylqrHGY---------------RVIPVNPGAKEILGEKVYASLADIPEPVDIVDV 77

                         90       100
                 ....*....|....*....|.
gi 489518605  72 CTPRNVVPSVLKDSAELGTKA 92
Cdd:COG1832   78 FRRSEAVPEIVDEAIAIGAKV 98
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 486-579 3.26e-07

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 52.18  E-value: 3.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 486 LDSKIEMK----KYGVPVPGQGNAKSIDELDEILKYIKYPVVLK-INSSeilhksdvG--GVKIgIKNRDEAVDAYNEIL 558
Cdd:COG0439   52 MRDKVLMRealaAAGVPVPGFALVDSPEEALAFAEEIGYPVVVKpADGA--------GsrGVRV-VRDEEELEAALAEAR 122

                         90       100
                 ....*....|....*....|.
gi 489518605 559 TNVKKAKPDaniDGILVQEMV 579
Cdd:COG0439  123 AEAKAGSPN---GEVLVEEFL 140
Ligase_CoA_2 pfam19045
Ligase-CoA domain; This domain is related to pfam00549 and adopts a flavodoxin fold.
 307-424 2.81e-05

Ligase-CoA domain; This domain is related to pfam00549 and adopts a flavodoxin fold.


Pssm-ID: 408815  Cd Length: 162  Bit Score: 44.95  E-value: 2.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605  307 INFSGGENTICADLAEENGVELAEISSETKEEMKKYLPGFATPKNPLDAT----------TALFHEKD-----MIVGLLH 371
Cdd:pfam19045   4 ITGAGGSGVLLSDACVDNGLTLMAIPPDLDAAFRKFIPPFGAAGNPVDITggeppstyeaTIRLGLEDprihaLILGYWH 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489518605  372 TFekdssVGFTMVGAnirdeenemhETLCQAVSEAREQGLKKPVfaVPTLEGN 424
Cdd:pfam19045  84 TI-----VTPPMVFA----------ELMVRVVEEMRAKGIDKPV--VASLAGD 119
COG3919 COG3919
Predicted ATP-dependent carboligase, ATP-grasp superfamily [General function prediction only];
494-579 7.49e-05

Predicted ATP-dependent carboligase, ATP-grasp superfamily [General function prediction only];


Pssm-ID: 443124 [Multi-domain]  Cd Length: 382  Bit Score: 45.69  E-value: 7.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605 494 KYGVPVPGQGNAKSIDELDEILKYIKYPVVLK-INSSEILHKSDVGGVKIG-IKNRDEAVDAYNEILtnvkkakpDANID 571
Cdd:COG3919  127 ELGVPVPKTVVLDSADDLDALAEDLGFPVVVKpADSVGYDELSFPGKKKVFyVDDREELLALLRRIA--------AAGYE 198


                 ....*...
gi 489518605 572 gILVQEMV 579
Cdd:COG3919  199 -LIVQEYI 205
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 496-556 1.27e-04

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 45.15  E-value: 1.27e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489518605 496 GVPVPGQGNAKSIDELDEILKYIKYPVVLKinsseilhKSDvG----GVKIGIKNRDEAVDAYNE 556
Cdd:PRK14016 226 GVPVPEGRVVTSAEDAWEAAEEIGYPVVVK--------PLD-GnhgrGVTVNITTREEIEAAYAV 281
PRK08654 PRK08654
acetyl-CoA carboxylase biotin carboxylase subunit;
484-553 2.76e-04

acetyl-CoA carboxylase biotin carboxylase subunit;


Pssm-ID: 236325 [Multi-domain]  Cd Length: 499  Bit Score: 44.20  E-value: 2.76e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489518605 484 SELDSKIEMKKYGVPV-PG-QGNAKSIDELDEILKYIKYPVVLkinsseilhKSDVGGVKIGIK---NRDEAVDA 553
Cdd:PRK08654 115 SKINAKKLMKKAGVPVlPGtEEGIEDIEEAKEIAEEIGYPVII---------KASAGGGGIGMRvvySEEELEDA 180
PurD COG0151
Phosphoribosylamine-glycine ligase [Nucleotide transport and metabolism]; ...
 492-560 1.60e-03

Phosphoribosylamine-glycine ligase [Nucleotide transport and metabolism]; Phosphoribosylamine-glycine ligase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439921 [Multi-domain]  Cd Length: 422  Bit Score: 41.54  E-value: 1.60e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489518605 492 MKKYGVPVPGqgnAKSIDELDEILKYIK---YPVVLKinsseilhksDVG-----GVKIgIKNRDEAVDAYNEILTN 560
Cdd:COG0151  110 MARYGIPTAA---YRVFTDLEEALAYLEeqgAPIVVK----------ADGlaagkGVVV-AETLEEALAAVDDMLAD 172
ATP-grasp_2 pfam08442
ATP-grasp domain;
483-579 3.56e-03

ATP-grasp domain;


Pssm-ID: 400651 [Multi-domain]  Cd Length: 202  Bit Score: 39.17  E-value: 3.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605  483 LSELDSKIEMKKYGVPVPGQGNAKSIDELDEILKyikypvvlKINSSEILHKSDV--------GGVKIgIKNRDEAVDAY 554
Cdd:pfam08442   2 LHEYQAKEIFAKYGIPVPRGEVATSPEEAEEIAK--------KLGGKVYVVKAQVlaggrgkaGGVKL-AKSPEEAKEVA 72

                          90       100
                  ....*....|....*....|....*....
gi 489518605  555 NEIL-TNVKKAKPDAN---IDGILVQEMV 579
Cdd:pfam08442  73 KEMLgKNLVTKQTGPDgqpVNKVLVEEAL 101
TyrA COG0287
Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is ...
 10-95 4.10e-03

Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440056 [Multi-domain]  Cd Length: 278  Bit Score: 39.72  E-value: 4.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518605  10 KSIAIVGvtdkLGF-GRSAALSIVKSKDTDRVYYVNPKREELF-------GRKCYKTIQEVPEIVDCVVVCTPRNVVPSV 81
Cdd:COG0287    2 MRIAIIG----LGLiGGSLALALKRAGLAHEVVGVDRSPETLEralelgvIDRAATDLEEAVADADLVVLAVPVGATIEV 77

                         90
                 ....*....|....
gi 489518605  82 LKDSAELGTKAAVV 95
Cdd:COG0287   78 LAELAPHLKPGAIV 91
SucC COG0045
Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Succinyl-CoA ...
 493-558 6.93e-03

Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Succinyl-CoA synthetase, beta subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439815 [Multi-domain]  Cd Length: 388  Bit Score: 39.26  E-value: 6.93e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489518605 493 KKYGVPVPGQGNAKSIDELDEILKYI-KYPVVLKinsSEILH----KSdvGGVKIgIKNRDEAVDAYNEIL 558
Cdd:COG0045   13 AKYGVPVPRGIVATTPEEAVAAAEELgGPPVVVK---AQVHAggrgKA--GGVKL-AKSPEEAREAAEEIL 77
PRK08462 PRK08462
acetyl-CoA carboxylase biotin carboxylase subunit;
488-525 7.31e-03

acetyl-CoA carboxylase biotin carboxylase subunit;


Pssm-ID: 236269 [Multi-domain]  Cd Length: 445  Bit Score: 39.34  E-value: 7.31e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 489518605 488 SKIEMKKYGVPV-PG-QGNAKSIDELDEILKYIKYPVVLK 525
Cdd:PRK08462 121 AKEVMKRAGVPViPGsDGALKSYEEAKKIAKEIGYPVILK 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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