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Conserved domains on  [gi|489622890|ref|WP_003527330|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Sinorhizobium]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
13-109 4.43e-45

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 142.31  E-value: 4.43e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489622890  13 PGCPVESALSFIDGKWKGVILYHLMsEGVLRFNELRRRLPSVTPRMLTRQLRELEEAALLSRTVFPVVPPRVDYALTARG 92
Cdd:COG1733    8 ADCPVRRALDVIGGKWKLLILRALL-DGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKG 86

                         90
                 ....*....|....*..
gi 489622890  93 ESLKPVIMALKAWGDEN 109
Cdd:COG1733   87 RSLLPVLDALAEWGEEH 103
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
13-109 4.43e-45

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 142.31  E-value: 4.43e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489622890  13 PGCPVESALSFIDGKWKGVILYHLMsEGVLRFNELRRRLPSVTPRMLTRQLRELEEAALLSRTVFPVVPPRVDYALTARG 92
Cdd:COG1733    8 ADCPVRRALDVIGGKWKLLILRALL-DGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKG 86

                         90
                 ....*....|....*..
gi 489622890  93 ESLKPVIMALKAWGDEN 109
Cdd:COG1733   87 RSLLPVLDALAEWGEEH 103
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 24-109 2.92e-36

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 119.33  E-value: 2.92e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489622890   24 IDGKWKGVILYHLMsEGVLRFNELRRRLPSVTPRMLTRQLRELEEAALLSRTVFPVVPPRVDYALTARGESLKPVIMALK 103
Cdd:pfam01638   2 IGGKWKGLILRELL-DGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*.
gi 489622890  104 AWGDEN 109
Cdd:pfam01638  81 DWGEEY 86
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
13-109 4.43e-45

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 142.31  E-value: 4.43e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489622890  13 PGCPVESALSFIDGKWKGVILYHLMsEGVLRFNELRRRLPSVTPRMLTRQLRELEEAALLSRTVFPVVPPRVDYALTARG 92
Cdd:COG1733    8 ADCPVRRALDVIGGKWKLLILRALL-DGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKG 86

                         90
                 ....*....|....*..
gi 489622890  93 ESLKPVIMALKAWGDEN 109
Cdd:COG1733   87 RSLLPVLDALAEWGEEH 103
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 24-109 2.92e-36

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 119.33  E-value: 2.92e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489622890   24 IDGKWKGVILYHLMsEGVLRFNELRRRLPSVTPRMLTRQLRELEEAALLSRTVFPVVPPRVDYALTARGESLKPVIMALK 103
Cdd:pfam01638   2 IGGKWKGLILRELL-DGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*.
gi 489622890  104 AWGDEN 109
Cdd:pfam01638  81 DWGEEY 86
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
32-95 2.62e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 35.72  E-value: 2.62e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489622890  32 ILYHLMSEGVLRFNELRRRLpSVTPRMLTRQLRELEEAALLSRTVFPVVPPRVDYALTARGESL 95
Cdd:COG1846   43 VLAALAEAGGLTQSELAERL-GLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRAL 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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