|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
32-397 |
1.51e-72 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 231.91 E-value: 1.51e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 32 IALAVGGFGIGTGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFAS 111
Cdd:PRK10091 6 LSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 112 AVAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGG 191
Cdd:PRK10091 86 TLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIAV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 192 ISLMTMALIWLHVPRDRGDPQATPLRELSALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFG 271
Cdd:PRK10091 166 FNIAVLASIYFWVPDIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFIMMLVG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 272 AGMILGNIVGSRLAD-WSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVnVLFIG--GGFAVVPGVQTRLMDVAGKAQTL 348
Cdd:PRK10091 246 LGMVLGNLLSGRLSGrYSPLRIAAVTDFIIVLALLMLFFFGGMKTASLI-FAFICcaGLFALSAPLQILLLQNAKGGELL 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 489628962 349 AAALSHSAFNLANALGAWLGGIAIAAGYGWTSPGLVGAVLGIGGFAIFL 397
Cdd:PRK10091 325 GAAGGQIAFNLGSAIGAYCGGMMLTLGLAYNYVALPAALLSFAAMSSLL 373
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
32-397 |
3.62e-71 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 228.20 E-value: 3.62e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 32 IALAVGGFGIGTGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFAS 111
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 112 AVAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGG 191
Cdd:cd17324 82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 192 ISLMTMALIWLHVPRDRGDPQATPL---RELSALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLS 268
Cdd:cd17324 162 LALLAALLLWRLLPSLPPKKPGSLGllsSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 269 VFGAGMILGNIVGSRLADWSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIG-GGFAVVPGVQTRLMDVAGKAQT 347
Cdd:cd17324 242 LFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGlGFFAAHSALQTRVLRLAPEARG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 489628962 348 LAAALSHSAFNLANALGAWLGGIAIAAGyGWTSPGLVGAVLGIGGFAIFL 397
Cdd:cd17324 322 LASSLYLAAYNLGGALGAALGGLVLDHG-GWAGVGWVGAALLLLALLLAL 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
32-363 |
4.33e-36 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 135.10 E-value: 4.33e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 32 IALAVGGFGIGTGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFAS 111
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 112 AVAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGG 191
Cdd:COG2814 93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 192 ISLMTMALIWLHVPRDRGDPQATPLRELSA-LGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVF 270
Cdd:COG2814 173 LALLALLLLLRLLPESRPAARARLRGSLRElLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALF 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 271 GAGMILGNIVGSRLAD-WSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDVAGK-AQTL 348
Cdd:COG2814 253 GLGGVLGALLAGRLADrFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPeARGR 332
|
330
....*....|....*
gi 489628962 349 AAALSHSAFNLANAL 363
Cdd:COG2814 333 ASGLYNSAFFLGGPL 347
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
32-399 |
1.09e-33 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 129.63 E-value: 1.09e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 32 IALAVGGFGIGTGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFAS 111
Cdd:PRK03545 12 VTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASHVLS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 112 AVAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGG 191
Cdd:PRK03545 92 ALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLAIGG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 192 ISLMTMALIWLHVPRDRGDpQATPLRELSAL--GSLQVWLLLgICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSV 269
Cdd:PRK03545 172 GALITLLLLIKLLPLLPSE-HSGSLKSLPLLfrRPALVSLYL-LTVVVVTAHFTAYSYIEPFVQQVAGLSENFATLLLLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 270 FGAGMILGNIVGSRLADWSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVP-GVQTRLMDVAGKAQTL 348
Cdd:PRK03545 250 FGGAGIIGSVLFSRLGNRHPSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIGlAMQVKVLKLAPDATDV 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 489628962 349 AAALSHSAFNLANALGAWLGGIaIAAGYGWTSPGLVGAVLGIGGFAIFLAS 399
Cdd:PRK03545 330 AMALFSGIFNIGIGAGALLGNQ-VSLHLGLSSIGYVGAALALAALVWSILI 379
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
34-397 |
4.90e-26 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 108.05 E-value: 4.90e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 34 LAVGGFGIGTGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAV 113
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 114 APSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGIS 193
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 194 LMTMALIWLHVPRDRGDPQATPLRELSALGSLQ-------VWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVM 266
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGLRlllrdrrLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 267 LSVFGAGMILGNIVGSRLAD-WSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDVAGK- 344
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDrIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPe 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 489628962 345 AQTLAAALSHSAFNLANALGAWLGGiAIAAGYGWTSPGLVGAVLGIGGFAIFL 397
Cdd:cd17325 321 GRGTAMGLFNTAFSLGMVLGPLLGG-FLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
32-406 |
1.18e-22 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 98.80 E-value: 1.18e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 32 IALAVGGFGIGTGEFAIMGLL-PQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFA 110
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLaPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 111 SAVAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVG 190
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 191 GISLMTMALIWLHV---PRDRGDPQATPLRE-LSALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVM 266
Cdd:COG2223 167 ILLLVVAVLAWLFLrdpPAGAAAAAKASLRDqLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 267 LSVFGAGMILGNIVGSRLAD-WSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLM--DVAG 343
Cdd:COG2223 247 AALFALLGALGRPLGGWLSDrIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVpdIFPT 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489628962 344 KAQTLAAALSHSAFNLANALGAWLGGIAIAAGYGWTSPGLVGAVLGIGGFAIFLASVLVDRRR 406
Cdd:COG2223 327 KNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
51-398 |
5.38e-21 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 93.79 E-value: 5.38e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 51 LLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLP 130
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 131 HGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGtPLVAWFGQALGWRSAFAIVGGISLMTMALIWLHVPRDRGD 210
Cdd:cd17474 101 AAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 211 PQATPLRELSALGSLQ----VWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLAD 286
Cdd:cd17474 180 AKSSSATKLRDLKKALrgrgLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLK 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 287 --WSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDVAGKAQTLAA-ALSHSAFNLANAL 363
Cdd:cd17474 260 krFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTAsSLYNFVRFLGQAV 339
|
330 340 350
....*....|....*....|....*....|....*
gi 489628962 364 GAWLGGIaIAAGYGWTSPGLVGAVLGIGGFAIFLA 398
Cdd:cd17474 340 GPLLFGL-LLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
32-397 |
7.76e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 93.01 E-value: 7.76e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 32 IALAVGGFGIGTGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFAS 111
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 112 AVAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGG 191
Cdd:COG2271 93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 192 ISLmtmaliwlhvprdrgdpqatplrelsALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFG 271
Cdd:COG2271 173 PGL--------------------------LLALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 272 AGMILGNIVGSRLADW---SLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDVAGKAQT- 347
Cdd:COG2271 227 LAGIVGSLLGGWLSDRlgrRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARg 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 489628962 348 LAAALSHSAFNLANALGAWLGGIAIAAGYGWTSPGLVGAVLGIGGFAIFL 397
Cdd:COG2271 307 TASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
34-365 |
1.07e-19 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 89.40 E-value: 1.07e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 34 LAVGGFGIGTGEFAIMGLLPQ-VADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASA 112
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 113 VAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGI 192
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 193 SLMTMALIWLHVPR-------DRGDPQATPLRELSALGSLQVWLLLGICAIGCGGMFAVFTYIaPALTQVAGVSVANVPV 265
Cdd:pfam07690 161 SLLAAVLLLLPRPPpeskrpkPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYL-PLYQEVLGLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 266 MLSVFGAGMILGNIVGSRLAD----WSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDV 341
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDrlgrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
330 340
....*....|....*....|....*
gi 489628962 342 AGK-AQTLAAALSHSAFNLANALGA 365
Cdd:pfam07690 320 APKeERGTASGLYNTAGSLGGALGP 344
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
32-395 |
3.77e-19 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 88.39 E-value: 3.77e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 32 IALAVGGFGIGTGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFAS 111
Cdd:COG2807 21 LAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 112 AVAPSFHPLVAARFFAGLPhGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGG 191
Cdd:COG2807 101 SLAPSVALLLAGTALIGAG-IAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWAL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 192 ISLMTMALIWLHVPRDRGDPQATP--LRELSALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQvAGVSVANVPVMLSV 269
Cdd:COG2807 180 LALLALLLWLPLLRRRPAAAAAAPaaASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 270 FGAGMILGNIVGSRLADWSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGF-AVVPGVQTRLMDVAGKAQTL 348
Cdd:COG2807 259 FQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQgGLFPLALTLIGLRARTPAEA 338
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 489628962 349 AA--ALSHSAFNLANALGAWLGGIAIAAGYGWTSPGLVGAVLGIGGFAI 395
Cdd:COG2807 339 AAlsGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
52-394 |
1.05e-17 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 84.16 E-value: 1.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 52 LPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLPH 131
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 132 GAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWLHVP------ 205
Cdd:cd17320 102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPetlpee 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 206 RDRGDPQATPLRELSALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLA 285
Cdd:cd17320 182 KRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 286 -----DWSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAV-VPGVQTRLMDVAGKAQTLAAALSHSAFNL 359
Cdd:cd17320 262 rrfgpRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLiFPNATSLALEPFPHVAGTASALLGFLQFL 341
|
330 340 350
....*....|....*....|....*....|....*
gi 489628962 360 ANALGAWLggIAIAAGYGWTSPGLVGAVLGIGGFA 394
Cdd:cd17320 342 IGALAGAL--VGLLPNGTALPMGLLILVLGLLALL 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
34-397 |
1.07e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 84.02 E-value: 1.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 34 LAVGGFGIGTGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAV 113
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 114 APSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQAL--GWRSAFAIVGG 191
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 192 ISLMTMALIWLHVPRDRGDPQATPLRELSA---------LGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVAN 262
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKsvlkllkrvLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 263 VPVMLSVFGAGMILGNIVGSRLAD--WSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLF-IGGGFAVVPGVQTRLM 339
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDrlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLgFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 489628962 340 DVAGKAQTLAAALSHSAFNLANALGAWLGGIAIAAGYGWTSPGLVGAVLGIGGFAIFL 397
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
39-400 |
1.24e-17 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 83.80 E-value: 1.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 39 FGIGTGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFH 118
Cdd:cd17489 6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 119 PLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMA 198
Cdd:cd17489 86 LLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 199 LIWL--HVPRDRGDPQATPLRELSALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQvagVSVANVPVMLSVFGAGMIL 276
Cdd:cd17489 166 LVFLvkDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAE---RGISNAGLFFTVYAIALLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 277 GNIVGSRLAD-WSLTRAIGIALVFNVFAYILFYFtMTSPWMAIVNVLFIGGGF-AVVPGVQTRLMDVAGKAQ-TLAAALS 353
Cdd:cd17489 243 SRPFSGKLSDrKGPKTVIIPGLLLLALGLLLLSF-AGSPWMLLLAAVLYGLGFgLLFPALQALAVDLVPPHRrGAANGTF 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 489628962 354 HSAFNLANALGAWLGGIaIAAGYGWTSPGLVGAVLGIGGFAIFLASV 400
Cdd:cd17489 322 FIFFDLGIGLGGLLLGL-VAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
51-397 |
6.29e-17 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 81.46 E-value: 6.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 51 LLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLP 130
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 131 HGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWLHVPrdrgd 210
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR----- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 211 pqatplrelsalgslQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLADWSLT 290
Cdd:cd17319 180 ---------------QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 291 ---RAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGG-FAVVPGVQTRLMDVAGKAQT-LAAALSHSAFNLANALGA 365
Cdd:cd17319 245 garRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGiGAASPVFWSLPADLLPGEAAaTAGGLINSGGNLGGFVAP 324
|
330 340 350
....*....|....*....|....*....|...
gi 489628962 366 WLGGIAIAAGYGWTSP-GLVGAVLGIGGFAIFL 397
Cdd:cd17319 325 LLIGYLVDATGSYTAAfLFLAAVALLAALLVLL 357
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
52-375 |
1.70e-16 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 80.31 E-value: 1.70e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 52 LPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLPH 131
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 132 GAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAI---VGGISLMTMALIWLHVPRDR 208
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYInlpIGILALLLAPLLDLRLFKDR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 209 gdpqatplrelsalgslQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLADWS 288
Cdd:cd17503 179 -----------------NFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 289 LTR--AIGIALVFNVFAYILFYFTMTSPWMAIVNVLFI---GGGFAVVPGVQTRLMDVAGKAQTLAAALSHSAFNLANAL 363
Cdd:cd17503 242 GPRllLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIrglGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSI 321
|
330
....*....|..
gi 489628962 364 GAWLGGIAIAAG 375
Cdd:cd17503 322 GTALLATLLTNR 333
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
52-400 |
9.47e-16 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 77.98 E-value: 9.47e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 52 LPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLPH 131
Cdd:cd17321 19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 132 GAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALiwlhvprdrgdp 211
Cdd:cd17321 99 AAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL------------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 212 qatplrelsalgSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLADWSLTR 291
Cdd:cd17321 167 ------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPR 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 292 ---AIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFA-VVPGVQTRLMDVAGKAQT-LAAALSHSAFNLANALGAW 366
Cdd:cd17321 235 lvlVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGlFATPLTNAALSSVPKEKAgAASGILNTARQLGGALGVA 314
|
330 340 350
....*....|....*....|....*....|....
gi 489628962 367 LGGIAIAAGYGWTSPGLVGAVLGIGGFAIFLASV 400
Cdd:cd17321 315 LLGALLTAGLSANLGDSGVAALLSAAAAAFAAGF 348
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
34-402 |
9.59e-16 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 78.00 E-value: 9.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 34 LAVGGFGIGTGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAV 113
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 114 APSFHPLVAARFFAGLPhGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGIS 193
Cdd:cd17504 81 APNLPVLIAGRALQGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 194 LMTMALIwlhvprdrgdpqatPLRELSALGSLQVWLLLGICAIGCGGMFAVFtYIAPALTQV-----AGVSVANVPVMLS 268
Cdd:cd17504 160 VLLAALV--------------PLIDLRLLRRRNVLLANITALLAGFGMFMVF-QLLPQLLQLptptgFGLGITEAGLLLL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 269 VFGAGMILGNIVGSRLAD-WSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDVAGKAQT 347
Cdd:cd17504 225 PGALVMLIAGPLAGRLIArVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDR 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489628962 348 LAAA--LSHSAFNLANALGAWLGGIAIAA----GYGWTSPGLVGAVLGIGGFAIFLASVLV 402
Cdd:cd17504 305 TGIAtgMNTVLRTIGSAIGPAIAGAILTTytvsITSGGVPTEGAYVLAFLIGAALALAALL 365
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
47-406 |
1.70e-15 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 77.24 E-value: 1.70e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 47 AIMG-LLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARF 125
Cdd:cd17365 16 AVMGfVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 126 FAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWlhvp 205
Cdd:cd17365 96 LTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLR---- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 206 rdrgdpqatplrelsalgslqVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLA 285
Cdd:cd17365 172 ---------------------GTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 286 D-WSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIG----GGFAVVPGVQTRLMDVAGKAQTLAAALSHSafNLA 360
Cdd:cd17365 231 DrFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGacvnGAQVGLYALAARFYPTEVRATGVGWALGVG--RLG 308
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 489628962 361 NALGAWLGGIAIAAGYGWTSpglVGAVLGIGGFAIFLASVLVDRRR 406
Cdd:cd17365 309 AILGPLLGGLLLAAGLGPES---VFLALAIPAALGALAVLLLRLRR 351
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
25-372 |
2.06e-15 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 77.40 E-value: 2.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 25 NRVSATEIALAVGGFGIGTGEFAIMGL-LPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAV 103
Cdd:TIGR00895 12 SRYQWRAIILSFLIMLMDGYDLAAMGFaAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 104 FALGNFASAVAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWR 183
Cdd:TIGR00895 92 FSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 184 SAFAIVGGISLMTMALIWLHVP-------------------RDRGDPQATPLRELSALGS------------LQVWLLLG 232
Cdd:TIGR00895 172 SLFYVGGIAPLLLLLLLMRFLPesidflvskrpetvrrivnAIAPQMQAEAQSALPEQKStqgtkrsvfkalFQGKTARI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 233 ICAIGCGGMFAVFTYIA-----PALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLADWSLTRAI-GIALVFNVFAYIL 306
Cdd:TIGR00895 252 TVLLWLLYFMLLVGVYFltnwlPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTaLLLLLGAVFAVLV 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 307 fYFTMTSPWMAIVNVLFIG----GGFAVVPGVQTRLMDVAGKAQTLAAALSHSafNLANALGAWLGGIAI 372
Cdd:TIGR00895 332 -GSTLFSPTLLLLLGAIAGffvnGGQSGLYALMALFYPTAIRATGVGWAIGIG--RLGAIIGPILAGYLL 398
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
43-388 |
3.74e-15 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 76.49 E-value: 3.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 43 TGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVA 122
Cdd:PRK10213 34 IVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 123 ARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWL 202
Cdd:PRK10213 114 GRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAVMGVLCIFWIIK 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 203 HVPRDRGDPQATPLRELSALGSLQVwlLLGICAI--GCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIV 280
Cdd:PRK10213 194 SLPSLPGEPSHQKQNTFRLLQRPGV--MAGMIAIfmSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVLLSFGIASFVGTSL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 281 GSRLADWSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVP-----GVQTRLMDVAGKAQTLAAALshs 355
Cdd:PRK10213 272 SSFILKRSVKLALAGAPLVLAVSALVLTLWGSDKIVATGVAIIWGLTFALVPvgwstWITRSLADQAEKAGSIQVAV--- 348
|
330 340 350
....*....|....*....|....*....|...
gi 489628962 356 aFNLANALGAWLGGIAIaAGYGWTSPGLVGAVL 388
Cdd:PRK10213 349 -IQLANTCGAAIGGYAL-DNIGLTSPLMLSGTL 379
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
46-398 |
8.39e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 75.30 E-value: 8.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 46 FAIMGLLPQVADD-VAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAAR 124
Cdd:cd17473 16 AAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 125 FFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQaLGWRSAFAIVgGISLMTMALIWLHV 204
Cdd:cd17473 96 ALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVY-LLALPVLILVLLFL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 205 PRDRGDPQATPLRELSALGSLQVWLLLGICAIGCGGM---FAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVG 281
Cdd:cd17473 174 PEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMllfYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 282 SRLAD-WSLTRAIGIALVFNVFAYILFYFTmTSPWMAIVNVLFIGGGFA-VVPGVQTRLMDVAGKAQ-TLAAALSHSAFN 358
Cdd:cd17473 254 GRLKRrLGKRRLLAIGFALMALGFLLLALA-SGLWVVLLGAILAGLGFGlLLPTLNSWAMSLVPPELrGRAMGIVTSAFF 332
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 489628962 359 LANALGAWLGGIAIAAGYGWTSPGLVGAVLGIGGFAIFLA 398
Cdd:cd17473 333 LGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
51-397 |
2.87e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 73.73 E-value: 2.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 51 LLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLP 130
Cdd:COG0738 30 LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 131 HGAyFGVAALVAAGLAAPNQRARAVGRV----MMGLTIATLFGTPLVAWfGQALGWRSAFAIVGGISLMTMALIWL---- 202
Cdd:COG0738 110 LGL-LDVAANPYVAALGPETAASRLNLLhaffSLGALLGPLLGGLLILL-GLSLSWHLPYLILAVLLLLLALLFLRsklp 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 203 HVPRDRGDPQATPLRELSALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGS 282
Cdd:COG0738 188 EIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 283 RLAD-WSLTRAIGIALVFNVFAYILFYFTmTSPWMAIVNVLFIGGGFAVV-PGVQTRLMDVAGKAQTLAAALSHSAFNLA 360
Cdd:COG0738 268 FLLKrFGPVRLLRLSALLAAVGLLLALLA-PGPWLALIGLALVGLGLSLMfPTIFSLALDGLGKRTAAAVSAVLIMGIVG 346
|
330 340 350
....*....|....*....|....*....|....*...
gi 489628962 361 NALGAWL-GGIAIAAGYGWTSPGLVGAVLGIGGFAIFL 397
Cdd:COG0738 347 GAIGPPLiGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
26-398 |
9.12e-14 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 72.30 E-value: 9.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 26 RVSATEIALAVGGFGIGtgeFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFA 105
Cdd:cd17355 3 VVLAVTFLILILSWGIR---YYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 106 LGNFASAVAPSFHPLVAARFF-AGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRS 184
Cdd:cd17355 80 AGLVLLALATSLWQLYLLWGLlGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 185 AFAIVGGISLMTMALIWLHVPRDRGDPQATPLRELS----------ALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQ 254
Cdd:cd17355 160 ALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASpaspgstlkeALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 255 vAGVSVANVPVMLSVFGAGMILGNIVGSRLAD-WSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGG-FAVVP 332
Cdd:cd17355 240 -RGISPAAAAVALALIGLFNIVGRLLSGWLGDrYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGwGATVP 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489628962 333 GVQTRLMDVAG-KAQTLAAALSHSAFNLANALGAWLGGIAIAAGYGWTSPGLVGAVLGIGGFAIFLA 398
Cdd:cd17355 319 LTAALAARYFGaRSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLP 385
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
61-395 |
2.57e-13 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 70.71 E-value: 2.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 61 VSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLPHGAYFGVAAL 140
Cdd:cd17316 33 LSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGAST 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 141 VAAGLAAPNQRARAVGRVMM----GLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWLhvprdrgdpqatpl 216
Cdd:cd17316 113 YVAEFAPSKRRGFALGLLQSgwalGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLLRRR-------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 217 relsalgslqVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLADWSLTRAIGI- 295
Cdd:cd17316 179 ----------TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVi 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 296 -ALVFNVFAYILFYFTMTSPWMAIV----NVLFIGGGFAVVPGVQTRLMDVAGKAqtLAAALSHSAFNLANALGAWLGGI 370
Cdd:cd17316 249 gLILSGILALPLFYLLSGSPTLLLLllfiLSFFVGGVWGALYAYLAELFPTEVRA--TGVGLSYNLGRLGGGGAPPLIAL 326
|
330 340
....*....|....*....|....*
gi 489628962 371 AIAAGYGWTSPGLVGAVLGIGGFAI 395
Cdd:cd17316 327 LLASTGGTGVPALILALLAIVALIV 351
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
40-398 |
2.76e-13 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 70.80 E-value: 2.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 40 GIGTGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHP 119
Cdd:cd06180 10 AMGIGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 120 LVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQ-ALGWRSAFAIVGGISLMTMA 198
Cdd:cd06180 90 LLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGgGLSWRAGWLALALLSAVLLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 199 LIWLHVPRDRGDPQATPLRELSALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMlSVFGAGMILGN 278
Cdd:cd06180 170 LSFLLLRRGPSAPTEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLW-SLFGLAAVPSC 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 279 IVGSRLAD-WSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDVAGKAQTLAAALSHSAF 357
Cdd:cd06180 249 FLWGALSDrWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAAPRALALMTASF 328
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 489628962 358 NLANALGAWLGGIAIAAGYGWTSPGLVGAVLGIGGFAIFLA 398
Cdd:cd06180 329 GVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLALL 369
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
32-402 |
4.72e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 70.32 E-value: 4.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 32 IALAVGGFGIGTGEFAIMGLLPQV-ADDVAVSVPAAGAVISAYALGVVVGAPLIAVLA----ARFARFHVLLVLMAV-FA 105
Cdd:COG2211 13 LAYGLGDLGLNLAFGLLSAYLLYFyTDVLGLSAALVGLILLVARLWDAITDPLIGALSdrtrTRWGRRRPWILIGAIpLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 106 LGNFASAVAPSFHP------LVAARFFAGLPHGAYFG-VAALVAAGLAAPNQRARAVGRVMMGLTIATLFGT----PLVA 174
Cdd:COG2211 93 LSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLVNIpYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASvlppPLVA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 175 WFG--QALGWRSAFAIVGGISLMTMALIWLHVP-RDRGDPQATPLREL--SALGSLQVWLLLGICAIGCGGMFAVFTYIA 249
Cdd:COG2211 173 AFGgdAALGYRLTALIFAVLGLLAFLLTFFGTKeRPVPEEEKVSLKESlkALLKNRPFLLLLLAYLLFFLALALVAALLL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 250 PALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLAD-WSLTRAIGIALVFNVFAYILFYFT-MTSPWMAIVNVLFIGGG 327
Cdd:COG2211 253 YYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKrFGKKKAFIIGLLLAALGLLLLFFLgPGNLWLLLVLAALAGIG 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 328 FAVVPGVQTRLM-DVA----GKAQTLAAALSHSAFN----LANALGAWLGGIAIAA-GYGWTSPGLVGAVLGIGGFAIFL 397
Cdd:COG2211 333 LGAILVLPWAMLaDVVdydeWKTGRRREGLYFGIFTfaikLGQALAGALAGLLLALfGYVAGAAQSPSALTGIRLLFFLL 412
|
....*
gi 489628962 398 ASVLV 402
Cdd:COG2211 413 PAVLL 417
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
32-398 |
5.43e-13 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 69.51 E-value: 5.43e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 32 IALAVGGFGIGTGefAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFAS 111
Cdd:cd17477 1 LLLSVALLGLGSG--LLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 112 AVAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWrsAFAIVGG 191
Cdd:cd17477 79 ALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL--PFLIAAV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 192 ISLMTMALIWLhvpRDRGDPQATPLRELSALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFG 271
Cdd:cd17477 157 LLLLALVPLLL---TRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 272 AGMILGNIVGSRLADWSLTR--AIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDVAGKAQTLA 349
Cdd:cd17477 234 LGGLLLQWPLGWLADRFDRRrvLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVA 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 489628962 350 AAlshSAFNLANALGAWLGGIAIAAGYGWTSPGLVGAVLGIGGFAIFLA 398
Cdd:cd17477 314 AN---AALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
34-332 |
1.91e-12 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 68.10 E-value: 1.91e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 34 LAVGGFGIGTGEFAIMGL-LPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASA 112
Cdd:cd17371 3 AAFLGWALDGFDLLLLGLvLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 113 VAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTI----ATLFGTPLVAWFGQALGWRSAFaI 188
Cdd:cd17371 83 FAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVgwllATLLAALLFPLLPPEIAWRVLF-L 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 189 VGGISLMTMALIWLHVP----------RDRGDPQATPLRELSALGSLQVWLLLGICAIGC-GGMFAVFTYIAPALTQVAG 257
Cdd:cd17371 162 LGALPALLVLFIRRFVKeppqwqaaraARRHFADRPSLRELFSPPLLRTTLLASLLATGAlGGYYGITTWLPSYLTGERG 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489628962 258 VSVANVPVMLSVFGAGMILGNIVGSRLADWSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVP 332
Cdd:cd17371 242 LSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGP 316
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
32-406 |
7.52e-12 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 66.51 E-value: 7.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 32 IALAVGGFGIgtgefaIMGLLPQVADDVAVSVPAA----GAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALG 107
Cdd:cd17388 8 VLLDAMGIGL------IMPVLPTLLREFVGDSADAathyGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 108 NFASAVAPSFHPLVAARFFAGLPhGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQaLGWRSAFA 187
Cdd:cd17388 82 YLLMAFAPTLWWLYLGRIIAGIT-GATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRAPFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 188 IVGGISLMT--MALIWLHVPRDRGDPQATPLRELSALGSLqvWLLLGICAIgcGGMFAVFTYI-----APALTQVA---- 256
Cdd:cd17388 160 VAAGLNGLNflLGLFVLPESLPPERRRAFRWRRANPFGSL--RWLTGFPGL--LGLLAVFFLIqligqVPATTWVLfted 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 257 --GVSVANVPVMLSVFG--AGMILGNIVGSRLADWSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAvVP 332
Cdd:cd17388 236 rfDWSPTMVGLSLAVFGllHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIA-GP 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489628962 333 GVQTRLM-----DVAGKAQTLAAALshsafnlaNALGAWLGGIAIAAGYGWTSPGLVGAVLGIGGFAIFLASVLVDRRR 406
Cdd:cd17388 315 ALQGLLSrqvpeNEQGELQGVLTSL--------TSLTSIIGPLLFTGIFAASPATWPGLAWIIGAALYLICLVLAYRFF 385
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
32-309 |
3.66e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 63.68 E-value: 3.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 32 IALAVGGFGIGTGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFAS 111
Cdd:COG0477 17 LALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 112 AVAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGG 191
Cdd:COG0477 97 GLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 192 ISLMTMALIW-LHVPRDRGDPQATPLRELSALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVF 270
Cdd:COG0477 177 LGLLALVLRLrLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLAL 256
|
250 260 270
....*....|....*....|....*....|....*....
gi 489628962 271 GAGMILGNIVGSRLADWSLTRAIGIALVFNVFAYILFYF 309
Cdd:COG0477 257 LLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
69-369 |
6.56e-11 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 62.97 E-value: 6.56e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 69 VISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAP 148
Cdd:cd17502 35 VGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 149 NQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFaivgGISLmtmaliwlhvprdrgdpqatPLRELSALGSLQVW 228
Cdd:cd17502 115 RERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCF----YINL--------------------PIGGLALALLRTIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 229 LLLGICAIGCGGMFAVFTYIAPALTQVAGVSvanvPVMLSVFGAGMILGNIVGSRLADWSLTRA------IGIALVFNVF 302
Cdd:cd17502 171 LSSIFGFLFGGALFGLIYYLPLYFQLVLGDS----ATKSGVRLLPLIIGLVIGSIISGALISKTgrykplIVIGTILMSV 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 303 AYILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLM---DVAGKAQTLAAAlshSAFNLANALGAWLGG 369
Cdd:cd17502 247 GAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVavqNAVPPADVGVAT---ATNTFFRSLGGTLGV 313
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
32-403 |
3.06e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 61.47 E-value: 3.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 32 IALAVGGFGIGTGEFAIMGLLP-QVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFA 110
Cdd:cd17329 2 WVLLIGSFLNRLGFFMVWPFMAiYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 111 SAVAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQaLGWRSAFAIVG 190
Cdd:cd17329 82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 191 GISLMTMALIWLHVPRDR-GDPQATPLRELSALGSLQ----VWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPV 265
Cdd:cd17329 161 VLFLLAALVLLFLLPETRpKRRAAEKTEILRGYKIVLrdraFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 266 MLSVFGAGMILGNIVGSRLA-DWSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDVAGK 344
Cdd:cd17329 241 LLALNALLIVLLQFPVARLVeRFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPP 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 489628962 345 AQtlaAALSHSAFNLANALGAWLGGIAIAAGYGWTSPGLVGAVLGIGGFAIFLASVLVD 403
Cdd:cd17329 321 DK---RGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
45-324 |
6.17e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 60.71 E-value: 6.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 45 EFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAAR 124
Cdd:cd17328 15 RFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 125 FFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQA-LGWRSAFAIVGGISLMTMALIWLH 203
Cdd:cd17328 95 ALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLLLF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 204 VP-RDRGDPQATPLRELSALGSLQ-----------VWLLLGICAIGCGGM---FAVFTYIAPALTQVAGVSVANVPVMLS 268
Cdd:cd17328 175 VRePPRGAAEGGVMAKSTATSFLAdlkalaknpsfILSTLGFTAVSFVTGalaFWAPTFFLRAFGVGDLSSADVGLIFGA 254
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489628962 269 VFGAGMILGNIVGSRLADWSLTRAIG--------IALVFNVFAYILFYFTMTSPWMAIVNVLFI 324
Cdd:cd17328 255 ITCIAGVLGVLLGGILADRLRRKTPRadplvcavGLLAAAPFLFLALVLALSNLLLAWVLLFLG 318
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
52-371 |
1.56e-09 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 59.32 E-value: 1.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 52 LPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLPH 131
Cdd:TIGR00710 28 FPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 132 GAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWL-----HVPR 206
Cdd:TIGR00710 108 SAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFilpetLPYE 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 207 DRGDPQATPLRELSALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLad 286
Cdd:TIGR00710 188 ARIQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRF-- 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 287 wsltraIGIALVFNVFAYILFYFTMTSPWMAIVNV-------LFIGGGFAVVPGVQTRLMDVAGKAQTLAAALSHSAFNL 359
Cdd:TIGR00710 266 ------IKKWGAKSLLRMGLILFAVSAVLLEITAIlglgswaMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGTASAL 339
|
330
....*....|..
gi 489628962 360 ANALGAWLGGIA 371
Cdd:TIGR00710 340 FGTLRLVLGAIV 351
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
86-402 |
9.88e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 56.46 E-value: 9.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 86 VLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLphGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIA 165
Cdd:cd17472 54 LLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALIGASIGIA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 166 TLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWLHVPRDRGDPQATPLRELSALGSLQVWLLLGICAIGC---GGMF 242
Cdd:cd17472 132 FAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFilhFVLM 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 243 AVFTYIAPALTQvAGVSVAN-----VPVMLSVFGAgMILGNIVGSRLADWSLTRAIGIALVfnVFAYILFYFTMTSPWMA 317
Cdd:cd17472 212 AFFYILPLLLTQ-LGGGKGQlwkvyLPAILIGFIL-MVPFVIYAEKKGKMKQVFVSSILLI--AVGFLLLLFAATSLWLL 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 318 IVNVLFIGGGF----AVVPGVQTRLMDVAGKAQTLaaalshSAFNLANALGAWLGGiaIAAGYGWTSPGLVGAVLGIGGF 393
Cdd:cd17472 288 IIGLIIFFIGFnlleALLPSLVSKIAPKEYRGTAM------GIYNTSQFLGSFLGG--ALGGLLWGLLGYSSVFLTILIL 359
|
....*....
gi 489628962 394 AIFLASVLV 402
Cdd:cd17472 360 ALLWLLVSF 368
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
160-397 |
1.07e-08 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 56.40 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 160 MGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWLHVPRDRGDPQ--ATPLRELSALGSLQVWLLLGICAIG 237
Cdd:cd17471 132 AAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQkaTPASSLVKAPVNRRLLLLFAAFTLL 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 238 CGGMFAVFTYIAPALTQVAGVSVANVPVMLSVfGAG-----MILGNIVGSRladWSLTRAIGIALVFNVFAYILFYFTmT 312
Cdd:cd17471 212 FAANSMYIIAMPLYVTNELGGSESWVGLLFGL-AAAleipiMLLAGLLAKR---FGKRRLLLAGFLAGVLFYLGLALA-T 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 313 SPWMAIVNVLFIGGGFAVVPGVQTRLM-DVAGKAQTLAAALSHSAFNLANALGAWLGGIaIAAGYGWTSPGLVGAVLGIG 391
Cdd:cd17471 287 SLWQLIALQLLNAIFIGITAGLGISYFqDLMPGQPGLATTLYSNASRIGSLLGGLLAGV-IAQYFGYRAVFLVCAVLALL 365
|
....*.
gi 489628962 392 GFAIFL 397
Cdd:cd17471 366 ALVLLL 371
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
48-329 |
1.52e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 56.03 E-value: 1.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 48 IMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFA 127
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 128 GLPHGAyFGVAALVAAGLAAPNQRARAVGRVM----MGLTIATLFGTPLVA-WFGQALGWRSAFAIVGGISLMTMALIWL 202
Cdd:cd17478 95 GIGSAA-FHPEGARLASQAAGGRRGLAMSIFSvggnLGFALGPLIAAALVAlFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 203 HVPRDRGDPQATpLRELSALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVaGVSVANVPVMLSVFGAGMILGNIVGS 282
Cdd:cd17478 174 KPEAKKAAAKSS-ARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQR-GYSLVFAGLLLSLFLFAGAIGTLIGG 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 489628962 283 RLAD-WSLTRAIGIALVFNVFAYILFYFtmTSPWMAIVnVLFIGGGFA 329
Cdd:cd17478 252 PLSDrFGRRRVIIASLLLAAPFLLLFLL--TPGIWSYI-LLVLAGFLL 296
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
51-331 |
1.72e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 56.09 E-value: 1.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 51 LLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLP 130
Cdd:cd17475 18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 131 HGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWLhVPRDRGD 210
Cdd:cd17475 98 YGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWL-FYREPPA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 211 PQATPLRELSALGSL-------QVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSR 283
Cdd:cd17475 177 ASAATESASTLLRSLkevlrnrDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGR 256
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 489628962 284 LADWSLT----RAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVV 331
Cdd:cd17475 257 VSDRVFGgrrrPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAI 308
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
48-318 |
1.75e-08 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 56.04 E-value: 1.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 48 IMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFA 127
Cdd:cd17323 18 YSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 128 GLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWLHVPrd 207
Cdd:cd17323 98 GFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLP-- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 208 rgdpqatplrelsalgslQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLADW 287
Cdd:cd17323 176 ------------------IVLLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDY 237
|
250 260 270
....*....|....*....|....*....|.
gi 489628962 288 SLTRAIGIALVFNVFAYILFYFTMTSPWMAI 318
Cdd:cd17323 238 YYRRLKKKNGGKPEPEARLPPAFIGAFLFPI 268
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
67-342 |
4.29e-08 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 54.55 E-value: 4.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 67 GAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFH--PLVAARFFAGLPHGAYFGVAALVAAG 144
Cdd:cd17318 59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGygALIVLRILQGLAQGVTFPAMHALWAK 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 145 LAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWLHVPrdrgdpqatplrelsalgs 224
Cdd:cd17318 139 WAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVL------------------- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 225 lQVWlllGICAIGCGGMFAVFT---YIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLADWSLTR----AIGIAL 297
Cdd:cd17318 200 -PVW---AIVVAHFGHNWGFYTlltELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRgilsTTTVRK 275
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 489628962 298 VFN--------VFAYILFYFTmTSPWMAIVnVLFIGGGF--AVVPGVQTRLMDVA 342
Cdd:cd17318 276 LFTsigflgpgVFLIALGYLG-SNATLAVV-FLTLSVGLsgACYSGFLVNHLDLA 328
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
40-397 |
4.71e-08 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 54.68 E-value: 4.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 40 GIGTGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGApliavLAARFARFHV-------LLVLMAVFALGNFASA 112
Cdd:pfam06779 4 GMGIGRFSYTPILPVMIAEGQFSLSQAGLLAAANYAGYLAGA-----LLASFAWRHGasrlrpaLLAGLLATVLLLLAMA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 113 VAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTpLVAWFGQALGWRSAFAIVGG- 191
Cdd:pfam06779 79 ATSSFWAVLLIRFLAGVASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSG-LLVPLGLQLGLGGSSLWYGAg 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 192 -ISLMTMALIWLHVPRDRGDPQATPLRELSALGSLQVWLLLGIcAIGCGGM--FAVFTYIaPALTQVAGVSVANVPVMLS 268
Cdd:pfam06779 158 vLSAVLTLAVFPLLPRRAPRHASAPAPAAKPLQRSLPLWILTL-AYGLAGFgyIITATFL-PAMARDGFGGPAAAALFWS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 269 VFGAGMILGNIVGSRLAD-WSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDVAGKAQT 347
Cdd:pfam06779 236 LFGLAAALGVLVWLRAAKrWGTRPALTAALLIQALGVLLSLLSPSPAGLAVSSLLFGGTFMAITSLVMQLARELAPPAPR 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 489628962 348 LAAALSHSAFNLANALGAWLGGIAIAAGYGWTSPGLVGAVLGIGGFAIFL 397
Cdd:pfam06779 316 RLLGLMTASFGIGQILGPLLASLLTAATGGLTPALLLAAAALVLAALIVL 365
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
42-397 |
6.83e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 54.12 E-value: 6.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 42 GTGEFAIMGLLPQVADDVAV---SVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFH 118
Cdd:cd17330 9 ALGFGIVFPVLPFYVREFNKlgaSGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 119 PLVAARFFAGLpHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMA 198
Cdd:cd17330 89 LLFLARFLDGL-TGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 199 LIWLHVPRdrgdpqatplrelsalgslqVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGN 278
Cdd:cd17330 168 LVLFFLPP--------------------LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 279 IVGSRLADWSLT--RAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDVAG-KAQTLAAALSHS 355
Cdd:cd17330 228 LLLIPRLAKRLGerKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPsKEQGKAQGIIQS 307
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 489628962 356 AFNLANALGAWLGGIAIAAGYGWTSPGLVGAVLGIGGFAIFL 397
Cdd:cd17330 308 LQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
53-218 |
7.12e-07 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 51.12 E-value: 7.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 53 PQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLPHG 132
Cdd:PRK11551 39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 133 AYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWLHVPRDRGDPQ 212
Cdd:PRK11551 119 GALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQ 198
|
....*.
gi 489628962 213 ATPLRE 218
Cdd:PRK11551 199 AAGAGK 204
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
148-398 |
1.61e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 49.92 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 148 PNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISL--MTMALIWLHVPRDRGDPQATPLRELS----- 220
Cdd:cd17353 122 PDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLiiIVIGAFLIRDPPKGWVPPGVDPLANNaensp 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 221 -------ALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLAD-WSLTRA 292
Cdd:cd17353 202 rdytpreMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDkIGRKNT 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 293 IGIALVFNVFAYILFYFTMTSPWMAIVNVLFI----GGGFAVVPGVqtrLMDVAGKAQtlaAALSHSAFNLANALGAWLG 368
Cdd:cd17353 282 LSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIgfcyGGGFALFPAL---TADFFGTKN---AGTNYGLLYTAKGVGGLIG 355
|
250 260 270
....*....|....*....|....*....|...
gi 489628962 369 GIA---IAAGYGWTSPGLVGAVLGIGGFAIFLA 398
Cdd:cd17353 356 PIIaayVLYTGGYNAAFIIAAALSLVALALALL 388
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
52-205 |
1.81e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 49.53 E-value: 1.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 52 LPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLPH 131
Cdd:PRK11102 14 LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAA 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489628962 132 GAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWLHVP 205
Cdd:PRK11102 94 AAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIP 167
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
62-397 |
1.88e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.54 E-value: 1.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 62 SVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFH-----PLVAARFFAGLPHGAYFG 136
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGslslwLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 137 VAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIW-LHVPRDRGDPQATP 215
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLfIRRPPPAAPGESSS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 216 LRELSALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVA-------GVSVANVPVMLSVFGAGMILGNIVGSRLAD-W 287
Cdd:cd06173 192 LLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPllakevlGGGAAGYGLLLAAFGVGALLGALLLGRLSKrR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 288 SLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLF-IGGGFAVVPGVQTRLMDVAGKAQTLAAALSHSAFNLANALGAW 366
Cdd:cd06173 272 RRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLgLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGAL 351
|
330 340 350
....*....|....*....|....*....|.
gi 489628962 367 LGGIAiAAGYGWTSPGLVGAVLGIGGFAIFL 397
Cdd:cd06173 352 LAGLL-ADALGLSAVFLLAGALLLLAALLLL 381
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
69-202 |
2.00e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 49.12 E-value: 2.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 69 VISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAP 148
Cdd:cd17317 30 VQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGP 109
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 489628962 149 NQRARAVGRVMMGLTIATLFgTPLVAWFGQAlgWRSAFAIVGGISLMTMALIWL 202
Cdd:cd17317 110 KYRSFVGILFGLFWALGYML-LALLAYLIRD--WRWLQLAISLPGLLFLLLLWW 160
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
51-331 |
3.16e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 48.86 E-value: 3.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 51 LLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLP 130
Cdd:cd17333 18 LGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 131 HGAYFGVAALVAAGLAAPNQRARAV---GRVMMGLTIATLFGTPLVAWfgqALGWRSAFAIVGGISLMTMALI----WLH 203
Cdd:cd17333 98 AGILDTGANTFVGALFEESSATRLNvlhGFFGLGALIGPLIATSLLTS---ELSWSWAYLIIGLIYLLLAILIlltlFPE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 204 VPRDR---GDPQATPLRELSALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIV 280
Cdd:cd17333 175 LPSARnpqQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLL 254
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 489628962 281 GSRLADWSLTRAIgiaLVFNVFAYILFYFT---MTSPWMAIVNVLFIGGGFAVV 331
Cdd:cd17333 255 GGPISRRIKPHTL---LVLSGSGALLGLLIlllAPTLVVGLVATALLGLFMAAL 305
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
159-376 |
8.77e-06 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 47.60 E-value: 8.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 159 MMGLTIATLFGTPLVAWFG---QALGWRSAFAIVGGISLMTMALIWL-----HVPRDRGDPQATPLRELSALGSLQVWLL 230
Cdd:cd17332 146 TIGGLLVTVLPPPLVAYFGggnASRGYFLTALIIGIIGIILLLICFFgtrerVVPPEEEKSKLPLLKSLKALLKNRPFLI 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 231 LGICAIGCG-GMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLADWSLTRAIGIALVFNVFAYILFYF 309
Cdd:cd17332 226 LLLAYLLYFlAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFF 305
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489628962 310 -TMTSPWMAIVNVLFIGGGFAVVPGVQTRLM-DVAG--------KAQTLAAALSHSAFNLANALGAWL-GGIAIAAGY 376
Cdd:cd17332 306 lPPGNLVLILVLAVLAGIGYGGANLLPWAMLaDVIDygelktgkRREGIFYSVMTFFRKLGLALAGALvGLILSLAGY 383
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
32-204 |
1.11e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.19 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 32 IALAVGGFGIGTGEFAIMGLLPQVADDVAVSVPA-AGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFA 110
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAqIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 111 SAVAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVG 190
Cdd:cd17325 282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAA 361
|
170
....*....|....
gi 489628962 191 GISLMTMALIWLHV 204
Cdd:cd17325 362 ALLLLAAVLFLLLR 375
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
46-202 |
1.34e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 46 FAIMGLLPQVADDVAVSVPAA-GAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAAR 124
Cdd:cd06173 225 GALTVLLPLLAKEVLGGGAAGyGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAAL 304
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489628962 125 FFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWL 202
Cdd:cd06173 305 FLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
35-339 |
1.50e-05 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 46.79 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 35 AVGGFGIGTGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVA 114
Cdd:cd17359 7 ALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 115 PSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGR----VMMGLTIATLFGTPLVAWFGQAL----GWRSAF 186
Cdd:cd17359 87 PNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLnqlmIVFGQLLAYIVNYLIANAGGADWlgaeGWRWML 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 187 AIVGGISLMTMALIWLhVPRdrgdpqaTPlRELSALGSLQVWLLLGICAIG-CGGMFAVFtYIAPALTQVAGVSVANVPV 265
Cdd:cd17359 167 GLEAIPAILFLLGMLF-IPE-------SP-RWLVSKGKPILIIGIGLAIFQqFVGINVIF-YYGPEIFQNAGFSENAALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 266 MLSVFGAGMILGNIVGSRLADW------SLTRAIGIALVFNVFAYILFYFTM--TSPWMAIVNVLFIGGGFAVVPGVQTR 337
Cdd:cd17359 237 QTIGIGVVNVIFTIIAILLVDKvgrkplLLIGSIGMAISLLLIGTAFYFAPGsqASGIVALVLILLFVAFFAMSWGPVTW 316
|
..
gi 489628962 338 LM 339
Cdd:cd17359 317 VL 318
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
79-339 |
6.76e-05 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 44.59 E-value: 6.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 79 VGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHP--------LVAARFFAGLPHGAYFGVAALVAAGLAAPNQ 150
Cdd:cd17367 55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATigiwapiiLLLARLLQGLSVGGEYGTSATYLSEVAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 151 RARAVG----RVMMGLTIATLFGTPLVAWFGQ----ALGWRSAFAIVGgisLMTMALIWLH----------VPRDRGDPQ 212
Cdd:cd17367 135 RGFYSSfqyvTLIGGQLLALGVLLVLQHTLGEdqmaAWGWRIPFLLGG---VLAVVVLWLRrgleetesfeAIAESNEAS 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 213 ATPLRELsALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLADWSLTRA 292
Cdd:cd17367 212 AGTLREL-RRHPRELLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRP 290
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 489628962 293 --IGIALVFNVFAYILFYF--TMTSPWMA----IVNVLFIGGGFAVVPGVQTRLM 339
Cdd:cd17367 291 llLFFGIGGTLATVPLLSAldHTDSPYTAfalvLVGLVFLSGYTSINAVVKAELF 345
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
227-411 |
6.82e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.53 E-value: 6.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 227 VWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLAD-WSLTRAIGIALVFNVFAYI 305
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADrFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 306 LFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDVA-GKAQTLAAALSHSAFNLANALGAWLGGIAIAAGYGWTSpgLV 384
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTtPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLF--LA 158
|
170 180
....*....|....*....|....*..
gi 489628962 385 GAVLGIGGFAIFLasVLVDRRRTGRVP 411
Cdd:cd17329 159 AAVLFLLAALVLL--FLLPETRPKRRA 183
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
33-213 |
1.00e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 44.10 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 33 ALAVGGFGIGTGEFAIMGLLPQVADDVA-VSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFAS 111
Cdd:COG2223 209 LLSLLYFGTFGSFIGFSSWLPPYLVDQFgLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 112 AVAP-SFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALG-WRSAFAIV 189
Cdd:COG2223 289 ALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVF 368
|
170 180
....*....|....*....|....
gi 489628962 190 GGISLMTMALIWLHVPRDRGDPQA 213
Cdd:COG2223 369 AVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
32-331 |
1.90e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 43.40 E-value: 1.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 32 IALAVGGFGIGTGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFAS 111
Cdd:cd17393 2 LAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 112 AVAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLaapnqrARAVGRVMMGL--------TIATLFGTPLVAWFGQALGWR 183
Cdd:cd17393 82 GLAPSVPALALALFLFGAANGALDVAMNAQGVAV------ERAYGRPIMSSlhamwslgGLAGALLGAAAIGAGVSPGVH 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 184 SAFAIVGGISLMTMALIWL--HVPRDRGDPQATPLRELSALGSLQVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVA 261
Cdd:cd17393 156 LLAAAVLLLLAALVAIRALlpGTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAA 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 262 NVPVMLSVFGAGMILGNIVGSRLADWSLTRAIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVV 331
Cdd:cd17393 236 LAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVV 305
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
161-396 |
5.05e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 41.80 E-value: 5.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 161 GLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWLHVPRDRGDPQATPLRELSA-LGSLQVWLLLGICAIGCG 239
Cdd:cd17335 133 GFGIAALLVGILIDRSSTYKNYTIAFYVFAVLMLLALLLALKFPFRPKHPEPNENTGGLLAlLRNPRVLAFLLVAFLMGF 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 240 GMFAVFTYIAPALTQvAGVSVANVPVMLSVFGAGMILGNIVGSRLAD-WSLTRAIGIALVFNVFAYiLFYFTMTSPWMAI 318
Cdd:cd17335 213 GHGLIYSFLFWHLQD-LGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQrFGHVGLLYLGLLAYVVRW-LLYSFLENPWLVL 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 319 VNVLFIGGGFAVVPGVQTRLMDVA---GKAQTLAAALSHSAFNLANALGAWLGGIAIAAgYGWTSPGLVGAVLGIGGFAI 395
Cdd:cd17335 291 PIELLHGLTFALVWAAAVSYASAAappGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEA-FGARTTFRFFAIAALAGLLA 369
|
.
gi 489628962 396 F 396
Cdd:cd17335 370 F 370
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
69-201 |
6.39e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 41.93 E-value: 6.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 69 VISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAP 148
Cdd:TIGR00898 132 TQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPK 211
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 489628962 149 NQRARAVGRVMMGLTIATLFgTPLVAWFGQalGWRSAFAIVGGISLMTMALIW 201
Cdd:TIGR00898 212 KQRAIVGTLIQVFFSLGLVL-LPLVAYFIP--DWRWLQLAVSLPTFLFFLLSW 261
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
228-400 |
9.93e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.11 E-value: 9.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 228 WLLLGICAIGCGGMFAVFTYIAPALTQVA---GVSVANVPVMLSVFGAGMILGNIVGSRLAD-WSLTRAIGIALVFNVFA 303
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAadlGASPAQAGLVVTAYLLGAALGAPLAGRLADrFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 304 YILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDVAGKAQ-TLAAALSHSAFNLANALGAWLGGiAIAAGYGWTSPG 382
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERrGRALGLLGAGLGLGPALGPLLGG-LLADLFGWRWVF 167
|
170
....*....|....*...
gi 489628962 383 LVGAVLGIGGFAIFLASV 400
Cdd:COG2814 168 LVNAVLALLALLLLLRLL 185
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
167-397 |
1.36e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 40.67 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 167 LFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWLHvpRDRGDPQATPLRELSALGSLQVWLLLGICAIGCGGMFAVFT 246
Cdd:cd17485 142 LLGGGGLLWLYDLIGWQSLLLSLAALYLLLLLPVLFL--RELELPQQPPASERGAALKASLRAFLRRPGTRWLLLFLLLY 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 247 YIAPALTQV--------AGVSVANVPVMLSVFGAG-MILGNIVGSRLAD-WSLTRAIGIALVFNVFAYILFYFTMTSPWM 316
Cdd:cd17485 220 KLGEQGALAmlppflvdRGFSLSQIGLLSGVGGSLvSIAGSLLGGYLLKrRGRRRLLLLGGLLRLLLLGLYTLLALGGSG 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 317 AIVNVLFI-------GGGFAVVPgVQTRLMDVAGKAQtlaAALSHSAFNLANALGAWLGGIA---IAAGYGWTSPGLVGA 386
Cdd:cd17485 300 LNWVLLLAslallhlVGGMITTA-LFTLMMDCSQQAQ---AGTDYTLLATVEVLGKLLFGSLagfLADHLGYAAAFLLFA 375
|
250
....*....|.
gi 489628962 387 VLGIGGFAIFL 397
Cdd:cd17485 376 ILSALSVLLLL 386
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
67-379 |
1.89e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 40.05 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 67 GAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLA 146
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWF 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 147 APNQRARAVGRVMMGLTIATLFGTPLV-AWFGQALGWRSAFAIVGGISLMtMALIWLHV----PRDRGDPQATPLR---- 217
Cdd:TIGR00881 113 SRSERGTWVSFWNCSHNVGGGLLPPLVlFGIAELYSWHWVFIVPGIIAII-VSLICFLLlrdsPQSCGLPPAEEMPneep 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 218 ---------ELSALGSLQVWLLLGICAIG-CGGMFAVF-------TYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIV 280
Cdd:TIGR00881 192 dgdaekkeeELTKKQIFLQYVLLNKVLWYiSLGYVFVYvvrtgilDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 281 GSRLADWSLTR---AIGIALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDVAGKAQTLAAALSHSAF 357
Cdd:TIGR00881 272 AGWLSDKLFNGrrgPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFV 351
|
330 340
....*....|....*....|....*
gi 489628962 358 NLANALGAWLGGIA---IAAGYGWT 379
Cdd:TIGR00881 352 GFFAYLGGILAGLPlgyLADGFGWA 376
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
52-221 |
2.37e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 39.89 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 52 LPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLPH 131
Cdd:PRK11652 31 IADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 132 GAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWLHVPRDRgdP 211
Cdd:PRK11652 111 GVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPETR--P 188
|
170
....*....|
gi 489628962 212 QATPLRELSA 221
Cdd:PRK11652 189 ADARRTRVLA 198
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
227-390 |
2.84e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.47 E-value: 2.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 227 VWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLAD-WSLTRAIGIALVFNVFAYI 305
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADrFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 306 LFYFTmTSPWMAIVNVLFIGGGFAVVPGVQTRLMD--VAGKAQTLAAALSHSAFNLANALGAWLGGiAIAAGYGWTSPGL 383
Cdd:COG2271 91 LFGFA-TSFWQLLLLRFLLGLGEAGFFPAALKLIAewFPPKERGRALGIFNAGGPLGGALAPPLLG-WLLAAFGWRAAFL 168
|
....*..
gi 489628962 384 VGAVLGI 390
Cdd:COG2271 169 ILGLPGL 175
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
52-402 |
3.29e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 39.18 E-value: 3.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 52 LPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFAGLPH 131
Cdd:cd17312 26 KPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 132 GAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWLHVprdRGDP 211
Cdd:cd17312 106 SMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFL---RDSP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 212 QAtplrelsalgslqVWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLAD--WSL 289
Cdd:cd17312 183 PY-------------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDklFGG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 290 TRAIGIAL--VFNVFAYILFYFTMTSPWMAIVNV----LFIGGGFAVVPGVQTrlmDVAGKAQTLAAAlsHSAFNLANAL 363
Cdd:cd17312 250 RRAPIAVIymLLMTLSLALFWFFPHNKLLSIVLLfligFFVGGPINLIGGAAA---QDIGRKEAAGTA--TGFVGLFGYL 324
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 489628962 364 GAWLGGIAIA---AGYGWTSPGLVgaVLGIGGFAIFLASVLV 402
Cdd:cd17312 325 GASLAGLPLGyiiDHYGWSTVFYF--LISAALLSVLLLLSLW 364
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
52-398 |
3.39e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.51 E-value: 3.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 52 LPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFA-LGNFASAVAPSFHPLVAARFFAGLP 130
Cdd:cd17490 19 LSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTvLASLIMILFPSPWGLLIARFLSGIA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 131 hGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAF---AIVGGISLMTMALIwlHVPRD 207
Cdd:cd17490 99 -AATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFllaALAGVLGFILSLFI--KEERR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 208 RGDPQATPLRELSALGSLQ-VWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFgagmILGNIVGSRLAD 286
Cdd:cd17490 176 EKKPVLTELKELLSVLKDKkLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIY----LLPNALASLLSG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 287 WSLTRAIG----IALVFNVFAYILFY-FTMTSPWMAIVNVLFIGGGFAVVPGVQTRL--MDVAGKAQTLAAALSHSAFNL 359
Cdd:cd17490 252 TLFYKKLGerntIIIGFLLLGAYCFLiPFAPNLTLLYLLQALNGFGTGILFPLLMSLsiEGVPAEQRSTAMGFFQAIYAL 331
|
330 340 350
....*....|....*....|....*....|....*....
gi 489628962 360 ANALGAWLGGIaIAAGYGWTSPGLVGAVLGIGGFAIFLA 398
Cdd:cd17490 332 GMFLGPVLVGI-ISEAFGLQTGFFVIGVIALLAAILSLA 369
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
230-397 |
3.68e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.32 E-value: 3.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 230 LLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGNIVGSRLAD-WSLTRAIGIALVFNVFAYILFY 308
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDrFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 309 FTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDVAGKAQ-TLAAALSHSAFNLANALGAWLGGIaIAAGYGWTSPGLVGAV 387
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGL-LASLFGWRAAFLILAI 159
|
170
....*....|
gi 489628962 388 LGIGGFAIFL 397
Cdd:pfam07690 160 LSLLAAVLLL 169
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
48-398 |
5.29e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 38.75 E-value: 5.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 48 IMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASAVAPSFHPLVAARFFA 127
Cdd:cd17390 15 ILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 128 GLPHGAyFGVAALVAAGLAAPNQRARAVGRV----MMGLTIATLFGTPLVAWFGqalGWRSAFAIVGGISLMTMALIWLH 203
Cdd:cd17390 95 GIFKHT-QSLCKAYLSDLVSEQERSRVLGRFnaasSLGFILGPVVGGHLAETDG---GFYYVALLCSAIFILNAGLVWFL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 204 VPrdrgdpqatplrelSALGSLQVWLLLGICAIGCGGMFAVftyiapALTQVAGVSVANVPVMLSVFGA-GMILGNIVG- 281
Cdd:cd17390 171 LS--------------KLWDLLLVRFLMGFSVLLFRSNFSL------YLEERFDLSPKTIGYLISYSGVlGALSGFLVGr 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 282 -SRLADWSLTRAIGIAlVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDVAGKAQTLAAAL--SHSAFN 358
Cdd:cd17390 231 iLKLYKNNEYLLLLHS-FILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLgvGQSVTS 309
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 489628962 359 LANALGAWLGGiaIAAGYGWTSPGLVGAVLGIGGFAIFLA 398
Cdd:cd17390 310 LARILAPLLSG--LLQEFSVSGPGLLGAVLALAAILLMLA 347
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
151-399 |
6.24e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 38.30 E-value: 6.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 151 RARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISL--MTMALIwlhvprdrgdpqatplrelsalgsLQVW 228
Cdd:cd17352 125 RGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLnlCVCGLL------------------------LRLL 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 229 LLLGICAIGCGGMFAVFTYIAPALTQVA-----GVSVANVPVMLSVFGAGMILGNIVGSRLADWSLTRA--IGIALVFNV 301
Cdd:cd17352 181 KDPTFVLLALGVSFAMLGFFVPFVYLPSyakslGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRlyLYIFTLLIL 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 302 FAYILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDVAGKAQTLAAALshSAFNLANALGAWLGGIAIAAGYGWTSP 381
Cdd:cd17352 261 GLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAY--GLVLLFQGLAALVGPPIAGLLRDYTGD 338
|
250 260
....*....|....*....|...
gi 489628962 382 GLV-----GAVLGIGGFAIFLAS 399
Cdd:cd17352 339 YDAafyfcGACLLLSGVLLFLLP 361
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
148-388 |
6.67e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 38.35 E-value: 6.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 148 PNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGGISLMTMALIWLHVP------------RDRGDPQATP 215
Cdd:cd17331 117 PGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPsntkskrekeakESASPPSVFN 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 216 LRELSALGSLQ-VWLLLGICAIGCGGMFAVFTYIAPALTQVAGVSVANVPVMLSVFGAGMILGN-----IVGSRLADWSL 289
Cdd:cd17331 197 LKEILRLLRLPgVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQgllvgPLTKRFGERSL 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 290 TRAigiALVFNVFAYILFYFTMTSPWMAIVNVLFIGGGFAVVPGVQTRLMDVAGKAQTLAA-ALSHSAFNLANALGAWLG 368
Cdd:cd17331 277 LKL---SVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTAlGLSHALFSLVRTVSPTIG 353
|
250 260
....*....|....*....|
gi 489628962 369 GiAIAAGYGWTSPGLVGAVL 388
Cdd:cd17331 354 G-ALLQAYGFPSFGLLGAAI 372
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
32-205 |
7.19e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 38.30 E-value: 7.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 32 IALAVGGFGIGTGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAAR--FARFHVLLVLMAVFALGNF 109
Cdd:cd17352 186 VLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLL 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 110 ASAVAPSFHPLVAARFFAGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIV 189
Cdd:cd17352 266 AFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYF 345
|
170
....*....|....*.
gi 489628962 190 GGISLMTMALIWLHVP 205
Cdd:cd17352 346 CGACLLLSGVLLFLLP 361
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
33-200 |
7.34e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.31 E-value: 7.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 33 ALAVGGFGIGTGEFAIMGLLPQVADDVAVSVPAAGAVISAYALGVVVGAPLIAVLAARFARFHVLLVLMAVFALGNFASA 112
Cdd:cd17477 192 LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLP 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489628962 113 VAPSFHPLVAARFF-AGLPHGAYFGVAALVAAGLAAPNQRARAVGRVMMGLTIATLFGTPLVAWFGQALGWRSAFAIVGG 191
Cdd:cd17477 272 LVPGLPLALLVLLFlWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAA 351
|
....*....
gi 489628962 192 ISLMTMALI 200
Cdd:cd17477 352 VALLFLLFL 360
|
|
| |
