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Conserved domains on  [gi|489527705|ref|WP_003432452|]
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stage II sporulation protein D [Clostridioides difficile]

Protein Classification

SpoIID/LytB domain-containing protein( domain architecture ID 11457258)

SpoIID/LytB domain-containing protein similar to Bacillus subtilis stage II sporulation protein D (spoIID) that may act at the level of sigma-G activity or its stability

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SpoIID COG2385
Peptidoglycan hydrolase (amidase) enhancer domain SpoIID [Cell wall/membrane/envelope ...
64-354 1.42e-109

Peptidoglycan hydrolase (amidase) enhancer domain SpoIID [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 441951  Cd Length: 357  Bit Score: 323.93  E-value: 1.42e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705  64 NYETVNKKA--PIINVY--NHITGKTEKMDMENYLCGVLAGEMSSEFDIEALKAQSVAARTYVVYKQEHGKsskHKNAVV 139
Cdd:COG2385   79 GLISVNGRDyrGSLEVYpnGGGLTLVNEVPLEEYLKGVVAAEMPASWPLEALKAQAVAARTYALRNLLRHA---HDGYDL 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705 140 CTDyKHCQEYKSYDTLkklngeewiknkYSKIQEAVRGTKGQIITYNDKAILPLYFSTSSGKTENSEEVFSAKYPYLKSV 219
Cdd:COG2385  156 CDT-THCQVYKGLEEE------------TPKIRKAVEATRGEVLTYNGEPIDAVFHSTSGGYTENAEDVWGSDLPYLRSV 222
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705 220 ESPYDKYSPKFASTLKISNTDFVKSLRRAYStiviDVNNLsKQVSITKRSDAGTVEKIKL----GNKELTGKDIRTVF-K 294
Cdd:COG2385  223 PDPYDKESPKYRWTKTFSLAELAKALGKKLG----DVGDI-KDIKVLERTPSGRVKKLKIvgdkGTKTISGEEIRRALgK 297
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705 295 LNSANFDIKFGEGYIDFVVKGYGHGVGMSQWGAEGMAEEGYKYYDILSHYYTDTKIKDIY 354
Cdd:COG2385  298 LRSTLFTVEKKGDGFTFTGKGYGHGVGMSQWGANGMAKQGKSYREILKHYYPGTELEKLY 357
 
Name Accession Description Interval E-value
SpoIID COG2385
Peptidoglycan hydrolase (amidase) enhancer domain SpoIID [Cell wall/membrane/envelope ...
64-354 1.42e-109

Peptidoglycan hydrolase (amidase) enhancer domain SpoIID [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441951  Cd Length: 357  Bit Score: 323.93  E-value: 1.42e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705  64 NYETVNKKA--PIINVY--NHITGKTEKMDMENYLCGVLAGEMSSEFDIEALKAQSVAARTYVVYKQEHGKsskHKNAVV 139
Cdd:COG2385   79 GLISVNGRDyrGSLEVYpnGGGLTLVNEVPLEEYLKGVVAAEMPASWPLEALKAQAVAARTYALRNLLRHA---HDGYDL 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705 140 CTDyKHCQEYKSYDTLkklngeewiknkYSKIQEAVRGTKGQIITYNDKAILPLYFSTSSGKTENSEEVFSAKYPYLKSV 219
Cdd:COG2385  156 CDT-THCQVYKGLEEE------------TPKIRKAVEATRGEVLTYNGEPIDAVFHSTSGGYTENAEDVWGSDLPYLRSV 222
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705 220 ESPYDKYSPKFASTLKISNTDFVKSLRRAYStiviDVNNLsKQVSITKRSDAGTVEKIKL----GNKELTGKDIRTVF-K 294
Cdd:COG2385  223 PDPYDKESPKYRWTKTFSLAELAKALGKKLG----DVGDI-KDIKVLERTPSGRVKKLKIvgdkGTKTISGEEIRRALgK 297
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705 295 LNSANFDIKFGEGYIDFVVKGYGHGVGMSQWGAEGMAEEGYKYYDILSHYYTDTKIKDIY 354
Cdd:COG2385  298 LRSTLFTVEKKGDGFTFTGKGYGHGVGMSQWGANGMAKQGKSYREILKHYYPGTELEKLY 357
spore_II_D TIGR02870
stage II sporulation protein D; Stage II sporulation protein D (SpoIID) is a protein of the ...
56-353 1.01e-106

stage II sporulation protein D; Stage II sporulation protein D (SpoIID) is a protein of the endospore formation program in a number of lineages in the Firmicutes (low-GC Gram-positive bacteria). It is expressed in the mother cell compartment, under control of Sigma-E. SpoIID, along with SpoIIM and SpoIIP, is one of three major proteins involved in engulfment of the forespore by the mother cell. [Cellular processes, Sporulation and germination]


Pssm-ID: 274332 [Multi-domain]  Cd Length: 338  Bit Score: 315.89  E-value: 1.01e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705   56 NKEEKNTVNYETVNKKapiINVYNHITGKTEKMDMENYLCGVLAGEMSSEFDIEALKAQSVAARTYVVYKQEHG---KSS 132
Cdd:TIGR02870  43 KKPEKGVTNLKEEEVA---IKVYRSNEDKIEKVPLEEYVKGVVASEMPAEFEIEALKAQAVAARTFAVRRMLQFggtGCG 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705  133 KHKNAVVCTDYKHCQEYKSYDTLKKLNGEEWIKnKYSKIQEAVRGTKGQIITYNDKAILPLYFSTSSGKTENSEEVFSAK 212
Cdd:TIGR02870 120 DHPGGDVCTDTTHCQAYQSKEELKKKWGKDYDE-YWSKISQAVASTKGKVLTYNGELIDPVYFSTSGGKTENAEDVWGED 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705  213 YPYLKSVESPYDKYSPKFASTLKISNTDFVKSLRRAYSTIVIDvNNLSKQVSITKRSDAGTVEKIKLGNKELTGKDIRTV 292
Cdd:TIGR02870 199 VPYLKSVTSPWEEQSPKYKTETVMSISEFVDKLKSSLPNLKLQ-NAASVGVKILARTAGGRVKTIKIGGVTLKGREIRER 277
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489527705  293 FKLNSANFDIKFGEGYIDFVVKGYGHGVGMSQWGAEGMAEEGYKYYDILSHYYTDTKIKDI 353
Cdd:TIGR02870 278 LGLNSTDFTWKVQGDKIVITTIGYGHGVGMSQYGANAMAKEGKTYDEILKHYYQGVEIEEI 338
SpoIID pfam08486
Stage II sporulation protein; This domain is found in the stage II sporulation protein SpoIID. ...
78-184 7.75e-36

Stage II sporulation protein; This domain is found in the stage II sporulation protein SpoIID. SpoIID is necessary for membrane migration as well as for some of the earlier steps in engulfment during bacterial endospore formation. The domain is also found in amidase enhancer proteins. Amidases, like SpoIID, are cell wall hydrolases.


Pssm-ID: 462491 [Multi-domain]  Cd Length: 100  Bit Score: 125.79  E-value: 7.75e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705   78 YNHITGKTEKMDMENYLCGVLAGEMSSEFDIEALKAQSVAARTYVVYKQEHGKSSKHKNAVVCTDyKHCQEYKSYDtlkk 157
Cdd:pfam08486   1 YDGGLTVVNEVPLEEYLKGVVAAEMPASFPLEALKAQAVAARTYALRREAQLGAHDGPGADVCDD-THCQVYLGVE---- 75
                          90       100
                  ....*....|....*....|....*..
gi 489527705  158 lnGEEWIKNKYSKIQEAVRGTKGQIIT 184
Cdd:pfam08486  76 --EEWPGTDYYAKIRQAVEATRGEVLT 100
 
Name Accession Description Interval E-value
SpoIID COG2385
Peptidoglycan hydrolase (amidase) enhancer domain SpoIID [Cell wall/membrane/envelope ...
64-354 1.42e-109

Peptidoglycan hydrolase (amidase) enhancer domain SpoIID [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441951  Cd Length: 357  Bit Score: 323.93  E-value: 1.42e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705  64 NYETVNKKA--PIINVY--NHITGKTEKMDMENYLCGVLAGEMSSEFDIEALKAQSVAARTYVVYKQEHGKsskHKNAVV 139
Cdd:COG2385   79 GLISVNGRDyrGSLEVYpnGGGLTLVNEVPLEEYLKGVVAAEMPASWPLEALKAQAVAARTYALRNLLRHA---HDGYDL 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705 140 CTDyKHCQEYKSYDTLkklngeewiknkYSKIQEAVRGTKGQIITYNDKAILPLYFSTSSGKTENSEEVFSAKYPYLKSV 219
Cdd:COG2385  156 CDT-THCQVYKGLEEE------------TPKIRKAVEATRGEVLTYNGEPIDAVFHSTSGGYTENAEDVWGSDLPYLRSV 222
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705 220 ESPYDKYSPKFASTLKISNTDFVKSLRRAYStiviDVNNLsKQVSITKRSDAGTVEKIKL----GNKELTGKDIRTVF-K 294
Cdd:COG2385  223 PDPYDKESPKYRWTKTFSLAELAKALGKKLG----DVGDI-KDIKVLERTPSGRVKKLKIvgdkGTKTISGEEIRRALgK 297
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705 295 LNSANFDIKFGEGYIDFVVKGYGHGVGMSQWGAEGMAEEGYKYYDILSHYYTDTKIKDIY 354
Cdd:COG2385  298 LRSTLFTVEKKGDGFTFTGKGYGHGVGMSQWGANGMAKQGKSYREILKHYYPGTELEKLY 357
spore_II_D TIGR02870
stage II sporulation protein D; Stage II sporulation protein D (SpoIID) is a protein of the ...
56-353 1.01e-106

stage II sporulation protein D; Stage II sporulation protein D (SpoIID) is a protein of the endospore formation program in a number of lineages in the Firmicutes (low-GC Gram-positive bacteria). It is expressed in the mother cell compartment, under control of Sigma-E. SpoIID, along with SpoIIM and SpoIIP, is one of three major proteins involved in engulfment of the forespore by the mother cell. [Cellular processes, Sporulation and germination]


Pssm-ID: 274332 [Multi-domain]  Cd Length: 338  Bit Score: 315.89  E-value: 1.01e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705   56 NKEEKNTVNYETVNKKapiINVYNHITGKTEKMDMENYLCGVLAGEMSSEFDIEALKAQSVAARTYVVYKQEHG---KSS 132
Cdd:TIGR02870  43 KKPEKGVTNLKEEEVA---IKVYRSNEDKIEKVPLEEYVKGVVASEMPAEFEIEALKAQAVAARTFAVRRMLQFggtGCG 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705  133 KHKNAVVCTDYKHCQEYKSYDTLKKLNGEEWIKnKYSKIQEAVRGTKGQIITYNDKAILPLYFSTSSGKTENSEEVFSAK 212
Cdd:TIGR02870 120 DHPGGDVCTDTTHCQAYQSKEELKKKWGKDYDE-YWSKISQAVASTKGKVLTYNGELIDPVYFSTSGGKTENAEDVWGED 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705  213 YPYLKSVESPYDKYSPKFASTLKISNTDFVKSLRRAYSTIVIDvNNLSKQVSITKRSDAGTVEKIKLGNKELTGKDIRTV 292
Cdd:TIGR02870 199 VPYLKSVTSPWEEQSPKYKTETVMSISEFVDKLKSSLPNLKLQ-NAASVGVKILARTAGGRVKTIKIGGVTLKGREIRER 277
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489527705  293 FKLNSANFDIKFGEGYIDFVVKGYGHGVGMSQWGAEGMAEEGYKYYDILSHYYTDTKIKDI 353
Cdd:TIGR02870 278 LGLNSTDFTWKVQGDKIVITTIGYGHGVGMSQYGANAMAKEGKTYDEILKHYYQGVEIEEI 338
SpoIID_LytB TIGR02669
SpoIID/LytB domain; This model describes a domain found typically in two or three proteins per ...
86-351 1.23e-80

SpoIID/LytB domain; This model describes a domain found typically in two or three proteins per genome in Cyanobacteria and Firmicutes, and sporadically in other genomes. One member is SpoIID of Bacillus subtilis. Another in B. subtilis is the C-terminal half of LytB, encoded immediately upstream of an amidase, the autolysin LytC, to which its N-terminus is homologous. Gene neighborhoods are not well conserved for members of this family, as many, such as SpoIID, are monocistronic. One early modelling-based study suggests a DNA-binding role for SpoIID, but the function of this domain is unknown. [Unknown function, General]


Pssm-ID: 274252 [Multi-domain]  Cd Length: 267  Bit Score: 246.98  E-value: 1.23e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705   86 EKMDMENYLCGVLAGEMSSEFDIEALKAQSVAARTYVVYkqeHGKSSKHKNAVVCTDyKHCQEYKSYDtlkklngEEWik 165
Cdd:TIGR02669   4 NELPLEDYLKGVVPAEMPASWPMEALKAQAVAARTYALR---NLKRFAGDGYDLCAD-TQCQVYRGVE-------EET-- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705  166 nkySKIQEAVRGTKGQIITYNDKAILPLYFSTSSGKTENSEEVFSAKYPYLKSVESPYDKYSPKFASTLKISNTDFVKSL 245
Cdd:TIGR02669  71 ---PRTEQAVEATAGQVLTYNGQLINAVYHSSSGGYTENSEDVWGKDLPYLKSVPDPYQNAAPWSWSLPLKSVELFLRFL 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705  246 ----RRAYSTIVIDVNNLSKQVSITKRSDAGTVEKIK---------LGNKELTGKDIRTVFKLNSANFDIKFGEGYIDFV 312
Cdd:TIGR02669 148 gvavGGLYPSKILKRRNSGRVIKLKIRGSGGSVKLIGigfrrklglKSGKDITGRKFRELLGLNSTNFSVKSRGNAILFT 227
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 489527705  313 VKGYGHGVGMSQWGAEGMAEEGYKYYDILSHYYTDTKIK 351
Cdd:TIGR02669 228 GKGYGHGVGMSQWGANGLAKLGKDYREILKHYYPGTELS 266
SpoIID pfam08486
Stage II sporulation protein; This domain is found in the stage II sporulation protein SpoIID. ...
78-184 7.75e-36

Stage II sporulation protein; This domain is found in the stage II sporulation protein SpoIID. SpoIID is necessary for membrane migration as well as for some of the earlier steps in engulfment during bacterial endospore formation. The domain is also found in amidase enhancer proteins. Amidases, like SpoIID, are cell wall hydrolases.


Pssm-ID: 462491 [Multi-domain]  Cd Length: 100  Bit Score: 125.79  E-value: 7.75e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489527705   78 YNHITGKTEKMDMENYLCGVLAGEMSSEFDIEALKAQSVAARTYVVYKQEHGKSSKHKNAVVCTDyKHCQEYKSYDtlkk 157
Cdd:pfam08486   1 YDGGLTVVNEVPLEEYLKGVVAAEMPASFPLEALKAQAVAARTYALRREAQLGAHDGPGADVCDD-THCQVYLGVE---- 75
                          90       100
                  ....*....|....*....|....*..
gi 489527705  158 lnGEEWIKNKYSKIQEAVRGTKGQIIT 184
Cdd:pfam08486  76 --EEWPGTDYYAKIRQAVEATRGEVLT 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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