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Conserved domains on  [gi|489525974|ref|WP_003430730|]
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5-bromo-4-chloroindolyl phosphate hydrolysis family protein [Clostridioides difficile]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
XpaC super family cl44159
5-bromo-4-chloroindolyl phosphatase XpaC [Secondary metabolites biosynthesis, transport and ...
 162-302 1.88e-22

5-bromo-4-chloroindolyl phosphatase XpaC [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


The actual alignment was detected with superfamily member COG4915:

Pssm-ID: 443943  Cd Length: 208  Bit Score: 92.73  E-value: 1.88e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489525974 162 YESNEVDTIINKGMNYLTQIKEANKNIKSESMGDKIVQVEDVTSKIFDVVKHDPSKLTQIQKFMDYYLPTTLKLLNSYHT 241
Cdd:COG4915   68 SEYKYIRKQLEEARKKIRRLEKALKRIRSLELFKQLNDIQKIARRIFRIVEKDPRRFYQAERFFYYYLDSAVELTEKYAE 147

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489525974 242 LEEQGIDRENITTTMESIENTMNTIVVAFENQLDYLFEDEAIDISTDITVLENMLVQEGLT 302
Cdd:COG4915  148 LSNQPIKTKEIRQALEETRETLDELEEAFEEDLKKLLEDDLLDLDVEIEVLKQSLKREGLT 208
Phage_holin_3_6 pfam07332
Putative Actinobacterial Holin-X, holin superfamily III; Phage_holin_3_6 is a family of small ...
 19-80 2.88e-03

Putative Actinobacterial Holin-X, holin superfamily III; Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.


:

Pssm-ID: 462148  Cd Length: 113  Bit Score: 36.74  E-value: 2.88e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489525974   19 SKFLKIIGWGLVSL-FTLSALVLSTISIIIGWAVILP-----IQVCAVFLLIGGVCIFKGKRLADQIS 80
Cdd:pfam07332  28 KRAGKGAGLLGAAGvLALFGLLFLLAALALALALVLPlwlaaLIVAAVLLVVAGVLALVGRKRLKRAS 95
 
Name Accession Description Interval E-value
XpaC COG4915
5-bromo-4-chloroindolyl phosphatase XpaC [Secondary metabolites biosynthesis, transport and ...
 162-302 1.88e-22

5-bromo-4-chloroindolyl phosphatase XpaC [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 443943  Cd Length: 208  Bit Score: 92.73  E-value: 1.88e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489525974 162 YESNEVDTIINKGMNYLTQIKEANKNIKSESMGDKIVQVEDVTSKIFDVVKHDPSKLTQIQKFMDYYLPTTLKLLNSYHT 241
Cdd:COG4915   68 SEYKYIRKQLEEARKKIRRLEKALKRIRSLELFKQLNDIQKIARRIFRIVEKDPRRFYQAERFFYYYLDSAVELTEKYAE 147

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489525974 242 LEEQGIDRENITTTMESIENTMNTIVVAFENQLDYLFEDEAIDISTDITVLENMLVQEGLT 302
Cdd:COG4915  148 LSNQPIKTKEIRQALEETRETLDELEEAFEEDLKKLLEDDLLDLDVEIEVLKQSLKREGLT 208
Halogen_Hydrol pfam10112
5-bromo-4-chloroindolyl phosphate hydrolysis protein; Members of this family of prokaryotic ...
 143-292 7.10e-10

5-bromo-4-chloroindolyl phosphate hydrolysis protein; Members of this family of prokaryotic proteins mediate the hydrolysis of 5-bromo-4-chloroindolyl phosphate bonds.


Pssm-ID: 431063 [Multi-domain]  Cd Length: 191  Bit Score: 57.28  E-value: 7.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489525974  143 FIPPRYEDVAYEVKEEEKTYESNEVDTIINKGMNYLTQIKEANKNIKSESMGDKIVQVEDVTSKIFDVVKHDPSKLTQIQ 222
Cdd:pfam10112  42 LASRWKKRRAHLKPSGLSRKEYKYIRENLKEAKQKIKRLEKALFRIRSLQAFKQVNRILRIARRIFKIVEKEPKRFYLAE 121

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489525974  223 KFMDYYLPTTLKLLNSYHTLEEQGIDRENITTTMESIENTMNTIVVAFENQLDYLFEDEAIDISTDITVL 292
Cdd:pfam10112 122 RFLYSHLDSAVELTEKYAELSKQPVKSKEIYQALEETRQTLDELSRAFEKDLQKLLSDDLDDLDVEIDVA 191
Phage_holin_3_6 pfam07332
Putative Actinobacterial Holin-X, holin superfamily III; Phage_holin_3_6 is a family of small ...
 19-80 2.88e-03

Putative Actinobacterial Holin-X, holin superfamily III; Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.


Pssm-ID: 462148  Cd Length: 113  Bit Score: 36.74  E-value: 2.88e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489525974   19 SKFLKIIGWGLVSL-FTLSALVLSTISIIIGWAVILP-----IQVCAVFLLIGGVCIFKGKRLADQIS 80
Cdd:pfam07332  28 KRAGKGAGLLGAAGvLALFGLLFLLAALALALALVLPlwlaaLIVAAVLLVVAGVLALVGRKRLKRAS 95
 
Name Accession Description Interval E-value
XpaC COG4915
5-bromo-4-chloroindolyl phosphatase XpaC [Secondary metabolites biosynthesis, transport and ...
 162-302 1.88e-22

5-bromo-4-chloroindolyl phosphatase XpaC [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 443943  Cd Length: 208  Bit Score: 92.73  E-value: 1.88e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489525974 162 YESNEVDTIINKGMNYLTQIKEANKNIKSESMGDKIVQVEDVTSKIFDVVKHDPSKLTQIQKFMDYYLPTTLKLLNSYHT 241
Cdd:COG4915   68 SEYKYIRKQLEEARKKIRRLEKALKRIRSLELFKQLNDIQKIARRIFRIVEKDPRRFYQAERFFYYYLDSAVELTEKYAE 147

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489525974 242 LEEQGIDRENITTTMESIENTMNTIVVAFENQLDYLFEDEAIDISTDITVLENMLVQEGLT 302
Cdd:COG4915  148 LSNQPIKTKEIRQALEETRETLDELEEAFEEDLKKLLEDDLLDLDVEIEVLKQSLKREGLT 208
Halogen_Hydrol pfam10112
5-bromo-4-chloroindolyl phosphate hydrolysis protein; Members of this family of prokaryotic ...
 143-292 7.10e-10

5-bromo-4-chloroindolyl phosphate hydrolysis protein; Members of this family of prokaryotic proteins mediate the hydrolysis of 5-bromo-4-chloroindolyl phosphate bonds.


Pssm-ID: 431063 [Multi-domain]  Cd Length: 191  Bit Score: 57.28  E-value: 7.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489525974  143 FIPPRYEDVAYEVKEEEKTYESNEVDTIINKGMNYLTQIKEANKNIKSESMGDKIVQVEDVTSKIFDVVKHDPSKLTQIQ 222
Cdd:pfam10112  42 LASRWKKRRAHLKPSGLSRKEYKYIRENLKEAKQKIKRLEKALFRIRSLQAFKQVNRILRIARRIFKIVEKEPKRFYLAE 121

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489525974  223 KFMDYYLPTTLKLLNSYHTLEEQGIDRENITTTMESIENTMNTIVVAFENQLDYLFEDEAIDISTDITVL 292
Cdd:pfam10112 122 RFLYSHLDSAVELTEKYAELSKQPVKSKEIYQALEETRQTLDELSRAFEKDLQKLLSDDLDDLDVEIDVA 191
Phage_holin_3_6 pfam07332
Putative Actinobacterial Holin-X, holin superfamily III; Phage_holin_3_6 is a family of small ...
 19-80 2.88e-03

Putative Actinobacterial Holin-X, holin superfamily III; Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.


Pssm-ID: 462148  Cd Length: 113  Bit Score: 36.74  E-value: 2.88e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489525974   19 SKFLKIIGWGLVSL-FTLSALVLSTISIIIGWAVILP-----IQVCAVFLLIGGVCIFKGKRLADQIS 80
Cdd:pfam07332  28 KRAGKGAGLLGAAGvLALFGLLFLLAALALALALVLPlwlaaLIVAAVLLVVAGVLALVGRKRLKRAS 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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