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Conserved domains on  [gi|489535147|ref|WP_003439874|]
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4Fe-4S binding protein [Clostridioides difficile]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
QueG super family cl34317
Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and ...
 73-204 1.06e-12

Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and biogenesis]; Epoxyqueuosine reductase QueG (queuosine biosynthesis) is part of the Pathway/BioSystem: tRNA modification


The actual alignment was detected with superfamily member COG1600:

Pssm-ID: 441208 [Multi-domain]  Cd Length: 345  Bit Score: 66.00  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489535147  73 ADWISKYIQNKGYRAYSQSeknnlehgyfekayinpemqsgiSPLPHKTIANISGIGFMGKNNLFVTEEYGCAFSMCTVL 152
Cdd:COG1600  115 AEFLEEEGPGVGYRVFVDT-----------------------APVLERALAERAGLGWIGKNTNLITPEFGSWFFLGEIL 171

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489535147 153 TDAPISVERyPLIDsKCMDCNVCVENCPAKAIHGnewtlPGKresiIDVSKC 204
Cdd:COG1600  172 TDLELPPDE-PVED-HCGSCTRCLDACPTGAIVA-----PYV----LDARRC 212
 
Name Accession Description Interval E-value
QueG COG1600
Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and ...
 73-204 1.06e-12

Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and biogenesis]; Epoxyqueuosine reductase QueG (queuosine biosynthesis) is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441208 [Multi-domain]  Cd Length: 345  Bit Score: 66.00  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489535147  73 ADWISKYIQNKGYRAYSQSeknnlehgyfekayinpemqsgiSPLPHKTIANISGIGFMGKNNLFVTEEYGCAFSMCTVL 152
Cdd:COG1600  115 AEFLEEEGPGVGYRVFVDT-----------------------APVLERALAERAGLGWIGKNTNLITPEFGSWFFLGEIL 171

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489535147 153 TDAPISVERyPLIDsKCMDCNVCVENCPAKAIHGnewtlPGKresiIDVSKC 204
Cdd:COG1600  172 TDLELPPDE-PVED-HCGSCTRCLDACPTGAIVA-----PYV----LDARRC 212
RDH TIGR02486
reductive dehalogenase; This model represents a family of corrin and 8-iron Fe-S ...
 75-217 4.10e-08

reductive dehalogenase; This model represents a family of corrin and 8-iron Fe-S cluster-containing reductive dehalogenases found primarily in halorespiring microorganisms such as dehalococcoides ethenogenes which contains as many as 17 enzymes of this type with varying substrate ranges. One example of a characterized species is the tetrachloroethene reductive dehalogenase (1.97.1.8) which also acts on trichloroethene converting it to dichloroethene.


Pssm-ID: 274158  Cd Length: 314  Bit Score: 52.44  E-value: 4.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489535147   75 WISKYIQNKGYRAYSqseknnleHGyfekayinpemqSGISPLPHKTIANISGIGFMGKN-NLFVTEEYGCAFSMCTV-L 152
Cdd:TIGR02486 129 RLQQFIRNLGYNAVP--------SG------------NGNGLGSSVAFAVLAGLGEHGRMgQAIISPEYGPRVRIAKViL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489535147  153 TDAPISVERyPlIDSK----CMDCNVCVENCPAKAI-HGNEWTL-------------PGKRESIIDVSKC---------- 204
Cdd:TIGR02486 189 TDLPLVPTK-P-IDAGmakfCETCGKCADECPSGAIsKGGEPTWdpedsngdppgenNPGLKWQYDGWRCllfrcynegg 266

                         170
                  ....*....|...
gi 489535147  205 FCVLRCMMSCPWS 217
Cdd:TIGR02486 267 GGCGVCQAVCPFN 279
PRK13795 PRK13795
hypothetical protein; Provisional
 167-222 3.75e-06

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 46.91  E-value: 3.75e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489535147 167 SKCMDCNVCVENCPAKAIhgnewTLPGKRESI-IDVSKCFCVLRCMMSCPwSLRYAN 222
Cdd:PRK13795 581 AECVGCGVCVGACPTGAI-----RIEEGKRKIsVDEEKCIHCGKCTEVCP-VVKYKD 631
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 169-216 5.16e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 41.78  E-value: 5.16e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489535147 169 CMDCN--VCVENCPAKAIHgnewtlpgKRES---IIDVSKCFCVLRCMMSCPW 216
Cdd:cd16371   54 CNHCEnpACVKVCPTGAIT--------KREDgivVVDQDKCIGCGYCVWACPY 98
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 169-216 5.46e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 36.74  E-value: 5.46e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 489535147  169 CMDCNVCVENCPAKAIHGNEWTLPGKRESI-IDVSKCFCVLRCMMSCPW 216
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKGTKTVvIDPERCVGCGACVAVCPT 49
 
Name Accession Description Interval E-value
QueG COG1600
Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and ...
 73-204 1.06e-12

Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and biogenesis]; Epoxyqueuosine reductase QueG (queuosine biosynthesis) is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441208 [Multi-domain]  Cd Length: 345  Bit Score: 66.00  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489535147  73 ADWISKYIQNKGYRAYSQSeknnlehgyfekayinpemqsgiSPLPHKTIANISGIGFMGKNNLFVTEEYGCAFSMCTVL 152
Cdd:COG1600  115 AEFLEEEGPGVGYRVFVDT-----------------------APVLERALAERAGLGWIGKNTNLITPEFGSWFFLGEIL 171

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489535147 153 TDAPISVERyPLIDsKCMDCNVCVENCPAKAIHGnewtlPGKresiIDVSKC 204
Cdd:COG1600  172 TDLELPPDE-PVED-HCGSCTRCLDACPTGAIVA-----PYV----LDARRC 212
RDH TIGR02486
reductive dehalogenase; This model represents a family of corrin and 8-iron Fe-S ...
 75-217 4.10e-08

reductive dehalogenase; This model represents a family of corrin and 8-iron Fe-S cluster-containing reductive dehalogenases found primarily in halorespiring microorganisms such as dehalococcoides ethenogenes which contains as many as 17 enzymes of this type with varying substrate ranges. One example of a characterized species is the tetrachloroethene reductive dehalogenase (1.97.1.8) which also acts on trichloroethene converting it to dichloroethene.


Pssm-ID: 274158  Cd Length: 314  Bit Score: 52.44  E-value: 4.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489535147   75 WISKYIQNKGYRAYSqseknnleHGyfekayinpemqSGISPLPHKTIANISGIGFMGKN-NLFVTEEYGCAFSMCTV-L 152
Cdd:TIGR02486 129 RLQQFIRNLGYNAVP--------SG------------NGNGLGSSVAFAVLAGLGEHGRMgQAIISPEYGPRVRIAKViL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489535147  153 TDAPISVERyPlIDSK----CMDCNVCVENCPAKAI-HGNEWTL-------------PGKRESIIDVSKC---------- 204
Cdd:TIGR02486 189 TDLPLVPTK-P-IDAGmakfCETCGKCADECPSGAIsKGGEPTWdpedsngdppgenNPGLKWQYDGWRCllfrcynegg 266

                         170
                  ....*....|...
gi 489535147  205 FCVLRCMMSCPWS 217
Cdd:TIGR02486 267 GGCGVCQAVCPFN 279
PRK13795 PRK13795
hypothetical protein; Provisional
 167-222 3.75e-06

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 46.91  E-value: 3.75e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489535147 167 SKCMDCNVCVENCPAKAIhgnewTLPGKRESI-IDVSKCFCVLRCMMSCPwSLRYAN 222
Cdd:PRK13795 581 AECVGCGVCVGACPTGAI-----RIEEGKRKIsVDEEKCIHCGKCTEVCP-VVKYKD 631
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 154-215 1.01e-05

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 41.96  E-value: 1.01e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489535147 154 DAPISVERYPLID-SKCMDCNVCVENCPAKAIHGNEWTLpgkresIIDVSKCFCVLRCMMSCP 215
Cdd:COG2221    1 PYGIIGTWPPKIDeEKCIGCGLCVAVCPTGAISLDDGKL------VIDEEKCIGCGACIRVCP 57
NapF COG1145
Ferredoxin [Energy production and conversion];
167-215 4.77e-05

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 43.17  E-value: 4.77e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 489535147 167 SKCMDCNVCVENCPAKAIHGNEwtlpGKRESIIDVSKC-FCvLRCMMSCP 215
Cdd:COG1145  182 EKCIGCGLCVKVCPTGAIRLKD----GKPQIVVDPDKCiGC-GACVKVCP 226
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 168-215 4.97e-05

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 40.11  E-value: 4.97e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 489535147 168 KCMDCNVCVENCPAKAIHGNEWtlPGKRESIIDVSKC-FCVLrCMMSCP 215
Cdd:COG1143    3 KCIGCGLCVRVCPVDAITIEDG--EPGKVYVIDPDKCiGCGL-CVEVCP 48
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 169-216 5.16e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 41.78  E-value: 5.16e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489535147 169 CMDCN--VCVENCPAKAIHgnewtlpgKRES---IIDVSKCFCVLRCMMSCPW 216
Cdd:cd16371   54 CNHCEnpACVKVCPTGAIT--------KREDgivVVDQDKCIGCGYCVWACPY 98
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
158-215 1.08e-04

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 39.33  E-value: 1.08e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489535147 158 SVERYPLIDSKCMDCNVCVENCPAKAIHGnewtlpGKRESIIDVSKCFCVLRCMMSCP 215
Cdd:COG2768    2 SLGKPYVDEEKCIGCGACVKVCPVGAISI------EDGKAVIDPEKCIGCGACIEVCP 53
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
144-215 1.25e-04

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 42.32  E-value: 1.25e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489535147 144 CAFSMCTVLTDAPISVERYPLID--SKCMDCNVCVENCPAKAIHGNEwtlpgKRESIIDVSkcfCVL--RCMMSCP 215
Cdd:COG4624   66 VAISCIQVRGIIIIDKRGPSIIRdkEKCKNCYPCVRACPVKAIKVDD-----GKAEIDEEK---CIScgQCVAVCP 133
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 169-216 5.46e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 36.74  E-value: 5.46e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 489535147  169 CMDCNVCVENCPAKAIHGNEWTLPGKRESI-IDVSKCFCVLRCMMSCPW 216
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKGTKTVvIDPERCVGCGACVAVCPT 49
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 162-215 5.56e-04

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 37.38  E-value: 5.56e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489535147 162 YPLID-SKCMDCNVCVENCPAKAIHGNEwtlPGKRESIIDVSKCFCVLRCMMSCP 215
Cdd:COG1146    2 MPVIDtDKCIGCGACVEVCPVDVLELDE---EGKKALVINPEECIGCGACELVCP 53
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 166-216 5.72e-04

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 38.53  E-value: 5.72e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489535147 166 DSKCMDCNVCVENCPAKAIHGNEwtlpgKRESIIDVSKC-FCvLRCMMSCPW 216
Cdd:cd10549   77 EEKCIGCGLCVKVCPVDAITLED-----ELEIVIDKEKCiGC-GICAEVCPV 122
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 159-224 1.06e-03

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 38.77  E-value: 1.06e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489535147 159 VERYPLIDSkCMDCN--VCVENCPAKAIHgnewtlpgKRES---IIDVSKCF-CvLRCMMSCPWSLRYANQK 224
Cdd:COG0437   51 VEWLFVPVL-CNHCDdpPCVKVCPTGATY--------KREDgivLVDYDKCIgC-RYCVAACPYGAPRFNPE 112
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 161-217 1.14e-03

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 36.56  E-value: 1.14e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489535147 161 RYPLIDSKCMDCNVCVENCPAKAIHgnewtlPGKRESIIDVSKCFCVLRCMMSCPWS 217
Cdd:COG4231   16 RYVIDEDKCTGCGACVKVCPADAIE------EGDGKAVIDPDLCIGCGSCVQVCPVD 66
Fer4_16 pfam13484
4Fe-4S double cluster binding domain;
169-216 1.16e-03

4Fe-4S double cluster binding domain;


Pssm-ID: 463893 [Multi-domain]  Cd Length: 65  Bit Score: 36.31  E-value: 1.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489535147  169 CMDCNVCVENCPAKAIHGNE----------WTLPGKRESIIDVSKCFCVLR------CMMSCPW 216
Cdd:pfam13484   1 CGSCGKCIDACPTGAIVGPEgvldarrcisYLTIEKKGLIPDELRCLLGNRcygcdiCQDVCPW 64
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 169-222 1.58e-03

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 38.28  E-value: 1.58e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489535147 169 CMDCNV--CVENCPAKAIHgnewtlpgKRES---IIDVSKCFCVLRCMMSCPWSLRYAN 222
Cdd:cd10551   53 CNHCENppCVKVCPTGATY--------KREDgivLVDYDKCIGCRYCMAACPYGARYFN 103
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
142-215 3.06e-03

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 38.30  E-value: 3.06e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489535147 142 YGCAFSMCTVLTDAPISVER-YPLID-SKCMDCNVCVENCPAKAIHGNEwtlpgKRESIIDVSKCF-CVLrCMMSCP 215
Cdd:COG1148  469 TAAAARAIQLLSKGELGVEPsVAEVDpEKCTGCGRCVEVCPYGAISIDE-----KGVAEVNPALCKgCGT-CAAACP 539
HybA_like cd10561
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ...
 169-217 3.12e-03

the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction.


Pssm-ID: 319883 [Multi-domain]  Cd Length: 196  Bit Score: 37.19  E-value: 3.12e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489535147 169 CMDCN--VCVENCPAKAIHgnewtlpgKRES---IIDVSKCF-CvlR-CMMSCPWS 217
Cdd:cd10561   69 CMHCLdpACVSACPVGALR--------KTPEgpvTYDEDKCIgC--RyCMVACPFN 114
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 156-215 5.46e-03

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 35.84  E-value: 5.46e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489535147 156 PISVERYPLID-SKCMDCNVCVENCPAKAIH---GNEWTLPGKRESIIDVSKCFCVLRCMMSCP 215
Cdd:cd10549   28 NGAIARGPEIDeDKCVFCGACVEVCPTGAIEltpEGKEYVPKEKEAEIDEEKCIGCGLCVKVCP 91
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 161-210 8.54e-03

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 33.93  E-value: 8.54e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489535147 161 RYPLID-SKCMDCNVCVENCPAKAIhgnewTLPGKRESIIDVSKC----FCVLRC 210
Cdd:COG1149    4 KIPVIDeEKCIGCGLCVEVCPEGAI-----KLDDGGAPVVDPDLCtgcgACVGVC 53
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 160-185 8.97e-03

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 33.93  E-value: 8.97e-03
                         10        20
                 ....*....|....*....|....*..
gi 489535147 160 ERYPLID-SKCMDCNVCVENCPAKAIH 185
Cdd:COG1149   33 GGAPVVDpDLCTGCGACVGVCPTGAIT 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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