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Conserved domains on  [gi|489530199|ref|WP_003434933|]
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UPF0489 family protein [Clostridioides difficile]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UPF0489 super family cl15002
UPF0489 domain; This family is probably an enzyme which is related to the Arginase family.
 78-160 4.72e-09

UPF0489 domain; This family is probably an enzyme which is related to the Arginase family.


The actual alignment was detected with superfamily member pfam12640:

Pssm-ID: 432689  Cd Length: 177  Bit Score: 54.08  E-value: 4.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489530199   78 IYVFDNHNHAFYFWAKSLLKGEFTKGCKLVHVDQHKDTREPENYDVD-------VNNLKDVFRYTNEVLNVGSFIKPALK 150
Cdd:pfam12640   1 VYIVEDHHEALWFWYRAIGRKKLPSDNTLVHFDSHPDLLIPPAMSADdvynallDIGLDNNFSAVLEELSIENWILPAVY 80

                          90
                  ....*....|
gi 489530199  151 YNIFSELIII 160
Cdd:pfam12640  81 AGHISRVVWI 90
 
Name Accession Description Interval E-value
UPF0489 pfam12640
UPF0489 domain; This family is probably an enzyme which is related to the Arginase family.
 78-160 4.72e-09

UPF0489 domain; This family is probably an enzyme which is related to the Arginase family.


Pssm-ID: 432689  Cd Length: 177  Bit Score: 54.08  E-value: 4.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489530199   78 IYVFDNHNHAFYFWAKSLLKGEFTKGCKLVHVDQHKDTREPENYDVD-------VNNLKDVFRYTNEVLNVGSFIKPALK 150
Cdd:pfam12640   1 VYIVEDHHEALWFWYRAIGRKKLPSDNTLVHFDSHPDLLIPPAMSADdvynallDIGLDNNFSAVLEELSIENWILPAVY 80

                          90
                  ....*....|
gi 489530199  151 YNIFSELIII 160
Cdd:pfam12640  81 AGHISRVVWI 90
hPOT1_OB2 cd04498
hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of ...
 78-128 7.44e-03

hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ending with the sequence GGTTAG. The hPOT1 monomer consists of two closely connected OB folds (OB1-OB2) which cooperate to bind telomeric ssDNA. OB1 makes more extensive contact with the ssDNA than OB2. OB2 protects the 3' end of the ssDNA. hPOT1 is implicated in telomere length regulation.


Pssm-ID: 239944  Cd Length: 123  Bit Score: 35.47  E-value: 7.44e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489530199  78 IYVFDNHNHAfyfwAKSLLKGEFTKgCKLVHVDQHKDTREPENYDVDVNNL 128
Cdd:cd04498   64 ILVYDNHVEL----AKSLKPGDFVR-IYNVHAKSYSSKNEHDENDHLHFHL 109
 
Name Accession Description Interval E-value
UPF0489 pfam12640
UPF0489 domain; This family is probably an enzyme which is related to the Arginase family.
 78-160 4.72e-09

UPF0489 domain; This family is probably an enzyme which is related to the Arginase family.


Pssm-ID: 432689  Cd Length: 177  Bit Score: 54.08  E-value: 4.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489530199   78 IYVFDNHNHAFYFWAKSLLKGEFTKGCKLVHVDQHKDTREPENYDVD-------VNNLKDVFRYTNEVLNVGSFIKPALK 150
Cdd:pfam12640   1 VYIVEDHHEALWFWYRAIGRKKLPSDNTLVHFDSHPDLLIPPAMSADdvynallDIGLDNNFSAVLEELSIENWILPAVY 80

                          90
                  ....*....|
gi 489530199  151 YNIFSELIII 160
Cdd:pfam12640  81 AGHISRVVWI 90
hPOT1_OB2 cd04498
hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of ...
 78-128 7.44e-03

hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ending with the sequence GGTTAG. The hPOT1 monomer consists of two closely connected OB folds (OB1-OB2) which cooperate to bind telomeric ssDNA. OB1 makes more extensive contact with the ssDNA than OB2. OB2 protects the 3' end of the ssDNA. hPOT1 is implicated in telomere length regulation.


Pssm-ID: 239944  Cd Length: 123  Bit Score: 35.47  E-value: 7.44e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489530199  78 IYVFDNHNHAfyfwAKSLLKGEFTKgCKLVHVDQHKDTREPENYDVDVNNL 128
Cdd:cd04498   64 ILVYDNHVEL----AKSLKPGDFVR-IYNVHAKSYSSKNEHDENDHLHFHL 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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