|
Name |
Accession |
Description |
Interval |
E-value |
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
2-419 |
0e+00 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 733.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 2 YNKETICVQGNYKPGN-GEPRVLPLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVS 80
Cdd:COG2873 6 YGFETLALHAGQEPDPtTGARAVPIYQTTSYVFDDAEHAADLFALKEPGNIYTRIMNPTTDVLEKRIAALEGGVAALATA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 81 SGQSANMLAVLNICKSGDSILCSSKVYGGTFNLLGPSLKKFGIDLISFDLDSsEDEIVELAKENTKVVFAETLANPTLEV 160
Cdd:COG2873 86 SGQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDD-PEAFEAAIDPNTKAIFGETIGNPALDV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 161 IDFEKIANVAKRINVPFIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGNFNWD-NGKFPELVEPDP 239
Cdd:COG2873 165 LDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVDGGNFDWAaNGKFPELTEPDP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 240 TYHGISYTQKFGNAAYATKARVQLLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLE 319
Cdd:COG2873 245 SYHGLVYTEAFGNAAFITKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNYPGLP 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 320 DNKYYENAKKYLSRGCSGVLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLI 399
Cdd:COG2873 325 SHPYHELAQKYLPKGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAGVTPDLI 404
|
410 420
....*....|....*....|
gi 489534710 400 RLSVGIENVEDLIADLNQAL 419
Cdd:COG2873 405 RLSVGIEDIDDIIADLDQAL 424
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
3-419 |
0e+00 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 612.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 3 NKETICVQGNYKPGNGE-PRVLPLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSS 81
Cdd:TIGR01326 1 HFETLQLHAGQEPDPTTgSRAVPIYQTTSYVFDSTEHAAALFGLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 82 GQSANMLAVLNICKSGDSILCSSKVYGGTFNLLGPSLKKFGIDLISFDLDSSEdEIVELAKENTKVVFAETLANPTLEVI 161
Cdd:TIGR01326 81 GQAAITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPE-SLEKAIDENTKAVFAETIGNPQINVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 162 DFEKIANVAKRINVPFIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGNFNWDNGKFPELVEPDPTY 241
Cdd:TIGR01326 160 DIEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVDGGKFDWNNGRFPLFTTPDPSY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 242 HGISYTQKFGNAAYATKARVQLLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDN 321
Cdd:TIGR01326 240 HGLVFTETLGNPAFILKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASH 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 322 KYYENAKKYLSRGCSGVLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRL 401
Cdd:TIGR01326 320 PHHALAKKYLPKGFGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIRL 399
|
410
....*....|....*...
gi 489534710 402 SVGIENVEDLIADLNQAL 419
Cdd:TIGR01326 400 SVGIENIDDIIADLEQAL 417
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
2-419 |
0e+00 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 592.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 2 YNKETICVQGNYKPGNGEPRVLPLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSS 81
Cdd:PRK06702 5 WGKGTICVQGGYTPKNGEPRVLPLYQSTTYKYDTSDDLAALFNLEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATAS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 82 GQSANMLAVLNICKSGDSILCSSKVYGGTFNLLGPSLKKFGIDLISFDLDSSEDEIVELAKENTKVVFAETLANPTLEVI 161
Cdd:PRK06702 85 GQAAIMLAVLNICSSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTFFNPNLTADEIVALANDKTKLVYAESLGNPAMNVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 162 DFEKIANVAKRINVPFIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGNFNWDNGKFPELVEPDPTY 241
Cdd:PRK06702 165 NFKEFSDAAKELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIDGGNFDWTNGKYPELVEPDPSY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 242 HGISYTQKFGNAAYATKARVQLLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDN 321
Cdd:PRK06702 245 HGVSYVQNFGAAAYIVKARVQLLRDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSN 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 322 KYYENAKKYLSRGCSGVLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRL 401
Cdd:PRK06702 325 ENYSLAQKYLKKGASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRL 404
|
410
....*....|....*...
gi 489534710 402 SVGIENVEDLIADLNQAL 419
Cdd:PRK06702 405 SVGIEDVSDIIADLEAAL 422
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
21-419 |
3.82e-180 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 508.91 E-value: 3.82e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 21 RVLPLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSI 100
Cdd:PRK07812 32 RALPIYQTTSYTFDDTDHAAALFGLAEPGNIYTRIMNPTQDVVEQRIAALEGGVAALLLASGQAAETFAILNLAGAGDHI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 101 LCSSKVYGGTFNLLGPSLKKFGIDlISF-----DLDSSEDEIvelaKENTKVVFAETLANPTLEVIDFEKIANVAKRINV 175
Cdd:PRK07812 112 VSSPRLYGGTYNLFHYTLPKLGIE-VSFvedpdDLDAWRAAV----RPNTKAFFAETISNPQIDVLDIPGVAEVAHEAGV 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 176 PFIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGNFNWDNGKFPELVEPDPTYHGISYTQkFGNAAY 255
Cdd:PRK07812 187 PLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVDGGTFDWTQGRFPGFTTPDPSYHGVVFAE-LGPPAY 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 256 ATKARVQLLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSRGC 335
Cdd:PRK07812 266 ALKARVQLLRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSPWYERAKRLAPKGT 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 336 SGVLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADL 415
Cdd:PRK07812 346 GAVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLVRLAVGIEGIDDILADL 425
|
....
gi 489534710 416 NQAL 419
Cdd:PRK07812 426 EAGF 429
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
21-420 |
1.41e-171 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 486.91 E-value: 1.41e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 21 RVLPLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSI 100
Cdd:PRK05994 26 RATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRITNPTNAVLEERVAALEGGTAALAVASGHAAQFLVFHTLLQPGDEF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 101 LCSSKVYGGTFNLLGPSLKKFGIDLI---SFDLDSSEDEIvelaKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPF 177
Cdd:PRK05994 106 IAARKLYGGSINQFGHAFKSFGWQVRwadADDPASFERAI----TPRTKAIFIESIANPGGTVTDIAAIAEVAHRAGLPL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 178 IVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGNFNWD-NGKFPELVEPDPTYHGISYTQKFGNAAYA 256
Cdd:PRK05994 182 IVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVDGGTFDWSkSGKYPMLSEPRPEYHGLVLHETFGNFAFA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 257 TKARVQLLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSRGCS 336
Cdd:PRK05994 262 IAARVLGLRDLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPDDPYHALAQKYSPKGAG 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 337 GVLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLN 416
Cdd:PRK05994 342 AVFTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVRLSIGIEDVDDIIADLE 421
|
....
gi 489534710 417 QALN 420
Cdd:PRK05994 422 QALA 425
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
21-419 |
2.24e-171 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 486.66 E-value: 2.24e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 21 RVLPLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSI 100
Cdd:PRK08248 27 RAVPIYQTTSYGFRDSEHAANLFSLKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALAVSSGQAAITYSILNIASAGDEI 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 101 LCSSKVYGGTFNLLGPSLKKFGIDlISFdLDSSEDEIVELA-KENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIV 179
Cdd:PRK08248 107 VSSSSLYGGTYNLFAHTLPKLGIT-VKF-VDPSDPENFEAAiTDKTKALFAETIGNPKGDVLDIEAVAAIAHEHGIPLIV 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 180 DNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGNFNW-DNGKFPELVEPDPTYHGISYTQKFGNAAYATK 258
Cdd:PRK08248 185 DNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVDSGKFDWkGSGKFPGLTEPDPSYHGLVYTDAVGEAAYITK 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 259 ARVQLLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSRGCSGV 338
Cdd:PRK08248 265 ARVQLLRDLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPSHPSYELAKKYLPKGQGAI 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 339 LSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQA 418
Cdd:PRK08248 345 LTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGLVRLSVGTEAIDDILDDLRQA 424
|
.
gi 489534710 419 L 419
Cdd:PRK08248 425 I 425
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
20-420 |
3.64e-158 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 450.50 E-value: 3.64e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 20 PRVLPLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDS 99
Cdd:cd00614 2 AVAPPIYQTSTFVFPSPAEAADLFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGDH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 100 ILCSSKVYGGTFNLLGPSLKKFGIDLISFDLDsSEDEIVELAKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIV 179
Cdd:cd00614 82 VVASDDLYGGTYRLFERLLPKLGIEVTFVDPD-DPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 180 DNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGnfnwdngkfpelvepdptyhgisytqkfgnAAYATKA 259
Cdd:cd00614 161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSG------------------------------EALIQRL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 260 RVQLLRdYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSrGCSGVL 339
Cdd:cd00614 211 RFLRLA-LGTILSPFDAWLLLRGLKTLPLRMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMS-GYGGVF 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 340 SFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQAL 419
Cdd:cd00614 289 SFELKGGLEAAKKFLNALKLFSLAVSLGGVESLVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQAL 368
|
.
gi 489534710 420 N 420
Cdd:cd00614 369 K 369
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
21-419 |
1.02e-155 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 446.88 E-value: 1.02e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 21 RVLPLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSI 100
Cdd:PRK08134 27 RAVPIHLTTSFVFRDSDHAAALFNLERAGHVYSRISNPTVAVLEERVAALEGGVGAIATASGQAALHLAIATLMGAGSHI 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 101 LCSSKVYGGTFNLLGPSLKKFGIDlISF----DLDSSEDEIvelaKENTKVVFAETLANPTLEVIDFEKIANVAKRINVP 176
Cdd:PRK08134 107 VASSALYGGSHNLLHYTLRRFGIE-TTFvkpgDIDGWRAAI----RPNTRLLFGETLGNPGLEVLDIPTVAAIAHEAGVP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 177 FIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGNFNWD-NGKFPELVEPDPTYHGISYTQKFGNAAY 255
Cdd:PRK08134 182 LLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGGRFDWEaSGKFPELTEPYAGFHGMVFAEESTVAAF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 256 ATKARVQLLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSRGC 335
Cdd:PRK08134 262 LLRARREGLRDFGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELESHPDHALAKRLLPRGA 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 336 SGVLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADL 415
Cdd:PRK08134 342 GSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTIRLSIGLEDADDLIDDL 421
|
....
gi 489534710 416 NQAL 419
Cdd:PRK08134 422 KRAL 425
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
5-420 |
1.83e-152 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 436.28 E-value: 1.83e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 5 ETICVQGNYKPGNG-EPRVLPLYQSTTFKYSSIDQlaelfdlkVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQ 83
Cdd:pfam01053 1 DTLAVHAGQRPDPQtGAVSVPIYLTSTYVFDFAGE--------EGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGM 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 84 SANMLAVLNICKSGDSILCSSKVYGGTFNLLGPSLKKFGIDLISFDLdSSEDEIVELAKENTKVVFAETLANPTLEVIDF 163
Cdd:pfam01053 73 AAITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDT-SDPEDLEAAIKPNTKAVYLETPTNPLLKVVDI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 164 EKIANVAKRINVPFIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGnFNWDNGKFpelvepdptyhg 243
Cdd:pfam01053 152 EAIAKLAKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNG-EELGKELY------------ 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 244 isytqkfgnaayatkarvQLLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKY 323
Cdd:pfam01053 219 ------------------FLQNATGAVLSPFDAWLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPG 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 324 YENAKKYLsRGCSGVLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSV 403
Cdd:pfam01053 281 HELAKRQM-KGFGGMLSFELKGGLEAAKKFLDNLKLFSLAVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSV 359
|
410
....*....|....*..
gi 489534710 404 GIENVEDLIADLNQALN 420
Cdd:pfam01053 360 GIEDVDDLIADLKQALE 376
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
2-420 |
4.18e-151 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 433.32 E-value: 4.18e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 2 YNKETICVQGNYKP--GNGEPrVLPLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAV 79
Cdd:COG0626 1 MGPATRAVHAGRDPdpQTGAV-SPPIYLTSTFVFPSAEALAARFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 80 SSGQSANMLAVLNICKSGDSILCSSKVYGGTFNLLGPSLKKFGIDLISFDLdSSEDEIVELAKENTKVVFAETLANPTLE 159
Cdd:COG0626 80 ASGMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDP-TDLAAVEAAIRPNTKLVFLETPSNPTLE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 160 VIDFEKIANVAKRINVPFIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVdggnfnwdngkfpelvepdp 239
Cdd:COG0626 159 VVDIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVV-------------------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 240 tyhgisytqkfGNAAYATKARVQLLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLE 319
Cdd:COG0626 219 -----------GRDEELAERLRFLQNALGAVLSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLP 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 320 DNKYYENAKKYLsRGCSGVLSFGVRGGLENAKKFVEKLQIASLVthVS--DVRTCVIHPASTTHRQLTEEQLIASGVLPS 397
Cdd:COG0626 288 SHPGHELAKRQM-SGFGGMLSFELKGGREAARRFLDALKLFTLA--VSlgGVESLITHPATMTHRSLPPEERAALGITDG 364
|
410 420
....*....|....*....|...
gi 489534710 398 LIRLSVGIENVEDLIADLNQALN 420
Cdd:COG0626 365 LVRLSVGLEDVDDLIADLEQALA 387
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
5-420 |
5.24e-151 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 434.71 E-value: 5.24e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 5 ETICVQGNYKPGNGEPRV-LPLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQ 83
Cdd:PRK06084 4 ETLAIHAGYSPDPTTKAVaVPIYQTTSYAFDDTQHGADLFDLKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVASGM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 84 SANMLAVLNICKSGDSILCSSKVYGGTFNLLGPSLKKFGIDlISFDLDSSEDEIVELAKENTKVVFAETLANPTLEVIDF 163
Cdd:PRK06084 84 AAITYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIE-TRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIIDI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 164 EKIANVAKRINVPFIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGNFNWDNGK--FPELVEPDPTY 241
Cdd:PRK06084 163 QALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKFPWAEHKerFALLNTPDPSY 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 242 HGISYTQKFGNAAYATKARVQLLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDN 321
Cdd:PRK06084 243 HGVTYTEAFGPAAFIGRCRVVPLRNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDH 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 322 KYYENAKKYLSRGCSGVLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRL 401
Cdd:PRK06084 323 PEHELARRYMGGKPASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVRL 402
|
410
....*....|....*....
gi 489534710 402 SVGIENVEDLIADLNQALN 420
Cdd:PRK06084 403 SIGIEHIDDIIADLAQALD 421
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
21-418 |
3.28e-136 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 397.32 E-value: 3.28e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 21 RVLPLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSI 100
Cdd:PRK05613 32 RNLPIYQTTSYVFDSAEHAKQRFALEDLGPIYSRLTNPTVEALENRIASLEGGVHAVAFASGQAAETAAILNLAGAGDHI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 101 LCSSKVYGGTFNLLGPSLKKFGIDlISFDLDSSEDEIVELA-KENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIV 179
Cdd:PRK05613 112 VTSPRLYGGTETLFLVTLNRLGIE-VTFVENPDDPESWQAAvQPNTKAFFGETFANPQADVLDIPAVAEVAHRNQVPLIV 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 180 DNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGNFNWD---NGK--FPELVEPDPTYHGISYTQkFGNAA 254
Cdd:PRK05613 191 DNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIDGGKFDWTverDGKpvFPYFVTPDPAYHGLKYAD-LGAPA 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 255 YATKARVQLLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSRG 334
Cdd:PRK05613 270 FGLKARAGLLRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFAGLKDSPWYATKEKLGLKY 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 335 CSGVLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIAD 414
Cdd:PRK05613 350 TGSVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGITQATVRLSVGIEDIDDIIAD 429
|
....
gi 489534710 415 LNQA 418
Cdd:PRK05613 430 LEGG 433
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
24-419 |
9.67e-112 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 333.12 E-value: 9.67e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 24 PLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSILCS 103
Cdd:PRK08133 27 ALFLTSSFVFESAAEAAARFAGEEPGNIYSRFTNPTVTMFQERLAALEGAEACVATASGMAAILAVVMALLQAGDHVVSS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 104 SKVYGGTFNLLGPSLKKFGIDlISF----DLDSSEDEIvelaKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIV 179
Cdd:PRK08133 107 RSLFGSTVSLFEKIFARFGIE-TTFvdltDLDAWRAAV----RPNTKLFFLETPSNPLTELADIAALAEIAHAAGALLVV 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 180 DNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGnfnwdngkfpELVEPdptyhgisytqKFGnaayatka 259
Cdd:PRK08133 182 DNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSK----------ELMEE-----------VFG-------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 260 rvqLLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSRGcSGVL 339
Cdd:PRK08133 233 ---FLRTAGPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGG-GAIV 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 340 SFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQAL 419
Cdd:PRK08133 309 SFEVKGGREAAWRVIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGL 388
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
24-420 |
4.38e-111 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 332.18 E-value: 4.38e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 24 PLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSILCS 103
Cdd:PRK06234 30 PIYQTSTFIFDSAEQGGRRFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAASGMGAISSSLWSALKAGDHVVAS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 104 SKVYGGTFNLLGPSLKKFGIDlISFdLDSSEDEIVELA-KENTKVVFAETLANPTLEVIDFEKIANVAKRIN--VPFIVD 180
Cdd:PRK06234 110 DTLYGCTFALLNHGLTRYGVE-VTF-VDTSNLEEVRNAlKANTKVVYLETPANPTLKVTDIKAISNIAHENNkeCLVFVD 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 181 NSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVdggnfnwdngkfpelvepdptyhgisytqkfGNAAYATKAR 260
Cdd:PRK06234 188 NTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVV-------------------------------GKEEFINQVK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 261 VQLLRDY-GNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLsRGCSGVL 339
Cdd:PRK06234 237 LFGIKDMtGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQM-SLPGAMI 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 340 SFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQAL 419
Cdd:PRK06234 316 SFELKGGVEEGKVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQAL 395
|
.
gi 489534710 420 N 420
Cdd:PRK06234 396 D 396
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
2-420 |
1.71e-100 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 304.46 E-value: 1.71e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 2 YNKETICVQGNYKPGNGEPRVLP-LYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVS 80
Cdd:PRK06767 4 KHMETALIHHGYTSEEHKGSLTPpLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAFG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 81 SGQSANMLAVLNICKSGDSILCSSKVYGGTFNLLGPSLKKFGIDlISFDLDSSEDEIVELAKENTKVVFAETLANPTLEV 160
Cdd:PRK06767 84 SGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMIT-HSFCDMETEADIENKIRPNTKLIFVETPINPTMKL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 161 IDFEKIANVAKRINVPFIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVdggnfnwdnGKFPELVEPDPT 240
Cdd:PRK06767 163 IDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTI---------CKTRALAEKIRP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 241 yhgisyTQKfgnaayatkarvqllrDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGled 320
Cdd:PRK06767 234 ------MRK----------------DIGGIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPE--- 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 321 nkyYENAKKYLSRGcSGVLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIR 400
Cdd:PRK06767 289 ---GELASRQMKRG-GGVISFSIKGGKEETQAFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIR 364
|
410 420
....*....|....*....|
gi 489534710 401 LSVGIENVEDLIADLNQALN 420
Cdd:PRK06767 365 LSVGLESWEDIVSDLEQALK 384
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
25-419 |
1.61e-99 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 301.76 E-value: 1.61e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 25 LYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSILCSS 104
Cdd:TIGR01325 21 LYLTSGYVYDSAAVAAKRFAGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGMAAIFAALMALLGAGDHVVASR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 105 KVYGGTFNLLGPSLKKFGIDLISFDL-DSSEDEIVelAKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIVDNSL 183
Cdd:TIGR01325 101 SLFGSCFVVCSEILPRFGVQTVFVDGtDLSAWEAA--LKPNTKAVFVETPSNPLQELVDIAAVAELAHAAGAKVVVDNVF 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 184 ASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVdggnfnwdngkfpelvepdptyhgisytqkfGNAAYATKARVQL 263
Cdd:TIGR01325 179 ATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAIL-------------------------------GSEEYMDEPVQKL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 264 LRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSrGCSGVLSFGV 343
Cdd:TIGR01325 228 LRHTGPAMSPFNAWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMS-GGGTVVTFDL 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489534710 344 rGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQAL 419
Cdd:TIGR01325 307 -DCRQAAFKVLDAMRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLSVGLEDVDDLIADIDRAL 381
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
19-420 |
1.94e-97 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 296.59 E-value: 1.94e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 19 EPRVLPLYQSTTFKYSSIDQLAEL-FDLKvdghiYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSG 97
Cdd:PRK08574 18 GSLQPPIYLTALFRQEGEAYPSDRgFDLK-----YSREENPTLRPLEEALAKLEGGVDALAFNSGMAAISTLFFSLLKAG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 98 DSILCSSKVYGGTFNLLgPSLKKFGIDLIsFDLDSSEDEIVELAKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPF 177
Cdd:PRK08574 93 DRVVLPMEAYGTTLRLL-KSLEKFGVKVV-LAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDVPEVAKAAKELGAIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 178 IVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGgnfnwdNGKFPELVepdptyhgisytqkfgnaaYAT 257
Cdd:PRK08574 171 VVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAW------SGEFLEEL-------------------WEW 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 258 KARVqllrdyGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSRGC-S 336
Cdd:PRK08574 226 RRRL------GTIMQPFEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRLFGKDLyG 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 337 GVLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLN 416
Cdd:PRK08574 300 GVVSFRVKGGRDAVLKFLRSLKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLD 379
|
....
gi 489534710 417 QALN 420
Cdd:PRK08574 380 QALG 383
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
23-420 |
2.27e-96 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 294.34 E-value: 2.27e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 23 LPLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSILC 102
Cdd:PRK08249 29 VPVVLSVAYGYDDIDEWYDVALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFSTGMAAISNTLYTFLKPGDRVVS 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 103 SSKVYGGTFNLLGPSLKKFGIDLI---SFDLDSSEDEIvelAKeNTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIV 179
Cdd:PRK08249 109 IKDTYGGTNKIFTEFLPRMGVDVTlceTGDHEQIEAEI---AK-GCDLLYLETPTNPTLKIVDIERLAAAAKKVGALVVV 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 180 DNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVdgGNfnwdngkfPELVEPDPTYHGISytqkfgnaayatka 259
Cdd:PRK08249 185 DNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVC--GS--------KELMEQVYHYREIN-------------- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 260 rvqllrdyGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLsRGCSGVL 339
Cdd:PRK08249 241 --------GATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQM-RGFGGIL 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 340 SFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQAL 419
Cdd:PRK08249 312 SFVLKGGMDTVKRLLPKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQAF 391
|
.
gi 489534710 420 N 420
Cdd:PRK08249 392 A 392
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
24-421 |
1.34e-94 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 289.67 E-value: 1.34e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 24 PLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSILCS 103
Cdd:PRK05939 13 PIHTSVTYGYEDARDLIDVFQGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGDHLVSS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 104 SKVYGGTFNLLGpSLKKFGIDlISFdLDSSEDEIVELA-KENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIVDNS 182
Cdd:PRK05939 93 QFLFGNTNSLFG-TLRGLGVE-VTM-VDATDVQNVAAAiRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVVDNT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 183 LASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGNFNWDngKFPELVEP----DPTYHGISYTQKFGnaayatk 258
Cdd:PRK05939 170 MTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTDTGLFDWS--AYPNIFPAyrkgDPQQWGLTQIRKKG------- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 259 arvqlLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLsRGCSGV 338
Cdd:PRK05939 241 -----LRDMGATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELF-RHYGGL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 339 LSFGVRGGlENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQA 418
Cdd:PRK05939 315 LSFELADG-IDCFDFLNRLKLVIKATHLGDTRTLVIPVAPTIYYEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQA 393
|
...
gi 489534710 419 LNF 421
Cdd:PRK05939 394 LDA 396
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
5-420 |
1.88e-92 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 283.84 E-value: 1.88e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 5 ETICVQGNYKPgngEPR----VLPLYQSTTFKYSSIDQLAelfdlkvDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVS 80
Cdd:PRK07811 14 ATRAIHAGYEP---DPAtgavNPPIYASSTFAQDGVGGLR-------GGYEYARTGNPTRTALEEQLAALEGGAYGRAFS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 81 SGQSANMLAVLNICKSGDSILCSSKVYGGTFNLLGPSLKKFGIDLISFDLdsSEDEIVELA-KENTKVVFAETLANPTLE 159
Cdd:PRK07811 84 SGMAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDL--SDLDAVRAAiTPRTKLIWVETPTNPLLS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 160 VIDFEKIANVAKRINVPFIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGnfnwdngkfPELVEpdp 239
Cdd:PRK07811 162 ITDIAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTND---------EELDE--- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 240 tyhGISYTQkfgNAAyatkarvqllrdyGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLE 319
Cdd:PRK07811 230 ---AFAFLQ---NGA-------------GAVPGPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLP 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 320 DNKYYENAKKYLsRGCSGVLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLiasGVLPSLI 399
Cdd:PRK07811 291 SHPGHEVAARQM-RGFGGMVSVRLAGGEEAARDFCARTKVFTLAESLGGVESLIEHPSAMTHASTAGSQL---EVPDDLV 366
|
410 420
....*....|....*....|.
gi 489534710 400 RLSVGIENVEDLIADLNQALN 420
Cdd:PRK07811 367 RLSVGIEDVADLLADLEQALG 387
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
24-419 |
2.98e-91 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 281.31 E-value: 2.98e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 24 PLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSILCS 103
Cdd:PRK07503 31 PVYLTATFAFPTAEYGAECFAGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALASGMGAITATLWTLLRPGDEVIVD 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 104 SKVYGGTFNLLGPSLKKFGIDLISFDLDSSEdEIVELAKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIVDNSL 183
Cdd:PRK07503 111 QTLYGCTFAFLHHGLGEFGVTVRHVDLTDPA-ALKAAISDKTRMVYFETPANPNMRLVDIAAVAEIAHGAGAKVVVDNTY 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 184 ASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVdggnfnwdngkfpelvepdptyhgisytqkfGNAAYATKARVQL 263
Cdd:PRK07503 190 CTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVV-------------------------------GGKALADRIRLEG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 264 LRDY-GNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSRGcSGVLSFG 342
Cdd:PRK07503 239 LKDMtGAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALP-GGMIAFE 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489534710 343 VRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQAL 419
Cdd:PRK07503 318 LKGGIAAGRRFMNALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQAL 394
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
1-420 |
2.51e-84 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 262.33 E-value: 2.51e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 1 MYNKETICVQ-GNykpgNGEPRV----LPLYQSTTFKYSSIDqlaelfdlKVDGHIYSRISNPTIQAFEEKISLLEGGVS 75
Cdd:PRK08247 2 MSTIETKLAQiGN----RSDERTgtvnPPVYFSTAYRHEGIG--------ESTGFDYSRTGNPTRGVLEQAIADLEGGDQ 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 76 SVAVSSGQSAnMLAVLNICKSGDSILCSSKVYGGTFNLLGPSLKKFGIDLISFDLdSSEDEIVELAKENTKVVFAETLAN 155
Cdd:PRK08247 70 GFACSSGMAA-IQLVMSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNT-ASLKAIEQAITPNTKAIFIETPTN 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 156 PTLEVIDFEKIANVAKRINVPFIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGNfnwdngkfpELV 235
Cdd:PRK08247 148 PLMQETDIAAIAKIAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQ---------ELC 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 236 EPDPTYHgisytqkfgNAAyatkarvqllrdyGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINY 315
Cdd:PRK08247 219 ERLAYYQ---------NAA-------------GAVLSPFDSWLLIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLY 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 316 PGlednkyyenakkylsRGcsGVLSFGVRGglEN-AKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGV 394
Cdd:PRK08247 277 PG---------------RG--GMLSFRLQD--EEwVNPFLKSLKLITFAESLGGVESFITYPATQTHADIPEEIRIANGV 337
|
410 420
....*....|....*....|....*.
gi 489534710 395 LPSLIRLSVGIENVEDLIADLNQALN 420
Cdd:PRK08247 338 CNRLLRFSVGIENVEDLIADLKQAFK 363
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
24-420 |
1.92e-80 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 252.72 E-value: 1.92e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 24 PLYQSTTFKYSSIDQLAelfdlkvdGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSAnMLAVLNICKSGDSILCS 103
Cdd:PRK07671 24 PIYQVSTYKQEAVGKHQ--------GYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAA-ITAVMMLFSSGDHVILT 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 104 SKVYGGTFNLLGPSLKKFGIDlISFdLDSSEDEIVELA-KENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIVDNS 182
Cdd:PRK07671 95 DDVYGGTYRVMTKVLNRFGIE-HTF-VDTSNLEEVEEAiRPNTKAIYVETPTNPLLKITDIKKISTIAKEKGLLTIVDNT 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 183 LASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVdggnfnwdnGKFPELVEPdptyhgISYTQkfgNAAyatkarvq 262
Cdd:PRK07671 173 FMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVV---------VNSPELAED------LHFVQ---NST-------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 263 llrdyGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYlSRGCSGVLSFG 342
Cdd:PRK07671 227 -----GGILGPQDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQ-ANGFGGMISFD 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489534710 343 VrGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQALN 420
Cdd:PRK07671 301 V-GSEETANKVLERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
23-419 |
9.82e-80 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 250.97 E-value: 9.82e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 23 LPLYQSTTFKYSSIDQlaelfdlkVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQsANMLAVLNICKSGDSILC 102
Cdd:PRK06176 23 VPIYQTSTYRQDAIGR--------PKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGL-AGIHAVFSLFQSGDHVLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 103 SSKVYGGTFNLLGPSLKKFGIdliSFDL-DSSEDEIVELA-KENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIVD 180
Cdd:PRK06176 94 GDDVYGGTFRLFDKVLVKNGL---SCTIiDTSDLSQIKKAiKPNTKALYLETPSNPLLKITDLAQCASVAKDHGLLTIVD 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 181 NSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGnfnwdngkfPELVEPdptyhgISYTQkfgNAayatkar 260
Cdd:PRK06176 171 NTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNN---------EALAQE------IAFFQ---NA------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 261 vqllrdYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLsRGCSGVLS 340
Cdd:PRK06176 226 ------IGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQM-RGFSGMLS 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489534710 341 FGVRGGlENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQAL 419
Cdd:PRK06176 299 FTLKND-SEAVAFVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAF 376
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
20-419 |
7.91e-78 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 245.90 E-value: 7.91e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 20 PRVLPLYQSTTFKYSsidqLAELFDlkvdghiYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDS 99
Cdd:PRK06460 18 AITTPIYQTTAYHYP----EGEKYR-------YSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTALALLKPGNS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 100 ILCSSKVYGGTFNLLGPSLKKFGIDL-ISfdlDSSEDEIVELAKEN-TKVVFAETLANPTLEVIDFEKIANVAKRINVPF 177
Cdd:PRK06460 87 VLVHRDMFGRSYRFFTDYLKNWGVNVdAS---NPGSDNIIEKAKSKrYDVVFVENITNPLLRVVDITELSKVCKENGSIL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 178 IVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVdggnfnwdngkfpelvepdptyhgisytqkfGNAAYAT 257
Cdd:PRK06460 164 IVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAA-------------------------------GYGKLLN 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 258 KARvQLLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLsRGCSG 337
Cdd:PRK06460 213 VID-QMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVL-KGFGG 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 338 VLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQ 417
Cdd:PRK06460 291 VLSFEVNGGQESALKVMKSLKLIIPAQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDR 370
|
..
gi 489534710 418 AL 419
Cdd:PRK06460 371 AL 372
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
2-421 |
1.30e-74 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 238.13 E-value: 1.30e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 2 YNKETICVQGNYK--PGNGEPRVlPLYQSTTFKYSSIDQLAElFDlkvdghiYSRISNPTIQAFEEKISLLEGGVSSVAV 79
Cdd:PRK08064 5 YSIDTLLLHNQYKhdKQTGAVNV-PIYHASTFHQFDFDTFGK-YD-------YSRSGNPTREALEDIIAELEGGTKGFAF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 80 SSGQSANMLAVLNICKsGDSILCSSKVYGGTFNLLGPSLKKFGIDLISFDLDSSeDEIVELAKENTKVVFAETLANPTLE 159
Cdd:PRK08064 76 ASGMAAISTAFLLLSK-GDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNL-EEVAQNIKPNTKLFYVETPSNPLLK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 160 VIDFEKIANVAKRINVPFIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDggnfnwdngKFPELvepdp 239
Cdd:PRK08064 154 VTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVV---------KDEEL----- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 240 tyhgisytqkfGNAAYatkarvQLLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLE 319
Cdd:PRK08064 220 -----------AQKLY------FLQNSFGAVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQ 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 320 DNKYYEnAKKYLSRGCSGVLSFGVrGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLI 399
Cdd:PRK08064 283 THLGFD-IQQSQATSAGAVLSFTL-QSEEAVRQFVSHVKLPVFAVSLGAVESILSYPAKMSHAAMPKEERDERGITDGLL 360
|
410 420
....*....|....*....|..
gi 489534710 400 RLSVGIENVEDLIADLNQALNF 421
Cdd:PRK08064 361 RLSVGLENVDDLIADFEQALSY 382
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
25-419 |
1.33e-74 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 238.12 E-value: 1.33e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 25 LYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSILCSS 104
Cdd:PRK07504 32 LFLTQGFVYDTAEAAEARFKGEDPGFIYSRYSNPTVDMFEKRMCALEGAEDARATASGMAAVTAAILCQVKAGDHVVAAR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 105 KVYGGTFNLLGPSLKKFGID--LIS-FDLDSSEDEIvelaKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIVDN 181
Cdd:PRK07504 112 ALFGSCRYVVETLLPRYGIEstLVDgLDLDNWEKAV----RPNTKVFFLESPTNPTLEVIDIAAVAKIANQAGAKLVVDN 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 182 SLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGNFNWDNgkfpelvepdptyhgisyTQKFgnaayatkarv 261
Cdd:PRK07504 188 VFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDKAWIEEH------------------LQDY----------- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 262 qlLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLsRGCSGVLSF 341
Cdd:PRK07504 239 --FRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQADIIAKQM-TGGSTLVAF 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489534710 342 GVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQAL 419
Cdd:PRK07504 316 ELKGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELGISEGFLRLSAGLEDTDDLIEDLAAAL 393
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
5-419 |
1.38e-74 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 238.48 E-value: 1.38e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 5 ETICVQGNYKPGNGEPRVLPLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQS 84
Cdd:PRK07810 17 ATIGVRGGLLRSGFEETAEALYLTSGYVYESAAAAEAAFTGELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATASGMS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 85 ANMLAVLNICKSGDSILCSSKVYGGTFNLLGPSLKKFGIDLISFD---LDSSEdeivELAKENTKVVFAETLANPTLEVI 161
Cdd:PRK07810 97 AVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDgedLSQWE----EALSVPTQAVFFETPSNPMQSLV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 162 DFEKIANVAKRINVPFIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVdggnfnwdngkfpelvepdpty 241
Cdd:PRK07810 173 DIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAIL---------------------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 242 hgisytqkfGNAAYATKARVQLLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDN 321
Cdd:PRK07810 231 ---------GDREYIDGPVQKLMRHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPFLPSH 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 322 KYYENAKKYLSRGCSgVLSFGVRGGLENAKK----FVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPS 397
Cdd:PRK07810 302 PQYDLAKRQMSGGGT-VVTFELDAPEDAAKKrafeVLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDG 380
|
410 420
....*....|....*....|..
gi 489534710 398 LIRLSVGIENVEDLIADLNQAL 419
Cdd:PRK07810 381 VVRLSVGLEDTDDLIADLDRAL 402
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
22-420 |
5.52e-72 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 230.94 E-value: 5.52e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 22 VLPLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSIL 101
Cdd:PRK06434 28 TTPIFETSTFVYPNSEKEAYMDSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSGMGAITSAILSLIKKGKRIL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 102 CSSKVYGGTFNLLGPSLKKFGI--DLISFDLDSSedeiVELAKENTKVVFAETLANPTLEVIDFEKIANVAKRINVpfIV 179
Cdd:PRK06434 108 SISDLYGQTFYFFNKVLKTLGIhvDYIDTDRLNS----LDFDPSNYDLIYAESITNPTLKVPDIKNVSSFCHENDV--IV 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 180 DNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIvdGGNfnwDNGKFPELVEPDPTyhgisytqkfgnaayatka 259
Cdd:PRK06434 182 DATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVA--GTN---NKSIFNNLVERRKT------------------- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 260 rvqllrdYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLednkyyENAKKYLsRGCSGVL 339
Cdd:PRK06434 238 -------LGSNPDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGKKVL-RGFGGML 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 340 SFGVRgGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQAL 419
Cdd:PRK06434 304 SFELR-SMEDVHKFIRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENAL 382
|
.
gi 489534710 420 N 420
Cdd:PRK06434 383 S 383
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
22-418 |
1.24e-70 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 227.47 E-value: 1.24e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 22 VLPLYQSTTFKYSSIDQLAElFDlkvdghiYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSIL 101
Cdd:PRK08861 25 VPPIYLSTNYGFPAFGEVPK-YD-------YTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLWVSALLGPDDLIV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 102 CSSKVYGGTFNLLGPSLKKFGIDLISFDLDSSEDEIVELAKeNTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIVDN 181
Cdd:PRK08861 97 APHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAK-KPKLILLETPSNPLVRVVDIAELCQKAKAVGALVAVDN 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 182 SLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDggnfnwdngkfpelvepdptyhgisytqkfgnaayATKARV 261
Cdd:PRK08861 176 TFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLIT-----------------------------------KTKEHA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 262 QLLRDYGNCL----SPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSrGCSG 337
Cdd:PRK08861 221 EELAWWGNCIgatgTPFDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQS-GFGS 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 338 VLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQ 417
Cdd:PRK08861 300 MLSFEFAGSFEQLKVFVKALALFSLAESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQ 379
|
.
gi 489534710 418 A 418
Cdd:PRK08861 380 A 380
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
24-420 |
2.36e-70 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 228.02 E-value: 2.36e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 24 PLYQSTTFKYSSIDQLAELFDL----------KVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNI 93
Cdd:PRK07049 39 PVFLTSTFVFRSAEDGRDFFDYvsgrkeppagEGAGLVYSRFNHPNSEIVEDRLAVYEGAESAALFSSGMSAIATTLLAF 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 94 CKSGDSILCSSKVYGGTFNLLGPSLKKFGIDLISFDLDSSEDEIVE-----LAKENTKVVFAETLANPTLEVIDFEKIAN 168
Cdd:PRK07049 119 VRPGDVILHSQPLYGGTETLLAKTFRNFGVGAVGFADGLSEAAIGAaaeaaAAKGRVSLILIETPANPTNSLVDVAAVRR 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 169 VAKRI-----NVPFIV-DNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVdggnfnwdngkfpelvepdptyh 242
Cdd:PRK07049 199 VADAIearqgHRPIIAcDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAGAVL----------------------- 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 243 gisytqkfGNAAYATKarVQLLRD-YGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDN 321
Cdd:PRK07049 256 --------GRKALIRQ--VRALRSaIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPFLDP 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 322 KyyENAKKYLSRGCSG---VLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSL 398
Cdd:PRK07049 326 D--SAYGAVYKRQCTGagsTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLEST 403
|
410 420
....*....|....*....|..
gi 489534710 399 IRLSVGIENVEDLIADLNQALN 420
Cdd:PRK07049 404 IRLSIGIEHPDDLIADLAQALD 425
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
20-419 |
5.33e-70 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 225.86 E-value: 5.33e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 20 PRVLPLYQSTTFKYSSIDQLAElFDlkvdghiYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSAnMLAVLNICKSGDS 99
Cdd:TIGR01329 17 ASSMPIYQTATFKQPLAIENGP-YD-------YTRSGNPTRTALESLLAKLDKADRAFAFSSGMAA-LDVITRLLNNGDE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 100 ILCSSKVYGGTFNLLGPSLKKFGIDLISFDLdSSEDEIVELAKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIV 179
Cdd:TIGR01329 88 IIAGDDLYGGTDRLLTQVVPRSGVVVVHVDT-TDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHAQNALVVV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 180 DNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVdggnfnwdnGKFPELVepDPTYHGISYTqkfgnaayatka 259
Cdd:TIGR01329 167 DNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLA---------VKGEEIA--KKVYFLQNST------------ 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 260 rvqllrdyGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYEnAKKYLSRGCSGVL 339
Cdd:TIGR01329 224 --------GSGLAPFDCWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFH-LHFSQAKGAGSVL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 340 SFgVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQAL 419
Cdd:TIGR01329 295 SF-ETGSVALSKRLVEATKLFSITVSFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAF 373
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
52-419 |
8.84e-65 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 212.93 E-value: 8.84e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 52 YSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSILCSSKVYGGTFNLLGPSLKKFGIDLISFDLd 131
Cdd:PRK08776 54 YTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVLNALLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADL- 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 132 SSEDEIVELAKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHA 211
Cdd:PRK08776 133 TDPRSLADALAQSPKLVLIETPSNPLLRITDLRFVIEAAHKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHS 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 212 SSVGGIIvdggnfnwdngkfpelVEPDPTYHgisytqkfgnaayatkarvQLLRDYGNCL----SPFNAYLTNLNVETLH 287
Cdd:PRK08776 213 DVVGGAV----------------VARDAELH-------------------QQLVWWANALgltgSPFDAFLTLRGLRTLD 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 288 LRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYlSRGCSGVLSFGVRGGLENAKKFVEKLQIASLVTHVS 367
Cdd:PRK08776 258 ARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQ-QKGFGAMLSFELEGGEAAVRAFVDGLRYFTLAESLG 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 489534710 368 DVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQAL 419
Cdd:PRK08776 337 GVESLIAHPASMTHAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDLRAGL 388
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
22-419 |
3.32e-64 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 211.09 E-value: 3.32e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 22 VLPLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSIL 101
Cdd:PRK05968 27 VPPIFQTSLFTFDSYDEMEDVYAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAISSTVLSFVEPGDRIV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 102 CSSKVYGGTFNLLGPSLKKFGIdLISFdLDSSEDEIVELAKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIVDN 181
Cdd:PRK05968 107 AVRHVYPDAFRLFETILKRMGV-EVDY-VDGRDEEAVAKALPGAKLLYLESPTSWVFELQDVAALAALAKRHGVVTMIDN 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 182 SLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVdggnfnwdngkfpelvepdptyhgisytqkfGNAAYATKARV 261
Cdd:PRK05968 185 SWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVA-------------------------------GSKEHIARINA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 262 QLLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDnkyyeNAKKYLSrGCSGVLSF 341
Cdd:PRK05968 234 EAYPYLGAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALAN-----HPPAGLS-GTSGLFSF 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 342 GVRGGLEnakkfveklqIASLVTHVSDVRTCV--------IHPASTTHRQLTE-EQLIASGVLPSLIRLSVGIENVEDLI 412
Cdd:PRK05968 308 IFREGID----------VRAFADALKLFRLGVswggheslVVPAEVVLQQKAQpNSAARFGVSPRSVRLHVGLEGTEALW 377
|
....*..
gi 489534710 413 ADLNQAL 419
Cdd:PRK05968 378 ADLEQAL 384
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
22-419 |
2.19e-60 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 200.89 E-value: 2.19e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 22 VLPLYQSTTFKYSSIDQlaelfdlkVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSIL 101
Cdd:PRK08045 24 VPPIHLSSTYNFTGFNE--------PRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLLV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 102 CSSKVYGGTFNLLGpSLKKFGIDLISFDLDSSEDEIVELAKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIVDN 181
Cdd:PRK08045 96 APHDCYGGSYRLFD-SLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREAGAVSVVDN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 182 SLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVdggnfnwdnGKFPELVepdptyhgiSYTQKFGNAAYATKArv 261
Cdd:PRK08045 175 TFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI---------AKDPDVV---------TELAWWANNIGVTGG-- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 262 qllrdygnclsPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYlSRGCSGVLSF 341
Cdd:PRK08045 235 -----------AFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQ-QKGFGAMLSF 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489534710 342 GVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQAL 419
Cdd:PRK08045 303 ELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGF 380
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
24-420 |
1.23e-58 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 198.33 E-value: 1.23e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 24 PLYQSTTFKYSSIDQLAElFDlkvdghiYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSAnMLAVLNICKSGDSILCS 103
Cdd:PLN02509 107 PLYQTATFKQPSAIENGP-YD-------YTRSGNPTRDALESLLAKLDKADRAFCFTSGMAA-LSAVTHLIKNGEEIVAG 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 104 SKVYGGTFNLLGPSLKKFGIDLISFDlDSSEDEIVELAKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIVDNSL 183
Cdd:PLN02509 178 DDVYGGSDRLLSQVVPRSGVVVKRVN-TTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLVDNSI 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 184 ASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGnfnwdngkfpelvepdptyhgisytQKFGNAAYAtkarvqL 263
Cdd:PLN02509 257 MSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKG-------------------------EKLAKEVYF------L 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 264 LRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNK----YYENAKkylsrGCSGVL 339
Cdd:PLN02509 306 QNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPghhlHFSQAK-----GAGSVF 380
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 340 SFgVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQAL 419
Cdd:PLN02509 381 SF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 459
|
.
gi 489534710 420 N 420
Cdd:PLN02509 460 R 460
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
22-419 |
4.10e-56 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 189.26 E-value: 4.10e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 22 VLPLYQSTTFKYSSIDQLAelfdlkvdGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAvLNICKSGDSIL 101
Cdd:PRK07269 26 VTPLHFSTTYQHPEFGQST--------GFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIVLA-FSVFPVGSKVV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 102 CSSKVYGGTFNLLGPSLKkfgIDLISFDLDSSEDEIVELAKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIVDN 181
Cdd:PRK07269 97 AVRDLYGGSFRWFNQQEK---EGRFHFTYANTEEELIAAIEEDTDIVYIETPTNPLMVEFDIEKVAKLAHAKGAKVIVDN 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 182 SLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVdggnfnwdngkfpelvepdpTYHGISYTQKFGNaayatkarv 261
Cdd:PRK07269 174 TFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVV--------------------TNDLELYEKLFYN--------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 262 qlLRDYGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLednkyyenakkylsrgcSGVLSF 341
Cdd:PRK07269 225 --LNTTGAVLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGK-----------------GGMISF 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 342 GVrgglENAKK---FVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIASGVLPSLIRLSVGIENVEDLIADLNQA 418
Cdd:PRK07269 286 KV----ADETRiphILNSLKVFTFAESLGGVESLITYPTTQTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQA 361
|
.
gi 489534710 419 L 419
Cdd:PRK07269 362 L 362
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
15-420 |
1.17e-47 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 166.71 E-value: 1.17e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 15 PGNGEPRVLPLYQSTTFKYSSidqlaelfDLKVDGHIYSRISNPTIQAFEEKISLLEGGvSSVAVSSGQSANMLAVLNIC 94
Cdd:PRK07582 16 AVPGEPVLPGPVFAAPYHLSP--------GEPTGPDTYGRASNPTWRALEAALGELEGA-EALVFPSGMAAITAVLRALL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 95 KSGDSILCSSKVYGGTFNLLGPSLKKFGIDLISfdldSSEDEIVELAKENTKVVFAETLANPTLEVIDFEKIANVAKRIN 174
Cdd:PRK07582 87 RPGDTVVVPADGYYQVRALAREYLAPLGVTVRE----APTAGMAEAALAGADLVLAETPSNPGLDVCDLAALAAAAHAAG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 175 VPFIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVdggnfnwdnGKFPELVepdptyhgisytqkfgnaa 254
Cdd:PRK07582 163 ALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVA---------GRDPELM------------------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 255 yatkARVQLLRDY-GNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSR 333
Cdd:PRK07582 215 ----AAVERWRLLaGAIPGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRR 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 334 gCSGVLSFGVrGGLENAKKFVEKLQIASLVTHVSDVRTcvihpastthrqlTEEQLIASG--VLPSLIRLSVGIENVEDL 411
Cdd:PRK07582 291 -FGGLVSFEL-ADAAAAERFVAASRLVVAATSFGGVHT-------------SADRRARWGdaVPEGFVRLSCGIEDTDDL 355
|
....*....
gi 489534710 412 IADLNQALN 420
Cdd:PRK07582 356 VADLERALD 364
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
24-419 |
2.66e-45 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 161.44 E-value: 2.66e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 24 PLYQSTTFKYSSIDQLAELFDLKVDGHI-YSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSILC 102
Cdd:PRK09028 26 PVFRASTVVFDTVAEMRHAAKNRANGEMfYGRRGTPTHFAFQAAIVELEGGAGTALYPSGAAAISNALLSFLKAGDHLLM 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 103 SSKVYGGTFNLLGPSLKKFGIDLISFDLDSSEDeIVELAKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIVDNS 182
Cdd:PRK09028 106 VDSCYEPTRDLCDKILKGFGIETTYYDPMIGEG-IRELIRPNTKVLFLESPGSITMEVQDVPTLSRIAHEHDIVVMLDNT 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 183 LASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGiivdggnfnwdngkfpelvepdptyhgisytqkfgnAAYATKARVQ 262
Cdd:PRK09028 185 WASPINSRPFEMGVDISIQAATKYIVGHSDVMLG------------------------------------TATANEKHWD 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 263 LLRDY----GNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSrGCSGV 338
Cdd:PRK09028 229 QLREHsylmGQCTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFS-GSNGL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 339 LSFGV-RGGLENAKKFVEKLQIASL-------------VTHVSDVRTcVIHPASTThrqlteeqliasgvlpSLIRLSVG 404
Cdd:PRK09028 308 FSFVLkQGDPKAVTALVEGMQHFKMgfswggfeslilgVFGINKLRT-ATNWDFSK----------------PLIRLHIG 370
|
410
....*....|....*
gi 489534710 405 IENVEDLIADLNQAL 419
Cdd:PRK09028 371 LEDVDDLIADLEAGF 385
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
28-405 |
4.32e-44 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 158.78 E-value: 4.32e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 28 STTFKYSSIDQLAELFDLKV----DGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSILCS 103
Cdd:PLN02242 42 SATFTVMEPDTMRRMFSGELgpdrDFYIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQLCSSGGHVVAS 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 104 SKVYGGTFNLLGPSL-KKFGIDLISFDLDSSEDEIVELAKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIVDNS 182
Cdd:PLN02242 122 NTLYGGTHALLAHFLpRKCNITTTFVDITDLEAVKKAVVPGKTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNT 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 183 LAsPVLCNPLKYGANIVTHSTTKYLDGHASSVGGIIVDGGnfnwdngkfpELVEP--DPTyHGisytqkfgnaayatkaR 260
Cdd:PLN02242 202 FA-PMVLSPARLGADVVVHSISKFISGGADIIAGAVCGPA----------ELVNSmmDLH-HG----------------A 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 261 VQLLrdyGNCLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHeNVDWInYPGLEDNKYYENAKKYLSR--GCSGV 338
Cdd:PLN02242 254 LMLL---GPTMNPKVAFELSERLPHLSLRMKEHCRRAMEYAKRMKEL-GLKVI-YPGLEDHPQHALLKSMANKgyGFGGL 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489534710 339 LSFGVrGGLENAKKFVEKLQ-------IASLVTHVSDVRTCvihPASTTHRQLTEEQLIASGVLPSLIRLSVGI 405
Cdd:PLN02242 329 LCLDM-DTEERANRLMRYLQnstqfgfMAVSLGYYETLMSC---SGSSTSSELDPEEKAAAGISPGLVRMSVGY 398
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
40-419 |
7.65e-41 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 149.57 E-value: 7.65e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 40 AELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSILCSSKVYGGTFNLLGPSLK 119
Cdd:PRK05967 46 AETMATRGQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPSGLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLK 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 120 KFGIDLISFDlDSSEDEIVELAKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIVDNSLASPVLCNPLKYGANIV 199
Cdd:PRK05967 126 RLGVEVEYYD-PEIGAGIAKLMRPNTKVVHTEAPGSNTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDIS 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 200 THSTTKYLDGHASSVGGiIVDGGNFNWdngkfPELVEpdptyhgisytqkfgnaayatkARVQLlrdyGNCLSPFNAYLT 279
Cdd:PRK05967 205 IHAATKYPSGHSDILLG-TVSANEKCW-----PQLLE----------------------AHGTL----GLCAGPDDTYQI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 280 NLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSrGCSGVLSFGVRGGLENAKK----FVE 355
Cdd:PRK05967 253 LRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFS-GASGIFSFVLAAGPEKGKAkahaFLD 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489534710 356 KLQI----------ASLVTHVSdvrtcvihpastthrqlTEEQLIASGVLPS-LIRLSVGIENVEDLIADLNQAL 419
Cdd:PRK05967 332 ALEIfglgyswggyESLALHVK-----------------LGDRTVAKAPYAGpVIRLQIGLEDVPDLKADLERGF 389
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
41-415 |
5.70e-36 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 136.37 E-value: 5.70e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 41 ELFdlkvdghiYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSILCSSKVYGGTFNLLGPSLKK 120
Cdd:PRK08114 53 ELF--------YGRRGTLTHFSLQEAMCELEGGAGCALYPCGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 121 FGIDLISFDLDSSEDeIVELAKENTKVVFAETLANPTLEVIDFEKIANVAKRINvPFIV---DNSLASPVLCNPLKYGAN 197
Cdd:PRK08114 125 LGVTTTWFDPLIGAD-IAKLIQPNTKVVFLESPGSITMEVHDVPAIVAAVRSVN-PDAVimiDNTWAAGVLFKALDFGID 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 198 IVTHSTTKYLDGHASSVGGIIVDGGNFnWDngkfpELVEPdptyhgiSYTQkfgnaayatkarvqllrdyGNCLSPFNAY 277
Cdd:PRK08114 203 ISIQAGTKYLVGHSDAMIGTAVANARC-WE-----QLREN-------SYLM-------------------GQMVDADTAY 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 278 LTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSrGCSGVLSFGVRGGLENAK--KFVE 355
Cdd:PRK08114 251 MTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFT-GSSGLFSFVLKKKLTDEQlaNYLD 329
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 356 KLQI----------ASLVTHVSDVRTCVIHPASTthRQLTEeqliasgvlpSLIRLSVGIENVEDLIADL 415
Cdd:PRK08114 330 NFSLfsmayswggfESLILANQPEEIAAIRPAGE--VDFTG----------TLIRLHIGLEDVDDLIADL 387
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
22-419 |
1.87e-32 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 126.38 E-value: 1.87e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 22 VLPLYQSTTFKYSSIDQLAELFDLKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSIL 101
Cdd:PRK07050 29 VTPVARASTVVFPDLATMRALDWRQDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQPSGLAAISLVYFGLVKAGDDVL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 102 CSSKVYGGTFNLLGPSLKKFGIDLISFD-LDSSEdeIVELAKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIVD 180
Cdd:PRK07050 109 IPDNAYGPNRDHGEWLARDFGITVRFYDpLIGAG--IADLIQPNTRLIWLEAPGSVTMEVPDVPAITAAARARGVVTAID 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 181 NSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGG--IIVDGgnfnwdngkfpelvepdptyhgisytqkfgnAAYATK 258
Cdd:PRK07050 187 NTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGatITADA-------------------------------ELHAKL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 259 ARVQLLRDYGncLSPFNAYLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSrGCSGV 338
Cdd:PRK07050 236 KLARMRLGIG--VSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFT-GAGGL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 339 LSFGVRGGLENAK--KFVEKLQI----------ASL--VTHVSDVRtcvihPASTTHRQlteeqliasgvlpSLIRLSVG 404
Cdd:PRK07050 313 FSVVFDERYSPAQvdAFVEALELfaigwswggaCSLamPYDVASMR-----TAKWPHRG-------------TLVRLYIG 374
|
410
....*....|....*
gi 489534710 405 IENVEDLIADLNQAL 419
Cdd:PRK07050 375 LEDEADLIADLEQAL 389
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
60-220 |
2.41e-07 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 50.46 E-value: 2.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 60 IQAFEEKIS--LLEGGVSSVAVSSGQSANMLAVLNICKSGDSILCSSKVYGGTfnlLGPSLKKFGIDLISFDLDSSED-- 135
Cdd:cd01494 2 LEELEEKLArlLQPGNDKAVFVPSGTGANEAALLALLGPGDEVIVDANGHGSR---YWVAAELAGAKPVPVPVDDAGYgg 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 136 -EIVEL----AKENTKVVFAETLANPTLEVIDFEKIANVAKRINVPFIVDNS---LASPVLCNPLKYG-ANIVTHSTTKY 206
Cdd:cd01494 79 lDVAILeelkAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAAsagGASPAPGVLIPEGgADVVTFSLHKN 158
|
170
....*....|....
gi 489534710 207 LDGhaSSVGGIIVD 220
Cdd:cd01494 159 LGG--EGGGVVIVK 170
|
|
| AHBA_syn |
cd00616 |
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal ... |
36-182 |
1.96e-05 |
|
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.
Pssm-ID: 99740 [Multi-domain] Cd Length: 352 Bit Score: 46.38 E-value: 1.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 36 IDQLAELFDlkvDGHIysrISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLA--VLNIcKSGDSILCSSKVYGGTFN- 112
Cdd:cd00616 2 LEAVEEVLD---SGWL---TLGPKVREFEKAFAEYLGVKYAVAVSSGTAALHLAlrALGI-GPGDEVIVPSFTFVATANa 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489534710 113 --LLG--PslkKF-GIDLISFDLDssEDEIVELAKENTKVVFAETLA-NPtlevIDFEKIANVAKRINVPFIVDNS 182
Cdd:cd00616 75 ilLLGatP---VFvDIDPDTYNID--PELIEAAITPRTKAIIPVHLYgNP----ADMDAIMAIAKRHGLPVIEDAA 141
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
77-180 |
8.22e-05 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 44.25 E-value: 8.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 77 VAVSSG-QSANMLAVLNICKSGDSILCSSKVYGGTFNLlgpsLKKFGIDLISFDLDS------SEDEIVELAKENTKVVF 149
Cdd:cd00609 62 IVVTNGaQEALSLLLRALLNPGDEVLVPDPTYPGYEAA----ARLAGAEVVPVPLDEeggfllDLELLEAAKTPKTKLLY 137
|
90 100 110
....*....|....*....|....*....|....
gi 489534710 150 AETLANPTLEVID---FEKIANVAKRINVPFIVD 180
Cdd:cd00609 138 LNNPNNPTGAVLSeeeLEELAELAKKHGILIISD 171
|
|
| GDC-P |
pfam02347 |
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ... |
68-216 |
1.15e-03 |
|
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
Pssm-ID: 396772 [Multi-domain] Cd Length: 428 Bit Score: 40.82 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 68 SLLEGGvssvavSSGQSANMLAVLNICKSGDSILCSSKVYGGTFNLLGPSLKKFGIDLIsfdldssEDEIVELAKENTKV 147
Cdd:pfam02347 131 SLLDEG------TAAAEAMALAARASKKKGKKFVVDKDVHPQTLEVLKTRAKPFGIEIV-------EVDYTEEGVTDLKD 197
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489534710 148 VFAETLANPTLE--VIDFEKIANVAKRINVPFIV-DNSLASPVLCNPLKYGANIVTHSTTKYldGHASSVGG 216
Cdd:pfam02347 198 VFGVLVQYPNTDgrIEDYKELIELAHQRKSLVVVaADLLALTLLKPPGEFGADIAVGSAQRF--GVPLGYGG 267
|
|
| DegT_DnrJ_EryC1 |
pfam01041 |
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all ... |
55-180 |
7.29e-03 |
|
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA, StsC and StsS. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin.
Pssm-ID: 395827 Cd Length: 360 Bit Score: 38.42 E-value: 7.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489534710 55 ISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLA--VLNIcKSGDSILCSSKVYGGTFN---LLGPSLKKFGIDLISFD 129
Cdd:pfam01041 21 TTGPYVREFERAFAAYLGVKHAIAVSSGTAALHLAlrALGV-GPGDEVITPSFTFVATANaalRLGAKPVFVDIDPDTYN 99
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 489534710 130 LDssEDEIVELAKENTKVVFAETLA-NPTleviDFEKIANVAKRINVPFIVD 180
Cdd:pfam01041 100 ID--PEAIEAAITPRTKAIIPVHLYgQPA----DMDAIRAIAARHGLPVIED 145
|
|
| |
