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Conserved domains on  [gi|489519266|ref|WP_003424068|]
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acetyl-CoA carboxylase biotin carboxyl carrier protein [Clostridioides difficile]

Protein Classification

acetyl-CoA carboxylase biotin carboxyl carrier protein( domain architecture ID 11423502)

acetyl-CoA carboxylase biotin carboxyl carrier protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

CATH:  2.40.50.100
Gene Ontology:  GO:0003989|GO:0006633|GO:0009317
PubMed:  1370469
SCOP:  4002909
TCDB:  3.B.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 9-148 1.56e-45

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 145.04  E-value: 1.56e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519266   9 LLKAIDSTNLEYVKLESSDLRLEVSKKAQATSSPVLSVQQESVVdlslEKPVVNDTPVTSNENLSVVVAPLMGTFYDSPS 88
Cdd:COG0511    1 LIELLEESGLTELEVEEGEYKVRIKRGGAAAAAPVAAPAAAAPA----AAAPAAAAAAAAASGGGAVKSPMVGTFYRAPS 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519266  89 PDADNFVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKIK 148
Cdd:COG0511   77 PGAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVIE 136
 
Name Accession Description Interval E-value
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 9-148 1.56e-45

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 145.04  E-value: 1.56e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519266   9 LLKAIDSTNLEYVKLESSDLRLEVSKKAQATSSPVLSVQQESVVdlslEKPVVNDTPVTSNENLSVVVAPLMGTFYDSPS 88
Cdd:COG0511    1 LIELLEESGLTELEVEEGEYKVRIKRGGAAAAAPVAAPAAAAPA----AAAPAAAAAAAAASGGGAVKSPMVGTFYRAPS 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519266  89 PDADNFVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKIK 148
Cdd:COG0511   77 PGAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVIE 136
BCCP TIGR00531
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify ...
 1-148 2.66e-41

acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase.The gene name is accB or fabE. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273123 [Multi-domain]  Cd Length: 155  Bit Score: 134.96  E-value: 2.66e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519266    1 MNINEIKELLKAIDSTNLEYVKLESSDLRLEVSKKAQATSSPVLS-------VQQESVVDLSLEKPVVNDTPVTSNENLS 73
Cdd:TIGR00531   1 MNIREIKELIKLVEESGITELELKEEEFSVRLSKAAAAASFSVVQqaaapvpAQVPAQSSAAVPAPAPAAPAPAADIKGH 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489519266   74 VVVAPLMGTFYDSPSPDADNFVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKIK 148
Cdd:TIGR00531  81 IVRSPMVGTFYRAPSPDAKPFVEVGDKVNKGQTVCIVEAMKMMNEIEAEKAGTVVAILVENGQPVEYGEPLIVIE 155
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 32-149 1.01e-25

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 101.46  E-value: 1.01e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519266  32 VSKKAQATSSPVLSVQQESVVDLSLEKPVVNDTPVTSNENlsVVVAPLMGTFYDSpspdadnFVKVGDVVEEGDTLCILE 111
Cdd:PRK09282 484 VKAEGKRPFYLRVDGMPEEVVVEPLKEIVVGGRPRASAPG--AVTSPMPGTVVKV-------KVKEGDKVKAGDTVLVLE 554

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 489519266 112 AMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKIKP 149
Cdd:PRK09282 555 AMKMENEIQAPVDGTVKEILVKEGDRVNPGDVLMEIEP 592
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 74-147 3.22e-22

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 83.62  E-value: 3.22e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489519266  74 VVVAPLMGTFYDSpspdadnFVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKI 147
Cdd:cd06850    1 EVTAPMPGTVVKV-------LVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 74-147 3.72e-16

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 68.40  E-value: 3.72e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489519266   74 VVVAPLMGTFYDSPspDADNFVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKI 147
Cdd:pfam00364   2 EIKSPMIGESVREG--VVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLAKI 73
 
Name Accession Description Interval E-value
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 9-148 1.56e-45

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 145.04  E-value: 1.56e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519266   9 LLKAIDSTNLEYVKLESSDLRLEVSKKAQATSSPVLSVQQESVVdlslEKPVVNDTPVTSNENLSVVVAPLMGTFYDSPS 88
Cdd:COG0511    1 LIELLEESGLTELEVEEGEYKVRIKRGGAAAAAPVAAPAAAAPA----AAAPAAAAAAAAASGGGAVKSPMVGTFYRAPS 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519266  89 PDADNFVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKIK 148
Cdd:COG0511   77 PGAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVIE 136
BCCP TIGR00531
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify ...
 1-148 2.66e-41

acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase.The gene name is accB or fabE. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273123 [Multi-domain]  Cd Length: 155  Bit Score: 134.96  E-value: 2.66e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519266    1 MNINEIKELLKAIDSTNLEYVKLESSDLRLEVSKKAQATSSPVLS-------VQQESVVDLSLEKPVVNDTPVTSNENLS 73
Cdd:TIGR00531   1 MNIREIKELIKLVEESGITELELKEEEFSVRLSKAAAAASFSVVQqaaapvpAQVPAQSSAAVPAPAPAAPAPAADIKGH 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489519266   74 VVVAPLMGTFYDSPSPDADNFVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKIK 148
Cdd:TIGR00531  81 IVRSPMVGTFYRAPSPDAKPFVEVGDKVNKGQTVCIVEAMKMMNEIEAEKAGTVVAILVENGQPVEYGEPLIVIE 155
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 32-149 1.01e-25

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 101.46  E-value: 1.01e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519266  32 VSKKAQATSSPVLSVQQESVVDLSLEKPVVNDTPVTSNENlsVVVAPLMGTFYDSpspdadnFVKVGDVVEEGDTLCILE 111
Cdd:PRK09282 484 VKAEGKRPFYLRVDGMPEEVVVEPLKEIVVGGRPRASAPG--AVTSPMPGTVVKV-------KVKEGDKVKAGDTVLVLE 554

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 489519266 112 AMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKIKP 149
Cdd:PRK09282 555 AMKMENEIQAPVDGTVKEILVKEGDRVNPGDVLMEIEP 592
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 3-149 4.91e-24

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 93.75  E-value: 4.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519266   3 INEIKELLKAIDSTNLEYVKLESSDLRLEVSKK---AQATS-SPVLSVQ---QESVVDLSL---------------EKPV 60
Cdd:PLN02983 106 MTQVSSLVKLVDSRDIVELQLKQLDCELVIRKKealPQPPPpAPVVMMQpppPHAMPPASPpaaqpapsapassppPTPA 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519266  61 VNDTPVTSNENLSVVVAPLMGTFYDSPSPDADNFVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEY 140
Cdd:PLN02983 186 SPPPAKAPKSSHPPLKSPMAGTFYRSPAPGEPPFVKVGDKVQKGQVVCIIEAMKLMNEIEADQSGTIVEILAEDGKPVSV 265


                 ....*....
gi 489519266 141 NQPLFKIKP 149
Cdd:PLN02983 266 DTPLFVIEP 274
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 74-147 3.22e-22

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 83.62  E-value: 3.22e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489519266  74 VVVAPLMGTFYDSpspdadnFVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKI 147
Cdd:cd06850    1 EVTAPMPGTVVKV-------LVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
PRK07051 PRK07051
biotin carboxyl carrier domain-containing protein;
75-147 5.29e-20

biotin carboxyl carrier domain-containing protein;


Pssm-ID: 180811 [Multi-domain]  Cd Length: 80  Bit Score: 78.52  E-value: 5.29e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489519266  75 VVAPLMGTFYDSPSPDADNFVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKI 147
Cdd:PRK07051   6 IVSPLPGTFYRRPSPDAPPYVEVGDAVAAGDVVGLIEVMKQFTEVEAEAAGRVVEFLVEDGEPVEAGQVLARI 78
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 74-147 3.72e-16

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 68.40  E-value: 3.72e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489519266   74 VVVAPLMGTFYDSPspDADNFVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKI 147
Cdd:pfam00364   2 EIKSPMIGESVREG--VVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLAKI 73
Biotinyl_lipoyl_domains cd06663
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the ...
 94-147 2.49e-10

Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, or methylamine, respectively, between components of the complex/protein via a biotinyl or lipoyl group, which is covalently attached to a highly conserved lysine residue.


Pssm-ID: 133456 [Multi-domain]  Cd Length: 73  Bit Score: 53.21  E-value: 2.49e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489519266  94 FVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKI 147
Cdd:cd06663   20 LKKVGDKVKKGDVLAEIEAMKATSDVEAPKSGTVKKVLVKEGTKVEGDTPLVKI 73
PycA COG1038
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
 94-139 8.75e-10

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 55.86  E-value: 8.75e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 489519266   94 FVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVE 139
Cdd:COG1038  1091 LVKEGDEVKKGDPLLTIEAMKMETTITAPRDGTVKEVLVKEGDQVE 1136
PRK14040 PRK14040
oxaloacetate decarboxylase subunit alpha;
64-147 1.46e-08

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 237592 [Multi-domain]  Cd Length: 593  Bit Score: 52.24  E-value: 1.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519266  64 TPVTSNENLSVVVAPLMGTFYDSpspdadnFVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQP 143
Cdd:PRK14040 516 AAAPAAAAGEPVTAPLAGNIFKV-------IVTEGQTVAEGDVLLILEAMKMETEIRAAQAGTVRGIAVKEGDAVAVGDT 588


                 ....
gi 489519266 144 LFKI 147
Cdd:PRK14040 589 LLTL 592
PRK12999 PRK12999
pyruvate carboxylase; Reviewed
 95-149 1.50e-08

pyruvate carboxylase; Reviewed


Pssm-ID: 237263 [Multi-domain]  Cd Length: 1146  Bit Score: 52.06  E-value: 1.50e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 489519266   95 VKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKIKP 149
Cdd:PRK12999 1092 VKEGDEVKAGDPLAVIEAMKMETTITAPVDGTVKRVLVKAGDQVEAGDLLVELEP 1146
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 22-147 5.12e-07

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 46.39  E-value: 5.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489519266  22 KLESSDLRLEVSKKAQATSSPVlSVQQESVVDLSLEKPVVNDTPVTSNENLSVVVAPLMGTFYDSpspdadnFVKVGDVV 101
Cdd:PRK05641  35 EVEAKGLGIDLSAVQEQVPTPA-PAPAPAVPSAPTPVAPAAPAPAPASAGENVVTAPMPGKILRI-------LVREGQQV 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 489519266 102 EEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKI 147
Cdd:PRK05641 107 KVGQGLLILEAMKMENEIPAPKDGVVKKILVKEGDTVDTGQPLIEL 152
PRK06549 PRK06549
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 95-148 1.01e-06

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235826 [Multi-domain]  Cd Length: 130  Bit Score: 45.19  E-value: 1.01e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489519266  95 VKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKIK 148
Cdd:PRK06549  77 VAVGDQVTENQPLLILEAMKMENEIVASSAGTVTAIHVTPGQVVNPGDGLITIG 130
AceF COG0508
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component ...
 94-147 1.39e-06

Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [Energy production and conversion]; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440274 [Multi-domain]  Cd Length: 77  Bit Score: 43.52  E-value: 1.39e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489519266  94 FVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKI 147
Cdd:COG0508   23 LVKEGDTVKEGDPLAEVETDKATMEVPAPAAGVLLEILVKEGDTVPVGAVIAVI 76
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 94-148 1.33e-05

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 43.66  E-value: 1.33e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489519266  94 FVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKIK 148
Cdd:PRK11855 139 LVKVGDTVEEDQSLITVETDKATMEIPSPVAGVVKEIKVKVGDKVSVGSLLVVIE 193
PRK08225 PRK08225
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 95-138 4.15e-05

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 181304 [Multi-domain]  Cd Length: 70  Bit Score: 39.39  E-value: 4.15e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 489519266  95 VKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELV 138
Cdd:PRK08225  17 VKVGDTVEEGQDVVILESMKMEIPIVAEEAGTVKKINVQEGDFV 60
PRK00624 PRK00624
glycine cleavage system protein H; Provisional
 97-144 3.34e-04

glycine cleavage system protein H; Provisional


Pssm-ID: 167014  Cd Length: 114  Bit Score: 37.89  E-value: 3.34e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 489519266  97 VGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVlvsNEELVEYNQPL 144
Cdd:PRK00624  42 VGSFCKEGEVLVILESSKSAIEVLSPVSGEVIEV---NTALEDDIQPI 86
PTZ00144 PTZ00144
dihydrolipoamide succinyltransferase; Provisional
 95-149 5.77e-04

dihydrolipoamide succinyltransferase; Provisional


Pssm-ID: 240289 [Multi-domain]  Cd Length: 418  Bit Score: 38.90  E-value: 5.77e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489519266  95 VKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKIKP 149
Cdd:PTZ00144  66 KKVGDYVKEDEVICIIETDKVSVDIRAPASGVITKIFAEEGDTVEVGAPLSEIDT 120
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 94-149 6.14e-04

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 38.65  E-value: 6.14e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489519266  94 FVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKIKP 149
Cdd:PRK11855  22 LVKEGDTVEEDQPLVTVETDKATMEIPSPAAGVVKEIKVKVGDTVSVGGLLAVIEA 77
PRK01202 PRK01202
glycine cleavage system protein GcvH;
96-149 1.30e-03

glycine cleavage system protein GcvH;


Pssm-ID: 234918  Cd Length: 127  Bit Score: 36.68  E-value: 1.30e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489519266  96 KVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVlvsNEELVEynQP------------LFKIKP 149
Cdd:PRK01202  46 EVGDEVKAGETFGVVESVKAASDIYAPVSGEVVEV---NEALED--SPelvnedpygegwLFKIKP 106
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 96-149 2.07e-03

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440275  Cd Length: 128  Bit Score: 35.87  E-value: 2.07e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489519266  96 KVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVlvsNEELVEynQP------------LFKIKP 149
Cdd:COG0509   46 EVGTEVEAGEPFGVVESVKAVSDLYAPVSGEVVEV---NEALED--DPelvnedpygegwLFKIKP 106
PLN02528 PLN02528
2-oxoisovalerate dehydrogenase E2 component
 94-147 2.37e-03

2-oxoisovalerate dehydrogenase E2 component


Pssm-ID: 215289 [Multi-domain]  Cd Length: 416  Bit Score: 37.01  E-value: 2.37e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489519266  94 FVKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKI 147
Cdd:PLN02528  19 FVKEGDQVEEFQPLCEVQSDKATIEITSRYKGKVAQINFSPGDIVKVGETLLKI 72
PRK14042 PRK14042
pyruvate carboxylase subunit B; Provisional
 95-148 9.37e-03

pyruvate carboxylase subunit B; Provisional


Pssm-ID: 172536 [Multi-domain]  Cd Length: 596  Bit Score: 35.47  E-value: 9.37e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489519266  95 VKVGDVVEEGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKIK 148
Cdd:PRK14042 541 VSAGDEVKAGQAVLVIEAMKMETEIKAPANGVVAEILCQKGDKVTPGQVLIRVE 594
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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