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Conserved domains on  [gi|489525382|ref|WP_003430147|]
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TetR/AcrR family transcriptional regulator [Clostridioides difficile]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
18-115 4.71e-12

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 61.45  E-value: 4.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489525382  18 IMDASIEIINQHGYENLSIRKIATKIEYSPTTIYLYYKDKAEIISDMTNKLYNTVESNAIDIMNNCSTLpidKQIIEIMT 97
Cdd:COG1309   11 ILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPR---ERLRALLR 87

                         90
                 ....*....|....*...
gi 489525382  98 SFIKTLSSEPEMSKAIMH 115
Cdd:COG1309   88 AYLEFLAENPALARLLLA 105
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
18-115 4.71e-12

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 61.45  E-value: 4.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489525382  18 IMDASIEIINQHGYENLSIRKIATKIEYSPTTIYLYYKDKAEIISDMTNKLYNTVESNAIDIMNNCSTLpidKQIIEIMT 97
Cdd:COG1309   11 ILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPR---ERLRALLR 87

                         90
                 ....*....|....*...
gi 489525382  98 SFIKTLSSEPEMSKAIMH 115
Cdd:COG1309   88 AYLEFLAENPALARLLLA 105
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
18-61 4.28e-09

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 50.48  E-value: 4.28e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 489525382   18 IMDASIEIINQHGYENLSIRKIATKIEYSPTTIYLYYKDKAEII 61
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELL 44
PRK13756 PRK13756
TetR family transcriptional regulator;
18-57 9.89e-03

TetR family transcriptional regulator;


Pssm-ID: 172294 [Multi-domain]  Cd Length: 205  Bit Score: 35.64  E-value: 9.89e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 489525382  18 IMDASIEIINQHGYENLSIRKIATKIEYSPTTIYLYYKDK 57
Cdd:PRK13756   9 VIDSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNK 48
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
18-115 4.71e-12

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 61.45  E-value: 4.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489525382  18 IMDASIEIINQHGYENLSIRKIATKIEYSPTTIYLYYKDKAEIISDMTNKLYNTVESNAIDIMNNCSTLpidKQIIEIMT 97
Cdd:COG1309   11 ILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPR---ERLRALLR 87

                         90
                 ....*....|....*...
gi 489525382  98 SFIKTLSSEPEMSKAIMH 115
Cdd:COG1309   88 AYLEFLAENPALARLLLA 105
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
18-61 4.28e-09

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 50.48  E-value: 4.28e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 489525382   18 IMDASIEIINQHGYENLSIRKIATKIEYSPTTIYLYYKDKAEII 61
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELL 44
PRK13756 PRK13756
TetR family transcriptional regulator;
18-57 9.89e-03

TetR family transcriptional regulator;


Pssm-ID: 172294 [Multi-domain]  Cd Length: 205  Bit Score: 35.64  E-value: 9.89e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 489525382  18 IMDASIEIINQHGYENLSIRKIATKIEYSPTTIYLYYKDK 57
Cdd:PRK13756   9 VIDSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNK 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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