|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
14-433 |
1.29e-110 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 332.55 E-value: 1.29e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 14 FLKFVSPAIISMIFISLYTIIDGIFVSTLVGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFS 93
Cdd:cd13143 6 FLKFALPAIIGMLVNGLYNIVDGIFVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANRIFS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 94 FIVLFSLIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGV 173
Cdd:cd13143 86 TALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 174 TNIILDYVFIKYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKSTLKLRKP--KTDFRLIRDTMINGSSEMVTELSTGIT 251
Cdd:cd13143 166 LNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLrfKLSLKIIKEILALGFPSFLMQLSSSVV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 252 TFLFNVVALKLAGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIAL 331
Cdd:cd13143 246 TIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFLILL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 332 VFAPFIVRVFVSpDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFVFIIIGIIILPPMLNMT 411
Cdd:cd13143 326 LFPEQIVSLFTD-DPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLLILPRLFGLD 404
|
410 420
....*....|....*....|..
gi 489534622 412 GLWLTVPFAEVITIFISILFIK 433
Cdd:cd13143 405 GIWLAFPLAEILTLLLALILLK 426
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
5-431 |
9.10e-90 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 278.95 E-value: 9.10e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 5 FTRKFTTFEFLKFVSPAIISMIFISLYTIIDGIFVStLVGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENR 84
Cdd:COG0534 1 LTEGPILKLLLRLALPIILGNLLQSLYGLVDTIFVG-RLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 85 QDEANSTFSFIVLFSLIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFS 164
Cdd:COG0534 80 REEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 165 LFLSVIGGVTNIILDYVFIKYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKSTLKLRKP--KTDFRLIRDTMINGSSEM 242
Cdd:COG0534 160 MIIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRdlRPDRKILKRILRIGLPAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 243 VTELSTGITTFLFNVVALKLaGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVS 322
Cdd:COG0534 240 LQQLAESLGFLVLNALVARL-GTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 323 SLLVFIIALVFAPFIVRVFvSPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFVFIIIGII 402
Cdd:COG0534 319 GLLLALLLFLFPEPIIGLF-TDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAY 397
|
410 420 430
....*....|....*....|....*....|
gi 489534622 403 ILPPM-LNMTGLWLTVPFAEVITIFISILF 431
Cdd:COG0534 398 LLAFLgLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
14-427 |
4.10e-64 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 213.32 E-value: 4.10e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 14 FLKFVSPAIISMIFISLYTIIDGIFVSTLVGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFS 93
Cdd:PRK09575 14 FWRYTIPSIAAMLVNGLYQIVDGIFIGHYVGAEGLAGINMAWPVIGIILGIGLMVGMGTGSLLSIKRGEGDLEKAKRILT 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 94 FIVLFSLIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGV 173
Cdd:PRK09575 94 TGLLLLLLLGPIVSVILFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDESPNLATGLMVIGAL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 174 TNIILDYVFIKYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKSTLKL--RKPKTDFRLIRDTMINGSSEMVTELSTGIT 251
Cdd:PRK09575 174 INIVLDYLFIGWLDWGLTGAAIATALAQLVVTVLGLGYFFSSRANIRLtlKELRFNWSLAPKIVLLGSSSFFMYLYGSFV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 252 TFLFNVVALKLAGENGLAALTIVLYahfLMTSVYL---GFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFI 328
Cdd:PRK09575 254 VALHNRLFMEYGSALTVGAYAIVGY---LMVLYYLvaeGIAEGMQPPVSYYFGARQYDNIKKLLKLAMKVTVLAGIAWVL 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 329 IALVFAPFIVRVFVSPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRaFVFIIIGIIILPPML 408
Cdd:PRK09575 331 LLNLFPETMIALFNSGDSELIAETIVGIRLHLFAMFLDGFLVLASAYFMAVNQGGKALFISIGN-MLIQLPFLFILPKWL 409
|
410
....*....|....*....
gi 489534622 409 NMTGLWLTVPFAEVITIFI 427
Cdd:PRK09575 410 GVDGVWLAMPLSNIALSLV 428
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
15-436 |
1.66e-57 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 194.99 E-value: 1.66e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 15 LKFVSPAIISMIFISLYTIIDGIFVSTLVGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSF 94
Cdd:cd13138 6 LLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKAVGT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 95 IVLFSLIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVT 174
Cdd:cd13138 86 LLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVIIACVL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 175 NIILDYVFIKYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKS--TLKLRKPKTDFRLIRDTMINGSSEMVTELSTGITT 252
Cdd:cd13138 166 NIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLpfKLSLKDFRFDKEILKEILKIGLPSALQQSLVSISF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 253 FLFNVVALKLaGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIALV 332
Cdd:cd13138 246 LIINSIVNSY-GVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLVFF 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 333 FAPFIVRVFVSpDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFVFIIIGIIILPPMLNM-- 410
Cdd:cd13138 325 FAPQLLGLFTS-DPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLSRLTGLgl 403
|
410 420
....*....|....*....|....*.
gi 489534622 411 TGLWLTVPFAEVITIFISILFIKKYK 436
Cdd:cd13138 404 FGIWLAMPISNILSAIICIIYYRKGR 429
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
14-435 |
3.04e-54 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 186.59 E-value: 3.04e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 14 FLKFVSPAIISMIFISLYTIIDGIFVSTLvGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFS 93
Cdd:cd13147 11 IIKLSIPMIIAMLLQTLYNLVDAIWVAGL-GADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 94 FIVLFSLIVGILFTVISYFFIKEISILLGATDkLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGV 173
Cdd:cd13147 90 HSILLGLIISIILTIVLLPFLEPILVLMGAGE-VLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 174 TNIILDYVFIKYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKST---LKLRKPKTDFRLIRDTMINGSSEMVTELSTGI 250
Cdd:cd13147 169 LNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLLYWFFVKKDTyvsLSLKNFKFDKKIVKDILKVGIPASLEQLIMSV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 251 TTFLFNVVALKLAGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIA 330
Cdd:cd13147 249 LMIILNLILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIELIIAILI 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 331 LVFAPFIVRVF--------VSPDNTVFklalqgLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFVFIIIGII 402
Cdd:cd13147 329 FIFAPQIAYLFtyseesahLAPEIVAF------LRIMCLFLPFVPFGMMSSSMFQGIGKGLTSLIITILRELIFQVLFAY 402
|
410 420 430
....*....|....*....|....*....|....*
gi 489534622 403 ILPPMLNM--TGLWLTVPFAEVITIFISILFIKKY 435
Cdd:cd13147 403 LFAIVLGLglFGVWWGIVLGNAIGSIVGYLWARLY 437
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-434 |
1.54e-53 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 184.74 E-value: 1.54e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 20 PAIISMIFISLYTIIDGIFVSTLvGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFS 99
Cdd:cd13144 16 PAMISMLFQALYNIVDSIFVARL-GENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEANKAANNGLLLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 100 LIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVTNIILD 179
Cdd:cd13144 95 LLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIGAIINIILD 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 180 YVFIKYF----GMGLLGAAVATAIGIILTCVLGIIYFLSNK--STLKLRKPKTDFRLIRDTMINGSSEMVTELSTGITTF 253
Cdd:cd13144 175 PILIFGLfgfpAMGIAGAAIATVIGQILAMFLAFFFLLRKNkdVQPDLRLFRPSLRIIKEIYAVGLPSIIMQAISSVMVF 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 254 LFNVVaLKLAGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIALVF 333
Cdd:cd13144 255 GLNKI-LAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAVVIMLAGGLLFQLF 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 334 APFIVRVFvSPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFVFIIIGIIILPPMLNMTGL 413
Cdd:cd13144 334 PDQLLGLF-NASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLPLAWLLAKMFGLNGV 412
|
410 420
....*....|....*....|.
gi 489534622 414 WLTVPFAEVITIFISILFIKK 434
Cdd:cd13144 413 WWSFPIAEIVSFLLSLLFLKR 433
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
20-433 |
2.10e-44 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 160.18 E-value: 2.10e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 20 PAIISMIFISLYTIIDGIFVSTLvGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFS 99
Cdd:cd12082 3 PLLLSMLLQTLYNLVDTFFLGRL-LGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 100 LIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVTNIILD 179
Cdd:cd12082 82 ILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILLD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 180 YVFIKYFG---MGLLGAAVATAIGIILTCVLGIIYFLSNKS--TLKLRKPKTDFRLIRDTMINGSSEMVTELSTGITTFL 254
Cdd:cd12082 162 PLLIFGLGppeLGIAGAALATVISYVIGALLLLIYLRKGKKilKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGLLI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 255 FNVVALKLAGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIALVFA 334
Cdd:cd12082 242 IVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILLFP 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 335 PFIVRVFvSPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFVFIIIGIIILPPM-LNMTGL 413
Cdd:cd12082 322 EPILSLF-TNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLgLGLYGI 400
|
410 420
....*....|....*....|
gi 489534622 414 WLTVPFAEVITIFISILFIK 433
Cdd:cd12082 401 WLALVISLILAALVLLLFFR 420
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
20-436 |
1.21e-43 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 158.06 E-value: 1.21e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 20 PAIISMIFISLYTIIDGIFVSTLvGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFS 99
Cdd:cd13137 9 PVILENLLQTLVGLVDVFMVGRL-GAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALGQSLLLA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 100 LIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVTNIILD 179
Cdd:cd13137 88 LLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVLNIVLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 180 YVFI----KYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKSTLKLRKP--KTDFRLIRDTMINGSSEMVTELSTGITTF 253
Cdd:cd13137 168 YVLIfglwGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKISFKgfRLDRKIIKKLLRIGLPAGLEQLLRSLGFL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 254 LFNVVALKLaGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIALVF 333
Cdd:cd13137 248 VLLAIVASY-GTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLLGLLLFIF 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 334 APFIVRVFvSPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFVFIIIGIIILPPMLNM--T 411
Cdd:cd13137 327 APPLASLF-TPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLGFVLGLglT 405
|
410 420
....*....|....*....|....*
gi 489534622 412 GLWLTVPFAEVITIFISILFIKKYK 436
Cdd:cd13137 406 GIWLAMFVDTIVRAILLLYRFRKGK 430
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-434 |
2.51e-40 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 149.65 E-value: 2.51e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 20 PAIISMIFISLYTIIDGIFVSTLvGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFS 99
Cdd:cd13142 19 PIIVSNLLQVAYNLADTFWLGRL-GADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAGDYDKANKVAGQTFSFV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 100 LIVGILFTVISYFFIKEI-SILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVTNIIL 178
Cdd:cd13142 98 IILSLILAVLGYILSRPLlLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKIMFGSVLLNVIL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 179 DYVFI----KYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKSTLKLRKP--KTDFRLIRDTM---INGSSEMVTElSTG 249
Cdd:cd13142 178 DPLLIfgigPFPGLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKISLRdlKPDWEWLKKIFrigLPSSIEQSAR-ALG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 250 ITTFLFNVVALklaGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFII 329
Cdd:cd13142 257 FTVMTALVAGF---GTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLILVIGGVL 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 330 ALVFAPFIVRVFVsPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFVFIIIGIIILPPMLN 409
Cdd:cd13142 334 AFLFAEPIVRVFI-NDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPLAYLLAYVLG 412
|
410 420
....*....|....*....|....*..
gi 489534622 410 M--TGLWLTVPFAEVITIFISILFIKK 434
Cdd:cd13142 413 LgvTGIWIAMAISNIVAALIALAWFKR 439
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-431 |
5.90e-38 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 143.14 E-value: 5.90e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 20 PAIISMIFISLYTIIDGIFVSTLvGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFS 99
Cdd:cd13139 22 PMVLEMVMESLFAVVDLYFVSRL-GALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGAGFAAVQAILLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 100 LIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVTNIILD 179
Cdd:cd13139 101 VALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWLANGLNIILD 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 180 YVFIKYFG----MGLLGAAVATAIGIILTCVLGIIYFLSNKSTLKLRKP--KTDFRLIRDTMINGSSEMVTELsTGITTF 253
Cdd:cd13139 181 PLFIFGLGpipaMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQIRRRhlKLDWAIIKKIIKIAVGGILQFL-IASSSW 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 254 LFNVVALKLAGENGLAALTIVL--YAHFLMTSVYLGFAAGVspLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIAL 331
Cdd:cd13139 260 IFLVRIIAEFGSTALAGYTIAIriIMFALLPAWGLSNAAAT--LVGQNLGAGQPDRAEKSVWRAGKYNMVFLGIVSLVFF 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 332 VFAPFIVRVFvSPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFVFIIIGIIILPPMLNM- 410
Cdd:cd13139 338 LFAEPLVSFF-TTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPLAYLLARHLNLg 416
|
410 420
....*....|....*....|...
gi 489534622 411 -TGLWLTVPFAE-VITIFISILF 431
Cdd:cd13139 417 pKGVFIAIPIAEtVLAIAAIILF 439
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
20-360 |
1.63e-36 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 136.99 E-value: 1.63e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 20 PAIISMIFISLYTIIDGIFVSTLvGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFS 99
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHL-GPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 100 LIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVTNIILD 179
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 180 YVFI--KYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKST--LKLRKPKTDFRLIRDTMINGSSEMVTELSTGITTFLF 255
Cdd:TIGR00797 160 YILIfgKFGFLGIVGAALATVISYWLMFLLLLYYIKKAKKIglKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 256 NVVALKLaGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIALVFAP 335
Cdd:TIGR00797 240 ALLVARL-GSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFRE 318
|
330 340
....*....|....*....|....*
gi 489534622 336 FIVRVFVSpDNTVFKLALQGLKIFA 360
Cdd:TIGR00797 319 FIARLFTN-DPEVLELAAIYLIFVA 342
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
15-434 |
3.28e-35 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 135.12 E-value: 3.28e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 15 LKFVSPAIISMIFISLYTIIDGIFVSTLvGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSF 94
Cdd:cd13149 12 IKLTLPMIFGILAMLIFNLTDTFFVGKL-GTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNKAKRLATD 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 95 IVLFSLIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVT 174
Cdd:cd13149 91 SLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVMLGAALV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 175 NIILDYVFIKYFG----MGLLGAAVATAIGIILTCVLGiIYFLSNKSTL---KLRKPKTDFR----LIRDTMINGSSEMV 243
Cdd:cd13149 171 NVILDPILIFGFGpipgMGIAGAAIATVISRALGLGAA-LYFLHYHHRLidfSEPSLKALFRswkdILSIGIPAALSNIL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 244 TELSTGITTFLfnvvaLKLAGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSS 323
Cdd:cd13149 250 TPLSAAFITAL-----VATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIYG 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 324 LLVFIIALVFAPFIVRVFvSPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFVFIIIGIII 403
Cdd:cd13149 325 AILGIVLALFAGWLASLF-SAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYIPLAYV 403
|
410 420 430
....*....|....*....|....*....|.
gi 489534622 404 LPPMLNMTGLWLTVPFAEVITIFISILFIKK 434
Cdd:cd13149 404 GSHLLGFAGVFIGALAGNLIAGILAYFIAKK 434
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
13-415 |
3.23e-32 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 126.91 E-value: 3.23e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 13 EFLKFVSPAIISMIFISLYTIIDGIFVSTLVGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTF 92
Cdd:cd13136 4 EILALALPAILSNITVPLLGLVDTAVVGHLGSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAIALL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 93 SFIVLFSLIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGG 172
Cdd:cd13136 84 VRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQIVGN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 173 VTNIILDYVFIKYFGMGLLGAAVATAIGIILTCVLGIIYFL--SNKSTLKLRKPKTDFRLIRDTMINGSSEMVTELSTGI 250
Cdd:cd13136 164 VVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRrrVRLLGKSLSRRLPSKAALKRLFKLNRDIFIRTLALLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 251 TTFLFNVVALKLaGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIA 330
Cdd:cd13136 244 AFLFFTALAARL-GDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLALLF 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 331 LVFAPFIVRVFvSPDNTVFKLALQGLkIFAFAFLFVGINIFA-SGFFTAFHNGKISAIISFSrAFVFIIIGIIILPPMLN 409
Cdd:cd13136 323 FLGGEPIIRLF-TDDPAVLALAATYL-PWLALLPPIGALAFVlDGIFIGATDTRYLRNSMLV-SLAVFLPLLFLLVPLWG 399
|
....*.
gi 489534622 410 MTGLWL 415
Cdd:cd13136 400 NHGLWL 405
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
22-436 |
8.68e-31 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 123.02 E-value: 8.68e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 22 IISMIFI-SLYTIIDGIFVSTLvGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFSL 100
Cdd:cd13140 14 IMGTSFIqMAYNLTDMFWVGRL-GSDAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEARKYARNALQLNL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 101 IVGILFTVISYFFIKEISILLGATDKLLPY-CITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVTNIILD 179
Cdd:cd13140 93 LLGILYGLLLLLFAKPLIGFFNLGDAEVISlAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINAIGLVLNIILD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 180 YVFIKYFG----MGLLGAAVATAIGIILTCVLGIIYFLSNKSTLKLRKPKT--DFRLIRDTMINGssemvteLSTGITTF 253
Cdd:cd13140 173 PLLIFGFGpfpaLGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKrpDRKYIKEILKLG-------LPVALQSI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 254 LFNVVALKLA------GENGLAALTI--VLYAHFLMTSVylGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLL 325
Cdd:cd13140 246 LFALISMILAriiasfGPVAIAAQKVgsQIESISWMTAE--GFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAIGLF 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 326 VFIIALVFAPFIVRVFVsPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFVFIIIGIIILP 405
Cdd:cd13140 324 ATLLLFFFGEPLFSLFI-PDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISIVFNGLRIPLALLLSP 402
|
410 420 430
....*....|....*....|....*....|..
gi 489534622 406 PMLNMTGLWLTVPFAEVIT-IFISILFIKKYK 436
Cdd:cd13140 403 TGLGLNGIWWAISISSILKgIILTIWFLLYKK 434
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-378 |
1.64e-29 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 119.53 E-value: 1.64e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 20 PAIISMIFISLYTIIDGIFVSTlVGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFS 99
Cdd:cd13134 11 PIFIELLLQMLLGTIDTFMLSR-YSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAGVALLFN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 100 LIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVTNIILD 179
Cdd:cd13134 90 LLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILNIVGN 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 180 YVFIKYFG----MGLLGAAVATAIGIILTCVLGIIYFLSNKSTLKLRKP--KTDFRLIRDTMINGSSEMVTELSTGITTF 253
Cdd:cd13134 170 YLLIFGWFglpkLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDlrPFPKKLLKKILKIGLPSAGEELSYNLSQT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 254 LFNVVALKLaGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIALVF 333
Cdd:cd13134 250 VITAFIARL-GTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAVALLLALF 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 489534622 334 APFIVRVFvSPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTA 378
Cdd:cd13134 329 REPILGLF-TDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRA 372
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-430 |
1.78e-29 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 119.43 E-value: 1.78e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 20 PAIISMIFISLYTIIDGIFVSTLVGSDA--LASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVL 97
Cdd:cd13146 16 PILIGQLFQLLYNITDTIWISMIDPSDPalVGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGAQRAKELDQAADSGLA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 98 FSLIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVTNII 177
Cdd:cd13146 96 LALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 178 LDYVFIKYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKS--TLKLRKPKTDFRLIRDTMINGSSEMVTELSTGITTFLF 255
Cdd:cd13146 176 LDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGKSnvTIHIKLSNISSSVIVEILRVGLPQMLLQLISSISFLIY 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 256 NVVALKLAgENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIALVFAP 335
Cdd:cd13146 256 NRIIIDID-PVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAP 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 336 FIVRVFvSPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFVFIIIGIIILPPMLNM--TGL 413
Cdd:cd13146 335 WLFSLF-TTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLLAYVFGKgiTGV 413
|
410
....*....|....*..
gi 489534622 414 WLTVPFAEVITIFISIL 430
Cdd:cd13146 414 YFGIVSANFFTALLAMF 430
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-370 |
3.84e-27 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 112.62 E-value: 3.84e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 20 PAIISMIFISLYTIIDGIFVSTlVGSDALASiniVLP--IINLVC-GFGIMMATGGGAIVSIRMGENRQDEANSTFSFIV 96
Cdd:cd13133 13 PLVLSMLSQTVMGFTDRAFLGR-LSEVALAA---SGPagVLYFAIlMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLWQGL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 97 LFSLIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVTNI 176
Cdd:cd13133 89 YFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMVVVNI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 177 ILDYVFIkyFG------MGLLGAAVATAIGIILTCVLGIIYFLSNK-----STLKLRKPktDFRLIRDTMINGSSEMVTE 245
Cdd:cd13133 169 VLDYALI--FGklgfpaMGIAGAAIATVIAEAVSLLFFLLLLFRRKnrrrfGLRRAWRF--DRELLRRILRLGLPSGLQF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 246 LsTGITTFLFNVVALKLAGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLL 325
Cdd:cd13133 245 F-LDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLL 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 489534622 326 VFIIALVFAPFIVRVFVSPDNT--VFKLALQGLKIFAFAFLFVGINI 370
Cdd:cd13133 324 LGILFLLFPELLLSIFTPGADFalIAELAVPLLRFVAAYILFDALAL 370
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-434 |
1.93e-25 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 107.79 E-value: 1.93e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 20 PAIISMIFISLYTIIDGIFVSTLvGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFS 99
Cdd:cd13141 19 PIAIGMIIQTLYFLVDLYFVGQL-GDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEANAVFNQSLLLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 100 LIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMIlctPFYILKFIFEYFA---RTDGNSKFSLFLSVIGGVTNI 176
Cdd:cd13141 98 AVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYWFI---PSLALQFILTVLGaalRGTGIVKPFMVIQILAVLLNI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 177 ILDYVFIKYFG----MGLLGAAVATAIGIILTCVLGIIYFLSNKSTLKLRKP--KTDFRLIRDTMINGSSEMVTELSTGI 250
Cdd:cd13141 175 ILAPILITGWGtgraLGVAGAGLASSISVAIAVVLLLYYFLRLEKYLRLDLAlwRPDLPTWKRLLKIGLPSGGEFLLTFV 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 251 TTFLfNVVALKLAGENGLAALTI---VLYAHFlMTSVYLGFAAGvsPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVF 327
Cdd:cd13141 255 YMAV-IYWALRPFGAAAQAGFGIgsrIMQSLF-LPAMAIAFAAP--AIAGQNFGAGNYDRVRETFRITAILTTALMLVLT 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 328 IIALVFAPFIVRVFvSPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFVFII-IGIIILPP 406
Cdd:cd13141 331 LLCQLVPELLVTPF-SDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSLLSSASRLLTFALpVIWLSAQP 409
|
410 420
....*....|....*....|....*...
gi 489534622 407 MLNMTGLWLTVPFAEVITIFISILFIKK 434
Cdd:cd13141 410 DFRIEQIWYLSVATTILQAALSLLLLRR 437
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-435 |
5.72e-25 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 106.53 E-value: 5.72e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 20 PAIISMIFISLYTIIDGIFVStLVGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFS 99
Cdd:cd13145 17 PASVGFFFNTMFNVVDTFFAG-KISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 100 LIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVTNIILD 179
Cdd:cd13145 96 IILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIGFFLNIILD 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 180 YVFI----KYFGMGLLGAAVATaigiILTCVLGIIYFLS------NKSTLKLRKPKTDFRLIRDTMINGSSEMVTELSTG 249
Cdd:cd13145 176 PLFIfgggGIPAMGVSGIALAT----IISQFIGMFYLLYkvrksgIISGCRLRDFIPRLDVYKEILKQGFPASLNMMTIG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 250 ITTFLFnVVALKLAGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFII 329
Cdd:cd13145 252 LGIFVI-TYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVATVF 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 330 ALVFAPFIVRVFvSPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFVFIIIGIIILPPMLN 409
Cdd:cd13145 331 LLFFAEPLMSLF-TNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGLKRPIFALWIGLYRQLVGPALVFWLLVNVLG 409
|
410 420
....*....|....*....|....*...
gi 489534622 410 --MTGLWLTVPFAEVITIFISILFIKKY 435
Cdd:cd13145 410 lgVTGIWWGIFTIVWSAAIIALLYTRRV 437
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
20-181 |
7.18e-19 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 83.38 E-value: 7.18e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 20 PAIISMIFISLYTIIDGIFVStLVGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFS 99
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVG-HLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 100 LIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVTNIILD 179
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 489534622 180 YV 181
Cdd:pfam01554 160 YL 161
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
13-390 |
2.22e-18 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 86.78 E-value: 2.22e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 13 EFLKFVSPAIISMIFISLYTIIDGIFVStLVGSDALASI----NIVLPIInlVCGFGIMMATGggAIVSIRMGENRQDEA 88
Cdd:cd13131 4 ALLRLALPILIAQLAQMAMGFVDTVMAG-RLGADDLAAValgsSLWFPVF--TFGMGLLLAVT--PLVAQAHGAGDRRRI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 89 NSTFSFIVLFSLIVGILFTVIsYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLS 168
Cdd:cd13131 79 RRAVRQGLWLALLLSLPLMLL-LWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVIT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 169 VIGGVTNIILDYVFIK-YFG---MGLLGAAVATAIGIILTCVLGIIYFLSNKST----LKLRKPKTDFRLIRDTMINGss 240
Cdd:cd13131 158 LLALVLNIPLNYVLIFgKFGlpaLGGAGAGLATAIVYWLMFLALAFYIRRHKRFrryrLFARFWRPDWARLKELLRLG-- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 241 emvteLSTGITTF----LFNVVALKLA--GENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKH 314
Cdd:cd13131 236 -----LPIGLTIFfevsLFAAVALLMGrlGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLV 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489534622 315 SLKFIFVSSLLVFIIALVFAPFIVRVFvSPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISF 390
Cdd:cd13131 311 GLGLGVGFAALTALLLLLFPEQIAGLY-TNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLAL 385
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-436 |
1.32e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 81.57 E-value: 1.32e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 20 PAIISMIFISLYTIIDGIFVSTlVGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFS 99
Cdd:cd13135 9 PLILQNLVSQLQMLVDRAFLGR-ISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAISSIVYN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 100 LIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVTNIILD 179
Cdd:cd13135 88 SIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLLNVILD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 180 YVFIkyFG------MGLLGAAVATAIGIILTCVLGIIY-FLSNKSTLKLR---KPKTDFRLIRDTMINGSSEMVTELSTG 249
Cdd:cd13135 168 YVLI--FGnfgfprLGIIGAAIATTIANVLNLIILVYLcRKIKKLTFKLSntkVLKANIRPYKFTIKLGLPLGGEEFLWN 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 250 ITTFLFNVVALKLaGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFII 329
Cdd:cd13135 246 IGNLAVIRILNRI-GELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIAAAIV 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 330 ALVFAPFIVRVFVSpDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIIS-FSRAFVFIIIGIIILPPML 408
Cdd:cd13135 325 FLAFPYKILSLFTN-DPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQiIGTIIVVSVALLLIFVFKL 403
|
410 420
....*....|....*....|....*...
gi 489534622 409 NMTGLWLTVPFAEVItifISILFIKKYK 436
Cdd:cd13135 404 GLAGVYITLFIDEII---RAIINFLKYR 428
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
15-374 |
7.84e-15 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 76.07 E-value: 7.84e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 15 LKFVSPAIISMIFISLYTIIDGIFVSTLvGSDALASINIVLPIINlVCGFGIM--MATGGGAIVSIRMGENRQDEANSTF 92
Cdd:cd13132 6 LRLAAPLVLTSLLQYSLSVVSVVFVGHL-GKLELAAASLASSFAN-VTGFSILlgLASALDTLCGQAFGAKNYKLVGVYL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 93 --SFIVLFSLIVGILFTvisYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVI 170
Cdd:cd13132 84 qrALVILLLCCVPISLL---WLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 171 GGVTNIILDYVFIKYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKSTLKLRKPKT--DFRLIRDTMINGSSEMVTELST 248
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSreAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 249 GITTFLFNVVALKLAGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFI 328
Cdd:cd13132 241 WWAFEILVLLAGLLPGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVAI 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 489534622 329 IALVFAPFIVRVFvSPDNTVFKLALQGLKIFAFAFLFVGINIFASG 374
Cdd:cd13132 321 LLLVLRDVWAYLF-TSDEEVIALVADLLPILALFQIFDGLQAVLSG 365
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
15-373 |
1.76e-14 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 75.00 E-value: 1.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 15 LKFVSPAIISMIFISLYTIIDGIFVSTLvGSDALASINIVLPIINLVcgfgIMMATG--GGAI---VSIRMGENRQDEAN 89
Cdd:cd13148 15 LRLALPNILALLVQTLVGLAETYFVGQL-GTDALAGVALVFPLLMLT----QMMSNGamGGGVssaIARALGAGDRERAE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 90 STFSFIVLFSLIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSV 169
Cdd:cd13148 90 ALVWHALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALVTL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 170 IGGVTNIILDYVFIKYFG----MGLLGAAVATAIGIILTCVLGIIYFLSNKSTLKLRK--PKTDFRLIRDTMINGSSEMV 243
Cdd:cd13148 170 VGAVVQIPLSPGLILGWGplprLGVAGAAVAAVLYYALAALVLLRYLASGRSRLRLRLraLRLERRLFRDILRVGLLAAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 244 TELSTGITTFLFnVVALKLAGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETfkhSLKFIFVSS 323
Cdd:cd13148 250 SPLQTNLTVLLL-TGLVGRFGTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQIARARRI---AWTGALMAA 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 489534622 324 LLVFIIALVFAPF---IVRVFvSPDNTVFKLALQGLKIFAFAFLFVGINI---FAS 373
Cdd:cd13148 326 VLAGAIGLVLALFpelWLGLF-THDPAVLAAGASYLRIVGPFYGFFGLGLalyFAS 380
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
264-395 |
1.46e-09 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 56.80 E-value: 1.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 264 GENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIALVFAPFIVRVFvS 343
Cdd:pfam01554 24 GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGLLLSLPIALLVLLFSEPILSLF-G 102
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 489534622 344 PDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFV 395
Cdd:pfam01554 103 QDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLL 154
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
22-390 |
2.17e-09 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 59.09 E-value: 2.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 22 IISMIFISLYTIIDGIFVSTLVGSDALASINIVLPIINLvcgFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFSLI 101
Cdd:cd13128 9 FVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGL---FSIFADLGLPTALVREIARYRKEKIREIISTSLVLKLI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 102 VGILFTVISYFFIKEISILLGATDKLLpycitygKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVTNIILDYV 181
Cdd:cd13128 86 LGILALLLLFLFAFLIAFYDPELVLLL-------YILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILALI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 182 FIkYFGMGLLGAAVATAIGIILTCVLGIIYFLsnKSTLKLRKPKTDFRLIRDTMINGSSEMVTELSTGITTFLFNVVALK 261
Cdd:cd13128 159 LV-LLGGGLIGFALAYLIASVLSAILLLYIYR--KKILLPKFFSFDLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGY 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 262 LAGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFgAENSDKLKETFKHSLKFIFVSSLLVFIIALVFAPFIVRVF 341
Cdd:cd13128 236 FLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELY-KNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLL 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 489534622 342 VSPDntvFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISF 390
Cdd:cd13128 315 FGEE---YLPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILL 360
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
13-212 |
4.96e-09 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 57.94 E-value: 4.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 13 EFLKFVSPAIISMIFISLYTIIDGIFVSTLVGSDALASINIVLPIINLVCGFGIMMATgggAI--VSIRMGENRQDEANS 90
Cdd:cd13128 207 ELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAAVGIYNAAYRIAELLLFIPSAIST---ALfpRISELYKNDKDELKK 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 91 TFSFIVLFSLIVGILFTVISYFFIKEISILLGATDKLLPycITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVI 170
Cdd:cd13128 284 LLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYLPA--ALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLI 361
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 489534622 171 GGVTNIILDYVFIKYFGMglLGAAVATAIGIILTCVLGIIYF 212
Cdd:cd13128 362 GALLNVILNLLLIPKYGI--IGAAIATLISEFIIFILLLYLL 401
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
1-213 |
1.77e-07 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 53.10 E-value: 1.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 1 MENLFTRKFTTFEFLKFVSPAIISMIFISLYTIIDGIFVSTLVGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRM 80
Cdd:cd12082 208 LSLLKPDLELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 81 GENRQDEANSTFSFIVLFSLIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGN 160
Cdd:cd12082 288 GAGNFDRARRITWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGR 367
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 489534622 161 SKFSLFLSVIGGVTNIILDYVFIKYFGMGLLGAAVATAIGIILTCVLGIIYFL 213
Cdd:cd12082 368 TLKSLIVSLLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
13-216 |
3.56e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 52.12 E-value: 3.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 13 EFLKFVSPAIISMIFISLYTIIDGIFVSTLvGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTF 92
Cdd:cd13134 229 KILKIGLPSAGEELSYNLSQTVITAFIARL-GTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRV 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 93 SFIVLFSLIVGILFTVISYFFIKEISILLGATDKLlpycITYGKVMILCT----PFYILKFIFEYFARTDGNSKFSLFLS 168
Cdd:cd13134 308 LKSLKIGLLVSLAVALLLALFREPILGLFTDDPEI----IALGKTLLLISillePGRAFNIVLIGSLRAAGDARFPVLIG 383
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 489534622 169 VIG--GVTnIILDYVFIKYFGMGLLGAAVATAIGIILTCVLGIIYFLSNK 216
Cdd:cd13134 384 IISmwGIS-VPLAYLLGIVLGLGLLGVWIAFAADEWVRGIIMLWRWRSGK 432
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
14-407 |
6.46e-07 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 51.10 E-value: 6.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 14 FLKFVSPAIISMIFISLYTIIDGIFVSTLVGSDALASINIVLPIINLvcgFGIMMATGGGAIVSIRMGENRQDEANSTFS 93
Cdd:COG2244 4 LLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVAL---LSVLADLGLSTALVRFIAEYREEELRRLLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 94 FIVLFSLIVGILFTVISYFFIKEISILLGATDKLLPYCItygkvMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGV 173
Cdd:COG2244 81 TALLLRLLLSLLLALLLLLLAPFIAALLGEPELALLLLL-----LALALLLSALSAVLLALLRGLERFKLLALINILSSL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 174 TNIILDYVFIkYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKstlklrkpktdfrlirdtmingssemvtelstgittf 253
Cdd:COG2244 156 LSLLLALLLA-LLGLGLWGLVLKYSLPLLLSGLLGLLLTNLDR------------------------------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 254 lfnVVALKLAGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIALVF 333
Cdd:COG2244 198 ---LLLGALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALL 274
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489534622 334 APFIVRVFVSPDntvFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFVFIIIGIIILPPM 407
Cdd:COG2244 275 APPLLSLLFGPE---YAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRY 345
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
264-390 |
7.00e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 51.37 E-value: 7.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 264 GENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIALVFAPFIVRVFVS 343
Cdd:cd13133 36 SEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLWQGLYFSLLLAPLLALLSALAAPLLFLLLGH 115
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 489534622 344 PDNtVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISF 390
Cdd:cd13133 116 SPE-VQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANL 161
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
82-434 |
1.81e-05 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 47.07 E-value: 1.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 82 ENRQDEANSTFSFIVLFSLIVGILFTVISYFFIKEISILL--GATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDG 159
Cdd:COG0728 71 KEGEEEARRFASRVLTLLLLVLLVLTLLGILFAPLLVKLLapGFDPEKFALAVALTRIMFPYILFIGLSALLGGVLNARG 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 160 NSKFSLFLSVIGGVTNIILDYVFIKYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKSTLKLRKPKTDFRLiRDTMINGS 239
Cdd:COG0728 151 RFAAPALAPVLLNLVIIAGLLLLAPLFGPGIYALAWGVLLGGVLQLLIQLPALRRLGLRLRPRFDLRDPGV-RRVLKLML 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 240 SEMVTELSTGITTFLFNVVALKLaGENGLAALTivlYAHFLMTSVYLGFAAGVS----PLISYNFGAENSDKLKETFKHS 315
Cdd:COG0728 230 PALLGVSVSQINLLVDTILASFL-PEGSVSALY---YADRLYQLPLGLFGVAIGtallPRLSRAAAAGDLEEFRRTLSRG 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 316 LKFIFVSSLLVFIIALVFAPFIVRVF-----VSPDNTVfkLALQGLKIFAFAFLFVGIN-IFASGFFtAFHNGKISAIIS 389
Cdd:COG0728 306 LRLVLLLTLPAAVGLIVLAEPIVRLLfergaFTAEDTA--LTALALAAYALGLPAFALVkVLARAFY-ARQDTRTPVRIA 382
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 489534622 390 FSrAFVFIIIGIIILPPMLNMTGLWLTVPFAEVITIFISILFIKK 434
Cdd:COG0728 383 VI-AVVVNIVLNLLLVPPLGHAGLALATSLSALVNALLLLVLLRR 426
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
13-212 |
2.25e-04 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 43.21 E-value: 2.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 13 EFLKFVSPAIISMIFISLYTIIDGIFVSTLvGSDALASINIVLPIINLVCG-FGIMMATgggAI---VSIRMGENRQDEA 88
Cdd:cd13123 216 RVLKLMLPALLGVSVSQINLLVDTILASFL-PEGSISALYYADRLYQLPLGiFGVAIAT---ALlprLSRLAAAGDLDEF 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 89 NSTFSFIVLFSLIVGILFTVISYFFIKEISILL---GATDK---------LLPYCITygkvmilcTPFYILKFIFE--YF 154
Cdd:cd13123 292 RRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLferGAFTAedtlmtasaLAAYALG--------LPAFALVKLLSraFY 363
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 489534622 155 ARtdGNSKFSLFLSVIGGVTNIILDYVFIKYFGMGllGAAVATAIGIILTCVLGIIYF 212
Cdd:cd13123 364 AL--KDTKTPVKIAVIAVAVNILLNLLLIKPLGHV--GLALATSLSAWVNALLLLVLL 417
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
82-407 |
2.27e-04 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 43.21 E-value: 2.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 82 ENRQDEANSTFSFIVLFSLIVGILFTVISYFFIKEISILL--GATDKLLPYCITYGKVMILCTPFYILKFIFeyfartDG 159
Cdd:cd13123 64 KEGEEEARRFASRVLTLLLLVLLLLTLLGILFAPLLVKLLapGFSGDKFELAVALTRIMFPYLLFISLSALL------GG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 160 --NSKFSLFLSVIGGVTN----IILDYVFIKYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKSTLKLRKPKTD------ 227
Cdd:cd13123 138 ilNAHGRFFAPALAPVLLnlviIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRLDFRDpgvrrv 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 228 FRLIRDTMINGSsemVTELSTGITTFLFNvvalkLAGENGLAALTivlYAHFLMTSVYLGFAAGVS----PLISYNFGAE 303
Cdd:cd13123 218 LKLMLPALLGVS---VSQINLLVDTILAS-----FLPEGSISALY---YADRLYQLPLGIFGVAIAtallPRLSRLAAAG 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 304 NSDKLKETFKHSLKFIFVSSLLVFIIALVFAPFIVRVF-----VSPDNTVfkLALQGLKIFAFAFLFVGIN-IFASGFFt 377
Cdd:cd13123 287 DLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLfergaFTAEDTL--MTASALAAYALGLPAFALVkLLSRAFY- 363
|
330 340 350
....*....|....*....|....*....|
gi 489534622 378 AFHNGKISAIISFSRAFVFIIIGIIILPPM 407
Cdd:cd13123 364 ALKDTKTPVKIAVIAVAVNILLNLLLIKPL 393
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
14-365 |
2.45e-04 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 43.26 E-value: 2.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 14 FLKFVSPAIISMIFISLYTIIDGIfVSTLVGSDALASI----NIVLPIInlVCGFGIMMATGggAIVSIRMGENRQDEAN 89
Cdd:PRK01766 14 LLALALPILLAQVAQTAMGFVDTV-MAGGVSATDLAAVaigtSIWLPVI--LFGHGLLLALT--PIVAQLNGAGRRERIA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 90 STFSFIVLFSLIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSV 169
Cdd:PRK01766 89 HQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVIGF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 170 IGGVTNIILDYVFI-KYFGM---GLLGAAVATAIGIILTCVLGIIYFLSNKSTLKLRKPKT----DFRLIRDTMINGsse 241
Cdd:PRK01766 169 LGLLINIPLNYIFIyGKFGFpelGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLFKGlykpDWAVIKRLLKLG--- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 242 mvteLSTGITTF----LFNVVALKLA--GENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHS 315
Cdd:PRK01766 246 ----LPIGLAIFfevsLFAVVTLLVSplGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 489534622 316 LKFIFVSSLLVFIIALVFAPFIVRVFVSpDNTVFKLALQgLKIFAFAFLF 365
Cdd:PRK01766 322 LAVGLGMALLTAIFLVLFREQIALLYTD-DPEVVALASH-LLLFAALFQF 369
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
253-387 |
2.47e-04 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 43.23 E-value: 2.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 253 FLFNVVALKLAGENGLAALTIV--LYAHFLMTSVYlGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIA 330
Cdd:cd13124 15 AIYRIPLQNIIGDEGMGLYQMAypIYGIFLTLATA-GIPVAISKLVAEYNALGDYKGARRIFRVSLILLLILGLVFFLLL 93
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 489534622 331 LVFAPFIVRVFVSPDNTVFklalqGLKIFAFAFLFVGINIFASGFFTAFHNGKISAI 387
Cdd:cd13124 94 FFGAPFLAQLLLGDPRLAP-----VIRALAPAILIVPLLSVLRGYFQGLQNMTPTAV 145
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
13-211 |
3.08e-04 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 42.84 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 13 EFLKFVSPAIISMIFISLYTIIDGIFV-----STLVGSDALASI-----NIVLPIINLVCGFGIMMATGGGAIVSIRMGE 82
Cdd:cd13124 225 ELLSYAIPITLSSLILPLLQLIDSFTVprrlqAAGLSESEATALygiltGRAQPLVQLPTVIATALSTSLVPAISEAYAK 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 83 NRQDEANSTFSFIVLFSLIVGILFTVISYFFIKEISILLGATDKLlpycITYGKVMILCTPFYILKFIFEYFARTDGNSK 162
Cdd:cd13124 305 GDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSEG----GLILQILAPSILFLSLQQVTAAILQGLGKVK 380
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 489534622 163 FSLFLSVIGGVTNIILDYVFIKYFGMglLGAAVATAIGIILTCVLGIIY 211
Cdd:cd13124 381 IPVINLLIGLLVKIVLNYVLIPIFGI--YGAAIATVIGFLVAALLNLRA 427
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
13-213 |
5.75e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 42.11 E-value: 5.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 13 EFLKFVSPAIISMIFISLYTIIDGIFVSTLVGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTF 92
Cdd:cd13143 227 EILALGFPSFLMQLSSSVVTIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQAL 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 93 SFIVLFSLIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVI-G 171
Cdd:cd13143 307 KLALIVALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLrQ 386
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 489534622 172 GVTNIILDYVFIKYFGMGllGAAVATAIGIILTCVLGIIYFL 213
Cdd:cd13143 387 GLFLIPLLLILPRLFGLD--GIWLAFPLAEILTLLLALILLK 426
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
13-212 |
7.56e-04 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 41.67 E-value: 7.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 13 EFLKFVSPAIISMIFISLYTIIDGIFVSTLVGSdALASINIVLPIINLVCG-FGIMMATGGGAIVSIRMGENRQDEANST 91
Cdd:COG0728 223 RVLKLMLPALLGVSVSQINLLVDTILASFLPEG-SVSALYYADRLYQLPLGlFGVAIGTALLPRLSRAAAAGDLEEFRRT 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 92 FSFIVLFSLIVGILFTVISYFFIKEISILLGATDKLLPYCI--TYGKVMILCT--PFYILKFIFE--YFARtdGNSKFSL 165
Cdd:COG0728 302 LSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFERGAFTAEDTalTALALAAYALglPAFALVKVLAraFYAR--QDTRTPV 379
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 489534622 166 FLSVIGGVTNIILDYVFIKYFGMGllGAAVATAIGIILTCVLGIIYF 212
Cdd:COG0728 380 RIAVIAVVVNIVLNLLLVPPLGHA--GLALATSLSALVNALLLLVLL 424
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
22-435 |
1.41e-03 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 40.91 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 22 IISMIFIslytiidgIFVSTLVGSDALASINIVLPIINLVcgfgIMMATGG--GAI---VSIRMGENRQDEANSTFSFIV 96
Cdd:cd13124 12 ILGAIYR--------IPLQNIIGDEGMGLYQMAYPIYGIF----LTLATAGipVAIsklVAEYNALGDYKGARRIFRVSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 97 LFSLIVGILFTVISYFFIKEISILLGATDKLLPycitygkvmilctPFYILKFIFEYFArtdgnskfslFLSVIGG---- 172
Cdd:cd13124 80 ILLLILGLVFFLLLFFGAPFLAQLLLGDPRLAP-------------VIRALAPAILIVP----------LLSVLRGyfqg 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 173 -------------------VTNIILDYVFIKYFG---MGLLGAAVATAIGIILTCVLGIIYFLSNKSTLKLRKPKTDFRL 230
Cdd:cd13124 137 lqnmtptavsqvieqivrvIVILVLAYLLLPVGGglyYAAAGATFGAVIGALAGLLVLLYYYRKKRRELKRLLRKSPRSK 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 231 IRDTMINGS----------SEMVTELSTGITTFLFNVvALKLAGENGLAALtiVLYAHF---------LMTSVYLGFAAG 291
Cdd:cd13124 217 ISTKEILKEllsyaipitlSSLILPLLQLIDSFTVPR-RLQAAGLSESEAT--ALYGILtgraqplvqLPTVIATALSTS 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534622 292 VSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIALVFAPFIVRVFVSPDNtvfklALQGLKIFAFAFLFVGINIF 371
Cdd:cd13124 294 LVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSE-----GGLILQILAPSILFLSLQQV 368
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489534622 372 ASGFFTAFHNGKISAIISFSrAFVFIIIGIIILPPMLNMTGLWLTVPFAEVITIFISILFIKKY 435
Cdd:cd13124 369 TAAILQGLGKVKIPVINLLI-GLLVKIVLNYVLIPIFGIYGAAIATVIGFLVAALLNLRALKKL 431
|
|
| |
