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Conserved domains on  [gi|489519115|ref|WP_003423919|]
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prephenate dehydrogenase [Clostridioides difficile]

Protein Classification

prephenate dehydrogenase( domain architecture ID 11416637)

prephenate dehydrogenase catalyzes the conversion of prephenate and NAD(+) to 4-hydroxyphenylpyruvate, CO(2) and NADH

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TyrA COG0287
Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is ...
 1-274 3.96e-97

Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


:

Pssm-ID: 440056 [Multi-domain]  Cd Length: 278  Bit Score: 286.25  E-value: 3.96e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115   1 MNIVIVGLGVIGGSFAKALKKAGYE-NVFGVDVDLETLKKAEKAKIIKKGCTTGKELFKKADLIILSIYPRLVVDFLNNN 79
Cdd:COG0287    2 MRIAIIGLGLIGGSLALALKRAGLAhEVVGVDRSPETLERALELGVIDRAATDLEEAVADADLVVLAVPVGATIEVLAEL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115  80 KNFFKKGTIITDTTGIKETLINDVLQIIPDDIDFIFGHPMAGREKRGIDFASEQVFNGANYIITPTGRNNIRNLELVENL 159
Cdd:COG0287   82 APHLKPGAIVTDVGSVKGAVVEAAEALLPDGVRFVGGHPMAGTEKSGPEAADADLFEGAPYILTPTEGTDPEALERVEEL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115 160 ILKLGFkRVKKLTSQKHDEIIAFTSQLPHVMAVALINS---DEEDRDTGKFIGDSYRDLTRIANMNEDLWSELFLGNRDN 236
Cdd:COG0287  162 WEALGA-RVVEMDPEEHDRVVAAVSHLPHLLAFALVNTvadLEDEEEILRLAAGGFRDTTRIAASDPEMWRDIFLANREA 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 489519115 237 LLKVIENFESEVNLIKEAIFNNDKSKLIEYFKKSSIRR 274
Cdd:COG0287  241 LLEALDRFIEELDALRDALEAGDGEALEELLERARAAR 278
 
Name Accession Description Interval E-value
TyrA COG0287
Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is ...
 1-274 3.96e-97

Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440056 [Multi-domain]  Cd Length: 278  Bit Score: 286.25  E-value: 3.96e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115   1 MNIVIVGLGVIGGSFAKALKKAGYE-NVFGVDVDLETLKKAEKAKIIKKGCTTGKELFKKADLIILSIYPRLVVDFLNNN 79
Cdd:COG0287    2 MRIAIIGLGLIGGSLALALKRAGLAhEVVGVDRSPETLERALELGVIDRAATDLEEAVADADLVVLAVPVGATIEVLAEL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115  80 KNFFKKGTIITDTTGIKETLINDVLQIIPDDIDFIFGHPMAGREKRGIDFASEQVFNGANYIITPTGRNNIRNLELVENL 159
Cdd:COG0287   82 APHLKPGAIVTDVGSVKGAVVEAAEALLPDGVRFVGGHPMAGTEKSGPEAADADLFEGAPYILTPTEGTDPEALERVEEL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115 160 ILKLGFkRVKKLTSQKHDEIIAFTSQLPHVMAVALINS---DEEDRDTGKFIGDSYRDLTRIANMNEDLWSELFLGNRDN 236
Cdd:COG0287  162 WEALGA-RVVEMDPEEHDRVVAAVSHLPHLLAFALVNTvadLEDEEEILRLAAGGFRDTTRIAASDPEMWRDIFLANREA 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 489519115 237 LLKVIENFESEVNLIKEAIFNNDKSKLIEYFKKSSIRR 274
Cdd:COG0287  241 LLEALDRFIEELDALRDALEAGDGEALEELLERARAAR 278
PRK06545 PRK06545
prephenate dehydrogenase; Validated
 2-267 1.73e-48

prephenate dehydrogenase; Validated


Pssm-ID: 235824 [Multi-domain]  Cd Length: 359  Bit Score: 164.31  E-value: 1.73e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115   2 NIVIVGLGVIGGSFAKALKKAGYE-NVFGVDVDLETLKKAEKAKIIKKGCTTGKELFKKADLIILSIYPRLVVDFLNNNK 80
Cdd:PRK06545   2 TVLIVGLGLIGGSLALAIKAAGPDvFIIGYDPSAAQLARALGFGVIDELAADLQRAAAEADLIVLAVPVDATAALLAELA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115  81 NF-FKKGTIITDTTGIKETLINDVLQIIPDDIDFIFGHPMAGREKRGIDFASEQVFNGANYIITPTGRNNIRNLELVENL 159
Cdd:PRK06545  82 DLeLKPGVIVTDVGSVKGAILAEAEALLGDLIRFVGGHPMAGSHKSGVAAARADLFENAPWVLTPDDHTDPDAVAELKDL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115 160 ILKLGFKRVkKLTSQKHDEIIAFTSQLPHVMAVALINSDEEDRDTGK-FIGDSYRDLTRIANMNEDLWSELFLGNRDNLL 238
Cdd:PRK06545 162 LSGTGAKFV-VLDAEEHDRAVALVSHLPHILASSLAARLAGEHPLALrLAAGGFRDITRIASSDPGMWRDILESNAEALL 240

                        250       260
                 ....*....|....*....|....*....
gi 489519115 239 KVIENFESEVNLIKEAIFNNDKSKLIEYF 267
Cdd:PRK06545 241 DALDEWIEDLDRARDALESGDAEAIAELF 269
PDH_N pfam02153
Prephenate dehydrogenase, nucleotide-binding domain; Members of this family are prephenate ...
 15-169 4.99e-22

Prephenate dehydrogenase, nucleotide-binding domain; Members of this family are prephenate dehydrogenases (PDHs) EC:1.3.1.12 involved in tyrosine biosynthesis. This is the N-terminal nucleotide-binding domain of PDHs, which has a modified Rossmann nucleotide-binding fold with an extended beta-sheet sandwiched by three helices on each face.


Pssm-ID: 460467 [Multi-domain]  Cd Length: 154  Bit Score: 89.37  E-value: 4.99e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115   15 FAKALKKAGYE-NVFGVDVDLETlKKAEKAKIIKKGCTTGKELFKKADLIILSIYPRLVVDFLNNNKNFFKKGTIITDTT 93
Cdd:pfam02153   1 LALALRRHGFFvTVIGYDINPEA-AVAALRLGLGDEATDDIEAVREADIVFLAVPVEQTLPVLKELAPHLKEDALITDVG 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489519115   94 GIKETLINDVLQIIPDDIdFIFGHPMAGREKRGIDFASEQVFNGANYIITPTGRNNIRNLELVENLILKLGFKRVK 169
Cdd:pfam02153  80 SVKVKIIRELEQHLPDKS-FVPGHPMAGTEKSGPDAARANLFENAPVILTPTEKTDTEALNCVKELLEGVGARVIL 154
 
Name Accession Description Interval E-value
TyrA COG0287
Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is ...
 1-274 3.96e-97

Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440056 [Multi-domain]  Cd Length: 278  Bit Score: 286.25  E-value: 3.96e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115   1 MNIVIVGLGVIGGSFAKALKKAGYE-NVFGVDVDLETLKKAEKAKIIKKGCTTGKELFKKADLIILSIYPRLVVDFLNNN 79
Cdd:COG0287    2 MRIAIIGLGLIGGSLALALKRAGLAhEVVGVDRSPETLERALELGVIDRAATDLEEAVADADLVVLAVPVGATIEVLAEL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115  80 KNFFKKGTIITDTTGIKETLINDVLQIIPDDIDFIFGHPMAGREKRGIDFASEQVFNGANYIITPTGRNNIRNLELVENL 159
Cdd:COG0287   82 APHLKPGAIVTDVGSVKGAVVEAAEALLPDGVRFVGGHPMAGTEKSGPEAADADLFEGAPYILTPTEGTDPEALERVEEL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115 160 ILKLGFkRVKKLTSQKHDEIIAFTSQLPHVMAVALINS---DEEDRDTGKFIGDSYRDLTRIANMNEDLWSELFLGNRDN 236
Cdd:COG0287  162 WEALGA-RVVEMDPEEHDRVVAAVSHLPHLLAFALVNTvadLEDEEEILRLAAGGFRDTTRIAASDPEMWRDIFLANREA 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 489519115 237 LLKVIENFESEVNLIKEAIFNNDKSKLIEYFKKSSIRR 274
Cdd:COG0287  241 LLEALDRFIEELDALRDALEAGDGEALEELLERARAAR 278
PRK06545 PRK06545
prephenate dehydrogenase; Validated
 2-267 1.73e-48

prephenate dehydrogenase; Validated


Pssm-ID: 235824 [Multi-domain]  Cd Length: 359  Bit Score: 164.31  E-value: 1.73e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115   2 NIVIVGLGVIGGSFAKALKKAGYE-NVFGVDVDLETLKKAEKAKIIKKGCTTGKELFKKADLIILSIYPRLVVDFLNNNK 80
Cdd:PRK06545   2 TVLIVGLGLIGGSLALAIKAAGPDvFIIGYDPSAAQLARALGFGVIDELAADLQRAAAEADLIVLAVPVDATAALLAELA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115  81 NF-FKKGTIITDTTGIKETLINDVLQIIPDDIDFIFGHPMAGREKRGIDFASEQVFNGANYIITPTGRNNIRNLELVENL 159
Cdd:PRK06545  82 DLeLKPGVIVTDVGSVKGAILAEAEALLGDLIRFVGGHPMAGSHKSGVAAARADLFENAPWVLTPDDHTDPDAVAELKDL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115 160 ILKLGFKRVkKLTSQKHDEIIAFTSQLPHVMAVALINSDEEDRDTGK-FIGDSYRDLTRIANMNEDLWSELFLGNRDNLL 238
Cdd:PRK06545 162 LSGTGAKFV-VLDAEEHDRAVALVSHLPHILASSLAARLAGEHPLALrLAAGGFRDITRIASSDPGMWRDILESNAEALL 240

                        250       260
                 ....*....|....*....|....*....
gi 489519115 239 KVIENFESEVNLIKEAIFNNDKSKLIEYF 267
Cdd:PRK06545 241 DALDEWIEDLDRARDALESGDAEAIAELF 269
PRK08507 PRK08507
prephenate dehydrogenase; Validated
 1-277 1.78e-43

prephenate dehydrogenase; Validated


Pssm-ID: 181452 [Multi-domain]  Cd Length: 275  Bit Score: 148.89  E-value: 1.78e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115   1 MNIVIVGLGVIGGSFAKALKKAGYEN-VFGVDVDLETLKKAEKAKIIKkGCTTGKELfKKADLIILSIYPRLVVDFLNNN 79
Cdd:PRK08507   1 MKIGIIGLGLMGGSLGLALKEKGLISkVYGYDHNELHLKKALELGLVD-EIVSFEEL-KKCDVIFLAIPVDAIIEILPKL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115  80 KNFfKKGTIITDTTGIKETLINDVlqiiPDDI--DFIFGHPMAGREKRGIDFASEQVFNGANYIITPTGRNNIRNLELVE 157
Cdd:PRK08507  79 LDI-KENTTIIDLGSTKAKIIESV----PKHIrkNFIAAHPMAGTENSGPKAAIKGLYEGKVVVLCDVEKSGEKHQERAK 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115 158 NLILKLGFkRVKKLTSQKHDEIIAFTSQLPHVMAVALINS---DEEDRDTGKFIGDSYRDLTRIANMNEDLWSELFLGNR 234
Cdd:PRK08507 154 EIFSGLGM-RIVYMDAKEHDLHAAYISHLPHIISFALANTvlkEEDERNIFDLAGGGFRSMSRLAKSSPAMWSDIFKQNK 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 489519115 235 DNLLKVIENFESEVNLIKEAIFNNDKSKLIEYFKKSSIRREIL 277
Cdd:PRK08507 233 ENVLEAIDEFIKELEQFKQLIENEDWEELEEWMEQANKLREIL 275
PRK14806 PRK14806
bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; ...
 2-279 5.70e-43

bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


Pssm-ID: 237820 [Multi-domain]  Cd Length: 735  Bit Score: 155.92  E-value: 5.70e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115   2 NIVIVGLGVIGGSFAKALKKAGY-ENVFGVDVDLETLKKAEKAKIIKKGCTTGKELFKKADLIILSIYPRLVVDFLNNNK 80
Cdd:PRK14806   5 RVVVIGLGLIGGSFAKALRERGLaREVVAVDRRAKSLELAVSLGVIDRGEEDLAEAVSGADVIVLAVPVLAMEKVLADLK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115  81 NFFKKGTIITDTTGIKETLINDVLQI---IPddIDFIFGHPMAGREKRGIDFASEQVFNGANYIITPTGRNNIRNLELVE 157
Cdd:PRK14806  85 PLLSEHAIVTDVGSTKGNVVDAARAVfgeLP--AGFVPGHPIAGSEKSGVHAANADLFRNHKVILTPLAETDPAALARVD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115 158 NLILKLGFKrVKKLTSQKHDEIIAFTSQLPHVMAVALINS---DEEDRDTGKFIGDSYRDLTRIANMNEDLWSELFLGNR 234
Cdd:PRK14806 163 RLWRAVGAD-VLHMDVAHHDEVLAATSHLPHLLAFSLVDQlanREDNLDIFRYAAGGFRDFTRIAASDPVMWHDIFLANK 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 489519115 235 DNLLKVIENFESEVNLIKEAIFNNDKSKLIEYFKKSSIRRE----ILEK 279
Cdd:PRK14806 242 EAVLRALDHFRDDLDALRAAIEAGDGHALLGVFTRARAAREhfskMLAR 290
PRK07417 PRK07417
prephenate/arogenate dehydrogenase;
1-278 2.27e-37

prephenate/arogenate dehydrogenase;


Pssm-ID: 180970 [Multi-domain]  Cd Length: 279  Bit Score: 133.09  E-value: 2.27e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115   1 MNIVIVGLGVIGGSFAKALKKAGYEnVFGVDVDLETLKKAEKAKIIKKGcTTGKELFKKADLIILSIYPRLVVDFLNNNK 80
Cdd:PRK07417   1 MKIGIVGLGLIGGSLGLDLRSLGHT-VYGVSRRESTCERAIERGLVDEA-STDLSLLKDCDLVILALPIGLLLPPSEQLI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115  81 NFFKKGTIITDTTGIKETLINDVLQIIPDdidFIFGHPMAGREKRGIDFASEQVFNGANYIITPTGRNNIRNLELVENLI 160
Cdd:PRK07417  79 PALPPEAIVTDVGSVKAPIVEAWEKLHPR---FVGSHPMAGTAESGVEAGQRGLFKNRPWVLTPTENTDLNALAIVEELA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115 161 LKLGFKrVKKLTSQKHDEIIAFTSQLPHVMAVALIN-----SDEEDRDTGKFIGDS-YRDLTRIANMNEDLWSELFLGNR 234
Cdd:PRK07417 156 VSLGSK-IYTADPEEHDRAVALISHLPVMVSAALIQtcgteKDPSVLKLAQNLASSgFADTSRVGGGNPELGVMMAEYNR 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 489519115 235 DNLLKVIENFESEVNLIKEAIFNNDKSKLIEYFKKS-SIRREILE 278
Cdd:PRK07417 235 AALLRSLASYRQSLDQLEELIEQENWSALEQKLEQTqELRPNFLN 279
PRK07502 PRK07502
prephenate/arogenate dehydrogenase family protein;
3-278 1.37e-36

prephenate/arogenate dehydrogenase family protein;


Pssm-ID: 236034 [Multi-domain]  Cd Length: 307  Bit Score: 132.02  E-value: 1.37e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115   3 IVIVGLGVIGGSFAKALKKAGY-ENVFGVDVDLETLKKAEKAKIIKKGCTTGKELFKKADLIILS------------IYP 69
Cdd:PRK07502   9 VALIGIGLIGSSLARAIRRLGLaGEIVGADRSAETRARARELGLGDRVTTSAAEAVKGADLVILCvpvgasgavaaeIAP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115  70 RLvvdflnnnknffKKGTIITDTTGIKETLINDVLQIIPDDIDFIFGHPMAGREKRGID--FASeqVFNGANYIITPTGR 147
Cdd:PRK07502  89 HL------------KPGAIVTDVGSVKASVIAAMAPHLPEGVHFIPGHPLAGTEHSGPDagFAE--LFENRWCILTPPEG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115 148 NNIRNLELVENLILKLGfKRVKKLTSQKHDEIIAFTSQLPHVMAVALINS-DEEDRDTG----KFIGDSYRDLTRIANMN 222
Cdd:PRK07502 155 TDPAAVARLTAFWRALG-ARVEEMDPEHHDLVLAITSHLPHLIAYTIVGTaDDLERVTEseviKYSASGFRDFTRIAASD 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489519115 223 EDLWSELFLGNRDNLLKVIENFESEVNLIKEAIFNNDKSKLIEYFKKS-SIRREILE 278
Cdd:PRK07502 234 PTMWRDVFLHNKDAVLEMLGRFTEDLAALQRAIRWGDGDALFDLFTRTrAIRRGIIE 290
PDH_N pfam02153
Prephenate dehydrogenase, nucleotide-binding domain; Members of this family are prephenate ...
 15-169 4.99e-22

Prephenate dehydrogenase, nucleotide-binding domain; Members of this family are prephenate dehydrogenases (PDHs) EC:1.3.1.12 involved in tyrosine biosynthesis. This is the N-terminal nucleotide-binding domain of PDHs, which has a modified Rossmann nucleotide-binding fold with an extended beta-sheet sandwiched by three helices on each face.


Pssm-ID: 460467 [Multi-domain]  Cd Length: 154  Bit Score: 89.37  E-value: 4.99e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115   15 FAKALKKAGYE-NVFGVDVDLETlKKAEKAKIIKKGCTTGKELFKKADLIILSIYPRLVVDFLNNNKNFFKKGTIITDTT 93
Cdd:pfam02153   1 LALALRRHGFFvTVIGYDINPEA-AVAALRLGLGDEATDDIEAVREADIVFLAVPVEQTLPVLKELAPHLKEDALITDVG 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489519115   94 GIKETLINDVLQIIPDDIdFIFGHPMAGREKRGIDFASEQVFNGANYIITPTGRNNIRNLELVENLILKLGFKRVK 169
Cdd:pfam02153  80 SVKVKIIRELEQHLPDKS-FVPGHPMAGTEKSGPDAARANLFENAPVILTPTEKTDTEALNCVKELLEGVGARVIL 154
PDH_C pfam20463
Prephenate dehydrogenase, dimerization domain; Members of this family are prephenate ...
 172-268 5.75e-22

Prephenate dehydrogenase, dimerization domain; Members of this family are prephenate dehydrogenases EC:1.3.1.12 (PDHs) involved in tyrosine biosynthesis. This is the C-terminal, helical dimerization domain of PDHs.


Pssm-ID: 466612 [Multi-domain]  Cd Length: 102  Bit Score: 87.82  E-value: 5.75e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115  172 TSQKHDEIIAFTSQLPHVMAVALINSDEED----RDTGKFIGDSYRDLTRIANMNEDLWSELFLGNRDNLLKVIENFESE 247
Cdd:pfam20463   1 SPETHDRVVAVVSHLPHFVAIALAATLAELgvdiKEARKLASGGFRDMTRIAGSNPELWADIQTHNARAVLEALDDFIAE 80

                          90       100
                  ....*....|....*....|.
gi 489519115  248 VNLIKEAIFNNDKSKLIEYFK 268
Cdd:pfam20463  81 LKQLKELIRNGDWEELVEYMK 101
PRK11861 PRK11861
bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
 82-274 2.07e-19

bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


Pssm-ID: 183343 [Multi-domain]  Cd Length: 673  Bit Score: 87.84  E-value: 2.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115  82 FFKKGTIITDTTGIKETLINDVLQIIPDDI-DFIFGHPMAGREKRGIDFASEQVFNGANYIITPTGRNNIRNLELVENLi 160
Cdd:PRK11861  20 FLDASTIVTDAGSTKSDVVAAARAALGARIgQFVPGHPIAGRESSGVDAALADLYVGRNVVLCALPENAPDALARVEAM- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115 161 LKLGFKRVKKLTSQKHDEIIAFTSQLPHVMAVALIN-----SDEEDRDTgkFIGDSYRDLTRIANMNEDLWSELFLGNRD 235
Cdd:PRK11861  99 WRAARADVRAMSAEQHDRVFAAVSHLPHVLSFALVEqilgeSDAELKFS--YAAGGFRDFTRIAASSPEMWRDVCLANRA 176

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 489519115 236 NLLKVIENFESEVNLIKEAIFNNDKSKLIEYFKKSSIRR 274
Cdd:PRK11861 177 ALLDELDAYTAVLARLRAAIDAGDGAALEAVFARSRAAR 215
PRK08655 PRK08655
prephenate dehydrogenase; Provisional
 1-271 8.98e-09

prephenate dehydrogenase; Provisional


Pssm-ID: 236326 [Multi-domain]  Cd Length: 437  Bit Score: 55.76  E-value: 8.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115   1 MNIVIVG-LGVIGGSFAKALKKAGYE-NVFGVDVDLetlKKAEKAKIIKKGCTTGKELFKKADLIILSIYPRLVVDFLNN 78
Cdd:PRK08655   1 MKISIIGgTGGLGKWFARFLKEKGFEvIVTGRDPKK---GKEVAKELGVEYANDNIDAAKDADIVIISVPINVTEDVIKE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115  79 NKNFFKKGTIITDTTGIKETLINDVLQIIPDDIDFIFGHPMAGREKRGIdfaseqvfNGANYIITPTGRNNIRNLELVEN 158
Cdd:PRK08655  78 VAPHVKEGSLLMDVTSVKERPVEAMEEYAPEGVEILPTHPMFGPRTPSL--------KGQVVILTPTEKRSNPWFDKVKN 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115 159 LILKLGfKRVKKLTSQKHDEIIAFTSQLPH----VMAVALINSDEEDRDTGKFIGDSYR---DLT-RIANMNEDLWSELF 230
Cdd:PRK08655 150 FLEKEG-ARVIVTSPEEHDRIMSVVQGLTHfayiSIASTLKRLGVDIKESRKFASPIYElmiDIIgRILGQNPYLYASIQ 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 489519115 231 LGNRdNLLKVIENFESEVNLIKEAIFNNDKSKLIEYFKKSS 271
Cdd:PRK08655 229 MNNP-QIPEIHETFIKECEELSELVKNGDREEFVERMKEAA 268
PLN02712 PLN02712
arogenate dehydrogenase
 83-275 1.67e-06

arogenate dehydrogenase


Pssm-ID: 215382 [Multi-domain]  Cd Length: 667  Bit Score: 49.21  E-value: 1.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115  83 FKKGTIITDTTGIKETLINDVLQIIPDDIDFIFGHPMAGREK-----RGIDFASEQVFNGANyiitptgRNNIRNLELVE 157
Cdd:PLN02712 133 LKRNTLFVDVLSVKEFAKNLLLDYLPEDFDIICSHPMFGPQSakhgwDGLRFVYEKVRIGNE-------ELRVSRCKSFL 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115 158 NLILKLGFKRVkKLTSQKHDEIIAFTSQLPHVMA--VALINSDEEDRDTGKFigDSYRDLTR-IANMNEDLWSELFLGNR 234
Cdd:PLN02712 206 EVFEREGCKMV-EMSCTEHDKYAAESQFITHTVGrvLEMLKLESTPINTKGY--ESLLDLVEnTCGDSFDLYYGLFMYNK 282

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 489519115 235 dNLLKVIENFESEVNLIKEAIFnndkSKLIEYFKKSSIRRE 275
Cdd:PLN02712 283 -NSLEMLERLDLAFEALRKQLF----GRLHGVVRKQLFGNE 318
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 1-89 7.23e-06

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 46.21  E-value: 7.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115   1 MNIVIVGLGVIGGSFAKALKKAGY--ENVFGVDVDLETLKKAEKAKIIKKgCTTGKELFKKADLIILSIYPRLVVDFLNN 78
Cdd:COG0345    3 MKIGFIGAGNMGSAIIKGLLKSGVppEDIIVSDRSPERLEALAERYGVRV-TTDNAEAAAQADVVVLAVKPQDLAEVLEE 81

                         90
                 ....*....|.
gi 489519115  79 NKNFFKKGTII 89
Cdd:COG0345   82 LAPLLDPDKLV 92
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 2-93 3.60e-04

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 40.15  E-value: 3.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115    2 NIVIVGLGVIGGSFAKALKKAGYEnVFGVDVDLETLkkAEKAKIIKKGCTTGKELFKKADLIILSI-YPRLVVDFLNNN- 79
Cdd:pfam03446   1 KIGFIGLGVMGSPMALNLLKAGYT-VTVYNRTPEKV--EELVAAGAIAAASPAEFVAGLDVVITMVpAGAAVDAVIFGEg 77

                          90
                  ....*....|....*
gi 489519115   80 -KNFFKKGTIITDTT 93
Cdd:pfam03446  78 lLPGLKPGDIIIDGS 92
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
3-93 1.13e-03

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 39.38  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519115   3 IVIVGLGVIGGSFAKALKKAGYENVFGVDvDLETLKKAEKAKIIKKGCTTGKELFKKADLIILSIYPRLVVDFLNNNKNF 82
Cdd:COG2085    1 IGIIGTGNIGSALARRLAAAGHEVVIGSR-DPEKAAALAAELGPGARAGTNAEAAAAADVVVLAVPYEAVPDVLESLGDA 79

                         90
                 ....*....|.
gi 489519115  83 FkKGTIITDTT 93
Cdd:COG2085   80 L-AGKIVIDAT 89
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 1-66 1.71e-03

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 38.94  E-value: 1.71e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489519115   1 MNIVIVGLGVIGGSFAKALKKAGYEnVFGVDVD---LETLkkaekakiIKKG---CTTGKELFKKADLIILS 66
Cdd:COG2084    2 MKVGFIGLGAMGAPMARNLLKAGHE-VTVWNRTpakAEAL--------VAAGarvAASPAEAAAAADVVITM 64
PanE COG1893
Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of ...
 1-25 2.76e-03

Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 441497 [Multi-domain]  Cd Length: 305  Bit Score: 38.68  E-value: 2.76e-03
                         10        20
                 ....*....|....*....|....*
gi 489519115   1 MNIVIVGLGVIGGSFAKALKKAGYE 25
Cdd:COG1893    1 MKIAILGAGAIGGLLGARLARAGHD 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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