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Conserved domains on  [gi|489531415|ref|WP_003436147|]
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flavodoxin family protein BilS [Clostridioides difficile]

Protein Classification

flavodoxin family protein( domain architecture ID 10576918)

flavodoxin family protein similar to flavodoxin, a low-potential electron donor to a number of redox enzymes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Flavodoxin_3 pfam12641
Flavodoxin domain; This family represents a flavodoxin domain.
 4-166 3.89e-71

Flavodoxin domain; This family represents a flavodoxin domain.


:

Pssm-ID: 432690  Cd Length: 159  Bit Score: 211.75  E-value: 3.89e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531415    4 LVLYSSLTGNTKKIAYTIYDEIQEEKDIKDVNELVDYgidYENYDIVFLGYWVDKGICDKNSKQVLENIHNKKIALFGTM 83
Cdd:pfam12641   1 LILYSSLTGNTKKVAEAIFEALPEEKDIIDFGELKDK---IPEYDIVFVGFWVDKGNADEEALDFLETLKNKKIFLFGTL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531415   84 GASKKGSYGASIIEKIESIIPKDNEILGSFICQGKIAEGLKAKYKEMlKLSPDNEHIRQQLNNHEESQSHPDEQEIYEAS 163
Cdd:pfam12641  78 GAGPDSEYAKKILENVKALIPKNNEVLGGFICQGKMPPKVREKYKKM-PLDEPHAMTPELIENFDEAASHPDEEDLEKAK 156


                  ...
gi 489531415  164 MFA 166
Cdd:pfam12641 157 KFV 159
 
Name Accession Description Interval E-value
Flavodoxin_3 pfam12641
Flavodoxin domain; This family represents a flavodoxin domain.
 4-166 3.89e-71

Flavodoxin domain; This family represents a flavodoxin domain.


Pssm-ID: 432690  Cd Length: 159  Bit Score: 211.75  E-value: 3.89e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531415    4 LVLYSSLTGNTKKIAYTIYDEIQEEKDIKDVNELVDYgidYENYDIVFLGYWVDKGICDKNSKQVLENIHNKKIALFGTM 83
Cdd:pfam12641   1 LILYSSLTGNTKKVAEAIFEALPEEKDIIDFGELKDK---IPEYDIVFVGFWVDKGNADEEALDFLETLKNKKIFLFGTL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531415   84 GASKKGSYGASIIEKIESIIPKDNEILGSFICQGKIAEGLKAKYKEMlKLSPDNEHIRQQLNNHEESQSHPDEQEIYEAS 163
Cdd:pfam12641  78 GAGPDSEYAKKILENVKALIPKNNEVLGGFICQGKMPPKVREKYKKM-PLDEPHAMTPELIENFDEAASHPDEEDLEKAK 156


                  ...
gi 489531415  164 MFA 166
Cdd:pfam12641 157 KFV 159
FldA COG0716
Flavodoxin [Energy production and conversion]; Flavodoxin is part of the Pathway/BioSystem: ...
 4-121 6.91e-18

Flavodoxin [Energy production and conversion]; Flavodoxin is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440480 [Multi-domain]  Cd Length: 135  Bit Score: 75.32  E-value: 6.91e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531415   4 LVLYSSLTGNTKKIAYTIYDEIQEE-KDIKDVNELVDygIDYENYDIVFLGYWVDKGICDKNSKQVLENI----HNKKIA 78
Cdd:COG0716    2 LIVYGSTTGNTEKVAEAIAEALGAAgVDLFEIEDADL--DDLEDYDLLILGTPTWAGELPDDWEDFLEELkedlSGKKVA 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 489531415  79 LFGTMGaskKGSYGASIIEKIESIIPKDNEILGSFICQGKIAE 121
Cdd:COG0716   80 LFGTGD---SSGYGDALGELKELLEEKGAKVVGGYDFEGSKAP 119
PRK09271 PRK09271
flavodoxin; Provisional
 1-59 6.42e-07

flavodoxin; Provisional


Pssm-ID: 181744  Cd Length: 160  Bit Score: 46.72  E-value: 6.42e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489531415   1 MKSLVLYSSLTGNTKKIAYTIYDEIQEEKDI-----KDVNELVDYGIDYENYDIVFLGYWVDKG 59
Cdd:PRK09271   1 MRILLAYASLSGNTREVAREIEERCEEAGHEvdwveTDVQTLAEYPLDPEDYDLYLLGTWTDNA 64
flav_short TIGR01753
flavodoxin, short chain; Flavodoxins are small redox-active proteins with a flavin ...
 4-81 3.65e-06

flavodoxin, short chain; Flavodoxins are small redox-active proteins with a flavin mononucleotide (FMN) prosthetic group. They can act in nitrogen fixation by nitrogenase, in sulfite reduction, and light-dependent NADP+ reduction in during photosynthesis, among other roles. This model describes the short chain type. Many of these are involved in sulfite reduction. [Energy metabolism, Electron transport]


Pssm-ID: 273789 [Multi-domain]  Cd Length: 140  Bit Score: 44.25  E-value: 3.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531415    4 LVLYSSLTGNTKKIAYTIYDEIQE---EKDIKDVNElVDYGiDYENYDIVFLG--YWVDKGICDKNSKQVLENIH----- 73
Cdd:TIGR01753   2 LIVYASMTGNTEEMANIIAEGLKEagaEVDLLEVAD-ADAE-DLLSYDAVLLGcsTWGDEDLEQDDFEPFFEELEdidlg 79


                  ....*...
gi 489531415   74 NKKIALFG 81
Cdd:TIGR01753  80 GKKVALFG 87
 
Name Accession Description Interval E-value
Flavodoxin_3 pfam12641
Flavodoxin domain; This family represents a flavodoxin domain.
 4-166 3.89e-71

Flavodoxin domain; This family represents a flavodoxin domain.


Pssm-ID: 432690  Cd Length: 159  Bit Score: 211.75  E-value: 3.89e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531415    4 LVLYSSLTGNTKKIAYTIYDEIQEEKDIKDVNELVDYgidYENYDIVFLGYWVDKGICDKNSKQVLENIHNKKIALFGTM 83
Cdd:pfam12641   1 LILYSSLTGNTKKVAEAIFEALPEEKDIIDFGELKDK---IPEYDIVFVGFWVDKGNADEEALDFLETLKNKKIFLFGTL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531415   84 GASKKGSYGASIIEKIESIIPKDNEILGSFICQGKIAEGLKAKYKEMlKLSPDNEHIRQQLNNHEESQSHPDEQEIYEAS 163
Cdd:pfam12641  78 GAGPDSEYAKKILENVKALIPKNNEVLGGFICQGKMPPKVREKYKKM-PLDEPHAMTPELIENFDEAASHPDEEDLEKAK 156


                  ...
gi 489531415  164 MFA 166
Cdd:pfam12641 157 KFV 159
FldA COG0716
Flavodoxin [Energy production and conversion]; Flavodoxin is part of the Pathway/BioSystem: ...
 4-121 6.91e-18

Flavodoxin [Energy production and conversion]; Flavodoxin is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440480 [Multi-domain]  Cd Length: 135  Bit Score: 75.32  E-value: 6.91e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531415   4 LVLYSSLTGNTKKIAYTIYDEIQEE-KDIKDVNELVDygIDYENYDIVFLGYWVDKGICDKNSKQVLENI----HNKKIA 78
Cdd:COG0716    2 LIVYGSTTGNTEKVAEAIAEALGAAgVDLFEIEDADL--DDLEDYDLLILGTPTWAGELPDDWEDFLEELkedlSGKKVA 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 489531415  79 LFGTMGaskKGSYGASIIEKIESIIPKDNEILGSFICQGKIAE 121
Cdd:COG0716   80 LFGTGD---SSGYGDALGELKELLEEKGAKVVGGYDFEGSKAP 119
HemG COG4635
Protoporphyrinogen IX oxidase, menaquinone-dependent (flavodoxin domain) [Coenzyme transport ...
 1-53 2.74e-07

Protoporphyrinogen IX oxidase, menaquinone-dependent (flavodoxin domain) [Coenzyme transport and metabolism];


Pssm-ID: 443673  Cd Length: 179  Bit Score: 47.97  E-value: 2.74e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489531415   1 MKSLVLYSSLTGNTKKIAYTIYDEIQEEK---DIKDVNELVDygIDYENYDIVFLG 53
Cdd:COG4635    1 MKVLILYASRDGQTRKIAERIAEVLREAGhdvDLVDLEDAPD--LDLAGYDAVVIG 54
PRK09271 PRK09271
flavodoxin; Provisional
 1-59 6.42e-07

flavodoxin; Provisional


Pssm-ID: 181744  Cd Length: 160  Bit Score: 46.72  E-value: 6.42e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489531415   1 MKSLVLYSSLTGNTKKIAYTIYDEIQEEKDI-----KDVNELVDYGIDYENYDIVFLGYWVDKG 59
Cdd:PRK09271   1 MRILLAYASLSGNTREVAREIEERCEEAGHEvdwveTDVQTLAEYPLDPEDYDLYLLGTWTDNA 64
Flavodoxin_5 pfam12724
Flavodoxin domain; This is a family of flavodoxins. Flavodoxins are electron transfer proteins ...
 4-88 1.54e-06

Flavodoxin domain; This is a family of flavodoxins. Flavodoxins are electron transfer proteins that carry a molecule of non-covalently bound FMN.


Pssm-ID: 463681 [Multi-domain]  Cd Length: 144  Bit Score: 45.33  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531415    4 LVLYSSLTGNTKKIAYTIYDEIQEEKDIKDVNElVDYGIDYENYDIVFLG----YWVDKGICDKNSKQVLENIHNKKIAL 79
Cdd:pfam12724   1 LILYSSRDGQTKKIAERIAEELREEGELVDVED-VEAGEDLSSYDAVVIGasiyYGKHLPELRQFVTKHRDELSSKPVAF 79


                  ....*....
gi 489531415   80 FGTMGASKK 88
Cdd:pfam12724  80 FSVNLTARK 88
flav_short TIGR01753
flavodoxin, short chain; Flavodoxins are small redox-active proteins with a flavin ...
 4-81 3.65e-06

flavodoxin, short chain; Flavodoxins are small redox-active proteins with a flavin mononucleotide (FMN) prosthetic group. They can act in nitrogen fixation by nitrogenase, in sulfite reduction, and light-dependent NADP+ reduction in during photosynthesis, among other roles. This model describes the short chain type. Many of these are involved in sulfite reduction. [Energy metabolism, Electron transport]


Pssm-ID: 273789 [Multi-domain]  Cd Length: 140  Bit Score: 44.25  E-value: 3.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531415    4 LVLYSSLTGNTKKIAYTIYDEIQE---EKDIKDVNElVDYGiDYENYDIVFLG--YWVDKGICDKNSKQVLENIH----- 73
Cdd:TIGR01753   2 LIVYASMTGNTEEMANIIAEGLKEagaEVDLLEVAD-ADAE-DLLSYDAVLLGcsTWGDEDLEQDDFEPFFEELEdidlg 79


                  ....*...
gi 489531415   74 NKKIALFG 81
Cdd:TIGR01753  80 GKKVALFG 87
PRK06242 PRK06242
flavodoxin; Provisional
 1-173 7.60e-06

flavodoxin; Provisional


Pssm-ID: 180484 [Multi-domain]  Cd Length: 150  Bit Score: 43.75  E-value: 7.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531415   1 MKSLVLYSSLT-GNTKKIAYTIYDEIqeEKDIKDVNELVDYgiDYENYDIVFLGYWVDKGICDKNSKQVLENI---HNKK 76
Cdd:PRK06242   1 MKALIVYASVHhGNTEKIAKAIAEVL--DAEVIDPGDVNPE--DLSEYDLIGFGSGIYFGKFHKSLLKLIEKLppvSGKK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531415  77 IALFGTMGASKKGSYGASIIEKIEsiipKDNEILGSFICQG-------KIAEGLkakykemlklspdnehirqqlnnhee 149
Cdd:PRK06242  77 AFIFSTSGLPFLKYHKALKKKLKE----KGFEIVGEFSCKGfdtfgpfKLIGGI-------------------------- 126

                        170       180
                 ....*....|....*....|....
gi 489531415 150 SQSHPDEQEIYEASMFAKNMMIKA 173
Cdd:PRK06242 127 NKGHPNEKDLENAKEFAENLKKKL 150
hemG PRK11104
menaquinone-dependent protoporphyrinogen IX dehydrogenase;
1-81 1.13e-05

menaquinone-dependent protoporphyrinogen IX dehydrogenase;


Pssm-ID: 182966  Cd Length: 177  Bit Score: 43.41  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531415   1 MKSLVLYSSLTGNTKKIAYTIYDEIQE--EKDIKDVNELVDygIDYENYDIVFLGYWVDKGICDKNSKQVLEN----IHN 74
Cdd:PRK11104   1 MKTLILYSSRDGQTRKIASYIASELKEgiQCDVVNLHRIEE--PDLSDYDRVVIGASIRYGHFHSALYKFVKKhatqLNQ 78


                 ....*..
gi 489531415  75 KKIALFG 81
Cdd:PRK11104  79 MPSAFFS 85
PRK07116 PRK07116
flavodoxin; Provisional
 1-90 6.11e-05

flavodoxin; Provisional


Pssm-ID: 180850  Cd Length: 160  Bit Score: 41.20  E-value: 6.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531415   1 MKSLVLYSSLTGNTKKIAYTIYD-------EIQ---------------------EEKDIKDVNELVDYGIDYENYDIVFL 52
Cdd:PRK07116   3 NKTLVAYFSATGTTKKVAEKLAEvtgadlfEIKpeqpytaadldwndkksrssvEMADKSSRPAIAKKIENIAEYDVIFL 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 489531415  53 GYWVDKGICDKNSKQVLE--NIHNKKIALFGTMGASKKGS 90
Cdd:PRK07116  83 GFPIWWYVAPRIINTFLEsyDFSGKTVIPFATSGGSGIGN 122
PRK06703 PRK06703
flavodoxin; Provisional
 1-53 1.37e-04

flavodoxin; Provisional


Pssm-ID: 235854 [Multi-domain]  Cd Length: 151  Bit Score: 40.13  E-value: 1.37e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489531415   1 MKSLVLYSSLTGNTKKIAYTIYDEIQEEKDIKDVNELVDYGID-YENYDIVFLG 53
Cdd:PRK06703   2 AKILIAYASMSGNTEDIADLIKVSLDAFDHEVVLQEMDGMDAEeLLAYDGIILG 55
PRK09267 PRK09267
flavodoxin FldA; Validated
 1-82 9.68e-04

flavodoxin FldA; Validated


Pssm-ID: 236439 [Multi-domain]  Cd Length: 169  Bit Score: 37.89  E-value: 9.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531415   1 MKSL-VLYSSLTGNTKKIAYTIYDEIQEE-KDIKDVNEL-VDygiDYENYDIVFLG-----------YWvDKGIcdknsk 66
Cdd:PRK09267   1 MAKIgIFFGSDTGNTEDIAKMIQKKLGKDvADVVDIAKAsKE---DFEAYDLLILGiptwgygelqcDW-DDFL------ 70

                         90
                 ....*....|....*...
gi 489531415  67 QVLENI--HNKKIALFGT 82
Cdd:PRK09267  71 PELEEIdfSGKKVALFGL 88
Flavodoxin_1 pfam00258
Flavodoxin;
5-53 4.09e-03

Flavodoxin;


Pssm-ID: 425562 [Multi-domain]  Cd Length: 142  Bit Score: 35.81  E-value: 4.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 489531415    5 VLYSSLTGNTKKIAYTIYDEIQE------EKDIKDVNELVDygiDYENYDIVFLG 53
Cdd:pfam00258   1 IFYGSQTGNTEKLAEAIAEGLGEagfevdVVDLDDVDETLS---EIEEEDLLLVV 52
PRK06756 PRK06756
flavodoxin; Provisional
 1-140 7.67e-03

flavodoxin; Provisional


Pssm-ID: 168663 [Multi-domain]  Cd Length: 148  Bit Score: 35.24  E-value: 7.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531415   1 MKSLVLYSSLTGNTKKIAYTIYDEIQEEKDIKDVNELVDY--GIDYENYDIVFLG--YWVDKGICDK--NSKQVLENIH- 73
Cdd:PRK06756   2 SKLVMIFASMSGNTEEMADHIAGVIRETENEIEVIDIMDSpeASILEQYDGIILGayTWGDGDLPDDflDFYDAMDSIDl 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489531415  74 -NKKIALFGTMGASKKgSYGASIIEKIESIIPKDNEIlgsficqgkIAEGLKakykemLKLSPDNEHI 140
Cdd:PRK06756  82 tGKKAAVFGSCDSAYP-KYGVAVDILIEKLQERGAAV---------VLEGLK------VELTPEDEDV 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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