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Conserved domains on  [gi|489522510|ref|WP_003427297|]
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PTS glucose transporter subunit IIA [Clostridioides difficile]

Protein Classification

PTS glucose transporter subunit IIA( domain architecture ID 10005511)

PTS glucose transporter subunit IIA is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system that catalyzes the phosphorylation of incoming glucose substrates concomitantly with their translocation across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NagE COG2190
Phosphotransferase system IIA component [Carbohydrate transport and metabolism];
16-163 8.47e-61

Phosphotransferase system IIA component [Carbohydrate transport and metabolism];


:

Pssm-ID: 441793 [Multi-domain]  Cd Length: 154  Bit Score: 184.94  E-value: 8.47e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489522510  16 YSPFKGNLVNLEDVPDAVFAQKMMGDGVAIIPSEGKLYSPVDGEIVNVFDTKHAIMIKSNDNTNILIHVGLETMSLEGKP 95
Cdd:COG2190    9 YAPVSGEVVPLSEVPDPVFASKMMGDGVAIEPTGGKVVAPVDGTVTSVFPTKHAIGLTSDDGLEVLIHIGIDTVKLNGEG 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489522510  96 FDVKVKAGDKVKAKDLIMEVDLDFIMSNDLNIITPVVI--MDDADSVKRTvkdriEPGNVDINSIIMEVE 163
Cdd:COG2190   89 FTVLVKEGDKVKAGDPLIEFDLDAIKAAGYSLITPVVVtnSDEYKSVELT-----KSGQVKAGDPLLTVK 153
 
Name Accession Description Interval E-value
NagE COG2190
Phosphotransferase system IIA component [Carbohydrate transport and metabolism];
16-163 8.47e-61

Phosphotransferase system IIA component [Carbohydrate transport and metabolism];


Pssm-ID: 441793 [Multi-domain]  Cd Length: 154  Bit Score: 184.94  E-value: 8.47e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489522510  16 YSPFKGNLVNLEDVPDAVFAQKMMGDGVAIIPSEGKLYSPVDGEIVNVFDTKHAIMIKSNDNTNILIHVGLETMSLEGKP 95
Cdd:COG2190    9 YAPVSGEVVPLSEVPDPVFASKMMGDGVAIEPTGGKVVAPVDGTVTSVFPTKHAIGLTSDDGLEVLIHIGIDTVKLNGEG 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489522510  96 FDVKVKAGDKVKAKDLIMEVDLDFIMSNDLNIITPVVI--MDDADSVKRTvkdriEPGNVDINSIIMEVE 163
Cdd:COG2190   89 FTVLVKEGDKVKAGDPLIEFDLDAIKAAGYSLITPVVVtnSDEYKSVELT-----KSGQVKAGDPLLTVK 153
PTS_EIIA_1 pfam00358
phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;
16-133 3.78e-57

phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;


Pssm-ID: 459779 [Multi-domain]  Cd Length: 121  Bit Score: 174.49  E-value: 3.78e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489522510   16 YSPFKGNLVNLEDVPDAVFAQKMMGDGVAIIPSEGKLYSPVDGEIVNVFDTKHAIMIKSNDNTNILIHVGLETMSLEGKP 95
Cdd:pfam00358   4 YSPVSGEVIPLSEVPDPVFSQKMMGDGVAIEPSEGKVYAPVDGTVTTVFPTKHAIGITTDDGVEVLIHIGIDTVKLKGEG 83

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 489522510   96 FDVKVKAGDKVKAKDLIMEVDLDFIMSNDLNIITPVVI 133
Cdd:pfam00358  84 FESLVKEGDKVKAGDLLLEFDLEAIKAAGYSTTTPVVV 121
PTBA TIGR00830
PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside ...
 16-133 1.01e-46

PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside (Glc) SuperFamily. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). The IIA, IIB and IIC domains of all of the permeases listed below are demonstrably homologous. These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. The three-dimensional structures of the IIA and IIB domains of the E. coli glucose permease have been elucidated. IIAglchas a complex b-sandwich structure while IIBglc is a split ab-sandwich with a topology unrelated to the split ab-sandwich structure of HPr. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273289 [Multi-domain]  Cd Length: 121  Bit Score: 148.16  E-value: 1.01e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489522510   16 YSPFKGNLVNLEDVPDAVFAQKMMGDGVAIIPSEGKLYSPVDGEIVNVFDTKHAIMIKSNDNTNILIHVGLETMSLEGKP 95
Cdd:TIGR00830   2 VSPISGEIVPLDQVPDEVFASKIVGDGFAILPTDGKVVAPVDGKIGKIFPTKHAFGIESDNGVEILIHIGIDTVKLNGEG 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 489522510   96 FDVKVKAGDKVKAKDLIMEVDLDFIMSNDLNIITPVVI 133
Cdd:TIGR00830  82 FTSHVEEGDRVKKGDPLLEFDLKAIKKKGYSITTPVVV 119
PTS_IIA_glc cd00210
PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 17-138 1.90e-46

PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238128 [Multi-domain]  Cd Length: 124  Bit Score: 147.43  E-value: 1.90e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489522510  17 SPFKGNLVNLEDVPDAVFAQKMMGDGVAIIPSEGKLYSPVDGEIVNVFDTKHAIMIKSNDNTNILIHVGLETMSLEGKPF 96
Cdd:cd00210    3 SPITGEIVPLDQVPDEVFASKMMGDGFAIKPSDGKVVAPVDGTIVQIFPTKHAIGIESDSGVEILIHIGIDTVKLNGEGF 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 489522510  97 DVKVKAGDKVKAKDLIMEVDLDFIMSNDLNIITPVVIMDDAD 138
Cdd:cd00210   83 TSHVEEGQRVKQGDKLLEFDLPAIKAAGLDDTTPVIVTNSDE 124
PRK09824 PRK09824
PTS system beta-glucoside-specific transporter subunits IIABC; Provisional
 17-138 6.00e-38

PTS system beta-glucoside-specific transporter subunits IIABC; Provisional


Pssm-ID: 236627 [Multi-domain]  Cd Length: 627  Bit Score: 136.38  E-value: 6.00e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489522510  17 SPFKGNLVNLEDVPDAVFAQKMMGDGVAIIPSEGKLYSPVDGEIVNVFDTKHAIMIKSNDNTNILIHVGLETMSLEGKPF 96
Cdd:PRK09824 483 SPMTGEVVPLEQVADTTFASGLLGKGIAILPSVGEVRSPVAGRVASLFATLHAIGLESDDGVEVLIHVGIDTVKLDGKFF 562

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 489522510  97 DVKVKAGDKVKAKDLIMEVDLDFIMSNDLNIITPVVIMDDAD 138
Cdd:PRK09824 563 TAHVNVGDKVNTGDLLIEFDIPAIREAGYDLTTPVLISNSDD 604
 
Name Accession Description Interval E-value
NagE COG2190
Phosphotransferase system IIA component [Carbohydrate transport and metabolism];
16-163 8.47e-61

Phosphotransferase system IIA component [Carbohydrate transport and metabolism];


Pssm-ID: 441793 [Multi-domain]  Cd Length: 154  Bit Score: 184.94  E-value: 8.47e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489522510  16 YSPFKGNLVNLEDVPDAVFAQKMMGDGVAIIPSEGKLYSPVDGEIVNVFDTKHAIMIKSNDNTNILIHVGLETMSLEGKP 95
Cdd:COG2190    9 YAPVSGEVVPLSEVPDPVFASKMMGDGVAIEPTGGKVVAPVDGTVTSVFPTKHAIGLTSDDGLEVLIHIGIDTVKLNGEG 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489522510  96 FDVKVKAGDKVKAKDLIMEVDLDFIMSNDLNIITPVVI--MDDADSVKRTvkdriEPGNVDINSIIMEVE 163
Cdd:COG2190   89 FTVLVKEGDKVKAGDPLIEFDLDAIKAAGYSLITPVVVtnSDEYKSVELT-----KSGQVKAGDPLLTVK 153
PTS_EIIA_1 pfam00358
phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;
16-133 3.78e-57

phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;


Pssm-ID: 459779 [Multi-domain]  Cd Length: 121  Bit Score: 174.49  E-value: 3.78e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489522510   16 YSPFKGNLVNLEDVPDAVFAQKMMGDGVAIIPSEGKLYSPVDGEIVNVFDTKHAIMIKSNDNTNILIHVGLETMSLEGKP 95
Cdd:pfam00358   4 YSPVSGEVIPLSEVPDPVFSQKMMGDGVAIEPSEGKVYAPVDGTVTTVFPTKHAIGITTDDGVEVLIHIGIDTVKLKGEG 83

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 489522510   96 FDVKVKAGDKVKAKDLIMEVDLDFIMSNDLNIITPVVI 133
Cdd:pfam00358  84 FESLVKEGDKVKAGDLLLEFDLEAIKAAGYSTTTPVVV 121
PTBA TIGR00830
PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside ...
 16-133 1.01e-46

PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside (Glc) SuperFamily. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). The IIA, IIB and IIC domains of all of the permeases listed below are demonstrably homologous. These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. The three-dimensional structures of the IIA and IIB domains of the E. coli glucose permease have been elucidated. IIAglchas a complex b-sandwich structure while IIBglc is a split ab-sandwich with a topology unrelated to the split ab-sandwich structure of HPr. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273289 [Multi-domain]  Cd Length: 121  Bit Score: 148.16  E-value: 1.01e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489522510   16 YSPFKGNLVNLEDVPDAVFAQKMMGDGVAIIPSEGKLYSPVDGEIVNVFDTKHAIMIKSNDNTNILIHVGLETMSLEGKP 95
Cdd:TIGR00830   2 VSPISGEIVPLDQVPDEVFASKIVGDGFAILPTDGKVVAPVDGKIGKIFPTKHAFGIESDNGVEILIHIGIDTVKLNGEG 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 489522510   96 FDVKVKAGDKVKAKDLIMEVDLDFIMSNDLNIITPVVI 133
Cdd:TIGR00830  82 FTSHVEEGDRVKKGDPLLEFDLKAIKKKGYSITTPVVV 119
PTS_IIA_glc cd00210
PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 17-138 1.90e-46

PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238128 [Multi-domain]  Cd Length: 124  Bit Score: 147.43  E-value: 1.90e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489522510  17 SPFKGNLVNLEDVPDAVFAQKMMGDGVAIIPSEGKLYSPVDGEIVNVFDTKHAIMIKSNDNTNILIHVGLETMSLEGKPF 96
Cdd:cd00210    3 SPITGEIVPLDQVPDEVFASKMMGDGFAIKPSDGKVVAPVDGTIVQIFPTKHAIGIESDSGVEILIHIGIDTVKLNGEGF 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 489522510  97 DVKVKAGDKVKAKDLIMEVDLDFIMSNDLNIITPVVIMDDAD 138
Cdd:cd00210   83 TSHVEEGQRVKQGDKLLEFDLPAIKAAGLDDTTPVIVTNSDE 124
PTS-II-ABC-beta TIGR01995
PTS system, beta-glucoside-specific IIABC component; This model represents a family of PTS ...
 16-139 1.02e-40

PTS system, beta-glucoside-specific IIABC component; This model represents a family of PTS enzyme II proteins in which all three domains are found in the same polypeptide chain and which appear to have a broad specificity for beta-glucosides including salicin (beta-D-glucose-1-salicylate) and arbutin (Hydroquinone-O-beta-D-glucopyranoside). These are distinct from the closely related sucrose-specific and trehalose-specific PTS transporters.


Pssm-ID: 273919 [Multi-domain]  Cd Length: 610  Bit Score: 144.03  E-value: 1.02e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489522510   16 YSPFKGNLVNLEDVPDAVFAQKMMGDGVAIIPSEGKLYSPVDGEIVNVFDTKHAIMIKSNDNTNILIHVGLETMSLEGKP 95
Cdd:TIGR01995 466 YAPVAGEMLPLNEVPDEVFSSGAMGKGIAILPTEGEVVAPVDGTVTAVFPTKHAIGIRSDNGIEILIHVGIDTVELNGEG 545

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 489522510   96 FDVKVKAGDKVKAKDLIMEVDLDFIMSNDLNIITPVVIMDDADS 139
Cdd:TIGR01995 546 FEILVKVGDHVKAGQLLLTFDLDKIKEAGYDPTTPVVVTNTKDF 589
PRK09824 PRK09824
PTS system beta-glucoside-specific transporter subunits IIABC; Provisional
 17-138 6.00e-38

PTS system beta-glucoside-specific transporter subunits IIABC; Provisional


Pssm-ID: 236627 [Multi-domain]  Cd Length: 627  Bit Score: 136.38  E-value: 6.00e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489522510  17 SPFKGNLVNLEDVPDAVFAQKMMGDGVAIIPSEGKLYSPVDGEIVNVFDTKHAIMIKSNDNTNILIHVGLETMSLEGKPF 96
Cdd:PRK09824 483 SPMTGEVVPLEQVADTTFASGLLGKGIAILPSVGEVRSPVAGRVASLFATLHAIGLESDDGVEVLIHVGIDTVKLDGKFF 562

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 489522510  97 DVKVKAGDKVKAKDLIMEVDLDFIMSNDLNIITPVVIMDDAD 138
Cdd:PRK09824 563 TAHVNVGDKVNTGDLLIEFDIPAIREAGYDLTTPVLISNSDD 604
PRK09439 PRK09439
PTS system glucose-specific transporter subunit; Provisional
 16-136 2.17e-31

PTS system glucose-specific transporter subunit; Provisional


Pssm-ID: 181859 [Multi-domain]  Cd Length: 169  Bit Score: 110.83  E-value: 2.17e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489522510  16 YSPFKGNLVNLEDVPDAVFAQKMMGDGVAIIPSEGKLYSPVDGEIVNVFDTKHAIMIKSNDNTNILIHVGLETMSLEGKP 95
Cdd:PRK09439  24 IAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELKGEG 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 489522510  96 FDVKVKAGDKVKAKDLIMEVDLDFIMSNDLNIITPVVI--MDD 136
Cdd:PRK09439 104 FKRIAEEGQRVKVGDPIIEFDLPLLEEKAKSTLTPVVIsnMDE 146
PRK10255 PRK10255
PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional
 17-138 1.38e-27

PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional


Pssm-ID: 182338 [Multi-domain]  Cd Length: 648  Bit Score: 107.26  E-value: 1.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489522510  17 SPFKGNLVNLEDVPDAVFAQKMMGDGVAIIPSEGKLYSPVDGEIVNVFDTKHAIMIKSNDNTNILIHVGLETMSLEGKPF 96
Cdd:PRK10255 503 SPITGDVVALDQVPDEAFASKAVGDGVAVKPTDKIVVSPAAGTIVKIFNTNHAFCLETEKGAEIVVHMGIDTVALEGKGF 582

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 489522510  97 DVKVKAGDKVKAKDLIMEVDLDFIMSNDLNIITPVVIMDDAD 138
Cdd:PRK10255 583 KRLVEEGAQVSAGQPILEMDLDYLNANARSMISPVVCSNIDD 624
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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