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Conserved domains on  [gi|489530101|ref|WP_003434835|]
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YkgJ family cysteine cluster protein [Clostridioides difficile]

Protein Classification

YkgJ family cysteine cluster protein( domain architecture ID 10002295)

YkgJ family cysteine cluster protein similar to Escherichia coli YkgJ, containing a conserved cysteine motif (CxxCxxCC) which might chelate iron or zinc ions

Gene Ontology:  GO:0046872|GO:0051536

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YkgJ COG0727
Uncharacterized protein YkgJ, contains CxxCxxCC motif [General function prediction only];
37-129 1.90e-10

Uncharacterized protein YkgJ, contains CxxCxxCC motif [General function prediction only];


:

Pssm-ID: 440491  Cd Length: 120  Bit Score: 56.76  E-value: 1.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489530101  37 CSGCGNCC-MESVGINLIEFLNIfcylEDRVDLKKS-CISKILDYYFEEyTRKNPCPF-KDTNNRCLIYEVRPLNCRMFG 113
Cdd:COG0727   11 CLGCGACCrGFRVSLTPAEIGRL----AKHLGLSPEeFLERYLRYVLKG-TEDGRCVFlDGETRRCSIYEVRPSACREFP 85

                         90
                 ....*....|....*.
gi 489530101 114 HWKKEDYNKNLDNVIE 129
Cdd:COG0727   86 FVFEDGFGKTLKGDEA 101
 
Name Accession Description Interval E-value
YkgJ COG0727
Uncharacterized protein YkgJ, contains CxxCxxCC motif [General function prediction only];
37-129 1.90e-10

Uncharacterized protein YkgJ, contains CxxCxxCC motif [General function prediction only];


Pssm-ID: 440491  Cd Length: 120  Bit Score: 56.76  E-value: 1.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489530101  37 CSGCGNCC-MESVGINLIEFLNIfcylEDRVDLKKS-CISKILDYYFEEyTRKNPCPF-KDTNNRCLIYEVRPLNCRMFG 113
Cdd:COG0727   11 CLGCGACCrGFRVSLTPAEIGRL----AKHLGLSPEeFLERYLRYVLKG-TEDGRCVFlDGETRRCSIYEVRPSACREFP 85

                         90
                 ....*....|....*.
gi 489530101 114 HWKKEDYNKNLDNVIE 129
Cdd:COG0727   86 FVFEDGFGKTLKGDEA 101
CxxCxxCC pfam03692
Putative zinc- or iron-chelating domain; This family of proteins contains 8 conserved ...
 37-123 2.07e-08

Putative zinc- or iron-chelating domain; This family of proteins contains 8 conserved cysteines. It has in the past been annotated as being one of the complex of proteins of the flagellar Fli complex. However this was due to a mis-annotation of the original Salmonella LT2 Genbank entry of 'fliB'. With all its conserved cysteines it is possibly a domain that chelates iron or zinc ions.


Pssm-ID: 308985  Cd Length: 85  Bit Score: 50.32  E-value: 2.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489530101   37 CSGCGNCCmESVGINLIEflnifcylEDRVDLKKSCISKILDYYFEEYTRKNPCPFKDTNN-RCLIYEVRPLNCRMFGHW 115
Cdd:pfam03692   2 CDGCGACC-KALGIKLTD--------EDTERLAPTGVAEEDEDLEEYVKVDGRCVFLDEETcLCSIYEERPLCCRLFPFS 72


                  ....*...
gi 489530101  116 KKEDYNKN 123
Cdd:pfam03692  73 NIEEFGWL 80
 
Name Accession Description Interval E-value
YkgJ COG0727
Uncharacterized protein YkgJ, contains CxxCxxCC motif [General function prediction only];
37-129 1.90e-10

Uncharacterized protein YkgJ, contains CxxCxxCC motif [General function prediction only];


Pssm-ID: 440491  Cd Length: 120  Bit Score: 56.76  E-value: 1.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489530101  37 CSGCGNCC-MESVGINLIEFLNIfcylEDRVDLKKS-CISKILDYYFEEyTRKNPCPF-KDTNNRCLIYEVRPLNCRMFG 113
Cdd:COG0727   11 CLGCGACCrGFRVSLTPAEIGRL----AKHLGLSPEeFLERYLRYVLKG-TEDGRCVFlDGETRRCSIYEVRPSACREFP 85

                         90
                 ....*....|....*.
gi 489530101 114 HWKKEDYNKNLDNVIE 129
Cdd:COG0727   86 FVFEDGFGKTLKGDEA 101
CxxCxxCC pfam03692
Putative zinc- or iron-chelating domain; This family of proteins contains 8 conserved ...
 37-123 2.07e-08

Putative zinc- or iron-chelating domain; This family of proteins contains 8 conserved cysteines. It has in the past been annotated as being one of the complex of proteins of the flagellar Fli complex. However this was due to a mis-annotation of the original Salmonella LT2 Genbank entry of 'fliB'. With all its conserved cysteines it is possibly a domain that chelates iron or zinc ions.


Pssm-ID: 308985  Cd Length: 85  Bit Score: 50.32  E-value: 2.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489530101   37 CSGCGNCCmESVGINLIEflnifcylEDRVDLKKSCISKILDYYFEEYTRKNPCPFKDTNN-RCLIYEVRPLNCRMFGHW 115
Cdd:pfam03692   2 CDGCGACC-KALGIKLTD--------EDTERLAPTGVAEEDEDLEEYVKVDGRCVFLDEETcLCSIYEERPLCCRLFPFS 72


                  ....*...
gi 489530101  116 KKEDYNKN 123
Cdd:pfam03692  73 NIEEFGWL 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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