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Conserved domains on  [gi|489611716|ref|WP_003516157|]
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M56 family metallopeptidase [Acetivibrio thermocellus]

Protein Classification

MecR1 family protein( domain architecture ID 11467994)

MecR1 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MecR1 COG4219
Signal transducer regulating beta-lactamase production, contains metallopeptidase domain ...
 120-430 1.47e-61

Signal transducer regulating beta-lactamase production, contains metallopeptidase domain [Signal transduction mechanisms];


:

Pssm-ID: 443363 [Multi-domain]  Cd Length: 337  Bit Score: 203.74  E-value: 1.47e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 120 WVLGITALLVYSLVSFLKLKRQLKSAKLVDKN--------------------IFEAKNLKTPFVFGLINPRIYLPAG--- 176
Cdd:COG4219    1 WLAGVLLLLLRLLISLLRLRRLLRRARPVTDEellellerlarrlgirrpvrLLESDRITSPFSFGLLRPVILLPAGlee 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 177 LDATERRYILLHEQIHIRRKDYIIKILAFLILSIHWFNPLVWIAFRLMSKDMELSCDERVLKEMDEniKKPYAASLLSLA 256
Cdd:COG4219   81 LSEEELEAILAHELAHIRRRDLLDNLLAELLLALFWFNPLVWLARRRLRLDRELACDAAVLKAGGD--RKAYAETLLKLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 257 TERHiLNGSPLAFGEG--NVKDRIKNVLSYKKPAFWVITVALALAIVVGFGLLANPYVAKPDEDKYISQLLKNKTEYVGD 334
Cdd:COG4219  159 ERRS-QPALALAFGGSksTLKKRIKMLLKSKSKRRSRLKLLLALLLALLLALALLSAPEAAAEPEEAAAAAALEAASAAA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 335 NSKVGGIIFLLKFPKNVSYDFFELFTDKEPYGVNINLKTDTETKNLYVGEENRQQFQSNAVIMFSLIGNVEYISFTLDDG 414
Cdd:COG4219  238 SEAALALAEAAAVAAKVASVEDAEALIAEALAKDKEEKTAEAAVKASSEADVEEEAAVELDAAEKAAAAAAAGLSAGAGE 317

                        330
                 ....*....|....*.
gi 489611716 415 LEPYSIRYTREWANNQ 430
Cdd:COG4219  318 EGSGVADEAEAAIEAE 333
 
Name Accession Description Interval E-value
MecR1 COG4219
Signal transducer regulating beta-lactamase production, contains metallopeptidase domain ...
 120-430 1.47e-61

Signal transducer regulating beta-lactamase production, contains metallopeptidase domain [Signal transduction mechanisms];


Pssm-ID: 443363 [Multi-domain]  Cd Length: 337  Bit Score: 203.74  E-value: 1.47e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 120 WVLGITALLVYSLVSFLKLKRQLKSAKLVDKN--------------------IFEAKNLKTPFVFGLINPRIYLPAG--- 176
Cdd:COG4219    1 WLAGVLLLLLRLLISLLRLRRLLRRARPVTDEellellerlarrlgirrpvrLLESDRITSPFSFGLLRPVILLPAGlee 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 177 LDATERRYILLHEQIHIRRKDYIIKILAFLILSIHWFNPLVWIAFRLMSKDMELSCDERVLKEMDEniKKPYAASLLSLA 256
Cdd:COG4219   81 LSEEELEAILAHELAHIRRRDLLDNLLAELLLALFWFNPLVWLARRRLRLDRELACDAAVLKAGGD--RKAYAETLLKLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 257 TERHiLNGSPLAFGEG--NVKDRIKNVLSYKKPAFWVITVALALAIVVGFGLLANPYVAKPDEDKYISQLLKNKTEYVGD 334
Cdd:COG4219  159 ERRS-QPALALAFGGSksTLKKRIKMLLKSKSKRRSRLKLLLALLLALLLALALLSAPEAAAEPEEAAAAAALEAASAAA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 335 NSKVGGIIFLLKFPKNVSYDFFELFTDKEPYGVNINLKTDTETKNLYVGEENRQQFQSNAVIMFSLIGNVEYISFTLDDG 414
Cdd:COG4219  238 SEAALALAEAAAVAAKVASVEDAEALIAEALAKDKEEKTAEAAVKASSEADVEEEAAVELDAAEKAAAAAAAGLSAGAGE 317

                        330
                 ....*....|....*.
gi 489611716 415 LEPYSIRYTREWANNQ 430
Cdd:COG4219  318 EGSGVADEAEAAIEAE 333
Peptidase_M56 pfam05569
BlaR1 peptidase M56; Production of beta-Lactamase and penicillin-binding protein 2a (which ...
 6-281 4.43e-54

BlaR1 peptidase M56; Production of beta-Lactamase and penicillin-binding protein 2a (which mediate staphylococcal resistance to beta-lactam antibiotics) is regulated by a signal-transducing integral membrane protein and a transcriptional repressor. The signal transducer is a fusion protein with penicillin-binding and zinc metalloprotease domains. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. homologs to this peptidase domain, which corresponds to Merops family M56, are also found in a number of other bacterial genome sequences.


Pssm-ID: 428523  Cd Length: 296  Bit Score: 182.67  E-value: 4.43e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716    6 LSVLNMSFTASYVILCVILVRLLLKK-APKFISYALWGVVAFRLIVPFSFESMFSllprnmNAAPILHGVIYQQSPTVVS 84
Cdd:pfam05569   1 LFLLRASIAAAAAVLVVLLLRRPLRRyLGAIWAYALWLIVPLALLAPFIPESALS------NFTTSAIFMARSKAPINST 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716   85 GMEVMDsfsGQSLPVSNMGASANSSHVYIEIAaYIWVLGITALLVYSLVSFLKLKR-------QLKSAKLVDK------- 150
Cdd:pfam05569  75 APKVID---DQASPLATPFPVVAWSTILKILL-LLWIVGALILLLYMIAAYLVFRQrrvrrlgSLRAHELDDIlkeaked 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716  151 -------NIFEAKNLKTPFVFGLINPRIYLPAGLDAT----ERRYILLHEQIHIRRKDYIIKILAFLILSIHWFNPLVWI 219
Cdd:pfam05569 151 mgikrpiTISLSSNIDSPAVLGLWKPRIVLPADFDTRlsgeEIDYILAHELSHLKRGDLIINLLVAVLQCLHWFNPLVHL 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489611716  220 AFRLMSKDMELSCDERVLKEMDENIKKPYAASLLSLATERHILNGS----PLAFGEGNVKDRIKNV 281
Cdd:pfam05569 231 AFRKIRIDQELACDAAVLARLHPHERKEYGRTLLKLLAGPSNHIVPvacvWLAGAKSALKERIMML 296
M56_BlaR1_MecR1_like cd07341
Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase; ...
 119-285 1.01e-48

Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase; This family contains peptidase M56, which includes zinc metalloprotease domain in MecR1 as well as BlaR1. MecR1 is a transmembrane beta-lactam sensor/signal transducer protein that regulates the expression of an altered penicillin-binding protein PBP2a, which resists inactivation by beta-lactam antibiotics, in methicillin-resistant Staphylococcus aureus (MRSA). BlaR1 regulates the inducible expression of a class A beta-lactamase that hydrolytically destroys certain ?-lactam antibiotics in MRSA. Both, MecR1 and BlaR1, are transmembrane proteins that consist of four transmembrane helices, a cytoplasmic zinc protease domain, and the soluble C-terminal extracellular sensor domain, and are highly similar in sequence and function. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. All members contain the zinc metalloprotease motif (HEXXH). Homologs of this peptidase domain are also found in a number of other bacterial genome sequences, most of which are as yet uncharacterized.


Pssm-ID: 320700 [Multi-domain]  Cd Length: 187  Bit Score: 165.20  E-value: 1.01e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 119 IWVLGITALLVYSLVSFLKLKRQLKSAKLVD----------------KNIFEAKNLKTPFVFGLINPRIYLPAGL---DA 179
Cdd:cd07341    1 IWLAGALLLLLRLLRGLLRLRRLRRRAEPVPdslllelarrlglrrsVRLSVSALVASPMVVGLFRPVILLPEGLlegSP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 180 TERRYILLHEQIHIRRKDYIIKILAFLILSIHWFNPLVWIAFRLMSKDMELSCDERVLKEMDEniKKPYAASLLSLATER 259
Cdd:cd07341   81 EELRAILLHELAHIRRRDLLVNLLQRLLEALFWFNPLVWLLSRRLRLERELACDEAVLAALGD--KEDYAEALLRLAERR 158

                        170       180
                 ....*....|....*....|....*....
gi 489611716 260 HILNGSP-LAFGEG--NVKDRIKNVLSYK 285
Cdd:cd07341  159 SQPPPALaLALAGSksLLKRRIKRILKKK 187
 
Name Accession Description Interval E-value
MecR1 COG4219
Signal transducer regulating beta-lactamase production, contains metallopeptidase domain ...
 120-430 1.47e-61

Signal transducer regulating beta-lactamase production, contains metallopeptidase domain [Signal transduction mechanisms];


Pssm-ID: 443363 [Multi-domain]  Cd Length: 337  Bit Score: 203.74  E-value: 1.47e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 120 WVLGITALLVYSLVSFLKLKRQLKSAKLVDKN--------------------IFEAKNLKTPFVFGLINPRIYLPAG--- 176
Cdd:COG4219    1 WLAGVLLLLLRLLISLLRLRRLLRRARPVTDEellellerlarrlgirrpvrLLESDRITSPFSFGLLRPVILLPAGlee 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 177 LDATERRYILLHEQIHIRRKDYIIKILAFLILSIHWFNPLVWIAFRLMSKDMELSCDERVLKEMDEniKKPYAASLLSLA 256
Cdd:COG4219   81 LSEEELEAILAHELAHIRRRDLLDNLLAELLLALFWFNPLVWLARRRLRLDRELACDAAVLKAGGD--RKAYAETLLKLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 257 TERHiLNGSPLAFGEG--NVKDRIKNVLSYKKPAFWVITVALALAIVVGFGLLANPYVAKPDEDKYISQLLKNKTEYVGD 334
Cdd:COG4219  159 ERRS-QPALALAFGGSksTLKKRIKMLLKSKSKRRSRLKLLLALLLALLLALALLSAPEAAAEPEEAAAAAALEAASAAA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 335 NSKVGGIIFLLKFPKNVSYDFFELFTDKEPYGVNINLKTDTETKNLYVGEENRQQFQSNAVIMFSLIGNVEYISFTLDDG 414
Cdd:COG4219  238 SEAALALAEAAAVAAKVASVEDAEALIAEALAKDKEEKTAEAAVKASSEADVEEEAAVELDAAEKAAAAAAAGLSAGAGE 317

                        330
                 ....*....|....*.
gi 489611716 415 LEPYSIRYTREWANNQ 430
Cdd:COG4219  318 EGSGVADEAEAAIEAE 333
Peptidase_M56 pfam05569
BlaR1 peptidase M56; Production of beta-Lactamase and penicillin-binding protein 2a (which ...
 6-281 4.43e-54

BlaR1 peptidase M56; Production of beta-Lactamase and penicillin-binding protein 2a (which mediate staphylococcal resistance to beta-lactam antibiotics) is regulated by a signal-transducing integral membrane protein and a transcriptional repressor. The signal transducer is a fusion protein with penicillin-binding and zinc metalloprotease domains. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. homologs to this peptidase domain, which corresponds to Merops family M56, are also found in a number of other bacterial genome sequences.


Pssm-ID: 428523  Cd Length: 296  Bit Score: 182.67  E-value: 4.43e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716    6 LSVLNMSFTASYVILCVILVRLLLKK-APKFISYALWGVVAFRLIVPFSFESMFSllprnmNAAPILHGVIYQQSPTVVS 84
Cdd:pfam05569   1 LFLLRASIAAAAAVLVVLLLRRPLRRyLGAIWAYALWLIVPLALLAPFIPESALS------NFTTSAIFMARSKAPINST 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716   85 GMEVMDsfsGQSLPVSNMGASANSSHVYIEIAaYIWVLGITALLVYSLVSFLKLKR-------QLKSAKLVDK------- 150
Cdd:pfam05569  75 APKVID---DQASPLATPFPVVAWSTILKILL-LLWIVGALILLLYMIAAYLVFRQrrvrrlgSLRAHELDDIlkeaked 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716  151 -------NIFEAKNLKTPFVFGLINPRIYLPAGLDAT----ERRYILLHEQIHIRRKDYIIKILAFLILSIHWFNPLVWI 219
Cdd:pfam05569 151 mgikrpiTISLSSNIDSPAVLGLWKPRIVLPADFDTRlsgeEIDYILAHELSHLKRGDLIINLLVAVLQCLHWFNPLVHL 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489611716  220 AFRLMSKDMELSCDERVLKEMDENIKKPYAASLLSLATERHILNGS----PLAFGEGNVKDRIKNV 281
Cdd:pfam05569 231 AFRKIRIDQELACDAAVLARLHPHERKEYGRTLLKLLAGPSNHIVPvacvWLAGAKSALKERIMML 296
M56_BlaR1_MecR1_like cd07341
Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase; ...
 119-285 1.01e-48

Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase; This family contains peptidase M56, which includes zinc metalloprotease domain in MecR1 as well as BlaR1. MecR1 is a transmembrane beta-lactam sensor/signal transducer protein that regulates the expression of an altered penicillin-binding protein PBP2a, which resists inactivation by beta-lactam antibiotics, in methicillin-resistant Staphylococcus aureus (MRSA). BlaR1 regulates the inducible expression of a class A beta-lactamase that hydrolytically destroys certain ?-lactam antibiotics in MRSA. Both, MecR1 and BlaR1, are transmembrane proteins that consist of four transmembrane helices, a cytoplasmic zinc protease domain, and the soluble C-terminal extracellular sensor domain, and are highly similar in sequence and function. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. All members contain the zinc metalloprotease motif (HEXXH). Homologs of this peptidase domain are also found in a number of other bacterial genome sequences, most of which are as yet uncharacterized.


Pssm-ID: 320700 [Multi-domain]  Cd Length: 187  Bit Score: 165.20  E-value: 1.01e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 119 IWVLGITALLVYSLVSFLKLKRQLKSAKLVD----------------KNIFEAKNLKTPFVFGLINPRIYLPAGL---DA 179
Cdd:cd07341    1 IWLAGALLLLLRLLRGLLRLRRLRRRAEPVPdslllelarrlglrrsVRLSVSALVASPMVVGLFRPVILLPEGLlegSP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 180 TERRYILLHEQIHIRRKDYIIKILAFLILSIHWFNPLVWIAFRLMSKDMELSCDERVLKEMDEniKKPYAASLLSLATER 259
Cdd:cd07341   81 EELRAILLHELAHIRRRDLLVNLLQRLLEALFWFNPLVWLLSRRLRLERELACDEAVLAALGD--KEDYAEALLRLAERR 158

                        170       180
                 ....*....|....*....|....*....
gi 489611716 260 HILNGSP-LAFGEG--NVKDRIKNVLSYK 285
Cdd:cd07341  159 SQPPPALaLALAGSksLLKRRIKRILKKK 187
DUF4825 pfam16107
Domain of unknown function (DUF4825); This domain forms the N-terminal, extracellular domain ...
 324-423 1.30e-33

Domain of unknown function (DUF4825); This domain forms the N-terminal, extracellular domain of some homologs of Staph BlaR1 proteases, where it replaces the penicillin-binding domain of BlaR1. It is also found in many uncharacterized proteins in a broad range of bacteria. Its association with BlaR1 homologs suggests it may be involved in substrate-, possibly antibiotic-binding, but this prediction has not been verified experimentally.


Pssm-ID: 435140  Cd Length: 95  Bit Score: 121.98  E-value: 1.30e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716  324 LLKNKTEYVGDNSKVGGIIFLLKFPKNVSYDFFELFTDKEPYGVNINLKTDTETKNLYVGEenrQQFQSNAVIMFSLIGN 403
Cdd:pfam16107   1 LYKYKTPYVGDNSKVGKILGALPLPEGLGYYGIELQTSKEPYGLTVNYEEKDTKDEEEELK---DTMKRNAVILFALIDN 77

                          90       100
                  ....*....|....*....|
gi 489611716  404 VEYISFTLDDglEPYSIRYT 423
Cdd:pfam16107  78 LDYITFEYSD--DETTYTFT 95
M56_BlaR1_MecR1_like cd07326
Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase; ...
 162-283 4.42e-12

Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase; This family contains peptidase M56, which includes zinc metalloprotease domain in MecR1 as well as BlaR1. MecR1 is a transmembrane beta-lactam sensor/signal transducer protein that regulates the expression of an altered penicillin-binding protein PBP2a, which resists inactivation by beta-lactam antibiotics, in methicillin-resistant Staphylococcus aureus (MRSA). BlaR1 regulates the inducible expression of a class A beta-lactamase that hydrolytically destroys certain ?-lactam antibiotics in MRSA. Both, MecR1 and BlaR1, are transmembrane proteins that consist of four transmembrane helices, a cytoplasmic zinc protease domain, and the soluble C-terminal extracellular sensor domain, and are highly similar in sequence and function. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. All members contain the zinc metalloprotease motif (HEXXH). Homologs of this peptidase domain are also found in a number of other bacterial genome sequences, most of which are as yet uncharacterized.


Pssm-ID: 320685 [Multi-domain]  Cd Length: 165  Bit Score: 64.25  E-value: 4.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 162 FVFGLINPRIYLPAG----LDATERRYILLHEQIHIRRKDYIIKILAFLILSIHWFNPLVWIAFRLMSKDMELSCDERVL 237
Cdd:cd07326   40 FCLGGRRPRIVLSTGllelLSPEELRAVLAHERAHLRRRDPLLLLLASALARALPFLPLLRRLAAAYRLLRELAADDAAA 119

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 489611716 238 KEMDeniKKPYAASLLSLAT-ERHILNGSPLAFGEGNV-KDRIKNVLS 283
Cdd:cd07326  120 RRVG---PRALASALLKLARaGAPAAPAGALAFAGAAVnEARIRRLLD 164
M56_like cd07329
Peptidase M56-like, integral membrane metallopeptidase in bacteria; This family contains ...
 161-268 4.87e-08

Peptidase M56-like, integral membrane metallopeptidase in bacteria; This family contains peptidase M56, which includes zinc metalloprotease domain in MecR1 as well as BlaR1. MecR1 is a transmembrane beta-lactam sensor/signal transducer protein that regulates the expression of an altered penicillin-binding protein PBP2a, which resists inactivation by beta-lactam antibiotics, in methicillin-resistant Staphylococcus aureus (MRSA). BlaR1 regulates the inducible expression of a class A beta-lactamase that hydrolytically destroys certain beta-lactam antibiotics in MRSA. Both, MecR1 and BlaR1, are transmembrane proteins that consist of four transmembrane helices, a cytoplasmic zinc protease domain, and the soluble C-terminal extracellular sensor domain, and are highly similar in sequence and function. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. All members contain the zinc metalloprotease motif (HEXXH). Homologs of this peptidase domain are also found in a number of other bacterial genome sequences, most of which are as yet uncharacterized.


Pssm-ID: 320688 [Multi-domain]  Cd Length: 188  Bit Score: 52.84  E-value: 4.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489611716 161 PFVFGL-INPRIYLPAG----LDATERRYILLHEQIHIRRKDYIIKILAFLILSI-----------------HWFNPLVW 218
Cdd:cd07329   24 AFAVGRsRGPTVVVTTGlldlLDDDELEAVLAHELAHLKRRDVLVLLLFDPLLLLvvglllflslfifellgFFFQPLLF 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 489611716 219 IAFRLMSKDMELSCDERvlkemdenikkpyaASLLSLATERHILNGSPLA 268
Cdd:cd07329  104 LAFFALLRLAELLADAL--------------AVARTSAARRARLTGLPAA 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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