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Conserved domains on  [gi|489518989|ref|WP_003423793|]
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C-GCAxxG-C-C family (seleno)protein [Clostridioides difficile]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
C_GCAxxG_C_C super family cl09920
Putative redox-active protein (C_GCAxxG_C_C); This entry represents a putative redox-active ...
 12-118 2.11e-23

Putative redox-active protein (C_GCAxxG_C_C); This entry represents a putative redox-active protein of about 140 residues, with four perfectly conserved Cys residues. It includes a CGAXXG motif. Most members are found within one or two loci of transporter or oxidoreductase genes. A member from Geobacter sulfurreducens, located in a molybdenum transporter operon, has a TAT (twin-arginine translocation) signal sequence for Sec-independent transport across the plasma membrane, a hallmark of bound prosthetic groups such as FeS clusters.


The actual alignment was detected with superfamily member TIGR01909:

Pssm-ID: 471950  Cd Length: 120  Bit Score: 87.19  E-value: 2.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518989   12 YTCAEALIKSYNEEHNTDIPI---SIGSGMGFGM-NVGSVCGAVNAAVVIIGYLNG-RNSNLDENIARKYSRELMNRVRN 86
Cdd:TIGR01909   1 RNCAEAIFAALREEFNLDIPEeavNMASGFGGGVaGSGHICGALTGAVMALGLYFGtEGDGEQVNNTYALCAELYEKFRE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 489518989   87 KYSSEICVSLKKNK--------VTCEEIINFTYDALNDML 118
Cdd:TIGR01909  81 KNGSPNCGDLNPKKdlvskeqrRKCIEIVSTAAETLLEIL 120
 
Name Accession Description Interval E-value
C_GCAxxG_C_C TIGR01909
C_GCAxxG_C_C family probable redox protein; This model represents a putative redox-active ...
 12-118 2.11e-23

C_GCAxxG_C_C family probable redox protein; This model represents a putative redox-active protein of about 140 residues, with four perfectly conserved Cys residues. It includes a CGAXXG motif. Most members are found within one or two loci of transporter or oxidoreductase genes. A member from Geobacter sulfurreducens, located in a molybdenum transporter operon, has a TAT (twin-arginine translocation) signal sequence for Sec-independent transport across the plasma membrane, a hallmark of bound prosthetic groups such as FeS clusters.


Pssm-ID: 213664  Cd Length: 120  Bit Score: 87.19  E-value: 2.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518989   12 YTCAEALIKSYNEEHNTDIPI---SIGSGMGFGM-NVGSVCGAVNAAVVIIGYLNG-RNSNLDENIARKYSRELMNRVRN 86
Cdd:TIGR01909   1 RNCAEAIFAALREEFNLDIPEeavNMASGFGGGVaGSGHICGALTGAVMALGLYFGtEGDGEQVNNTYALCAELYEKFRE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 489518989   87 KYSSEICVSLKKNK--------VTCEEIINFTYDALNDML 118
Cdd:TIGR01909  81 KNGSPNCGDLNPKKdlvskeqrRKCIEIVSTAAETLLEIL 120
C_GCAxxG_C_C pfam09719
Putative redox-active protein (C_GCAxxG_C_C); This entry represents a putative redox-active ...
 19-117 4.33e-12

Putative redox-active protein (C_GCAxxG_C_C); This entry represents a putative redox-active protein of about 140 residues, with four perfectly conserved Cys residues. It includes a CGAXXG motif. Most members are found within one or two loci of transporter or oxidoreductase genes. A member from Geobacter sulfurreducens, located in a molybdenum transporter operon, has a TAT (twin-arginine translocation) signal sequence for Sec-independent transport across the plasma membrane, a hallmark of bound prosthetic groups such as FeS clusters.


Pssm-ID: 462853  Cd Length: 115  Bit Score: 58.00  E-value: 4.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518989   19 IKSYNEEHNTDIP--ISIGSGMGFGM-NVGSVCGAVNAAVVIIGYLNGRNSNLDENIARKY--SRELMNRVRNKYSSEIC 93
Cdd:pfam09719   1 LLAFADELGLDEEtaFKLASGFGGGMgRMGETCGALSGAVMALGLLYGRGDPDEEAKEKTYalVQELAEWFKEKNGSIIC 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 489518989   94 VSL-----------KKNKVTCEEIINFTYDALNDM 117
Cdd:pfam09719  81 RELlgkddsgegysKRPKERCPKLVADAAEILEEI 115
 
Name Accession Description Interval E-value
C_GCAxxG_C_C TIGR01909
C_GCAxxG_C_C family probable redox protein; This model represents a putative redox-active ...
 12-118 2.11e-23

C_GCAxxG_C_C family probable redox protein; This model represents a putative redox-active protein of about 140 residues, with four perfectly conserved Cys residues. It includes a CGAXXG motif. Most members are found within one or two loci of transporter or oxidoreductase genes. A member from Geobacter sulfurreducens, located in a molybdenum transporter operon, has a TAT (twin-arginine translocation) signal sequence for Sec-independent transport across the plasma membrane, a hallmark of bound prosthetic groups such as FeS clusters.


Pssm-ID: 213664  Cd Length: 120  Bit Score: 87.19  E-value: 2.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518989   12 YTCAEALIKSYNEEHNTDIPI---SIGSGMGFGM-NVGSVCGAVNAAVVIIGYLNG-RNSNLDENIARKYSRELMNRVRN 86
Cdd:TIGR01909   1 RNCAEAIFAALREEFNLDIPEeavNMASGFGGGVaGSGHICGALTGAVMALGLYFGtEGDGEQVNNTYALCAELYEKFRE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 489518989   87 KYSSEICVSLKKNK--------VTCEEIINFTYDALNDML 118
Cdd:TIGR01909  81 KNGSPNCGDLNPKKdlvskeqrRKCIEIVSTAAETLLEIL 120
C_GCAxxG_C_C pfam09719
Putative redox-active protein (C_GCAxxG_C_C); This entry represents a putative redox-active ...
 19-117 4.33e-12

Putative redox-active protein (C_GCAxxG_C_C); This entry represents a putative redox-active protein of about 140 residues, with four perfectly conserved Cys residues. It includes a CGAXXG motif. Most members are found within one or two loci of transporter or oxidoreductase genes. A member from Geobacter sulfurreducens, located in a molybdenum transporter operon, has a TAT (twin-arginine translocation) signal sequence for Sec-independent transport across the plasma membrane, a hallmark of bound prosthetic groups such as FeS clusters.


Pssm-ID: 462853  Cd Length: 115  Bit Score: 58.00  E-value: 4.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489518989   19 IKSYNEEHNTDIP--ISIGSGMGFGM-NVGSVCGAVNAAVVIIGYLNGRNSNLDENIARKY--SRELMNRVRNKYSSEIC 93
Cdd:pfam09719   1 LLAFADELGLDEEtaFKLASGFGGGMgRMGETCGALSGAVMALGLLYGRGDPDEEAKEKTYalVQELAEWFKEKNGSIIC 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 489518989   94 VSL-----------KKNKVTCEEIINFTYDALNDM 117
Cdd:pfam09719  81 RELlgkddsgegysKRPKERCPKLVADAAEILEEI 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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