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Conserved domains on  [gi|489520394|ref|WP_003425190|]
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FliM/FliN family flagellar motor switch protein [Clostridioides difficile]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK08119 super family cl35643
flagellar motor switch protein; Validated
 33-123 9.50e-32

flagellar motor switch protein; Validated


The actual alignment was detected with superfamily member PRK08119:

Pssm-ID: 236154 [Multi-domain]  Cd Length: 382  Bit Score: 114.96  E-value: 9.50e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520394  33 DVSEVNRNNIQRILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKITS 112
Cdd:PRK08119 291 PLATTEPRNLDLILDVPLQVTVELGRTKKSIKDILELGTGSIIELDKLAGEPVDILVNGKLIAKGEVVVIDENFGVRITD 370

                         90
                 ....*....|.
gi 489520394 113 IVSEEDMVKSL 123
Cdd:PRK08119 371 IVSQSERIKSL 381
 
Name Accession Description Interval E-value
PRK08119 PRK08119
flagellar motor switch protein; Validated
 33-123 9.50e-32

flagellar motor switch protein; Validated


Pssm-ID: 236154 [Multi-domain]  Cd Length: 382  Bit Score: 114.96  E-value: 9.50e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520394  33 DVSEVNRNNIQRILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKITS 112
Cdd:PRK08119 291 PLATTEPRNLDLILDVPLQVTVELGRTKKSIKDILELGTGSIIELDKLAGEPVDILVNGKLIAKGEVVVIDENFGVRITD 370

                         90
                 ....*....|.
gi 489520394 113 IVSEEDMVKSL 123
Cdd:PRK08119 371 IVSQSERIKSL 381
FliN COG1886
Flagellar motor switch/type III secretory pathway protein FliN [Cell motility, Intracellular ...
 21-115 8.04e-24

Flagellar motor switch/type III secretory pathway protein FliN [Cell motility, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441490 [Multi-domain]  Cd Length: 172  Bit Score: 90.06  E-value: 8.04e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520394  21 ESEVDGDDELALDVSEVNRNNIQRILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVV 100
Cdd:COG1886   78 EEPAEFEPLEDAPEAEEEPENLDLLLDVPVEVTVELGRTRLTLRELLKLGPGSVIELDRLAGEPVDILVNGRLIARGEVV 157

                         90
                 ....*....|....*
gi 489520394 101 VVDLNFGVKITSIVS 115
Cdd:COG1886  158 VVDDRFGVRITEIVS 172
FliMN_C pfam01052
Type III flagellar switch regulator (C-ring) FliN C-term; This family includes the C-terminal ...
 50-115 1.41e-18

Type III flagellar switch regulator (C-ring) FliN C-term; This family includes the C-terminal region of flagellar motor switch proteins FliN and FliM. It is associated with family FliM, pfam02154 and family FliN_N pfam16973.


Pssm-ID: 460043 [Multi-domain]  Cd Length: 66  Bit Score: 73.53  E-value: 1.41e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489520394   50 LELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKITSIVS 115
Cdd:pfam01052   1 VELSAELGRTTLTLRELLNLKVGDVIPLDKPADEPVDVLVNGKPKFRGELGVVGGNLAVRITEIID 66
fliN TIGR02480
flagellar motor switch protein FliN; Proteins that consist largely of the domain described by ...
 41-117 1.75e-18

flagellar motor switch protein FliN; Proteins that consist largely of the domain described by this model for this protein family can be designated flagellar motor switch protein FliN. Longer proteins in which this region is a C-terminal domain typically are designated FliY. More distantly related sequences, outside the scope of this family, are associated with type III secretion and include the surface presentation of antigens protein SpaO required or invasion of host cells by Salmonella enterica. [Cellular processes, Chemotaxis and motility]


Pssm-ID: 131533 [Multi-domain]  Cd Length: 77  Bit Score: 73.40  E-value: 1.75e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489520394   41 NIQRILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKITSIVSEE 117
Cdd:TIGR02480   1 NIDLILDIPVELTVELGRTRITLGDLLKLGEGSVIELDKLAGEPLDILVNGRLIARGEVVVVEDKFGIRITEIVDSS 77
 
Name Accession Description Interval E-value
PRK08119 PRK08119
flagellar motor switch protein; Validated
 33-123 9.50e-32

flagellar motor switch protein; Validated


Pssm-ID: 236154 [Multi-domain]  Cd Length: 382  Bit Score: 114.96  E-value: 9.50e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520394  33 DVSEVNRNNIQRILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKITS 112
Cdd:PRK08119 291 PLATTEPRNLDLILDVPLQVTVELGRTKKSIKDILELGTGSIIELDKLAGEPVDILVNGKLIAKGEVVVIDENFGVRITD 370

                         90
                 ....*....|.
gi 489520394 113 IVSEEDMVKSL 123
Cdd:PRK08119 371 IVSQSERIKSL 381
FliN COG1886
Flagellar motor switch/type III secretory pathway protein FliN [Cell motility, Intracellular ...
 21-115 8.04e-24

Flagellar motor switch/type III secretory pathway protein FliN [Cell motility, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441490 [Multi-domain]  Cd Length: 172  Bit Score: 90.06  E-value: 8.04e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520394  21 ESEVDGDDELALDVSEVNRNNIQRILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVV 100
Cdd:COG1886   78 EEPAEFEPLEDAPEAEEEPENLDLLLDVPVEVTVELGRTRLTLRELLKLGPGSVIELDRLAGEPVDILVNGRLIARGEVV 157

                         90
                 ....*....|....*
gi 489520394 101 VVDLNFGVKITSIVS 115
Cdd:COG1886  158 VVDDRFGVRITEIVS 172
PRK08432 PRK08432
flagellar motor switch protein FliY; Validated
 6-123 2.74e-22

flagellar motor switch protein FliY; Validated


Pssm-ID: 236264 [Multi-domain]  Cd Length: 283  Bit Score: 88.53  E-value: 2.74e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520394   6 LISDEEAKMLLNDKVESEVDGDDELALDVSEVNR--------NNIQRILDLKLELSVVIGRTKMTLRDILNLHKGSLIEL 77
Cdd:PRK08432 156 LLMDEAFENIFEKKPKEEGEETTDSASEEIKTHKaslsneeiKNINMILDVKLPVRVRIGQKKMLLKDVLSMDIGSVVEL 235

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 489520394  78 DTLADQDVEILIDNKVLAYGKVVVVDLNFGVKITSIVSEEDMVKSL 123
Cdd:PRK08432 236 NQLANDPLEILVDDKVIAKGEVVIVDGNFGIQITEIGTKKERLEQL 281
FliMN_C pfam01052
Type III flagellar switch regulator (C-ring) FliN C-term; This family includes the C-terminal ...
 50-115 1.41e-18

Type III flagellar switch regulator (C-ring) FliN C-term; This family includes the C-terminal region of flagellar motor switch proteins FliN and FliM. It is associated with family FliM, pfam02154 and family FliN_N pfam16973.


Pssm-ID: 460043 [Multi-domain]  Cd Length: 66  Bit Score: 73.53  E-value: 1.41e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489520394   50 LELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKITSIVS 115
Cdd:pfam01052   1 VELSAELGRTTLTLRELLNLKVGDVIPLDKPADEPVDVLVNGKPKFRGELGVVGGNLAVRITEIID 66
fliN TIGR02480
flagellar motor switch protein FliN; Proteins that consist largely of the domain described by ...
 41-117 1.75e-18

flagellar motor switch protein FliN; Proteins that consist largely of the domain described by this model for this protein family can be designated flagellar motor switch protein FliN. Longer proteins in which this region is a C-terminal domain typically are designated FliY. More distantly related sequences, outside the scope of this family, are associated with type III secretion and include the surface presentation of antigens protein SpaO required or invasion of host cells by Salmonella enterica. [Cellular processes, Chemotaxis and motility]


Pssm-ID: 131533 [Multi-domain]  Cd Length: 77  Bit Score: 73.40  E-value: 1.75e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489520394   41 NIQRILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKITSIVSEE 117
Cdd:TIGR02480   1 NIDLILDIPVELTVELGRTRITLGDLLKLGEGSVIELDKLAGEPLDILVNGRLIARGEVVVVEDKFGIRITEIVDSS 77
fliN PRK07963
flagellar motor switch protein FliN; Validated
 18-123 1.73e-16

flagellar motor switch protein FliN; Validated


Pssm-ID: 181183 [Multi-domain]  Cd Length: 137  Bit Score: 70.20  E-value: 1.73e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520394  18 DKVESEVDGDDELAldvsevNRNNIQRILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYG 97
Cdd:PRK07963  36 DAVFQQLGGGDVSG------TLQDIDLIMDIPVKLTVELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQG 109

                         90       100
                 ....*....|....*....|....*.
gi 489520394  98 KVVVVDLNFGVKITSIVSEEDMVKSL 123
Cdd:PRK07963 110 EVVVVADKYGVRITDIITPSERMRRL 135
fliN PRK05698
flagellar motor switch protein FliN;
41-123 5.56e-15

flagellar motor switch protein FliN;


Pssm-ID: 168189 [Multi-domain]  Cd Length: 155  Bit Score: 66.75  E-value: 5.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520394  41 NIQRILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKITSIVSEEDMV 120
Cdd:PRK05698  72 NLDVILDIPVSISMEVGSTDINIRNLLQLNQGSVIELDRLAGEPLDVLVNGTLIAHGEVVVVNEKFGIRLTDVISPSERI 151


                 ...
gi 489520394 121 KSL 123
Cdd:PRK05698 152 KKL 154
FliM COG1868
Flagellar motor switch protein FliM [Cell motility];
33-119 7.53e-15

Flagellar motor switch protein FliM [Cell motility];


Pssm-ID: 441473 [Multi-domain]  Cd Length: 326  Bit Score: 68.65  E-value: 7.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520394  33 DVSEVNRNNIQR-ILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKIT 111
Cdd:COG1868  239 ERDERWRERLREeLEEAEVELSAELGETEITLRELLNLKVGDVIPLDKKVDDPLTVYVGGVPKFEGKPGVSNGRLAVKIT 318


                 ....*...
gi 489520394 112 SIVSEEDM 119
Cdd:COG1868  319 EIIEEEEE 326
PRK06782 PRK06782
flagellar motor switch protein; Reviewed
 36-114 3.05e-13

flagellar motor switch protein; Reviewed


Pssm-ID: 235861 [Multi-domain]  Cd Length: 528  Bit Score: 64.86  E-value: 3.05e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489520394  36 EVNRNNIQRILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKITSIV 114
Cdd:PRK06782 450 EPVYMDTSILQDVPMNVKVVFGSTKKTIQDILSLQENEVVVLDEDIDEPIRIYVNGVLVAYGELVNVDGFFGVKVTKSL 528
fliN PRK08983
flagellar motor switch protein FliN;
23-123 1.11e-12

flagellar motor switch protein FliN;


Pssm-ID: 236360 [Multi-domain]  Cd Length: 127  Bit Score: 60.15  E-value: 1.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520394  23 EVDGDDELALDVSEVNRNNIQRILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVV 102
Cdd:PRK08983  26 ELDELVDDSAPITEDEARKLDTILDIPVTISMEVGRSFISIRNLLQLNQGSVVELDRVAGEPLDVMVNGTLIAHGEVVVV 105

                         90       100
                 ....*....|....*....|.
gi 489520394 103 DLNFGVKITSIVSEEDMVKSL 123
Cdd:PRK08983 106 NDKFGIRLTDVISQTERIKKL 126
PRK08916 PRK08916
flagellar motor switch protein FliN;
40-118 1.13e-11

flagellar motor switch protein FliN;


Pssm-ID: 236350 [Multi-domain]  Cd Length: 116  Bit Score: 57.07  E-value: 1.13e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489520394  40 NNIQRILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKITSIVSEED 118
Cdd:PRK08916  37 ADLEAVFDVPVQVSAVLGRSKMDVGQLLKLGPGSVLELDRKVGEAIDIYVNNRLVARGEVVLVEDRLGVTMTEIIKAER 115
PRK08433 PRK08433
flagellar motor switch protein FliN;
45-113 2.87e-09

flagellar motor switch protein FliN;


Pssm-ID: 181423 [Multi-domain]  Cd Length: 111  Bit Score: 50.90  E-value: 2.87e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489520394  45 ILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKITSI 113
Cdd:PRK08433  29 LLDIEVDFSAELGTTQISLLEILKFEKGSVIDLEKPAGESVELYINGRIIGKGEVMVYEKNLAIRINEI 97
fliM PRK06666
flagellar motor switch protein FliM; Validated
 43-122 1.69e-08

flagellar motor switch protein FliM; Validated


Pssm-ID: 235849 [Multi-domain]  Cd Length: 337  Bit Score: 50.99  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520394  43 QRILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKITSIVSEEDMVKS 122
Cdd:PRK06666 253 QQVQQAEVELVAELGEIKLTLSEILNLKVGDVIPLEKPADDPLIVYVDGKPKFLCQYGKSNGRKALQIEELIERELNEKN 332
SpaO_YscQ TIGR02551
type III secretion system apparatus protein YscQ/HrcQ; Genes in this family are found in type ...
 47-113 2.29e-08

type III secretion system apparatus protein YscQ/HrcQ; Genes in this family are found in type III secretion operons. The gene (YscQ) in Yersinia is essential for YOPs secretion, while SpaO in Shigella is involved in the Surface Presentation of Antigens apparatus found on the virulence plasmid, and HrcQ is involved in the Harpin secretory system in organisms like Pseudomonas syringae. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274196 [Multi-domain]  Cd Length: 298  Bit Score: 50.49  E-value: 2.29e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489520394   47 DLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKITSI 113
Cdd:TIGR02551 232 QLPVTLEFELGRLTLTLAELAALQPGSVLELNVPVDGPVRLRANGRLLGRGELVDVGGRLGVRILEL 298
PRK08158 PRK08158
YscQ/HrcQ family type III secretion apparatus protein;
35-121 2.99e-08

YscQ/HrcQ family type III secretion apparatus protein;


Pssm-ID: 181259 [Multi-domain]  Cd Length: 303  Bit Score: 50.25  E-value: 2.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520394  35 SEVNRNNIQRIL----DLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKI 110
Cdd:PRK08158 213 EENNTTETAETLpglnQLPVKLEFVLYRKNVTLAELEELCQQQLLSLPTNAELNVEIRANGALLGNGELVQMDDTLGVEI 292

                         90
                 ....*....|.
gi 489520394 111 TSIVSEEDMVK 121
Cdd:PRK08158 293 HEWLSGSGNVE 303
PRK06033 PRK06033
flagellar motor switch protein FliN;
50-111 1.84e-07

flagellar motor switch protein FliN;


Pssm-ID: 180359 [Multi-domain]  Cd Length: 83  Bit Score: 45.52  E-value: 1.84e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489520394  50 LELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKIT 111
Cdd:PRK06033   9 VELMVVLGRSSMPIHQVLRMGRGAVIPLDATEADEVWILANNHPIARGEVLIDRNRIAVEVT 70
PRK06788 PRK06788
flagellar motor switch protein; Validated
 28-113 1.04e-06

flagellar motor switch protein; Validated


Pssm-ID: 180693 [Multi-domain]  Cd Length: 119  Bit Score: 44.10  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489520394  28 DELALDVSEVNRNNIQRILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFG 107
Cdd:PRK06788  14 EDFAGKRNEASKAHIDTVSDISIELGVKLGKASITLGDVKQLKVGDVLEVEKNLGHKVDVYLSNMKVGIGEAIVMDEKFG 93


                 ....*.
gi 489520394 108 VKITSI 113
Cdd:PRK06788  94 IIISEI 99
PRK06933 PRK06933
YscQ/HrcQ family type III secretion apparatus protein;
47-111 1.15e-06

YscQ/HrcQ family type III secretion apparatus protein;


Pssm-ID: 235891 [Multi-domain]  Cd Length: 308  Bit Score: 45.88  E-value: 1.15e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489520394  47 DLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKIT 111
Cdd:PRK06933 236 QLPVQVSFEVGRQTLDLHTLTSLQPGSLIDLTTPVDGEVRLLANGRLLGHGRLVEIQGRLGVRVE 300
PRK06789 PRK06789
flagellar motor switch protein; Validated
 47-113 2.03e-04

flagellar motor switch protein; Validated


Pssm-ID: 180694 [Multi-domain]  Cd Length: 74  Bit Score: 37.16  E-value: 2.03e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489520394  47 DLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVVDLNFGVKITSI 113
Cdd:PRK06789   6 DIPLTIYFEIGNTKKKIEDLLHITKGTLYRLENSTKNTVRLMLENEEIGTGKILTKNGKMYVEIVEL 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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