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Conserved domains on  [gi|489520370|ref|WP_003425166|]
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PTS sugar transporter subunit IIC [Clostridioides difficile]

Protein Classification

PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC( domain architecture ID 10007905)

PTS mannose/fructose/sorbose/N-acetylgalactosamine-specific transporter subunit IIC is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system that catalyzes the phosphorylation of incoming sugar substrates (such as mannose, fructose, sorbose, and N-acetylgalactosamine) concomitantly with their translocation across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ManY COG3715
Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component ...
 1-251 7.56e-88

Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component [Carbohydrate transport and metabolism];


:

Pssm-ID: 442929  Cd Length: 259  Bit Score: 260.82  E-value: 7.56e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370   1 MESVLMLAIVTGLWYWFAaGLAGYTLFSTLKSPLFIGFSLGLLWGDVTTGMIVGASIEMVYLGMVAAGGNIPSDKCLAAL 80
Cdd:COG3715    1 MEISLIQAILIGLVAFLA-GIDGLLGQFQLHRPLVAGLLVGLILGDVKTGLIIGATLQLIYLGVVNIGGAVPPDPALAGI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370  81 IAIPVALQTGVNAEVAVSIAVPLGVIGVLVNNLRRTGNAVLVHKADKYAEEGNTKGIWRCATLYSLIFgFVLRFPIVFVC 160
Cdd:COG3715   80 IGTALAILSGQDPETAIALAVPVGLLGQVLDILVRTINSFFVHKADKYAEEGNFKGIERLHLLGPLLQ-FLLRAIPVFLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370 161 NFFGADLVQSLLDVIPQWLMNGLTVMGGILPALGFATTIFTIGKNKFLPMFIIGFFMVQYFEISITAAAIFGVCIALLIT 240
Cdd:COG3715  159 LYFGADAVQALLNAIPAWLTHGLSVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFVLAAYLKLPLLAIAIIGVAIALIYY 238

                        250
                 ....*....|.
gi 489520370 241 FMKEDKRVGEV 251
Cdd:COG3715  239 QLKKKKNAAAA 249
 
Name Accession Description Interval E-value
ManY COG3715
Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component ...
 1-251 7.56e-88

Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component [Carbohydrate transport and metabolism];


Pssm-ID: 442929  Cd Length: 259  Bit Score: 260.82  E-value: 7.56e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370   1 MESVLMLAIVTGLWYWFAaGLAGYTLFSTLKSPLFIGFSLGLLWGDVTTGMIVGASIEMVYLGMVAAGGNIPSDKCLAAL 80
Cdd:COG3715    1 MEISLIQAILIGLVAFLA-GIDGLLGQFQLHRPLVAGLLVGLILGDVKTGLIIGATLQLIYLGVVNIGGAVPPDPALAGI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370  81 IAIPVALQTGVNAEVAVSIAVPLGVIGVLVNNLRRTGNAVLVHKADKYAEEGNTKGIWRCATLYSLIFgFVLRFPIVFVC 160
Cdd:COG3715   80 IGTALAILSGQDPETAIALAVPVGLLGQVLDILVRTINSFFVHKADKYAEEGNFKGIERLHLLGPLLQ-FLLRAIPVFLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370 161 NFFGADLVQSLLDVIPQWLMNGLTVMGGILPALGFATTIFTIGKNKFLPMFIIGFFMVQYFEISITAAAIFGVCIALLIT 240
Cdd:COG3715  159 LYFGADAVQALLNAIPAWLTHGLSVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFVLAAYLKLPLLAIAIIGVAIALIYY 238

                        250
                 ....*....|.
gi 489520370 241 FMKEDKRVGEV 251
Cdd:COG3715  239 QLKKKKNAAAA 249
EII-Sor pfam03609
PTS system sorbose-specific iic component;
5-238 2.49e-81

PTS system sorbose-specific iic component;


Pssm-ID: 460987  Cd Length: 233  Bit Score: 243.47  E-value: 2.49e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370    5 LMLAIVTGLWYWFAaGLAGYTLFSTLKSPLFIGFSLGLLWGDVTTGMIVGASIEMVYLGMVAAGGNIPSDKCLAALIAIP 84
Cdd:pfam03609   1 LIQAILIGLVAFLA-GLDGLLGQFTLHRPLVAGTLVGLILGDVQTGLIIGATLQLMYLGVVTIGGAVPPDAALAGIIGTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370   85 VALQTGVNAEVAVSIAVPLGVIGVLVNNLRRTGNAVLVHKADKYAEEGNTKGIWRCATLYSLIFGFVLRFPIVFVCNFFG 164
Cdd:pfam03609  80 LAILSGIGPEAAIALAVPVALLGQQLDNLVRTINSFFVHKADKYAEEGNYKGIERIHLLGPQLLGLLIRFIPVFLALYFG 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489520370  165 ADLVQSLLDVIPQWLMNGLTVMGGILPALGFATTIFTIGKNKFLPMFIIGFFMVQYFEISITAAAIFGVCIALL 238
Cdd:pfam03609 160 ADAVQALLNAIPEWLTNGLTVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFVLAAYLKLPLIAIAIIGVAIALI 233
PRK15065 PRK15065
mannose/fructose/sorbose family PTS transporter subunit IIC;
40-238 2.97e-30

mannose/fructose/sorbose family PTS transporter subunit IIC;


Pssm-ID: 237895  Cd Length: 262  Bit Score: 113.40  E-value: 2.97e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370  40 LGLLWGDVTTGMIVGASIEMVYLGMVAAGGNIPSDKCLAALIA--IPVALQTGVNAevAVSIAVPLGVIGVLVNNLRRTG 117
Cdd:PRK15065  39 IGLVLGDLKTGIILGGTLEMIALGWMNIGAAVAPDAALASVISaiLVIAGHQGIGT--GIAIAIPLAAAGQVLTIIVRTI 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370 118 NAVLVHKADKYAEEGNTKGIWRCATLYSLIFGFVLRFPIVFVCNFFGADLVQSLLDVIPQWLMNGLTVMGGILPALGFAT 197
Cdd:PRK15065 117 TVAFQHAADKAAEEGNFRAIEWLHVSALLLQALRIAIPAALVALAVGTSAVQSMLNAIPEVLTGGLNIGGGMIVVVGYAM 196

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 489520370 198 TIFTIGKNKFLPMFIIGFFMVQYFEISITAAAIFGVCIALL 238
Cdd:PRK15065 197 VINMMATRELMPFFYLGFVLAAFTNLNLIALGVIGVVLALI 237
 
Name Accession Description Interval E-value
ManY COG3715
Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component ...
 1-251 7.56e-88

Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component [Carbohydrate transport and metabolism];


Pssm-ID: 442929  Cd Length: 259  Bit Score: 260.82  E-value: 7.56e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370   1 MESVLMLAIVTGLWYWFAaGLAGYTLFSTLKSPLFIGFSLGLLWGDVTTGMIVGASIEMVYLGMVAAGGNIPSDKCLAAL 80
Cdd:COG3715    1 MEISLIQAILIGLVAFLA-GIDGLLGQFQLHRPLVAGLLVGLILGDVKTGLIIGATLQLIYLGVVNIGGAVPPDPALAGI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370  81 IAIPVALQTGVNAEVAVSIAVPLGVIGVLVNNLRRTGNAVLVHKADKYAEEGNTKGIWRCATLYSLIFgFVLRFPIVFVC 160
Cdd:COG3715   80 IGTALAILSGQDPETAIALAVPVGLLGQVLDILVRTINSFFVHKADKYAEEGNFKGIERLHLLGPLLQ-FLLRAIPVFLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370 161 NFFGADLVQSLLDVIPQWLMNGLTVMGGILPALGFATTIFTIGKNKFLPMFIIGFFMVQYFEISITAAAIFGVCIALLIT 240
Cdd:COG3715  159 LYFGADAVQALLNAIPAWLTHGLSVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFVLAAYLKLPLLAIAIIGVAIALIYY 238

                        250
                 ....*....|.
gi 489520370 241 FMKEDKRVGEV 251
Cdd:COG3715  239 QLKKKKNAAAA 249
EII-Sor pfam03609
PTS system sorbose-specific iic component;
5-238 2.49e-81

PTS system sorbose-specific iic component;


Pssm-ID: 460987  Cd Length: 233  Bit Score: 243.47  E-value: 2.49e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370    5 LMLAIVTGLWYWFAaGLAGYTLFSTLKSPLFIGFSLGLLWGDVTTGMIVGASIEMVYLGMVAAGGNIPSDKCLAALIAIP 84
Cdd:pfam03609   1 LIQAILIGLVAFLA-GLDGLLGQFTLHRPLVAGTLVGLILGDVQTGLIIGATLQLMYLGVVTIGGAVPPDAALAGIIGTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370   85 VALQTGVNAEVAVSIAVPLGVIGVLVNNLRRTGNAVLVHKADKYAEEGNTKGIWRCATLYSLIFGFVLRFPIVFVCNFFG 164
Cdd:pfam03609  80 LAILSGIGPEAAIALAVPVALLGQQLDNLVRTINSFFVHKADKYAEEGNYKGIERIHLLGPQLLGLLIRFIPVFLALYFG 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489520370  165 ADLVQSLLDVIPQWLMNGLTVMGGILPALGFATTIFTIGKNKFLPMFIIGFFMVQYFEISITAAAIFGVCIALL 238
Cdd:pfam03609 160 ADAVQALLNAIPEWLTNGLTVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFVLAAYLKLPLIAIAIIGVAIALI 233
PRK15065 PRK15065
mannose/fructose/sorbose family PTS transporter subunit IIC;
40-238 2.97e-30

mannose/fructose/sorbose family PTS transporter subunit IIC;


Pssm-ID: 237895  Cd Length: 262  Bit Score: 113.40  E-value: 2.97e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370  40 LGLLWGDVTTGMIVGASIEMVYLGMVAAGGNIPSDKCLAALIA--IPVALQTGVNAevAVSIAVPLGVIGVLVNNLRRTG 117
Cdd:PRK15065  39 IGLVLGDLKTGIILGGTLEMIALGWMNIGAAVAPDAALASVISaiLVIAGHQGIGT--GIAIAIPLAAAGQVLTIIVRTI 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370 118 NAVLVHKADKYAEEGNTKGIWRCATLYSLIFGFVLRFPIVFVCNFFGADLVQSLLDVIPQWLMNGLTVMGGILPALGFAT 197
Cdd:PRK15065 117 TVAFQHAADKAAEEGNFRAIEWLHVSALLLQALRIAIPAALVALAVGTSAVQSMLNAIPEVLTGGLNIGGGMIVVVGYAM 196

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 489520370 198 TIFTIGKNKFLPMFIIGFFMVQYFEISITAAAIFGVCIALL 238
Cdd:PRK15065 197 VINMMATRELMPFFYLGFVLAAFTNLNLIALGVIGVVLALI 237
PRK09757 PRK09757
PTS N-acetylgalactosamine transporter subunit IIC;
3-237 1.35e-28

PTS N-acetylgalactosamine transporter subunit IIC;


Pssm-ID: 236621  Cd Length: 267  Bit Score: 109.16  E-value: 1.35e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370   3 SVLMLAIVTGLWYWfaagLAGYTLFStlksPLFIGFSLGLLWGDVTTGMIVGASIEMVYLGMVAAGGNIPSDKCLAALIA 82
Cdd:PRK09757  11 SLAALVFVLGIDFW----LEALFLFR----PIIVCTLTGAILGDIQTGLITGGLTELAFAGLTPAGGVQPPNPIMAGLMT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520370  83 IPVALQTGVNAEVAVSIAVPLGVIGVLVNNLRRTGNAVLVHKADKYAEEGNTKGIWRCATLYSLIFGFVLRFpIVFVCNF 162
Cdd:PRK09757  83 TVIAWSTGVDAKTAIGLGLPFSLLMQYVILFFYSAFSLFMTKADKCAKEADTAAFSRLNWTTMLIVASAYAV-IAFLCTY 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489520370 163 FGADLVQSLLDVIPQWLMNGLTVMGGILPALGFATTIFTIGKNKFLPMFIIGFFMVQYFEIS-ITAAAIFGVCIAL 237
Cdd:PRK09757 162 LAQGAMQALVKAMPAWLTHGFEVAGGILPAVGFGLLLRVMFKAQYIPYLIAGFLFVCYIQVSnLLPVAVLGAGFAV 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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