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Concise Results
Standard Results
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argininosuccinate synthase [Clostridioides difficile]
Protein Classification
argininosuccinate synthase ( domain architecture ID 10011457 )
argininosuccinate synthase reversibly catalyzes the ATP-dependent condensation of a citrulline with an aspartate to give argininosuccinate
List of domain hits
Name
Accession
Description
Interval
E-value
PRK00509
PRK00509 argininosuccinate synthase; Provisional
1-399
0e+00
argininosuccinate synthase; Provisional
Pssm-ID: 234785
Cd Length: 399
Bit Score: 711.06
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 1 MK E KVVLAYSGGLDTS I II P WLKE N Y e DID VIA VCGN VGQ EDKM E DVY EKAL Q SGAS KA YV D D IS EEFV TETI F K A VK A E 80
Cdd:PRK00509 1 MK K KVVLAYSGGLDTS V II K WLKE T Y - GCE VIA FTAD VGQ GEEL E PIR EKAL K SGAS EI YV E D LR EEFV RDYV F P A IR A N 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 81 A K YEGKY L LGT S LARP I IAKKLVE V A H KEGA KYIC HGCTGKGNDQVRFE AT IAAL D P TI KVIAPWR I WD I KSRE DA I D YA 160
Cdd:PRK00509 80 A L YEGKY P LGT A LARP L IAKKLVE I A R KEGA DAVA HGCTGKGNDQVRFE LG IAAL A P DL KVIAPWR E WD L KSRE EL I A YA 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 161 E K H N I KVTA TK AKI YS V DANLWH V S T EGG DI E HLE NE HKK DVY KQC V D PEDA C D VA EYVEI Y FEKGVP KKV NGE E LSP VA 240
Cdd:PRK00509 160 E E H G I PIPV TK KSP YS I DANLWH R S I EGG IL E DPW NE PPE DVY EWT V S PEDA P D EP EYVEI E FEKGVP VAI NGE A LSP AE 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 241 LI HK LNEL GC KHGIG V IDIVENRLVG M KSRG I YETPGGTIL YET H NI LES A TLD KDTL HFK QMVSY KY G EL I YNGLW YCK 320
Cdd:PRK00509 240 LI EE LNEL AG KHGIG R IDIVENRLVG I KSRG V YETPGGTIL IKA H RA LES L TLD REVA HFK DELEP KY A EL V YNGLW FSP 319
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489518975 321 LRE SID AF MEQ TQ DN VTG T V KV KLYKGN IKPA G IFTE N A LYDE GISSFGNSEL YD H KDAEGFI N L FT LP L KI R A MKAG K 399
Cdd:PRK00509 320 LRE ALQ AF IDE TQ EH VTG E V RL KLYKGN AIVV G RKSP N S LYDE DLATYEEDDV YD Q KDAEGFI K L WG LP S KI A A LVNK K 398
Name
Accession
Description
Interval
E-value
PRK00509
PRK00509 argininosuccinate synthase; Provisional
1-399
0e+00
argininosuccinate synthase; Provisional
Pssm-ID: 234785
Cd Length: 399
Bit Score: 711.06
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 1 MK E KVVLAYSGGLDTS I II P WLKE N Y e DID VIA VCGN VGQ EDKM E DVY EKAL Q SGAS KA YV D D IS EEFV TETI F K A VK A E 80
Cdd:PRK00509 1 MK K KVVLAYSGGLDTS V II K WLKE T Y - GCE VIA FTAD VGQ GEEL E PIR EKAL K SGAS EI YV E D LR EEFV RDYV F P A IR A N 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 81 A K YEGKY L LGT S LARP I IAKKLVE V A H KEGA KYIC HGCTGKGNDQVRFE AT IAAL D P TI KVIAPWR I WD I KSRE DA I D YA 160
Cdd:PRK00509 80 A L YEGKY P LGT A LARP L IAKKLVE I A R KEGA DAVA HGCTGKGNDQVRFE LG IAAL A P DL KVIAPWR E WD L KSRE EL I A YA 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 161 E K H N I KVTA TK AKI YS V DANLWH V S T EGG DI E HLE NE HKK DVY KQC V D PEDA C D VA EYVEI Y FEKGVP KKV NGE E LSP VA 240
Cdd:PRK00509 160 E E H G I PIPV TK KSP YS I DANLWH R S I EGG IL E DPW NE PPE DVY EWT V S PEDA P D EP EYVEI E FEKGVP VAI NGE A LSP AE 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 241 LI HK LNEL GC KHGIG V IDIVENRLVG M KSRG I YETPGGTIL YET H NI LES A TLD KDTL HFK QMVSY KY G EL I YNGLW YCK 320
Cdd:PRK00509 240 LI EE LNEL AG KHGIG R IDIVENRLVG I KSRG V YETPGGTIL IKA H RA LES L TLD REVA HFK DELEP KY A EL V YNGLW FSP 319
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489518975 321 LRE SID AF MEQ TQ DN VTG T V KV KLYKGN IKPA G IFTE N A LYDE GISSFGNSEL YD H KDAEGFI N L FT LP L KI R A MKAG K 399
Cdd:PRK00509 320 LRE ALQ AF IDE TQ EH VTG E V RL KLYKGN AIVV G RKSP N S LYDE DLATYEEDDV YD Q KDAEGFI K L WG LP S KI A A LVNK K 398
ArgG
COG0137 Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase ...
3-399
0e+00
Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase is part of the Pathway/BioSystem: Arginine biosynthesis
Pssm-ID: 439907
Cd Length: 397
Bit Score: 701.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 3 E KVVLAYSGGLDTS I IIPWLKE N Y e DID VIAV CGN VGQ EDKM E DVY EKAL QS GASKAYV D D IS EEFV TETI F K A V KA E A K 82
Cdd:COG0137 1 K KVVLAYSGGLDTS V IIPWLKE K Y - GYE VIAV TAD VGQ GEDL E AIE EKAL KL GASKAYV V D AR EEFV EDYV F P A I KA N A L 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 83 YEGKY L LGT S LARP I IAKKLVE V A HK EGA KYIC HGCTGKGNDQVRFE AT I A AL D P TI K V IAPWR I WD I KSRE DA I D YAE K 162
Cdd:COG0137 80 YEGKY P LGT A LARP L IAKKLVE I A RE EGA DAVA HGCTGKGNDQVRFE LA I R AL A P DL K I IAPWR E WD L KSRE EE I E YAE E 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 163 H N I K V T ATK A K I YS V D A NLW HV S T EGG DI E HLE NE HKK D V Y KQC V D PEDA C D VA EYV E I Y FEKGVP KKV NGE E LSPV A LI 242
Cdd:COG0137 160 H G I P V P ATK E K P YS I D E NLW GR S I EGG EL E DPW NE PPE D A Y EWT V S PEDA P D EP EYV T I T FEKGVP VAL NGE K LSPV E LI 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 243 HK LNE L G C KHG I G V IDIVENRLVG M KSRG I YE T PG G TIL YET H NI LES A TLD KD TLHFK QMVSY KY G EL I YNGLW YCK LR 322
Cdd:COG0137 240 EE LNE I G G KHG V G R IDIVENRLVG I KSRG V YE A PG A TIL ITA H RA LES L TLD RE TLHFK DILDQ KY A EL V YNGLW FSP LR 319
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489518975 323 E SI DAF MEQ TQ DN VTGTV KV KLYKGN IKPA G IFTENA LYDE GISSFGNSELY D H KDAEGFI N LF T LPL KIR A MKAG K 399
Cdd:COG0137 320 E AL DAF IDE TQ KR VTGTV RL KLYKGN ATVV G RKSPYS LYDE DLATYEEDDVF D Q KDAEGFI K LF G LPL RVA A RVRK K 396
ASS
cd01999 argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle ...
3-389
0e+00
argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate. In humans, a defect in the ASS gene causes citrullinemia, a genetic disease characterized by severe vomiting spells and mental retardation. ASS is a homotetrameric enzyme of about 400 amino-acid residues. An arginine residue seems to be important for the enzyme's catalytic mechanism. The sequences of ASS from various prokaryotes, archaeabacteria and eukaryotes show significant similarity.
Pssm-ID: 467503
Cd Length: 386
Bit Score: 590.28
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 3 E KVVLAYSGGLDTS I I IP WLKE N Y e DID VIA VCGNV GQ E D KM E DVY EKAL QS GA S K A YV D D IS EEF VTET IF K A V KA E A K 82
Cdd:cd01999 1 K KVVLAYSGGLDTS V I LK WLKE E Y - GYE VIA FTADL GQ G D EE E EIE EKAL KL GA V K V YV V D LR EEF AEDY IF P A I KA N A I 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 83 YEG K Y L LGT S LARP I IAKKLVEVA HK EGA KYIC HGCTGKGNDQVRFE AT I A AL D P TI KVIAPWR I W DIKS R EDA I D YA E K 162
Cdd:cd01999 80 YEG R Y P LGT A LARP L IAKKLVEVA RE EGA TAVA HGCTGKGNDQVRFE LA I K AL A P DL KVIAPWR D W NFLT R AEE I A YA K K 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 163 H N I K V TA TK A K I YS V D A NLW HV S T EGGD I E HLE NE HKK D VYKQC V D PE D A C D VA EYV E I Y FEKGVP KK VNGE E L S PV A LI 242
Cdd:cd01999 160 H G I P V PV TK K K P YS I D E NLW GR S Y EGGD L E DPW NE PPE D AFEWT V S PE K A P D EP EYV T I E FEKGVP VA VNGE K L D PV E LI 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 243 H KLNE LGCK HG I G V IDIVENRLVG M KSRG I YE T PG G T I L YET H NI LE SA TLD KDT LHFK QM VS Y KY G EL I YNGLW YCK LR 322
Cdd:cd01999 240 E KLNE IAGR HG V G R IDIVENRLVG I KSRG V YE A PG A T L L IKA H RD LE DL TLD REV LHFK DI VS R KY A EL V YNGLW FDP LR 319
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489518975 323 E SID AF MEQ TQ DN VTG T V KV KLYKGN IKPA G IFTE N A LY D E GISSFGNSELY D H KDAEGFI NLFT L P 389
Cdd:cd01999 320 E ALE AF IDK TQ ER VTG E V RL KLYKGN VIVV G RESP N S LY S E ELATYEEGDGF D Q KDAEGFI KIHG L Q 386
Arginosuc_synth
pfam00764 Arginosuccinate synthase; This family contains a PP-loop motif.
6-392
0e+00
Arginosuccinate synthase; This family contains a PP-loop motif.
Pssm-ID: 279148
Cd Length: 386
Bit Score: 528.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 6 VLAYSGGLDTS II IPWLKE NYED i D VIAV CGN VGQ - EDKMEDVY EKAL QS GA S K A YV D D IS EEFV TET IF K A VK A E A K YE 84
Cdd:pfam00764 1 VLAYSGGLDTS VC IPWLKE QGGY - E VIAV AVD VGQ g GEDIDEAR EKAL KL GA V K H YV I D AK EEFV EDY IF P A IQ A N A L YE 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 85 GK Y L LGT S LARP I IAKKLVE V A H KEGA KYIC HGCTGKGNDQVRFE ATIAA L D P TI KVIAP W R IWDI k S RE DA I D YAE K H N 164
Cdd:pfam00764 80 DR Y P LGT A LARP L IAKKLVE A A K KEGA SAVA HGCTGKGNDQVRFE VSFRS L A P DL KVIAP V R DPNL - T RE EE I E YAE E H G 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 165 I KVTA TK AKI YS V D A NLW HV S T E G G DI E HLE N EHKK D V Y KQCV DP ED A C D VAEY VEI Y FEKGVP KKVN GE EL SP VA LI H K 244
Cdd:pfam00764 159 I PIPV TK KSP YS I D E NLW GR S I E A G IL E DPW N APPE D I Y EWTK DP AK A P D EPDI VEI G FEKGVP VALD GE PV SP LE LI E K 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 245 LNE LGCK HG I G V IDIVE N RLVG M KSR G IYE T P GG T I L YET H NI LE SA TL DKDT L H FK QM V SY K YG EL I Y N GLW YCK L R E S 324
Cdd:pfam00764 239 LNE IAGA HG V G R IDIVE D RLVG I KSR E IYE A P AA T V L ITA H RD LE NL TL TREV L R FK RI V DQ K WA EL V Y D GLW FSP L K E A 318
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489518975 325 I DAF MEQ TQ DN VTGTV K VKL Y KG NIKPA G IFTENA LYDE GIS S FGNSELY D HK DA E GFI NLFT L PL KI 392
Cdd:pfam00764 319 L DAF IDK TQ ER VTGTV R VKL H KG SAIVL G RRSPYS LYDE ELV S YDEGDTF D QT DA T GFI KIHG L QA KI 386
argG
TIGR00032 argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a ...
4-396
1.96e-164
argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a very unusual clustering in the alignment, with a deep split between one cohort of E. coli, H. influenzae, and Streptomyces, and the other cohort of eukaryotes, archaea, and the rest of the eubacteria. [Amino acid biosynthesis, Glutamate family]
Pssm-ID: 199987
Cd Length: 394
Bit Score: 466.50
E-value: 1.96e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 4 KVVLAYSGGLDTS IIIP WL K E - N YE did VIA VCGN VGQ - E DKMEDVY EKAL QS GA SKA Y VD D IS EEFV TETI F K A VK A E A 81
Cdd:TIGR00032 1 KVVLAYSGGLDTS VCLK WL R E k G YE --- VIA YTAD VGQ p E EDIDAIP EKAL EY GA ENH Y TI D AR EEFV KDYG F A A IQ A N A 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 82 K YEG K Y L L G T S LARP I IAKKLVE V A H KEGA KYIC HGCTGKGNDQ V RFE AT I AA L D P TI KVIAPWR IWDI k S RE DA I D YA E 161
Cdd:TIGR00032 78 F YEG T Y P L S T A LARP L IAKKLVE A A K KEGA NAVA HGCTGKGNDQ E RFE RS I RL L N P DL KVIAPWR DLNF - T RE EE I E YA I 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 162 KHN I KVTAT K A K I YS V D A NLW HV S T E G G DI E HLEN E HKK D V Y KQCVD P - E DAC D VA E Y V E I Y FE K GVP KKV NG EE L S PV A 240
Cdd:TIGR00032 157 QCG I PYPMS K E K P YS I D E NLW GR S I E A G IL E DPST E PPE D I Y MWTKF P d E ATP D EP E V V T I D FE Q GVP VAL NG VS L D PV E 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 241 LI HKL NE LGC KHG I G V IDI V ENR LV G M KSR G IYE T PG GTI L YET H NI LE SA TL DK D T L H FK QM V SYK Y G ELIY N GLW YCK 320
Cdd:TIGR00032 237 LI LEA NE IAG KHG V G R IDI I ENR II G L KSR E IYE A PG AAL L IIA H RD LE TL TL TR D V L E FK DI V EEQ Y S ELIY Q GLW FDP 316
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489518975 321 L R E SI DAF MEQ TQ DN VTGTV K VKL Y KGN IKPA G IFTENA LYDE GIS S FGNSELY D HK DA E GFI NLFT L PL K IRAM K 396
Cdd:TIGR00032 317 L A E AL DAF IRK TQ ER VTGTV R VKL F KGN AIVI G RTSPYS LYDE ELV S MEKDDVF D PR DA I GFI TMRG L QI K DYRE K 392
Name
Accession
Description
Interval
E-value
PRK00509
PRK00509 argininosuccinate synthase; Provisional
1-399
0e+00
argininosuccinate synthase; Provisional
Pssm-ID: 234785
Cd Length: 399
Bit Score: 711.06
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 1 MK E KVVLAYSGGLDTS I II P WLKE N Y e DID VIA VCGN VGQ EDKM E DVY EKAL Q SGAS KA YV D D IS EEFV TETI F K A VK A E 80
Cdd:PRK00509 1 MK K KVVLAYSGGLDTS V II K WLKE T Y - GCE VIA FTAD VGQ GEEL E PIR EKAL K SGAS EI YV E D LR EEFV RDYV F P A IR A N 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 81 A K YEGKY L LGT S LARP I IAKKLVE V A H KEGA KYIC HGCTGKGNDQVRFE AT IAAL D P TI KVIAPWR I WD I KSRE DA I D YA 160
Cdd:PRK00509 80 A L YEGKY P LGT A LARP L IAKKLVE I A R KEGA DAVA HGCTGKGNDQVRFE LG IAAL A P DL KVIAPWR E WD L KSRE EL I A YA 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 161 E K H N I KVTA TK AKI YS V DANLWH V S T EGG DI E HLE NE HKK DVY KQC V D PEDA C D VA EYVEI Y FEKGVP KKV NGE E LSP VA 240
Cdd:PRK00509 160 E E H G I PIPV TK KSP YS I DANLWH R S I EGG IL E DPW NE PPE DVY EWT V S PEDA P D EP EYVEI E FEKGVP VAI NGE A LSP AE 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 241 LI HK LNEL GC KHGIG V IDIVENRLVG M KSRG I YETPGGTIL YET H NI LES A TLD KDTL HFK QMVSY KY G EL I YNGLW YCK 320
Cdd:PRK00509 240 LI EE LNEL AG KHGIG R IDIVENRLVG I KSRG V YETPGGTIL IKA H RA LES L TLD REVA HFK DELEP KY A EL V YNGLW FSP 319
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489518975 321 LRE SID AF MEQ TQ DN VTG T V KV KLYKGN IKPA G IFTE N A LYDE GISSFGNSEL YD H KDAEGFI N L FT LP L KI R A MKAG K 399
Cdd:PRK00509 320 LRE ALQ AF IDE TQ EH VTG E V RL KLYKGN AIVV G RKSP N S LYDE DLATYEEDDV YD Q KDAEGFI K L WG LP S KI A A LVNK K 398
ArgG
COG0137 Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase ...
3-399
0e+00
Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase is part of the Pathway/BioSystem: Arginine biosynthesis
Pssm-ID: 439907
Cd Length: 397
Bit Score: 701.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 3 E KVVLAYSGGLDTS I IIPWLKE N Y e DID VIAV CGN VGQ EDKM E DVY EKAL QS GASKAYV D D IS EEFV TETI F K A V KA E A K 82
Cdd:COG0137 1 K KVVLAYSGGLDTS V IIPWLKE K Y - GYE VIAV TAD VGQ GEDL E AIE EKAL KL GASKAYV V D AR EEFV EDYV F P A I KA N A L 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 83 YEGKY L LGT S LARP I IAKKLVE V A HK EGA KYIC HGCTGKGNDQVRFE AT I A AL D P TI K V IAPWR I WD I KSRE DA I D YAE K 162
Cdd:COG0137 80 YEGKY P LGT A LARP L IAKKLVE I A RE EGA DAVA HGCTGKGNDQVRFE LA I R AL A P DL K I IAPWR E WD L KSRE EE I E YAE E 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 163 H N I K V T ATK A K I YS V D A NLW HV S T EGG DI E HLE NE HKK D V Y KQC V D PEDA C D VA EYV E I Y FEKGVP KKV NGE E LSPV A LI 242
Cdd:COG0137 160 H G I P V P ATK E K P YS I D E NLW GR S I EGG EL E DPW NE PPE D A Y EWT V S PEDA P D EP EYV T I T FEKGVP VAL NGE K LSPV E LI 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 243 HK LNE L G C KHG I G V IDIVENRLVG M KSRG I YE T PG G TIL YET H NI LES A TLD KD TLHFK QMVSY KY G EL I YNGLW YCK LR 322
Cdd:COG0137 240 EE LNE I G G KHG V G R IDIVENRLVG I KSRG V YE A PG A TIL ITA H RA LES L TLD RE TLHFK DILDQ KY A EL V YNGLW FSP LR 319
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489518975 323 E SI DAF MEQ TQ DN VTGTV KV KLYKGN IKPA G IFTENA LYDE GISSFGNSELY D H KDAEGFI N LF T LPL KIR A MKAG K 399
Cdd:COG0137 320 E AL DAF IDE TQ KR VTGTV RL KLYKGN ATVV G RKSPYS LYDE DLATYEEDDVF D Q KDAEGFI K LF G LPL RVA A RVRK K 396
ASS
cd01999 argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle ...
3-389
0e+00
argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate. In humans, a defect in the ASS gene causes citrullinemia, a genetic disease characterized by severe vomiting spells and mental retardation. ASS is a homotetrameric enzyme of about 400 amino-acid residues. An arginine residue seems to be important for the enzyme's catalytic mechanism. The sequences of ASS from various prokaryotes, archaeabacteria and eukaryotes show significant similarity.
Pssm-ID: 467503
Cd Length: 386
Bit Score: 590.28
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 3 E KVVLAYSGGLDTS I I IP WLKE N Y e DID VIA VCGNV GQ E D KM E DVY EKAL QS GA S K A YV D D IS EEF VTET IF K A V KA E A K 82
Cdd:cd01999 1 K KVVLAYSGGLDTS V I LK WLKE E Y - GYE VIA FTADL GQ G D EE E EIE EKAL KL GA V K V YV V D LR EEF AEDY IF P A I KA N A I 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 83 YEG K Y L LGT S LARP I IAKKLVEVA HK EGA KYIC HGCTGKGNDQVRFE AT I A AL D P TI KVIAPWR I W DIKS R EDA I D YA E K 162
Cdd:cd01999 80 YEG R Y P LGT A LARP L IAKKLVEVA RE EGA TAVA HGCTGKGNDQVRFE LA I K AL A P DL KVIAPWR D W NFLT R AEE I A YA K K 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 163 H N I K V TA TK A K I YS V D A NLW HV S T EGGD I E HLE NE HKK D VYKQC V D PE D A C D VA EYV E I Y FEKGVP KK VNGE E L S PV A LI 242
Cdd:cd01999 160 H G I P V PV TK K K P YS I D E NLW GR S Y EGGD L E DPW NE PPE D AFEWT V S PE K A P D EP EYV T I E FEKGVP VA VNGE K L D PV E LI 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 243 H KLNE LGCK HG I G V IDIVENRLVG M KSRG I YE T PG G T I L YET H NI LE SA TLD KDT LHFK QM VS Y KY G EL I YNGLW YCK LR 322
Cdd:cd01999 240 E KLNE IAGR HG V G R IDIVENRLVG I KSRG V YE A PG A T L L IKA H RD LE DL TLD REV LHFK DI VS R KY A EL V YNGLW FDP LR 319
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489518975 323 E SID AF MEQ TQ DN VTG T V KV KLYKGN IKPA G IFTE N A LY D E GISSFGNSELY D H KDAEGFI NLFT L P 389
Cdd:cd01999 320 E ALE AF IDK TQ ER VTG E V RL KLYKGN VIVV G RESP N S LY S E ELATYEEGDGF D Q KDAEGFI KIHG L Q 386
PLN00200
PLN00200 argininosuccinate synthase; Provisional
1-399
0e+00
argininosuccinate synthase; Provisional
Pssm-ID: 177791
Cd Length: 404
Bit Score: 566.30
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 1 MKE KVVLAYSGGLDTS I I IP WL K ENY e DID V IAVCGN VGQ - EDKM E DVYE KA LQ SGA SKAY V D D IS EEFV TET IF KAVK A 79
Cdd:PLN00200 4 KLN KVVLAYSGGLDTS V I LK WL R ENY - GCE V VCFTAD VGQ g IEEL E GLEA KA KA SGA KQLV V K D LR EEFV RDY IF PCLR A 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 80 E A K YEGKYLLGTS L ARP I IAK KL V EV A HKE GA KYIC HG C TGKGNDQVRFE A T IA AL D P TI KV I APWR I WDIK S RED A I D Y 159
Cdd:PLN00200 83 N A I YEGKYLLGTS M ARP L IAK AM V DI A KEV GA DAVA HG A TGKGNDQVRFE L T FF AL N P EL KV V APWR E WDIK G RED L I E Y 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 160 A E KHNI K V TA TK AK IYS V D A NLWH V S T EG GDI E HLE NE H K K D VYKQC V D PE D A C D VA EY V EI Y FEKG V P KKV NG EE LSP V 239
Cdd:PLN00200 163 A K KHNI P V PV TK KS IYS R D R NLWH I S Y EG DIL E DPA NE P K E D MFMMS V S PE A A P D QP EY I EI E FEKG L P VAI NG KT LSP A 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 240 A L IH KLNE L G C KHGIG V ID I VENR L VGMKSRG I YETPGGTIL YET H NI LES A TLD KD T LHF K QMVSY KY G EL I YNG L W YC 319
Cdd:PLN00200 243 T L LT KLNE I G G KHGIG R ID M VENR F VGMKSRG V YETPGGTIL FAA H RE LES L TLD RE T MQV K DSLAL KY A EL V YNG F W FD 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 320 KL RES I DAFME QTQDNV TG T V KV KLYKGN IKP AG IFTENA LY DEG ISSF GNSE - L Y DHK DA E GFI N L FT L P L KI RAM KAG 398
Cdd:PLN00200 323 PE RES M DAFME KITETT TG S V RL KLYKGN VSV AG RKSPYS LY RQD ISSF EEGG g I Y NQA DA A GFI R L YA L R L RT RAM LRK 402
.
gi 489518975 399 K 399
Cdd:PLN00200 403 K 403
Arginosuc_synth
pfam00764 Arginosuccinate synthase; This family contains a PP-loop motif.
6-392
0e+00
Arginosuccinate synthase; This family contains a PP-loop motif.
Pssm-ID: 279148
Cd Length: 386
Bit Score: 528.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 6 VLAYSGGLDTS II IPWLKE NYED i D VIAV CGN VGQ - EDKMEDVY EKAL QS GA S K A YV D D IS EEFV TET IF K A VK A E A K YE 84
Cdd:pfam00764 1 VLAYSGGLDTS VC IPWLKE QGGY - E VIAV AVD VGQ g GEDIDEAR EKAL KL GA V K H YV I D AK EEFV EDY IF P A IQ A N A L YE 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 85 GK Y L LGT S LARP I IAKKLVE V A H KEGA KYIC HGCTGKGNDQVRFE ATIAA L D P TI KVIAP W R IWDI k S RE DA I D YAE K H N 164
Cdd:pfam00764 80 DR Y P LGT A LARP L IAKKLVE A A K KEGA SAVA HGCTGKGNDQVRFE VSFRS L A P DL KVIAP V R DPNL - T RE EE I E YAE E H G 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 165 I KVTA TK AKI YS V D A NLW HV S T E G G DI E HLE N EHKK D V Y KQCV DP ED A C D VAEY VEI Y FEKGVP KKVN GE EL SP VA LI H K 244
Cdd:pfam00764 159 I PIPV TK KSP YS I D E NLW GR S I E A G IL E DPW N APPE D I Y EWTK DP AK A P D EPDI VEI G FEKGVP VALD GE PV SP LE LI E K 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 245 LNE LGCK HG I G V IDIVE N RLVG M KSR G IYE T P GG T I L YET H NI LE SA TL DKDT L H FK QM V SY K YG EL I Y N GLW YCK L R E S 324
Cdd:pfam00764 239 LNE IAGA HG V G R IDIVE D RLVG I KSR E IYE A P AA T V L ITA H RD LE NL TL TREV L R FK RI V DQ K WA EL V Y D GLW FSP L K E A 318
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489518975 325 I DAF MEQ TQ DN VTGTV K VKL Y KG NIKPA G IFTENA LYDE GIS S FGNSELY D HK DA E GFI NLFT L PL KI 392
Cdd:pfam00764 319 L DAF IDK TQ ER VTGTV R VKL H KG SAIVL G RRSPYS LYDE ELV S YDEGDTF D QT DA T GFI KIHG L QA KI 386
argG
TIGR00032 argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a ...
4-396
1.96e-164
argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a very unusual clustering in the alignment, with a deep split between one cohort of E. coli, H. influenzae, and Streptomyces, and the other cohort of eukaryotes, archaea, and the rest of the eubacteria. [Amino acid biosynthesis, Glutamate family]
Pssm-ID: 199987
Cd Length: 394
Bit Score: 466.50
E-value: 1.96e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 4 KVVLAYSGGLDTS IIIP WL K E - N YE did VIA VCGN VGQ - E DKMEDVY EKAL QS GA SKA Y VD D IS EEFV TETI F K A VK A E A 81
Cdd:TIGR00032 1 KVVLAYSGGLDTS VCLK WL R E k G YE --- VIA YTAD VGQ p E EDIDAIP EKAL EY GA ENH Y TI D AR EEFV KDYG F A A IQ A N A 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 82 K YEG K Y L L G T S LARP I IAKKLVE V A H KEGA KYIC HGCTGKGNDQ V RFE AT I AA L D P TI KVIAPWR IWDI k S RE DA I D YA E 161
Cdd:TIGR00032 78 F YEG T Y P L S T A LARP L IAKKLVE A A K KEGA NAVA HGCTGKGNDQ E RFE RS I RL L N P DL KVIAPWR DLNF - T RE EE I E YA I 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 162 KHN I KVTAT K A K I YS V D A NLW HV S T E G G DI E HLEN E HKK D V Y KQCVD P - E DAC D VA E Y V E I Y FE K GVP KKV NG EE L S PV A 240
Cdd:TIGR00032 157 QCG I PYPMS K E K P YS I D E NLW GR S I E A G IL E DPST E PPE D I Y MWTKF P d E ATP D EP E V V T I D FE Q GVP VAL NG VS L D PV E 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 241 LI HKL NE LGC KHG I G V IDI V ENR LV G M KSR G IYE T PG GTI L YET H NI LE SA TL DK D T L H FK QM V SYK Y G ELIY N GLW YCK 320
Cdd:TIGR00032 237 LI LEA NE IAG KHG V G R IDI I ENR II G L KSR E IYE A PG AAL L IIA H RD LE TL TL TR D V L E FK DI V EEQ Y S ELIY Q GLW FDP 316
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489518975 321 L R E SI DAF MEQ TQ DN VTGTV K VKL Y KGN IKPA G IFTENA LYDE GIS S FGNSELY D HK DA E GFI NLFT L PL K IRAM K 396
Cdd:TIGR00032 317 L A E AL DAF IRK TQ ER VTGTV R VKL F KGN AIVI G RTSPYS LYDE ELV S MEKDDVF D PR DA I GFI TMRG L QI K DYRE K 392
PRK13820
PRK13820 argininosuccinate synthase; Provisional
1-388
4.76e-155
argininosuccinate synthase; Provisional
Pssm-ID: 237521
Cd Length: 394
Bit Score: 442.83
E-value: 4.76e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 1 M KE KVVLAYSGGLDTS III P W LKE N Y EDID VI A V CGN VGQ - E DKMEDVY EKA l QSGAS K A Y VD D IS EEF VTET IF K A V KA 79
Cdd:PRK13820 1 M MK KVVLAYSGGLDTS VCV P L LKE K Y GYDE VI T V TVD VGQ p E EEIKEAE EKA - KKLGD K H Y TI D AK EEF AKDY IF P A I KA 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 80 E A K YEG k Y L LGT S LARP I IA K K L VEVA H KEGA KY I C HGCTGKGNDQ V RFEA TIA A L D pt IK VIAP W R IWDI k S RE DA I D Y 159
Cdd:PRK13820 80 N A L YEG - Y P LGT A LARP L IA E K I VEVA E KEGA SA I A HGCTGKGNDQ L RFEA VFR A S D -- LE VIAP I R ELNL - T RE WE I E Y 155
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 160 A EKHN I K V TAT K A K IY S V D A NLW HV S T EGG DI E HLEN E HKKDV Y KQC V D PEDA C D VA E Y VEI Y FE K GVP KKV NGE ELSP V 239
Cdd:PRK13820 156 A KEKG I P V PVG K E K PW S I D E NLW SR S I EGG KL E DPAF E PPEEI Y AWT V S PEDA P D EP E I VEI E FE E GVP VAI NGE KMDG V 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 240 A LI H KLNE LGC KHG I G VI D IV E N R LV G M KSR GI YE T P GG T I L YET H NI LE SAT L DKDT L H FK QM V SY K YG EL I Y N GL WYC 319
Cdd:PRK13820 236 E LI R KLNE IAG KHG V G RT D MM E D R VL G L KSR EN YE H P AA T V L LTA H KA LE QLV L TREE L K FK EI V DS K WA EL A Y E GL VDE 315
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489518975 320 K LRE SID AF MEQ TQ DN VTGTV K VKLYKG NIKPA G IFTEN ALY D E GIS SF g N S ELY D HK DAEG FINLFT L 388
Cdd:PRK13820 316 P LRE DLN AF IDK TQ ER VTGTV T VKLYKG SARVV G RESPY ALY S E ELV SF - D S KTI D QR DAEG MAKYHG L 383
PRK04527
PRK04527 argininosuccinate synthase; Provisional
1-386
6.94e-62
argininosuccinate synthase; Provisional
Pssm-ID: 235305
Cd Length: 400
Bit Score: 204.68
E-value: 6.94e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 1 MKEKV VLA Y SGGLDTS II IP W L K E - N Y EDID V I A VC G N V G q EDKMEDVYEK A LQS GA SKAYVD D ISEEFVTETIFKA V K A 79
Cdd:PRK04527 1 SSKDI VLA F SGGLDTS FC IP Y L Q E r G Y AVHT V F A DT G G V D - AEERDFIEKR A AEL GA ASHVTV D GGPAIWEGFVKPL V W A 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 80 EAK Y E G K Y L L GT S l A R PI I AKKLVEV A HKE G AKY I C HGCTG K GNDQVRF EATIA AL D p TIKVI AP W R iw D I K ----- S R E 154
Cdd:PRK04527 80 GEG Y Q G Q Y P L LV S - D R YL I VDAALKR A EEL G TRI I A HGCTG M GNDQVRF DLAVK AL G - DYQIV AP I R -- E I Q kehtq T R A 155
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 155 DAID Y A E KHNIK V T A t K A K I Y SVDA NL WH V STE GG D I EHL E n EHKKDVYKQ C VDPEDACDV A EY V E I Y F EK G VPKKVN G E 234
Cdd:PRK04527 156 YEQK Y L E ERGFG V R A - K Q K A Y TINE NL LG V TMS GG E I DRW E - APGEGARGW C APRSAWPTE A LT V T I K F VE G EAVALD G K 233
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 235 E L SPVALIH KLN E L GCKH G I G VIDIVENRLV G M K S R GIY E T PG GTI L YET H NI LE S A T L D K DTLH FK QM V SY K YG EL I Y N 314
Cdd:PRK04527 234 P L PGAQILA KLN K L FAQY G V G RGVYTGDTVI G L K G R IVF E A PG LVS L LTA H RA LE D A V L T K QQNR FK PD V AR K WV EL V Y E 313
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489518975 315 G LWYCK L RES I D AF MEQT Q DN V T G T V KVKLYK G NIKPAGIFTENA L YDE G i SSFGN S ELYDHKD AEGFI N LF 386
Cdd:PRK04527 314 G FYHDP L KTD I E AF LKSS Q AK V N G E V TLETRG G RVDAVAVRSPHL L NSK G - ATYAQ S ADWGVEE AEGFI K LF 384
PRK05370
PRK05370 argininosuccinate synthase; Validated
3-348
2.38e-47
argininosuccinate synthase; Validated
Pssm-ID: 235434
Cd Length: 447
Bit Score: 167.46
E-value: 2.38e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 3 EK V VL A Y SGGLDTS IIIP W LKEN ye DIDVI A VCG N V GQ -- ED KMEDVYEK A LQS GA SK A YVD D ISEEF V T E T I f K A VKAE 80
Cdd:PRK05370 12 QR V GI A F SGGLDTS AALL W MRQK -- GAVPY A YTA N L GQ pd ED DYDAIPRR A MEY GA EN A RLI D CRAQL V A E G I - A A IQCG 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 81 A --- KYE G K - Y LLG T S L A R PIIAKK LV EVAHKE G AKYICH G C T G KGND QV RF EATIAALD P TI K VIA PW R ---- I WDIKS 152
Cdd:PRK05370 89 A fhi STG G V t Y FNT T P L G R AVTGTM LV AAMKED G VNIWGD G S T Y KGND IE RF YRYGLLTN P EL K IYK PW L dqdf I DELGG 168
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 153 R EDAIDYAEK H NIKVTATKA K I YS V D A N LWHVST E GG D I EHL enehkk DVYKQC V D P ------- EDACDV - AE Y V EIY FE 224
Cdd:PRK05370 169 R AEMSEFLIA H GFDYKMSVE K A YS T D S N MLGATH E AK D L EHL ------ NSGIKI V N P imgvafw DEDVEI k AE E V TVR FE 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518975 225 K G V P KKV NG EEL - S PV A L IHKL N EL G CK HG I G VI D IV ENR LVGM KSRGIYE T PG GTI L YETHNI L ESATLDK DT LHFKQM 303
Cdd:PRK05370 243 Q G R P VAL NG KTF s D PV E L MLEA N RI G GR HG L G MS D QI ENR IIEA KSRGIYE A PG MAL L HIAYER L VTGIHNE DT IEQYRI 322
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 489518975 304 VSYKY G E L I Y N G L W Y ---- CK LRES IDAFMEQT qdn V TG T V KVK L YK GN 348
Cdd:PRK05370 323 NGRRL G R L L Y Q G R W F dpqa LM LRES LQRWVASA --- I TG E V TLE L RR GN 368
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
