|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08997 |
PRK08997 |
isocitrate dehydrogenase; Provisional |
1-335 |
0e+00 |
|
isocitrate dehydrogenase; Provisional
Pssm-ID: 181606 Cd Length: 334 Bit Score: 622.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 1 MTQTITVIRGDGIGPEIMDATLFVLDALNAGLTYEYADAGLVALEKHGDLLPAATLDSIRKNKIALKSPLTTPVGEGFSS 80
Cdd:PRK08997 1 MKQTITVIPGDGIGPSIIDATLKILDKLGCDFEYEFADAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPVGEGFTS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 81 INVAMRRQFDLYANVRPAKSFPNTKSRFgAGVDLITVRENTEGAYLSEGQEVSADGETAVSMAKVTRKGSERIVRYAFDL 160
Cdd:PRK08997 81 INVTLRKKFDLYANVRPVLSFPGTKARY-DNIDIITVRENTEGMYSGEGQTVSEDGETAEATSIITRKGAERIVRFAYEL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 161 ARATGRKKVTAVHKANIIKSTSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTNLFGDILSDLCAGL 240
Cdd:PRK08997 160 ARKEGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 241 VGGLGLAPGANIGVDAAIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVATLEAKDGLTPDLGG 320
Cdd:PRK08997 240 VGGLGMAPGANIGRDAAIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRTTRDLGG 319
|
330
....*....|....*
gi 489575260 321 SGNTMGFAKAIASRL 335
Cdd:PRK08997 320 THGTTDFTQAVIDRL 334
|
|
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
2-335 |
4.51e-169 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 473.73 E-value: 4.51e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 2 TQTITVIRGDGIGPEIMDATLFVLDALNA----GLTYEYADAGLVALEKHGDLLPAATLDSIRKNKIALKSPLTTPV--- 74
Cdd:COG0473 1 TYKIAVLPGDGIGPEVVAAALKVLEAAAErfglDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKwdd 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 75 GEGFSSINVAMRRQFDLYANVRPAKSFPNTKSRF----GAGVDLITVRENTEGAYLSEG--QEVSADGETAVSMAKVTRK 148
Cdd:COG0473 81 GVRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeiVEGIDLVIVRENTEGLYFGIGgrIGTGTGEEVAIDTRVYTRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 149 GSERIVRYAFDLARATgRKKVTAVHKANIIKSTSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTNL 228
Cdd:COG0473 161 GIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTENL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 229 FGDILSDLCAGLVGGLGLAPGANIGVD-AAIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVAT 307
Cdd:COG0473 240 FGDILSDLAAGLTGSLGLAPSANIGDEgKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAAVEKV 319
|
330 340
....*....|....*....|....*....
gi 489575260 308 LEakDG-LTPDLGGSGNTMGFAKAIASRL 335
Cdd:COG0473 320 LA--EGvRTPDLGGKAGTSEMGDAIIAAL 346
|
|
| mito_nad_idh |
TIGR00175 |
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ... |
3-335 |
3.86e-124 |
|
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]
Pssm-ID: 272942 Cd Length: 333 Bit Score: 359.39 E-value: 3.86e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 3 QTITVIRGDGIGPEIMDATLFVLDALNAGLTYEYADaglVALEKHG--DLLPAAtLDSIRKNKIALKSPLTTPVGEGF-S 79
Cdd:TIGR00175 4 YTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEID---VSPQTDGktEIPDEA-VESIKRNKVALKGPLETPIGKGGhR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 80 SINVAMRRQFDLYANVRPAKSFPNTKSRFgAGVDLITVRENTEGAYlSEGQEVSADGeTAVSMAKVTRKGSERIVRYAFD 159
Cdd:TIGR00175 80 SLNVALRKELDLYANVVHCKSLPGFKTRH-EDVDIVIIRENTEGEY-SGLEHESVPG-VVESLKVITRDKSERIARYAFE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 160 LARATGRKKVTAVHKANIIKSTSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTNLFGDILSDLCAG 239
Cdd:TIGR00175 157 YARKNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 240 LVGGLGLAPGANIGVDAAIFE-AVHGSAPDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVATLEAKDGLTPDL 318
Cdd:TIGR00175 237 LVGGPGLVPGANIGRDYAVFEpGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDL 316
|
330
....*....|....*..
gi 489575260 319 GGSGNTMGFAKAIASRL 335
Cdd:TIGR00175 317 GGTATTSDFTEAVIKRL 333
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
4-331 |
7.29e-118 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 343.89 E-value: 7.29e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 4 TITVIRGDGIGPEIMDATLFVLDALN----AGLTYEYADAGLVALEKHGDLLPAATLDSIRKNKIALKSPLTTPVGEGFS 79
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAALekapLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 80 ----SINVAMRRQFDLYANVRPAKSFPNTKS-----RFGAGVDLITVRENTEGAYLseGQE---VSADGETAVSMAKVTR 147
Cdd:pfam00180 81 vrpeNGLLALRKELGLFANLRPAKVFPPLGDasplkNEVEGVDIVIVRELTGGIYF--GIEkgiKGSGNEVAVDTKLYSR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 148 KGSERIVRYAFDLARATGRKKVTAVHKANIIKSTSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTN 227
Cdd:pfam00180 159 DEIERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPN 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 228 LFGDILSDLCAGLVGGLGLAPGANIGVDA-AIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDH-VGQPQNAERLRSAIV 305
Cdd:pfam00180 239 LFGDILSDEASMLTGSLGLLPSASLGANGfGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVL 318
|
330 340
....*....|....*....|....*....
gi 489575260 306 ATLEAKDgLTPDLGGSG---NTMGFAKAI 331
Cdd:pfam00180 319 KVLESGI-RTGDLAGSAtyvSTSEFGEAV 346
|
|
| AksF2_Meth |
NF040626 |
homoisocitrate dehydrogenase; |
4-335 |
1.29e-117 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468598 Cd Length: 332 Bit Score: 342.87 E-value: 1.29e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 4 TITVIRGDGIGPEIMDATLFVLDALNAGLTYEYADAGLVALEKHGDLLPAATLDSIRKNKIALKSPLTTPVGEGfSSInV 83
Cdd:NF040626 3 KITVIPGDGIGKEVMEAALYVLDALDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTSTPGQK-SPI-I 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 84 AMRRQFDLYANVRPAKSFPNTKSRFgAGVDLITVRENTEGAYlsEGQEVSADGETAVSMAKVTRKGSERIVRYAFDLARA 163
Cdd:NF040626 81 TLRKELDLYANLRPIKSYEGINCLF-KDLDFLIVRENTEGLY--SGLEEEYTEEKAIAERVITRKASERICKFAFEYAIK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 164 TGRKKVTAVHKANIIKSTSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTNLFGDILSDLCAGLVGG 243
Cdd:NF040626 158 LGRKKVTAVHKANVLKKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTTNLFGDILSDEAAGLVGG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 244 LGLAPGANIGVDAAIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVATLEAKDGLTPDLGGSGN 323
Cdd:NF040626 238 LGLAPSANIGDKNGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENALEKVLREGKVVTPDLGGNAK 317
|
330
....*....|..
gi 489575260 324 TMGFAKAIASRL 335
Cdd:NF040626 318 TMEMANEIKKKI 329
|
|
| AksF_Meth |
NF040619 |
homoisocitrate dehydrogenase; |
5-324 |
4.44e-96 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468591 Cd Length: 332 Bit Score: 287.81 E-value: 4.44e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 5 ITVIRGDGIGPEIMDATLFVLDALnAGLTYEYADAGLVALEKHGDLLPAATLDSIRKNKIALKSPLTTP-----VGEGFS 79
Cdd:NF040619 4 ICVIEGDGIGKEVIPETVRVLKEL-GDFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPkptelKNKNYK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 80 SINVAMRRQFDLYANVRPAKSFPNTKSrfGAGVDLITVRENTEGAYLseGQE-VSADGETAVSMAKVTRKGSERIVRYAF 158
Cdd:NF040619 83 SPILTLRKELDLYANVRPINNFGDGQD--VKNIDFVIIRENTEGLYV--GREyYDEENEIAIAERIISKKGSERIIKFAF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 159 DLARATGRKKVTAVHKANIIKSTSGLFLKVARDVAANYPE--IEFQEMIVDNACMQLVMRPEQFDIIVTTNLFGDILSDL 236
Cdd:NF040619 159 EYAKKNNRKKVSCIHKANVLRVTDGLFLEIFNEIKKKYKNfnIEADDYLVDATAMYLIKNPEMFDVIVTTNLFGDILSDE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 237 CAGLVGGLGLAPGANIGVDAAIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVATLEAKDgLTP 316
Cdd:NF040619 239 ASGLIGGLGLAPSANIGDKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDLIREAVKKCLENGK-VTP 317
|
....*...
gi 489575260 317 DLGGSGNT 324
Cdd:NF040619 318 DLGGNLKT 325
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08997 |
PRK08997 |
isocitrate dehydrogenase; Provisional |
1-335 |
0e+00 |
|
isocitrate dehydrogenase; Provisional
Pssm-ID: 181606 Cd Length: 334 Bit Score: 622.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 1 MTQTITVIRGDGIGPEIMDATLFVLDALNAGLTYEYADAGLVALEKHGDLLPAATLDSIRKNKIALKSPLTTPVGEGFSS 80
Cdd:PRK08997 1 MKQTITVIPGDGIGPSIIDATLKILDKLGCDFEYEFADAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPVGEGFTS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 81 INVAMRRQFDLYANVRPAKSFPNTKSRFgAGVDLITVRENTEGAYLSEGQEVSADGETAVSMAKVTRKGSERIVRYAFDL 160
Cdd:PRK08997 81 INVTLRKKFDLYANVRPVLSFPGTKARY-DNIDIITVRENTEGMYSGEGQTVSEDGETAEATSIITRKGAERIVRFAYEL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 161 ARATGRKKVTAVHKANIIKSTSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTNLFGDILSDLCAGL 240
Cdd:PRK08997 160 ARKEGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 241 VGGLGLAPGANIGVDAAIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVATLEAKDGLTPDLGG 320
Cdd:PRK08997 240 VGGLGMAPGANIGRDAAIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRTTRDLGG 319
|
330
....*....|....*
gi 489575260 321 SGNTMGFAKAIASRL 335
Cdd:PRK08997 320 THGTTDFTQAVIDRL 334
|
|
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
2-335 |
4.51e-169 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 473.73 E-value: 4.51e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 2 TQTITVIRGDGIGPEIMDATLFVLDALNA----GLTYEYADAGLVALEKHGDLLPAATLDSIRKNKIALKSPLTTPV--- 74
Cdd:COG0473 1 TYKIAVLPGDGIGPEVVAAALKVLEAAAErfglDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKwdd 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 75 GEGFSSINVAMRRQFDLYANVRPAKSFPNTKSRF----GAGVDLITVRENTEGAYLSEG--QEVSADGETAVSMAKVTRK 148
Cdd:COG0473 81 GVRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeiVEGIDLVIVRENTEGLYFGIGgrIGTGTGEEVAIDTRVYTRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 149 GSERIVRYAFDLARATgRKKVTAVHKANIIKSTSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTNL 228
Cdd:COG0473 161 GIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTENL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 229 FGDILSDLCAGLVGGLGLAPGANIGVD-AAIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVAT 307
Cdd:COG0473 240 FGDILSDLAAGLTGSLGLAPSANIGDEgKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAAVEKV 319
|
330 340
....*....|....*....|....*....
gi 489575260 308 LEakDG-LTPDLGGSGNTMGFAKAIASRL 335
Cdd:COG0473 320 LA--EGvRTPDLGGKAGTSEMGDAIIAAL 346
|
|
| PRK09222 |
PRK09222 |
NADP-dependent isocitrate dehydrogenase; |
5-335 |
2.20e-126 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236416 [Multi-domain] Cd Length: 482 Bit Score: 370.38 E-value: 2.20e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 5 ITVIRGDGIGPEIMDATLFVLDALNAGLTYEYADAGL-VALEKHGDLLPAATLDSIRKNKIALKSPLTTPVGEGFSSINV 83
Cdd:PRK09222 7 ITVAYGDGIGPEIMEAVLKILEAAGAPLEIETIEIGEkVYKKGWTSGISPSAWESIRRTKVLLKAPITTPQGGGYKSLNV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 84 AMRRQFDLYANVRPAKSF-PNTKSRFgAGVDLITVRENTEGAYlsEGQEVSADGETAVSMAKVTRKGSERIVRYAFDLAR 162
Cdd:PRK09222 87 TLRKTLGLYANVRPCVSYhPFVETKH-PNLDVVIIRENEEDLY--AGIEHRQTPDVYQCLKLISRPGSEKIIRYAFEYAR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 163 ATGRKKVTAVHKANIIKSTSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTNLFGDILSDLCAGLVG 242
Cdd:PRK09222 164 ANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 243 GLGLAPGANIGVDAAIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVATLEakDG-LTPDLGGS 321
Cdd:PRK09222 244 SVGLAGSANIGEEYAMFEAVHGSAPDIAGKNIANPSGLLNAAVMMLVHIGQFDIAELIENAWLKTLE--DGiHTADIYNE 321
|
330 340
....*....|....*....|
gi 489575260 322 G------NTMGFAKAIASRL 335
Cdd:PRK09222 322 GvskkkvGTKEFAEAVIENL 341
|
|
| mito_nad_idh |
TIGR00175 |
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ... |
3-335 |
3.86e-124 |
|
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]
Pssm-ID: 272942 Cd Length: 333 Bit Score: 359.39 E-value: 3.86e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 3 QTITVIRGDGIGPEIMDATLFVLDALNAGLTYEYADaglVALEKHG--DLLPAAtLDSIRKNKIALKSPLTTPVGEGF-S 79
Cdd:TIGR00175 4 YTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEID---VSPQTDGktEIPDEA-VESIKRNKVALKGPLETPIGKGGhR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 80 SINVAMRRQFDLYANVRPAKSFPNTKSRFgAGVDLITVRENTEGAYlSEGQEVSADGeTAVSMAKVTRKGSERIVRYAFD 159
Cdd:TIGR00175 80 SLNVALRKELDLYANVVHCKSLPGFKTRH-EDVDIVIIRENTEGEY-SGLEHESVPG-VVESLKVITRDKSERIARYAFE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 160 LARATGRKKVTAVHKANIIKSTSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTNLFGDILSDLCAG 239
Cdd:TIGR00175 157 YARKNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 240 LVGGLGLAPGANIGVDAAIFE-AVHGSAPDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVATLEAKDGLTPDL 318
Cdd:TIGR00175 237 LVGGPGLVPGANIGRDYAVFEpGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDL 316
|
330
....*....|....*..
gi 489575260 319 GGSGNTMGFAKAIASRL 335
Cdd:TIGR00175 317 GGTATTSDFTEAVIKRL 333
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
4-331 |
7.29e-118 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 343.89 E-value: 7.29e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 4 TITVIRGDGIGPEIMDATLFVLDALN----AGLTYEYADAGLVALEKHGDLLPAATLDSIRKNKIALKSPLTTPVGEGFS 79
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAALekapLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 80 ----SINVAMRRQFDLYANVRPAKSFPNTKS-----RFGAGVDLITVRENTEGAYLseGQE---VSADGETAVSMAKVTR 147
Cdd:pfam00180 81 vrpeNGLLALRKELGLFANLRPAKVFPPLGDasplkNEVEGVDIVIVRELTGGIYF--GIEkgiKGSGNEVAVDTKLYSR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 148 KGSERIVRYAFDLARATGRKKVTAVHKANIIKSTSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTN 227
Cdd:pfam00180 159 DEIERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPN 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 228 LFGDILSDLCAGLVGGLGLAPGANIGVDA-AIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDH-VGQPQNAERLRSAIV 305
Cdd:pfam00180 239 LFGDILSDEASMLTGSLGLLPSASLGANGfGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVL 318
|
330 340
....*....|....*....|....*....
gi 489575260 306 ATLEAKDgLTPDLGGSG---NTMGFAKAI 331
Cdd:pfam00180 319 KVLESGI-RTGDLAGSAtyvSTSEFGEAV 346
|
|
| AksF2_Meth |
NF040626 |
homoisocitrate dehydrogenase; |
4-335 |
1.29e-117 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468598 Cd Length: 332 Bit Score: 342.87 E-value: 1.29e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 4 TITVIRGDGIGPEIMDATLFVLDALNAGLTYEYADAGLVALEKHGDLLPAATLDSIRKNKIALKSPLTTPVGEGfSSInV 83
Cdd:NF040626 3 KITVIPGDGIGKEVMEAALYVLDALDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTSTPGQK-SPI-I 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 84 AMRRQFDLYANVRPAKSFPNTKSRFgAGVDLITVRENTEGAYlsEGQEVSADGETAVSMAKVTRKGSERIVRYAFDLARA 163
Cdd:NF040626 81 TLRKELDLYANLRPIKSYEGINCLF-KDLDFLIVRENTEGLY--SGLEEEYTEEKAIAERVITRKASERICKFAFEYAIK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 164 TGRKKVTAVHKANIIKSTSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTNLFGDILSDLCAGLVGG 243
Cdd:NF040626 158 LGRKKVTAVHKANVLKKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTTNLFGDILSDEAAGLVGG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 244 LGLAPGANIGVDAAIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVATLEAKDGLTPDLGGSGN 323
Cdd:NF040626 238 LGLAPSANIGDKNGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENALEKVLREGKVVTPDLGGNAK 317
|
330
....*....|..
gi 489575260 324 TMGFAKAIASRL 335
Cdd:NF040626 318 TMEMANEIKKKI 329
|
|
| LEU3_arch |
TIGR02088 |
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ... |
5-332 |
1.94e-116 |
|
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.
Pssm-ID: 273962 Cd Length: 322 Bit Score: 339.43 E-value: 1.94e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 5 ITVIRGDGIGPEIMDATLFVLDALNAGLTYEYADAGLVALEKHGDLLPAATLDSIRKNKIALKSPLTTPVGEGFSSINVA 84
Cdd:TIGR02088 1 VAVIPGDGIGPEVIEAAIRILNKLGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTPANPGYKSVIVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 85 MRRQFDLYANVRPAKSFPNTKSRFGAGVDLITVRENTEGAYLSEGqEVSADGETAVSMakVTRKGSERIVRYAFDLARAT 164
Cdd:TIGR02088 81 LRKELDLYANVRPAKSLPGIPDLYPNGKDIVIVRENTEGLYAGFE-FGFSDRAIAIRV--ITREGSERIARFAFNLAKER 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 165 GRKkVTAVHKANIIKSTSGLFLKVARDVAANYpEIEFQEMIVDNACMQLVMRPEQFDIIVTTNLFGDILSDLCAGLVGGL 244
Cdd:TIGR02088 158 NRK-VTCVHKANVLKGTDGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRFDVIVTTNMFGDILSDLASALAGSL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 245 GLAPGANIGVDAAIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVATLEAKDgLTPDLGGSGNT 324
Cdd:TIGR02088 236 GLAPSANIGDRKALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGELEKGKLVWEAVEYYIIEGK-KTPDLGGTAKT 314
|
....*...
gi 489575260 325 MGFAKAIA 332
Cdd:TIGR02088 315 KEVGDEIA 322
|
|
| PLN00118 |
PLN00118 |
isocitrate dehydrogenase (NAD+) |
4-335 |
4.90e-111 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215062 Cd Length: 372 Bit Score: 327.61 E-value: 4.90e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 4 TITVIRGDGIGPEIMDATLFVLDALNAGLTYEYADAGLVALEKHGDLLPAATLDSIRKNKIALKSPLTTPVGEGFSSINV 83
Cdd:PLN00118 43 TATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVGTTVDPRTGSFLTWESLESVRRNKVGLKGPMATPIGKGHRSLNL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 84 AMRRQFDLYANVRPAKSFPNTKSRFGaGVDLITVRENTEGAYLS-EGQEVSADGEtavSMAKVTRKGSERIVRYAFDLAR 162
Cdd:PLN00118 123 TLRKELGLYANVRPCYSLPGYKTRYD-DVDLVTIRENTEGEYSGlEHQVVRGVVE---SLKIITRQASLRVAEYAFHYAK 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 163 ATGRKKVTAVHKANIIKSTSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTNLFGDILSDLCAGLVG 242
Cdd:PLN00118 199 THGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 243 GLGLAPGANIGVDA-AIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVATLEAKDGLTPDLGGS 321
Cdd:PLN00118 279 GLGLTPSCNIGENGlALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRHLKLNEQAEQIHNAILNTIAEGKYRTADLGGS 358
|
330
....*....|....
gi 489575260 322 GNTMGFAKAIASRL 335
Cdd:PLN00118 359 STTTDFTKAICDHL 372
|
|
| PRK14025 |
PRK14025 |
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional |
5-335 |
1.07e-110 |
|
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
Pssm-ID: 184462 Cd Length: 330 Bit Score: 325.16 E-value: 1.07e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 5 ITVIRGDGIGPEIMDATLFVLDALNAGLTYEYADAGLVALEKHGDLLPAATLDSIRKNKialkSPLTTPVGEGFSSINVA 84
Cdd:PRK14025 4 ICVIEGDGIGKEVVPAALHVLEATGLPFEFVYAEAGDEVFEKTGKALPEETIEAAKEAD----AVLFGAAGETAADVIVK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 85 MRRQFDLYANVRPAKSFPNTKSRFgAGVDLITVRENTEGAYLSEGQEVsADGeTAVSMAKVTRKGSERIVRYAFDLAR-- 162
Cdd:PRK14025 80 LRRILDTYANVRPVKSYKGVKCLY-PDIDYVIVRENTEGLYKGIEAEI-ADG-VTVATRVITRKASERIFRFAFEMAKrr 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 163 --ATGRKKVTAVHKANIIKSTSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTNLFGDILSDLCAGL 240
Cdd:PRK14025 157 kkMGKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 241 VGGLGLAPGANIGVDAAIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVATLEakDGL-TPDLG 319
Cdd:PRK14025 237 VGGLGLAPSANIGDKYGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLA--LGLtTPDLG 314
|
330
....*....|....*.
gi 489575260 320 GSGNTMGFAKAIASRL 335
Cdd:PRK14025 315 GNLSTMEMAEEVAKRV 330
|
|
| PRK00772 |
PRK00772 |
3-isopropylmalate dehydrogenase; Provisional |
1-335 |
4.43e-101 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 234832 Cd Length: 358 Bit Score: 301.64 E-value: 4.43e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 1 MTQTITVIRGDGIGPEIMDATLFVLDALNA----GLTYEYADAGLVALEKHGDLLPAATLDSIRK--------------- 61
Cdd:PRK00772 1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEkfgfDFEFEEALVGGAAIDAHGVPLPEETLEACRAadavllgavggpkwd 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 62 NKIALKSPLTtpvgeGFssinVAMRRQFDLYANVRPAKSFPNT------KSRFGAGVDLITVRENTEGAYLSE--GQEVS 133
Cdd:PRK00772 81 NLPPDVRPER-----GL----LALRKELGLFANLRPAKLYPGLadasplKPEIVAGLDILIVRELTGGIYFGEprGREGL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 134 ADGETAVSMAKVTRKGSERIVRYAFDLARaTGRKKVTAVHKANIIKStSGLFLKVARDVAANYPEIEFQEMIVDNACMQL 213
Cdd:PRK00772 152 GGEERAFDTMVYTREEIERIARVAFELAR-KRRKKVTSVDKANVLES-SRLWREVVTEVAKEYPDVELSHMYVDNAAMQL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 214 VMRPEQFDIIVTTNLFGDILSDLCAGLVGGLGLAPGANIGVDA-AIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDH-V 291
Cdd:PRK00772 230 VRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESGpGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYsL 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 489575260 292 GQPQNAERLRSAIVATLEakDGL-TPDLGGSGNTMG---FAKAIASRL 335
Cdd:PRK00772 310 GLEEAADAIEAAVEKVLA--QGYrTADIAEGGGKVStseMGDAILAAL 355
|
|
| PLN00123 |
PLN00123 |
isocitrate dehydrogenase (NAD+) |
3-335 |
3.98e-99 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215065 Cd Length: 360 Bit Score: 296.78 E-value: 3.98e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 3 QTITVIRGDGIGPEIMDATLFVLDALNAGLTYEyadaglvALEKHGDL--LPAATLDSIRKNKIALKSPLTTPVGEGFSS 80
Cdd:PLN00123 31 RAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFE-------RYEVHGDMkkVPEEVLESIRRNKVCLKGGLATPVGGGVSS 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 81 INVAMRRQFDLYANVRPAKSFPNTKSRFgAGVDLITVRENTEGAYLSEGQEVsADGeTAVSMAKVTRKGSERIVRYAFDL 160
Cdd:PLN00123 104 LNVQLRKELDLFASLVNCFNLPGLPTRH-ENVDIVVIRENTEGEYSGLEHEV-VPG-VVESLKVITKFCSERIAKYAFEY 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 161 ARATGRKKVTAVHKANIIKSTSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTNLFGDILSDLCAGL 240
Cdd:PLN00123 181 AYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGI 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 241 VGGLGLAPGANIGVDAAIFE--AVHGSA--PDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVATLEAKDGLTP 316
Cdd:PLN00123 261 AGGTGVMPGGNVGADHAVFEqgASAGNVgnEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYRTK 340
|
330
....*....|....*....
gi 489575260 317 DLGGSGNTMGFAKAIASRL 335
Cdd:PLN00123 341 DLGGSSTTQEVVDAVIANL 359
|
|
| AksF_Meth |
NF040619 |
homoisocitrate dehydrogenase; |
5-324 |
4.44e-96 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468591 Cd Length: 332 Bit Score: 287.81 E-value: 4.44e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 5 ITVIRGDGIGPEIMDATLFVLDALnAGLTYEYADAGLVALEKHGDLLPAATLDSIRKNKIALKSPLTTP-----VGEGFS 79
Cdd:NF040619 4 ICVIEGDGIGKEVIPETVRVLKEL-GDFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPkptelKNKNYK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 80 SINVAMRRQFDLYANVRPAKSFPNTKSrfGAGVDLITVRENTEGAYLseGQE-VSADGETAVSMAKVTRKGSERIVRYAF 158
Cdd:NF040619 83 SPILTLRKELDLYANVRPINNFGDGQD--VKNIDFVIIRENTEGLYV--GREyYDEENEIAIAERIISKKGSERIIKFAF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 159 DLARATGRKKVTAVHKANIIKSTSGLFLKVARDVAANYPE--IEFQEMIVDNACMQLVMRPEQFDIIVTTNLFGDILSDL 236
Cdd:NF040619 159 EYAKKNNRKKVSCIHKANVLRVTDGLFLEIFNEIKKKYKNfnIEADDYLVDATAMYLIKNPEMFDVIVTTNLFGDILSDE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 237 CAGLVGGLGLAPGANIGVDAAIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVATLEAKDgLTP 316
Cdd:NF040619 239 ASGLIGGLGLAPSANIGDKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDLIREAVKKCLENGK-VTP 317
|
....*...
gi 489575260 317 DLGGSGNT 324
Cdd:NF040619 318 DLGGNLKT 325
|
|
| Icd |
COG0538 |
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ... |
4-335 |
3.83e-84 |
|
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304 Cd Length: 409 Bit Score: 260.04 E-value: 3.83e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 4 TITVIRGDGIGPEIMDATLFVLDA-------LNAGLTYEYADAGLVALEKHGDLLPAATLDSIRKNKIALKSPLTTPVGE 76
Cdd:COG0538 20 IIPFIEGDGIGPEITRAIWKVIDAavekaygGKRDIEWKEVDAGEKARDETGDWLPDETAEAIKEYGVGIKGPLTTPVGG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 77 GFSSINVAMRRQFDLYANVRPAKSFPNTKS--RFGAGVDLITVRENTEGAY------------------LSEGQEVSA-- 134
Cdd:COG0538 100 GWRSLNVTIRQILDLYVCRRPVRYFKGVPSpvKHPEKVDIVIFRENTEDIYagiewkagspealkliffLEDEMGVTVir 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 135 -DGETAVSMAKVTRKGSERIVRYAFDLARATGRKKVTAVHKANIIKSTSGLFLKVARDVAAN-YPE-------------- 198
Cdd:COG0538 180 fPEDSGIGIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVAEEeFGDkfitegpwekykgp 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 199 -----IEFQEMIVDNACMQLVMRPEQFDIIVTTNLFGDILSDLCAGLVGGLGLAPGANIGVDA-AIFEAVHGSAPDIAGQ 272
Cdd:COG0538 260 kpagkIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDGgAEFEATHGTAPKYAGK 339
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489575260 273 GKANPCALLLGAAQLLDHVGQPQNAERLRSAIVATLEAKDgLTPDL----GGSG--NTMGFAKAIASRL 335
Cdd:COG0538 340 DSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGK-VTYDLarlmEGATelSTSEFGDAIIENL 407
|
|
| TTC |
TIGR02089 |
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ... |
5-335 |
6.75e-83 |
|
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]
Pssm-ID: 273963 Cd Length: 352 Bit Score: 255.14 E-value: 6.75e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 5 ITVIRGDGIGPEIMDATLFVLDAL---NAGLTYEYA--DAGLVALEKHGDLLPAATLDSIRK-NKI---ALKSPLTTPVG 75
Cdd:TIGR02089 6 IAAIPGDGIGKEVVAAALQVLEAAakrHGGFSLHFTefPWSCDYYKEHGKMMPEDGLEKLKKfDAIflgAVGWPALVPDH 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 76 EGFSSINVAMRRQFDLYANVRPAKSFPNTKS----RFGAGVDLITVRENTEGAYLSEGQEV--SADGETAVSMAKVTRKG 149
Cdd:TIGR02089 86 ISLWGLLLKIRREFDQYANVRPAKLLPGVTSplrnCGPGDFDFVVVRENSEGEYSGVGGRIhrGTDEEVATQNAIFTRKG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 150 SERIVRYAFDLARATgRKKVTAVHKANIIKSTSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTNLF 229
Cdd:TIGR02089 166 VERIMRFAFELAQKR-RKHLTSATKSNGIRHSMPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPETFDVIVASNLF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 230 GDILSDLCAGLVGGLGLAPGANIGVDA---AIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVA 306
Cdd:TIGR02089 245 GDILSDLGAALMGSLGVAPSANINPEGkfpSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEHLGEKEAGAKIMDAIER 324
|
330 340
....*....|....*....|....*....
gi 489575260 307 TLEAKDgLTPDLGGSGNTMGFAKAIASRL 335
Cdd:TIGR02089 325 VTAAGI-LTPDVGGKATTSEVTEAVCNAL 352
|
|
| leuB |
TIGR00169 |
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ... |
5-335 |
7.14e-83 |
|
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 272939 Cd Length: 346 Bit Score: 254.63 E-value: 7.14e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 5 ITVIRGDGIGPEIMDATLFVLDAL----NAGLTYEYADAGLVALEKHGDLLPAATLDSIRKNKIALKSPLTTPV-GEGFS 79
Cdd:TIGR00169 2 IAVLPGDGIGPEVMAQALKVLKAVaerfGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKwDNLPR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 80 SIN-----VAMRRQFDLYANVRPAKSFPN------TKSRFGAGVDLITVRENTEGAYLSEGQEVSADGEtAVSMAKVTRK 148
Cdd:TIGR00169 82 DQRpeqglLKLRKSLDLFANLRPAKVFPGledlspLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGE-AWDTEVYTVP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 149 GSERIVRYAFDLARATgRKKVTAVHKANIIKStSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTNL 228
Cdd:TIGR00169 161 EIERIARVAFEMARKR-RKKVTSVDKANVLES-SRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTSNL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 229 FGDILSDLCAGLVGGLGLAPGANIGVDA-AIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDH-VGQPQNAERLRSAIVA 306
Cdd:TIGR00169 239 FGDILSDEASVITGSLGMLPSASLGSDGfGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYsFNLEEAADAIEAAVKK 318
|
330 340 350
....*....|....*....|....*....|
gi 489575260 307 TLEakDGL-TPDLGGSGNTMGFAKAIASRL 335
Cdd:TIGR00169 319 VLA--EGYrTPDLGSSATTAVGTAEMGEEL 346
|
|
| PRK03437 |
PRK03437 |
3-isopropylmalate dehydrogenase; Provisional |
1-313 |
6.44e-82 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 179579 Cd Length: 344 Bit Score: 252.15 E-value: 6.44e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 1 MTQTITVIRGDGIGPEIMDATLFVLDA-LNAGLTYEYADAGLVALEKH--GDLLPAATLDSIRKNKI----ALKSPlTTP 73
Cdd:PRK03437 3 KTMKLAVIPGDGIGPEVVAEALKVLDAvAAGGPGVETTEYDLGARRYLrtGETLPDSVLAELRQHDAillgAIGDP-SVP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 74 VGEGFSSINVAMRRQFDLYANVRPAKSFPNTKSRF-GAG-VDLITVRENTEGAYLSEGQ--EVSADGETAVSMAKVTRKG 149
Cdd:PRK03437 82 SGVLERGLLLKLRFALDHYVNLRPSKLYPGVTSPLaGPGdIDFVVVREGTEGPYTGNGGalRVGTPHEVATEVSVNTAFG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 150 SERIVRYAFDLARATGRKKVTAVHKANIIKSTSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTNLF 229
Cdd:PRK03437 162 VERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVIVTDNLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 230 GDILSDLCAGLVGGLGLAPGANI---GVDAAIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVA 306
Cdd:PRK03437 242 GDIITDLAAAVTGGIGLAASGNInptGTNPSMFEPVHGSAPDIAGQGIADPTAAILSVALLLDHLGEEDAAARIEAAVEA 321
|
....*..
gi 489575260 307 TLEAKDG 313
Cdd:PRK03437 322 DLAERGK 328
|
|
| PRK08194 |
PRK08194 |
tartrate dehydrogenase; Provisional |
4-335 |
1.06e-78 |
|
tartrate dehydrogenase; Provisional
Pssm-ID: 181281 Cd Length: 352 Bit Score: 244.25 E-value: 1.06e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 4 TITVIRGDGIGPEIMDATLFVLDA---LNAGLTYEYADA--GLVALEKHGDLLPAATLDSIRK-NKI---ALKSPLTTPV 74
Cdd:PRK08194 5 KIAVIPGDGVGKEVVPAAVRVLKAvaeVHGGLKFEFTEFpwSCEYYLEHGEMMPEDGLEQLKQfDAIflgAVGNPKLVPD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 75 GEGFSSINVAMRRQFDLYANVRPAKSFPNTKS--RFGAGVDLITVRENTEGAYLSEGQEV-SADGETAVSMAKVTRKGSE 151
Cdd:PRK08194 85 HISLWGLLIKIRREFEQVINIRPAKQLRGIKSplANPKDFDLLVVRENSEGEYSEVGGRIhRGEDEIAIQNAVFTRKGTE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 152 RIVRYAFDLArATGRKKVTAVHKANIIKSTSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVTTNLFGD 231
Cdd:PRK08194 165 RAMRYAFELA-AKRRKHVTSATKSNGIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRPEEFDVIVASNLFGD 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 232 ILSDLCAGLVGGLGLAPGANIGVDA---AIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVATL 308
Cdd:PRK08194 244 ILTDIGAAIMGSIGIAPAANINVNGkypSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDHFGEEELGSHLLDVIEDVT 323
|
330 340
....*....|....*....|....*...
gi 489575260 309 EakDG-LTPDLGGSGNTMGFAKAIASRL 335
Cdd:PRK08194 324 E--DGiKTPDIGGRATTDEVTDEIISRL 349
|
|
| PRK07006 |
PRK07006 |
isocitrate dehydrogenase; Reviewed |
5-311 |
6.95e-66 |
|
isocitrate dehydrogenase; Reviewed
Pssm-ID: 180792 Cd Length: 409 Bit Score: 213.00 E-value: 6.95e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 5 ITVIRGDGIGPEIMDATLFVLDAlnaGLTYEYAD----------AGLVALEKHGDL--LPAATLDSIRKNKIALKSPLTT 72
Cdd:PRK07006 22 IPFIEGDGIGPDITPAMLKVVDA---AVEKAYKGerkiswmeiyAGEKATKVYGEDvwLPEETLDLIREYRVAIKGPLTT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 73 PVGEGFSSINVAMRRQFDLYANVRPAKSFPNTKS--RFGAGVDLITVRENTEGAYlsEGQEVSADGETAVSMAK------ 144
Cdd:PRK07006 99 PVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSpvKRPEDTDMVIFRENSEDIY--AGIEWKAGSAEAKKVIKflqeem 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 145 -----------------VTRKGSERIVRYAFDLARATGRKKVTAVHKANIIKSTSGLFLKVARDVAAN-----------Y 196
Cdd:PRK07006 177 gvkkirfpetsgigikpVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQLAEEefgdelidggpW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 197 PEIE---------FQEMIVDNACMQLVMRPEQFDIIVTTNLFGDILSDLCAGLVGGLGLAPGANIGVDAAIFEAVHGSAP 267
Cdd:PRK07006 257 DKIKnpetgkeiiVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANINDGHAIFEATHGTAP 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 489575260 268 DIAGQGKANPCALLLGAAQLLDHVGQPQNAERLRSAIVATLEAK 311
Cdd:PRK07006 337 KYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIASK 380
|
|
| PRK06451 |
PRK06451 |
NADP-dependent isocitrate dehydrogenase; |
5-318 |
7.19e-66 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 235803 Cd Length: 412 Bit Score: 213.15 E-value: 7.19e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 5 ITVIRGDGIGPEIMDATLFVLDA---LNAGLTYEYA----DAGLVALEKHGDLLPAATLDSIRKNKIALKSPLTTPVGEG 77
Cdd:PRK06451 26 ILYVEGDGIGPEITHAAMKVINKaveKAYGSDREIKwvevLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPIGKG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 78 FSSINVAMRRQFDLYANVRPAKSFPNTKS--RFGAGVDLITVRENTEGAY------------------LSEGQEVSADGE 137
Cdd:PRK06451 106 WKSINVAIRLMLDLYANIRPVKYIPGIESplKNPEKIDLIIFRENTDDLYrgieypydseeakkirdfLRKELGVEVEDD 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 138 TAVSMAKVTRKGSERIVRYAFDLARATGRKKVTAVHKANIIKSTSGLFLKVARDVAANypeiEFQEMIV----------- 206
Cdd:PRK06451 186 TGIGIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAYEVALK----EFRDYVVteeevtknyng 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 207 --------------DNACMQLVMRPEQFDIIVTTNLFGDILSDLCAGLVGGLGLAPGANIGVDAAIFEAVHGSAPDIAGQ 272
Cdd:PRK06451 262 vppsgkviindriaDNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFEAIHGTAPKYAGK 341
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 489575260 273 GKANPCALLLGAAQLLDHVGQPQNAERLRSAIVATLEAKDgLTPDL 318
Cdd:PRK06451 342 NVANPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQKK-VTQDL 386
|
|
| PRK07362 |
PRK07362 |
NADP-dependent isocitrate dehydrogenase; |
5-277 |
1.72e-54 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 180944 Cd Length: 474 Bit Score: 184.92 E-value: 1.72e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 5 ITVIRGDGIGPEIMDATLFVLDAlnaGLTYEYAD----------AGLVALEKHG--DLLPAATLDSIRKNKIALKSPLTT 72
Cdd:PRK07362 31 IPFIRGDGTGVDIWPATQKVLDA---AVAKAYGGerkinwfkvyAGDEACDLYGtyQYLPEDTLEAIREYGVAIKGPLTT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 73 PVGEGFSSINVAMRRQFDLYANVRPAKSFPNTKS--RFGAGVDLITVRENTEGAYLseGQEVSADGETAVSMAK------ 144
Cdd:PRK07362 108 PIGGGIRSLNVALRQIFDLYSCVRPCRYYAGTPSphKNPEKLDVIVYRENTEDIYM--GIEWEAGDEIGDKLIKhlneev 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 145 ----------------------VTRKGSERIVRYAFDLA-RATGRKK-VTAVHKANIIKSTSGLFLKVARDVAAN----- 195
Cdd:PRK07362 186 ipaspelgkrqiplgsgigikpVSKTGSQRHIRRAIEHAlRLPGDKRhVTLVHKGNIMKYTEGAFRDWGYELATTefrde 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 196 ---------------YPEIEFQE------------------------------------------------MIVDNACMQ 212
Cdd:PRK07362 266 cvtereswilsnkekNPNISIEDnarmiepgydsltpekkaaicaevkevldsiwsshgngkwkekvlvddRIADSIFQQ 345
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489575260 213 LVMRPEQFDIIVTTNLFGDILSDLCAGLVGGLGLAPGANIGVDAAIFEAVHGSAPDIAGQGKANP 277
Cdd:PRK07362 346 IQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFEATHGTAPKHAGLDRINP 410
|
|
| PLN02329 |
PLN02329 |
3-isopropylmalate dehydrogenase |
5-325 |
2.25e-44 |
|
3-isopropylmalate dehydrogenase
Pssm-ID: 215188 Cd Length: 409 Bit Score: 156.77 E-value: 2.25e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 5 ITVIRGDGIGPEIMDATLFVLDALNA--GLTYEYADA--GLVALEKHGDLLPAATLDSIRKNKIALKSPL---TTPVGEG 77
Cdd:PLN02329 49 IALLPGDGIGPEVISVAKNVLQKAGSleGLEFDFQEMpvGGAALDLVGVPLPEETFTAAKQSDAILLGAIggyKWDKNEK 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 78 FSSINVAM---RRQFDLYANVRPAKSFPN------TKSRFGAGVDLITVRENTEGAYLSE--GQEVSADG-ETAVSMAKV 145
Cdd:PLN02329 129 HLRPEMALfylRRDLKVFANLRPATVLPQlvdastLKKEVAEGVDMMIVRELTGGIYFGEprGITINENGeEVGVSTEIY 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 146 TRKGSERIVRYAFDLARATgRKKVTAVHKANIIKStSGLFLKVARDVAANYPEIEFQEMIVDNACMQLVMRPEQFDIIVT 225
Cdd:PLN02329 209 AAHEIDRIARVAFETARKR-RGKLCSVDKANVLDA-SILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVT 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489575260 226 TNLFGDILSDLCAGLVGGLGLAPGANIGVDA-AIFEAVHGSAPDIAGQGKANPCALLLGAAQLLDH-VGQPQNAERLRSA 303
Cdd:PLN02329 287 NNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKRIEDA 366
|
330 340
....*....|....*....|..
gi 489575260 304 IVATLEaKDGLTPDLGGSGNTM 325
Cdd:PLN02329 367 VVDALN-KGFRTGDIYSPGNKL 387
|
|
| |
