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Conserved domains on  [gi|489522688|ref|WP_003427474|]
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ferrous iron transport protein A [Clostridioides difficile]

Protein Classification

ferrous iron transport protein A( domain architecture ID 10004922)

ferrous iron transport protein A (FeoA) is part of the Feo (ferrous iron-transport) system that functions in the uptake of ferrous iron

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
3-73 6.32e-25

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


:

Pssm-ID: 441522  Cd Length: 73  Bit Score: 87.50  E-value: 6.32e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489522688  3 RLKDIKCGETVKVKKLEGEGATRRRIMDMGITRGVNIFIRKVAPLGDPIEVTVRDYELSIRKSDAEKIIVE 73
Cdd:COG1918   2 TLSELKPGEKARIVRISGDGELRRRLLELGLVPGTEVEVVRKAPLGGPLVVRVGGTRIALRREEAAKILVE 72
 
Name Accession Description Interval E-value
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
3-73 6.32e-25

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 87.50  E-value: 6.32e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489522688  3 RLKDIKCGETVKVKKLEGEGATRRRIMDMGITRGVNIFIRKVAPLGDPIEVTVRDYELSIRKSDAEKIIVE 73
Cdd:COG1918   2 TLSELKPGEKARIVRISGDGELRRRLLELGLVPGTEVEVVRKAPLGGPLVVRVGGTRIALRREEAAKILVE 72
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 3-73 6.55e-17

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 67.23  E-value: 6.55e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489522688   3 RLKDIKCGETVKVKKLEGE-GATRRRIMDMGITRGVNIFIRKVAPLGDPIEVTVRDYELSIRKSDAEKIIVE 73
Cdd:pfam04023  2 PLSELKEGETARIVRIRDGdPELLRRLLELGLVPGAEVTVVRKAPFGGPIIVRVGGTRIALRREEASKIFVE 73
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 3-73 1.19e-12

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 56.43  E-value: 1.19e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489522688    3 RLKDIKCGETVKVKKLEGEG-ATRRRIMDMGITRGVNIFIRKVAPLGdPIEVTVRDyELSIRKSDAEKIIVE 73
Cdd:smart00899  2 PLSELKPGEKARIVRIRDEDpELLRRLLELGLVPGTEVTVLRKAPFG-PLVVRVGG-ELALRREEAEKIFVE 71
feoA PRK09555
ferrous iron transporter A;
23-73 1.14e-07

ferrous iron transporter A;


Pssm-ID: 181949  Cd Length: 74  Bit Score: 43.97  E-value: 1.14e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 489522688 23 ATRRRIMDMGITRGVNIFIRKVAPLGDPIEVTVRDYELSIRKSDAEKIIVE 73
Cdd:PRK09555 21 AYRQKLLSLGMLPGSSFNVVRVAPLGDPIHIETRRVSLVLRKKDLALLELE 71
 
Name Accession Description Interval E-value
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
3-73 6.32e-25

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 87.50  E-value: 6.32e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489522688  3 RLKDIKCGETVKVKKLEGEGATRRRIMDMGITRGVNIFIRKVAPLGDPIEVTVRDYELSIRKSDAEKIIVE 73
Cdd:COG1918   2 TLSELKPGEKARIVRISGDGELRRRLLELGLVPGTEVEVVRKAPLGGPLVVRVGGTRIALRREEAAKILVE 72
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 3-73 6.55e-17

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 67.23  E-value: 6.55e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489522688   3 RLKDIKCGETVKVKKLEGE-GATRRRIMDMGITRGVNIFIRKVAPLGDPIEVTVRDYELSIRKSDAEKIIVE 73
Cdd:pfam04023  2 PLSELKEGETARIVRIRDGdPELLRRLLELGLVPGAEVTVVRKAPFGGPIIVRVGGTRIALRREEASKIFVE 73
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 3-73 1.19e-12

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 56.43  E-value: 1.19e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489522688    3 RLKDIKCGETVKVKKLEGEG-ATRRRIMDMGITRGVNIFIRKVAPLGdPIEVTVRDyELSIRKSDAEKIIVE 73
Cdd:smart00899  2 PLSELKPGEKARIVRIRDEDpELLRRLLELGLVPGTEVTVLRKAPFG-PLVVRVGG-ELALRREEAEKIFVE 71
feoA PRK09555
ferrous iron transporter A;
23-73 1.14e-07

ferrous iron transporter A;


Pssm-ID: 181949  Cd Length: 74  Bit Score: 43.97  E-value: 1.14e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 489522688 23 ATRRRIMDMGITRGVNIFIRKVAPLGDPIEVTVRDYELSIRKSDAEKIIVE 73
Cdd:PRK09555 21 AYRQKLLSLGMLPGSSFNVVRVAPLGDPIHIETRRVSLVLRKKDLALLELE 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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