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Conserved domains on  [gi|489520293|ref|WP_003425090|]
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methyl-accepting chemotaxis protein [Clostridioides difficile]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 11622275)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
107-556 2.23e-61

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


:

Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 211.42  E-value: 2.23e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 107 ESNKILEAKEISDSLVPTEQSAIKAVESNDKSKAQSIIFGSDYINSQEKMDSLINEFQEDIVTRSNSKIVEVKKELQSLI 186
Cdd:COG0840   56 LLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALA 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 187 LRTIFILSLLIILTIIEYTVIKLKIVIPINKVEKHFSRIASGDLRTSIDVEESKSEIGLLVSSVKKMQSMLLNYIDLIDS 266
Cdd:COG0840  136 ALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLE 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 267 TLTSIAKGDLRVEIDQEFIGDFKSIKISLESIINSFNGDFSEINLSAEQVASASEQVAAGAQALSQGATEQASSVEELAS 346
Cdd:COG0840  216 VLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAA 295
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 347 TINEISDGIKKCADSASLACEVSDQSASQVGFGSRCMDDMMTS--------------MGEISEKSSEISKIIKTIDEIAF 412
Cdd:COG0840  296 AMEELSATVQEVAENAQQAAELAEEASELAEEGGEVVEEAVEGieeiresveetaetIEELGESSQEIGEIVDVIDDIAE 375
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 413 QTNILALNAAVEAARAGQYGRGFAVVADEVRSLAGKSAKAAQNTAILI--------------EEAIKTVENGVRIAKETA 478
Cdd:COG0840  376 QTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAEATKEIEELIeeiqseteeaveamEEGSEEVEEGVELVEEAG 455
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489520293 479 NALDLVVNGVEKTTNYINGISSAVHSQEVAITQILSGIEQISIVVQMNSATAEESAAASEEMSAQAQILKELVEKFHL 556
Cdd:COG0840  456 EALEEIVEAVEEVSDLIQEIAAASEEQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
chemoreceptor_sensor super family cl00144
4-helix bundle ligand binding sensor domain of chemoreceptors such as Tar or Tsr; The ligand ...
8-165 1.27e-04

4-helix bundle ligand binding sensor domain of chemoreceptors such as Tar or Tsr; The ligand binding sensor domain of chemoreceptors and related sensor histidine kinases forms homodimers and binds to ligands via the dimerization interface, a feature that appears to be conserved in this domain superfamily. This family includes ligand binding sensor domain of several chemoreceptors, such as Escherichia coli Tar, Tsr, NarQ, NarX, Pseudomonas aeruginosa KinB, Rhodopseudomonas palustris histidine kinase HK9 chemoreceptors, Comamonas testosteroni CNB-2 MCP2201 and Anaeromyxobacter dehalogenans histidine kinase Adeh_2942, among others.


The actual alignment was detected with superfamily member pfam12729:

Pssm-ID: 444710 [Multi-domain]  Cd Length: 181  Bit Score: 43.01  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293    8 SKLAIVLLIIIVLAVLAGIFSSISSYKAFEKVEKSINDMNNLRTQSQYIKDTTREISDVLRRYVFTGEKKNKDIYEKEL- 86
Cdd:pfam12729   6 TKLILLFLLLALLLIIVGVVGLYSLKQINDNLDTMYEDRLLPIKWLGDIRANLLELRANLLELILTTDPAERDELLKDIe 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293   87 -YGKTRESALNKLEKIGLTKSESNKILEAKEISDSLVPTEQSAIKAVESNDKSKAQSiIFGSDYINSQEKMDSLINEFQE 165
Cdd:pfam12729  86 eLRAEIDKLLEKYEKTILTDEEKKLFAEFKENLNAYRAVRNKVLELAKAGNKDEAYQ-LYKTEGRPAREAMIEALEELVD 164
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
107-556 2.23e-61

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 211.42  E-value: 2.23e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 107 ESNKILEAKEISDSLVPTEQSAIKAVESNDKSKAQSIIFGSDYINSQEKMDSLINEFQEDIVTRSNSKIVEVKKELQSLI 186
Cdd:COG0840   56 LLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALA 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 187 LRTIFILSLLIILTIIEYTVIKLKIVIPINKVEKHFSRIASGDLRTSIDVEESKSEIGLLVSSVKKMQSMLLNYIDLIDS 266
Cdd:COG0840  136 ALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLE 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 267 TLTSIAKGDLRVEIDQEFIGDFKSIKISLESIINSFNGDFSEINLSAEQVASASEQVAAGAQALSQGATEQASSVEELAS 346
Cdd:COG0840  216 VLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAA 295
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 347 TINEISDGIKKCADSASLACEVSDQSASQVGFGSRCMDDMMTS--------------MGEISEKSSEISKIIKTIDEIAF 412
Cdd:COG0840  296 AMEELSATVQEVAENAQQAAELAEEASELAEEGGEVVEEAVEGieeiresveetaetIEELGESSQEIGEIVDVIDDIAE 375
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 413 QTNILALNAAVEAARAGQYGRGFAVVADEVRSLAGKSAKAAQNTAILI--------------EEAIKTVENGVRIAKETA 478
Cdd:COG0840  376 QTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAEATKEIEELIeeiqseteeaveamEEGSEEVEEGVELVEEAG 455
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489520293 479 NALDLVVNGVEKTTNYINGISSAVHSQEVAITQILSGIEQISIVVQMNSATAEESAAASEEMSAQAQILKELVEKFHL 556
Cdd:COG0840  456 EALEEIVEAVEEVSDLIQEIAAASEEQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
312-555 1.34e-48

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 169.39  E-value: 1.34e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293   312 SAEQVASASEQVAAGAQALSQGATEQASSVEELASTINEISDGIKKCADSASLACEVSDQSASQVGFGSRCMDDMMTSMG 391
Cdd:smart00283   5 AVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVSAVE 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293   392 EISEKSSEISKIIKTIDEIAFQTNILALNAAVEAARAGQYGRGFAVVADEVRSLAGKSAKAAQNTAILI----------- 460
Cdd:smart00283  85 ELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIkeiqeetneav 164
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293   461 ---EEAIKTVENGVRIAKETANALDLVVNGVEKTTNYINGISSAVHSQEVAITQILSGIEQISIVVQMNSATAEESAAAS 537
Cdd:smart00283 165 aamEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEISAAA 244
                          250
                   ....*....|....*...
gi 489520293   538 EEMSAQAQILKELVEKFH 555
Cdd:smart00283 245 EELSGLAEELDELVERFK 262
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
207-562 6.37e-48

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 175.53  E-value: 6.37e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 207 IKLKIVIPINKVEKHFSRIASGDLRTSIDVEESkSEIGLLVSSVKKMQSMLLNYIdlidstltsiakGDLRveidqefig 286
Cdd:PRK15041 214 IKASLVAPMNRLIDSIRHIAGGDLVKPIEVDGS-NEMGQLAESLRHMQGELMRTV------------GDVR--------- 271
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 287 dfksikislesiinsfNGdfseinlsAEQVASASEQVAAGAQALSQGATEQASSVEELASTINEISDGIKKCADSASLAC 366
Cdd:PRK15041 272 ----------------NG--------ANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNAENARQAS 327
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 367 EVSDQSASQVGFGSRCMDDMMTSMGEISEKSSEISKIIKTIDEIAFQTNILALNAAVEAARAGQYGRGFAVVADEVRSLA 446
Cdd:PRK15041 328 HLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLA 407
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 447 GKSAKAAQNTAILIEEAIKTVENGVRIAKETANALDLVVNGVEKTTNYINGISSAVHSQEVAITQILSGIEQISIVVQMN 526
Cdd:PRK15041 408 QRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEMDRVTQQN 487
                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 489520293 527 SATAEESAAASEEMSAQAQILKELVEKFHLKESEVR 562
Cdd:PRK15041 488 AALVEESAAAAAALEEQASRLTEAVAVFRIQQQQQQ 523
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
335-524 4.51e-41

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 147.00  E-value: 4.51e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 335 TEQASSVEELASTINEISDGIKKCADSASLACEVSDQSASQVGFGSRCMDDMMTSMGEISEKSSEISKIIKTIDEIAFQT 414
Cdd:cd11386    1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 415 NILALNAAVEAARAGQYGRGFAVVADEVRSLAGKSAKAAQNTAILIEEAIKTVENGVRIAKETANALDLVVNGVEKTTNY 494
Cdd:cd11386   81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160
                        170       180       190
                 ....*....|....*....|....*....|
gi 489520293 495 INGISSAVHSQEVAITQILSGIEQISIVVQ 524
Cdd:cd11386  161 FEEIVASVEEVADGIQEISAATQEQSASTQ 190
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
367-523 1.94e-36

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 133.71  E-value: 1.94e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293  367 EVSDQSASQVGFGSRCMDDMMTSMGEISEKSSEISKIIKTIDEIAFQTNILALNAAVEAARAGQYGRGFAVVADEVRSLA 446
Cdd:pfam00015   2 DLAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293  447 GKSAKAAQNTAILI--------------EEAIKTVENGVRIAKETANALDLVVNGVEKTTNYINGISSAVHSQEVAITQI 512
Cdd:pfam00015  82 ERSAQAAKEIEALIieiqkqtndstasiESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQV 161
                         170
                  ....*....|.
gi 489520293  513 LSGIEQISIVV 523
Cdd:pfam00015 162 NQAVARMDQVT 172
4HB_MCP_1 pfam12729
Four helix bundle sensory module for signal transduction; This family is a four helix bundle ...
8-165 1.27e-04

Four helix bundle sensory module for signal transduction; This family is a four helix bundle that operates as a ubiquitous sensory module in prokaryotic signal-transduction. The 4HB_MCP is always found between two predicted transmembrane helices indicating that it detects only extracellular signals. In many cases the domain is associated with a cytoplasmic HAMP domain suggesting that most proteins carrying the bundle might share the mechanism of transmembrane signalling which is well-characterized in E coli chemoreceptors. This domain recognizes citrate and TCA cycle intermediates, cis-aconitate, boric acid, Phenanthrene, pyrene and benzopyrene (Matilla et el., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 432749 [Multi-domain]  Cd Length: 181  Bit Score: 43.01  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293    8 SKLAIVLLIIIVLAVLAGIFSSISSYKAFEKVEKSINDMNNLRTQSQYIKDTTREISDVLRRYVFTGEKKNKDIYEKEL- 86
Cdd:pfam12729   6 TKLILLFLLLALLLIIVGVVGLYSLKQINDNLDTMYEDRLLPIKWLGDIRANLLELRANLLELILTTDPAERDELLKDIe 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293   87 -YGKTRESALNKLEKIGLTKSESNKILEAKEISDSLVPTEQSAIKAVESNDKSKAQSiIFGSDYINSQEKMDSLINEFQE 165
Cdd:pfam12729  86 eLRAEIDKLLEKYEKTILTDEEKKLFAEFKENLNAYRAVRNKVLELAKAGNKDEAYQ-LYKTEGRPAREAMIEALEELVD 164
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
107-556 2.23e-61

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 211.42  E-value: 2.23e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 107 ESNKILEAKEISDSLVPTEQSAIKAVESNDKSKAQSIIFGSDYINSQEKMDSLINEFQEDIVTRSNSKIVEVKKELQSLI 186
Cdd:COG0840   56 LLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALA 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 187 LRTIFILSLLIILTIIEYTVIKLKIVIPINKVEKHFSRIASGDLRTSIDVEESKSEIGLLVSSVKKMQSMLLNYIDLIDS 266
Cdd:COG0840  136 ALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLE 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 267 TLTSIAKGDLRVEIDQEFIGDFKSIKISLESIINSFNGDFSEINLSAEQVASASEQVAAGAQALSQGATEQASSVEELAS 346
Cdd:COG0840  216 VLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAA 295
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 347 TINEISDGIKKCADSASLACEVSDQSASQVGFGSRCMDDMMTS--------------MGEISEKSSEISKIIKTIDEIAF 412
Cdd:COG0840  296 AMEELSATVQEVAENAQQAAELAEEASELAEEGGEVVEEAVEGieeiresveetaetIEELGESSQEIGEIVDVIDDIAE 375
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 413 QTNILALNAAVEAARAGQYGRGFAVVADEVRSLAGKSAKAAQNTAILI--------------EEAIKTVENGVRIAKETA 478
Cdd:COG0840  376 QTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAEATKEIEELIeeiqseteeaveamEEGSEEVEEGVELVEEAG 455
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489520293 479 NALDLVVNGVEKTTNYINGISSAVHSQEVAITQILSGIEQISIVVQMNSATAEESAAASEEMSAQAQILKELVEKFHL 556
Cdd:COG0840  456 EALEEIVEAVEEVSDLIQEIAAASEEQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
312-555 1.34e-48

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 169.39  E-value: 1.34e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293   312 SAEQVASASEQVAAGAQALSQGATEQASSVEELASTINEISDGIKKCADSASLACEVSDQSASQVGFGSRCMDDMMTSMG 391
Cdd:smart00283   5 AVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVSAVE 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293   392 EISEKSSEISKIIKTIDEIAFQTNILALNAAVEAARAGQYGRGFAVVADEVRSLAGKSAKAAQNTAILI----------- 460
Cdd:smart00283  85 ELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIkeiqeetneav 164
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293   461 ---EEAIKTVENGVRIAKETANALDLVVNGVEKTTNYINGISSAVHSQEVAITQILSGIEQISIVVQMNSATAEESAAAS 537
Cdd:smart00283 165 aamEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEISAAA 244
                          250
                   ....*....|....*...
gi 489520293   538 EEMSAQAQILKELVEKFH 555
Cdd:smart00283 245 EELSGLAEELDELVERFK 262
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
207-562 6.37e-48

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 175.53  E-value: 6.37e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 207 IKLKIVIPINKVEKHFSRIASGDLRTSIDVEESkSEIGLLVSSVKKMQSMLLNYIdlidstltsiakGDLRveidqefig 286
Cdd:PRK15041 214 IKASLVAPMNRLIDSIRHIAGGDLVKPIEVDGS-NEMGQLAESLRHMQGELMRTV------------GDVR--------- 271
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 287 dfksikislesiinsfNGdfseinlsAEQVASASEQVAAGAQALSQGATEQASSVEELASTINEISDGIKKCADSASLAC 366
Cdd:PRK15041 272 ----------------NG--------ANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNAENARQAS 327
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 367 EVSDQSASQVGFGSRCMDDMMTSMGEISEKSSEISKIIKTIDEIAFQTNILALNAAVEAARAGQYGRGFAVVADEVRSLA 446
Cdd:PRK15041 328 HLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLA 407
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 447 GKSAKAAQNTAILIEEAIKTVENGVRIAKETANALDLVVNGVEKTTNYINGISSAVHSQEVAITQILSGIEQISIVVQMN 526
Cdd:PRK15041 408 QRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEMDRVTQQN 487
                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 489520293 527 SATAEESAAASEEMSAQAQILKELVEKFHLKESEVR 562
Cdd:PRK15041 488 AALVEESAAAAAALEEQASRLTEAVAVFRIQQQQQQ 523
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
207-556 1.03e-47

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 174.81  E-value: 1.03e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 207 IKLKIVIPINKVEKHFSRIASGDLRTSIDVEeSKSEIGLLVSSVKKMQSMLLNyidlidsTLTSIAKGdlrveidqefig 286
Cdd:PRK15048 212 IRRMLLTPLAKIIAHIREIAGGNLANTLTID-GRSEMGDLAQSVSHMQRSLTD-------TVTHVREG------------ 271
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 287 dfksikislesiinsfngdfseinlsAEQVASASEQVAAGAQALSQGATEQASSVEELASTINEISDGIKKCADSASLAC 366
Cdd:PRK15048 272 --------------------------SDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQAS 325
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 367 EVSDQSASQVGFGSRCMDDMMTSMGEISEKSSEISKIIKTIDEIAFQTNILALNAAVEAARAGQYGRGFAVVADEVRSLA 446
Cdd:PRK15048 326 QLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLA 405
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 447 GKSAKAAQNTAILIEEAIKTVENGVRIAKETANALDLVVNGVEKTTNYINGISSAVHSQEVAITQILSGIEQISIVVQMN 526
Cdd:PRK15048 406 SRSAQAAKEIKALIEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDRVTQQN 485
                        330       340       350
                 ....*....|....*....|....*....|
gi 489520293 527 SATAEESAAASEEMSAQAQILKELVEKFHL 556
Cdd:PRK15048 486 ASLVQESAAAAAALEEQASRLTQAVSAFRL 515
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
152-561 6.67e-46

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 169.48  E-value: 6.67e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 152 SQEKMDSLINEFQEDI--VTRSNSKIVEVKKELQSLILRTIFILSLLIILTIIEYTviKLKIVIPINKVEKHFSRIASGD 229
Cdd:PRK09793 155 SQNAFDVNFEAWQLEInhVLEAASAQSQRNYQISALVFISMIIVAAIYISSALWWT--RKMIVQPLAIIGSHFDSIAAGN 232
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 230 LRTSIDVeESKSEIGLLVSSVKKMQSMLlnyidliDSTLTSIAKGDLRVEIdqefigdfksikislesiinsfngDFSEI 309
Cdd:PRK09793 233 LARPIAV-YGRNEITAIFASLKTMQQAL-------RGTVSDVRKGSQEMHI------------------------GIAEI 280
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 310 nlsaeqvasaseqvAAGAQALSQGATEQASSVEELASTINEISDGIKKCADSASLACEVSDQSASQVGFGSRCMDDMMTS 389
Cdd:PRK09793 281 --------------VAGNNDLSSRTEQQAASLAQTAASMEQLTATVGQNADNARQASELAKNAATTAQAGGVQVSTMTHT 346
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 390 MGEISEKSSEISKIIKTIDEIAFQTNILALNAAVEAARAGQYGRGFAVVADEVRSLAGKSAKAAQNTAILIEEAIKTVEN 469
Cdd:PRK09793 347 MQEIATSSQKIGDIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKGLIEESVNRVQQ 426
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 470 GVRIAKETANALDLVVNGVEKTTNYINGISSAVHSQEVAITQILSGIEQISIVVQMNSATAEESAAASEEMSAQAQILKE 549
Cdd:PRK09793 427 GSKLVNNAAATMTDIVSSVTRVNDIMGEIASASEEQRRGIEQVAQAVSQMDQVTQQNASLVEEAAVATEQLANQADHLSS 506
                        410
                 ....*....|..
gi 489520293 550 LVEKFHLKESEV 561
Cdd:PRK09793 507 RVAVFTLEEHEV 518
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
335-524 4.51e-41

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 147.00  E-value: 4.51e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 335 TEQASSVEELASTINEISDGIKKCADSASLACEVSDQSASQVGFGSRCMDDMMTSMGEISEKSSEISKIIKTIDEIAFQT 414
Cdd:cd11386    1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293 415 NILALNAAVEAARAGQYGRGFAVVADEVRSLAGKSAKAAQNTAILIEEAIKTVENGVRIAKETANALDLVVNGVEKTTNY 494
Cdd:cd11386   81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160
                        170       180       190
                 ....*....|....*....|....*....|
gi 489520293 495 INGISSAVHSQEVAITQILSGIEQISIVVQ 524
Cdd:cd11386  161 FEEIVASVEEVADGIQEISAATQEQSASTQ 190
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
367-523 1.94e-36

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 133.71  E-value: 1.94e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293  367 EVSDQSASQVGFGSRCMDDMMTSMGEISEKSSEISKIIKTIDEIAFQTNILALNAAVEAARAGQYGRGFAVVADEVRSLA 446
Cdd:pfam00015   2 DLAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293  447 GKSAKAAQNTAILI--------------EEAIKTVENGVRIAKETANALDLVVNGVEKTTNYINGISSAVHSQEVAITQI 512
Cdd:pfam00015  82 ERSAQAAKEIEALIieiqkqtndstasiESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQV 161
                         170
                  ....*....|.
gi 489520293  513 LSGIEQISIVV 523
Cdd:pfam00015 162 NQAVARMDQVT 172
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
214-257 6.24e-05

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 40.51  E-value: 6.24e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 489520293 214 PINKVEKHFSRIASGDLRTSIDVeESKSEIGLLVSSVKKMQSML 257
Cdd:cd06225    3 PLRRLTEAARRIAEGDLDVRVPV-RSKDEIGELARAFNQMAERL 45
HAMP pfam00672
HAMP domain;
214-257 6.60e-05

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 40.69  E-value: 6.60e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 489520293  214 PINKVEKHFSRIASGDLRTSIDVeESKSEIGLLVSSVKKMQSML 257
Cdd:pfam00672   9 PLRRLAEAARRIASGDLDVRLPV-SGRDEIGELARAFNQMAERL 51
4HB_MCP_1 pfam12729
Four helix bundle sensory module for signal transduction; This family is a four helix bundle ...
8-165 1.27e-04

Four helix bundle sensory module for signal transduction; This family is a four helix bundle that operates as a ubiquitous sensory module in prokaryotic signal-transduction. The 4HB_MCP is always found between two predicted transmembrane helices indicating that it detects only extracellular signals. In many cases the domain is associated with a cytoplasmic HAMP domain suggesting that most proteins carrying the bundle might share the mechanism of transmembrane signalling which is well-characterized in E coli chemoreceptors. This domain recognizes citrate and TCA cycle intermediates, cis-aconitate, boric acid, Phenanthrene, pyrene and benzopyrene (Matilla et el., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 432749 [Multi-domain]  Cd Length: 181  Bit Score: 43.01  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293    8 SKLAIVLLIIIVLAVLAGIFSSISSYKAFEKVEKSINDMNNLRTQSQYIKDTTREISDVLRRYVFTGEKKNKDIYEKEL- 86
Cdd:pfam12729   6 TKLILLFLLLALLLIIVGVVGLYSLKQINDNLDTMYEDRLLPIKWLGDIRANLLELRANLLELILTTDPAERDELLKDIe 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520293   87 -YGKTRESALNKLEKIGLTKSESNKILEAKEISDSLVPTEQSAIKAVESNDKSKAQSiIFGSDYINSQEKMDSLINEFQE 165
Cdd:pfam12729  86 eLRAEIDKLLEKYEKTILTDEEKKLFAEFKENLNAYRAVRNKVLELAKAGNKDEAYQ-LYKTEGRPAREAMIEALEELVD 164
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
214-262 7.83e-04

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 37.61  E-value: 7.83e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 489520293   214 PINKVEKHFSRIASGDLRTSIDVeESKSEIGLLVSSVKKMQSMLLNYID 262
Cdd:smart00304   6 PLRRLAEAAQRIADGDLTVRLPV-DGRDEIGELARAFNEMADRLEETIA 53
HAMP_2 pfam18947
HAMP domain;
268-304 1.85e-03

HAMP domain;


Pssm-ID: 465927 [Multi-domain]  Cd Length: 67  Bit Score: 37.08  E-value: 1.85e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 489520293  268 LTSIAKGDLRVEIDQEFIGDFKSIKISLESIINSFNG 304
Cdd:pfam18947  31 VDRISKGDIPEKITDEYKGDFNEIKNNLNALIDAINA 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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