|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-588 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 848.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 1 MKKTKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHEAEKITGKTVGIMLDTKGAEIRT-TLEdt 79
Cdd:PRK06354 7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLgRFE-- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 80 pNGKIDFHTGDKVRISMDASLkGTKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKDEKNRELVTVVQNDGVLGGKK 159
Cdd:PRK06354 85 -DGPIELKTGDEFILTSREVL-GTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADGELHCKVLVGGVLSNKK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 160 GVNAPGVAINLPGITEKDSDDIRFGLDNGINFIAASFVRKPQDVLDIRELLEEKNALNVQIFPKIESQEGIDNIDDILKV 239
Cdd:PRK06354 163 GVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAILEL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 240 SDGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGESA 319
Cdd:PRK06354 243 CDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 320 NGDYPVESVAAMARIDEYTEAAMMDQDAFALKEYSNKNVTEAVGQSVAHTARNLGVKTIVAATESGYTARMISKYRPKAD 399
Cdd:PRK06354 323 AGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEFTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTP 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 400 ILAITFSEKTQRGLMVNWGVYPIIAEKPANTDAMFDLATKKAQDLGFAKEGDLILITAGVPVGESGTTNVMKVQLIGSKL 479
Cdd:PRK06354 403 ILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGAVV 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 480 VQGSGVGDESTIGKAVIASNAQEaAAKMQKGDILVVKTTDKDYLPAIEKAAALVVETGGLTSHAAVVGIAMGIPVVVGAE 559
Cdd:PRK06354 483 AKGQGIGRKSVSGKARVAKTAAE-VAKVNEGDILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGVK 561
|
570 580
....*....|....*....|....*....
gi 489661007 560 NATSVISDGQIITVDSRRGIIYKGATNAL 588
Cdd:PRK06354 562 NATSLIKDGQIITVDAARGVVYSGHASVL 590
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-475 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 735.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 1 MKKTKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHEAEKITGKTVGIMLDTKGAEIRTTleDTP 80
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTG--KFK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 81 NGKIDFHTGDKVRISMDASLkGTKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKDEKnrELVTVVQNDGVLGGKKG 160
Cdd:COG0469 80 EGPVELKKGDTFTLTTDDVE-GDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGD--EVVCEVVNGGVLSSRKG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 161 VNAPGVAINLPGITEKDSDDIRFGLDNGINFIAASFVRKPQDVLDIRELLEEKNAlNVQIFPKIESQEGIDNIDDILKVS 240
Cdd:COG0469 157 VNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG-RAPIIAKIEKPEAVENLDEIIEAS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 241 DGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGESAN 320
Cdd:COG0469 236 DGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAV 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 321 GDYPVESVAAMARIDEYTEAAMMDQDAF-ALKEYSNKNVTEAVGQSVAHTARNLGVKTIVAATESGYTARMISKYRPKAD 399
Cdd:COG0469 316 GKYPVEAVETMARIAEEAEKSLDYRRILdRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVP 395
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489661007 400 ILAITFSEKTQRGLMVNWGVYPIIAEKPANTDAMFDLATKKAQDLGFAKEGDLILITAGVPVGESGTTNVMKVQLI 475
Cdd:COG0469 396 ILALTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
1-475 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 663.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 1 MKKTKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHEAEKITGKTVGIMLDTKGAEIRTTLedTP 80
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGL--FK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 81 NG-KIDFHTGDKVRISMD-ASLKGTKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKDEkNRELVTVVQNDGVLGGK 158
Cdd:cd00288 79 GGkDISLKAGDKFLVTTDpAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDD-DKTLVCEVLNGGVLGSR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 159 KGVNAPGVAINLPGITEKDSDDIRFGLDNGINFIAASFVRKPQDVLDIRELLEEKnALNVQIFPKIESQEGIDNIDDILK 238
Cdd:cd00288 158 KGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEK-GKDIKIIAKIENQEGVNNFDEILE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 239 VSDGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGES 318
Cdd:cd00288 237 ASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 319 ANGDYPVESVAAMARIDEYTEAAMMDQDAFAL---KEYSNKNVTEAVGQSVAHTARNLGVKTIVAATESGYTARMISKYR 395
Cdd:cd00288 317 AKGKYPVEAVKAMARICLEAEKALSHRVLFNEmrrLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYR 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 396 PKADILAITFSEKTQRGLMVNWGVYPIIAEKPA-----NTDAMFDLATKKAQDLGFAKEGDLILITAGVPVGeSGTTNVM 470
Cdd:cd00288 397 PNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKpgwqeDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTM 475
|
....*
gi 489661007 471 KVQLI 475
Cdd:cd00288 476 RILTV 480
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
2-472 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 582.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 2 KKTKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHEAEKITGKTVGIMLDTKGAEIRTTLedTPN 81
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGE--IKG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 82 GKIDFHTGDKVRISMDASLK-GTKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKDEKnrELVTVVQNDGVLGGKKG 160
Cdd:TIGR01064 79 GEVKLKKGDKVIITTDDIKGeGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGD--KVICEVLNGGTLKSKKG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 161 VNAPGVAINLPGITEKDSDDIRFGLDNGINFIAASFVRKPQDVLDIRELLEEKNALNVQIFPKIESQEGIDNIDDILKVS 240
Cdd:TIGR01064 157 VNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEAS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 241 DGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGESAN 320
Cdd:TIGR01064 237 DGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAK 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 321 GDYPVESVAAMARIDEYTEAAMMDQDAFALKEYSNKNV---TEAVGQSVAHTARNLGVKTIVAATESGYTARMISKYRPK 397
Cdd:TIGR01064 317 GKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPstiTEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPN 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489661007 398 ADILAITFSEKTQRGLMVNWGVYPI-IAEKPANTDAMFDLATKKAQDLGFAKEGDLILITAGVPVGESGTTNVMKV 472
Cdd:TIGR01064 397 APIIAVTPNERVARQLALYWGVFPFlVDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
1-342 |
1.09e-180 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 513.45 E-value: 1.09e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 1 MKKTKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHEAEKITGKTVGIMLDTKGAEIRTTLEDTP 80
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 81 NGKIDFHTGDKVRISMDASLKG--TKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKDEKNReLVTVVQNDGVLGGK 158
Cdd:pfam00224 81 KKDIELKAGDEMIVSTDAKYKGacDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKT-LVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 159 KGVNAPGVAINLPGITEKDSDDIRFGLDNGINFIAASFVRKPQDVLDIRELLEEKNaLNVQIFPKIESQEGIDNIDDILK 238
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAG-KNIQIIAKIENQEGVNNFDEILE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 239 VSDGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGES 318
Cdd:pfam00224 239 ATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 318
|
330 340
....*....|....*....|....
gi 489661007 319 ANGDYPVESVAAMARIDEYTEAAM 342
Cdd:pfam00224 319 AKGNYPVEAVRMMHEICLEAEKAL 342
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-588 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 848.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 1 MKKTKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHEAEKITGKTVGIMLDTKGAEIRT-TLEdt 79
Cdd:PRK06354 7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLgRFE-- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 80 pNGKIDFHTGDKVRISMDASLkGTKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKDEKNRELVTVVQNDGVLGGKK 159
Cdd:PRK06354 85 -DGPIELKTGDEFILTSREVL-GTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADGELHCKVLVGGVLSNKK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 160 GVNAPGVAINLPGITEKDSDDIRFGLDNGINFIAASFVRKPQDVLDIRELLEEKNALNVQIFPKIESQEGIDNIDDILKV 239
Cdd:PRK06354 163 GVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAILEL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 240 SDGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGESA 319
Cdd:PRK06354 243 CDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 320 NGDYPVESVAAMARIDEYTEAAMMDQDAFALKEYSNKNVTEAVGQSVAHTARNLGVKTIVAATESGYTARMISKYRPKAD 399
Cdd:PRK06354 323 AGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEFTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTP 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 400 ILAITFSEKTQRGLMVNWGVYPIIAEKPANTDAMFDLATKKAQDLGFAKEGDLILITAGVPVGESGTTNVMKVQLIGSKL 479
Cdd:PRK06354 403 ILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGAVV 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 480 VQGSGVGDESTIGKAVIASNAQEaAAKMQKGDILVVKTTDKDYLPAIEKAAALVVETGGLTSHAAVVGIAMGIPVVVGAE 559
Cdd:PRK06354 483 AKGQGIGRKSVSGKARVAKTAAE-VAKVNEGDILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGVK 561
|
570 580
....*....|....*....|....*....
gi 489661007 560 NATSVISDGQIITVDSRRGIIYKGATNAL 588
Cdd:PRK06354 562 NATSLIKDGQIITVDAARGVVYSGHASVL 590
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-475 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 735.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 1 MKKTKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHEAEKITGKTVGIMLDTKGAEIRTTleDTP 80
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTG--KFK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 81 NGKIDFHTGDKVRISMDASLkGTKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKDEKnrELVTVVQNDGVLGGKKG 160
Cdd:COG0469 80 EGPVELKKGDTFTLTTDDVE-GDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGD--EVVCEVVNGGVLSSRKG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 161 VNAPGVAINLPGITEKDSDDIRFGLDNGINFIAASFVRKPQDVLDIRELLEEKNAlNVQIFPKIESQEGIDNIDDILKVS 240
Cdd:COG0469 157 VNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG-RAPIIAKIEKPEAVENLDEIIEAS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 241 DGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGESAN 320
Cdd:COG0469 236 DGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAV 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 321 GDYPVESVAAMARIDEYTEAAMMDQDAF-ALKEYSNKNVTEAVGQSVAHTARNLGVKTIVAATESGYTARMISKYRPKAD 399
Cdd:COG0469 316 GKYPVEAVETMARIAEEAEKSLDYRRILdRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVP 395
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489661007 400 ILAITFSEKTQRGLMVNWGVYPIIAEKPANTDAMFDLATKKAQDLGFAKEGDLILITAGVPVGESGTTNVMKVQLI 475
Cdd:COG0469 396 ILALTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
1-475 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 663.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 1 MKKTKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHEAEKITGKTVGIMLDTKGAEIRTTLedTP 80
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGL--FK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 81 NG-KIDFHTGDKVRISMD-ASLKGTKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKDEkNRELVTVVQNDGVLGGK 158
Cdd:cd00288 79 GGkDISLKAGDKFLVTTDpAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDD-DKTLVCEVLNGGVLGSR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 159 KGVNAPGVAINLPGITEKDSDDIRFGLDNGINFIAASFVRKPQDVLDIRELLEEKnALNVQIFPKIESQEGIDNIDDILK 238
Cdd:cd00288 158 KGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEK-GKDIKIIAKIENQEGVNNFDEILE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 239 VSDGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGES 318
Cdd:cd00288 237 ASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 319 ANGDYPVESVAAMARIDEYTEAAMMDQDAFAL---KEYSNKNVTEAVGQSVAHTARNLGVKTIVAATESGYTARMISKYR 395
Cdd:cd00288 317 AKGKYPVEAVKAMARICLEAEKALSHRVLFNEmrrLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYR 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 396 PKADILAITFSEKTQRGLMVNWGVYPIIAEKPA-----NTDAMFDLATKKAQDLGFAKEGDLILITAGVPVGeSGTTNVM 470
Cdd:cd00288 397 PNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKpgwqeDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTM 475
|
....*
gi 489661007 471 KVQLI 475
Cdd:cd00288 476 RILTV 480
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-465 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 632.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 1 MKKTKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHEAEKITGKTVGIMLDTKGAEIRTtlEDTP 80
Cdd:PRK05826 3 LRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRV--GKFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 81 NGKIDFHTGDKVRISMDASLKGTKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKDEKnrELVTVVQNDGVLGGKKG 160
Cdd:PRK05826 81 EGKITLKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGD--EVETEVKNGGPLSNNKG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 161 VNAPGVAINLPGITEKDSDDIRFGLDNGINFIAASFVRKPQDVLDIRELLEEKNALNVQIFPKIESQEGIDNIDDILKVS 240
Cdd:PRK05826 159 INIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDNIDEIIEAS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 241 DGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGESAN 320
Cdd:PRK05826 239 DGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 321 GDYPVESVAAMARIDEYTEaAMMDQDAFALKEYSN-KNVTEAVGQSVAHTARNL-GVKTIVAATESGYTARMISKYRPKA 398
Cdd:PRK05826 319 GKYPVEAVEAMARICKGAE-KEFSINLSKHRLDRQfDRIDEAIAMSAMYAANHLkGVKAIVALTESGRTARLISRFRPGA 397
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489661007 399 DILAITFSEKTQRGLMVNWGVYPIIAEKPANTDAMFDLATKKAQDLGFAKEGDLILITAGVPVGESG 465
Cdd:PRK05826 398 PIFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
2-472 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 582.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 2 KKTKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHEAEKITGKTVGIMLDTKGAEIRTTLedTPN 81
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGE--IKG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 82 GKIDFHTGDKVRISMDASLK-GTKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKDEKnrELVTVVQNDGVLGGKKG 160
Cdd:TIGR01064 79 GEVKLKKGDKVIITTDDIKGeGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGD--KVICEVLNGGTLKSKKG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 161 VNAPGVAINLPGITEKDSDDIRFGLDNGINFIAASFVRKPQDVLDIRELLEEKNALNVQIFPKIESQEGIDNIDDILKVS 240
Cdd:TIGR01064 157 VNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEAS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 241 DGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGESAN 320
Cdd:TIGR01064 237 DGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAK 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 321 GDYPVESVAAMARIDEYTEAAMMDQDAFALKEYSNKNV---TEAVGQSVAHTARNLGVKTIVAATESGYTARMISKYRPK 397
Cdd:TIGR01064 317 GKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPstiTEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPN 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489661007 398 ADILAITFSEKTQRGLMVNWGVYPI-IAEKPANTDAMFDLATKKAQDLGFAKEGDLILITAGVPVGESGTTNVMKV 472
Cdd:TIGR01064 397 APIIAVTPNERVARQLALYWGVFPFlVDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
1-475 |
0e+00 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 545.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 1 MKKTKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHEAEKITGKTVGIMLDTKGAEIRT-TLEdt 79
Cdd:PRK09206 1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTmKLE-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 80 pNGK-IDFHTGDKVRISMDASLKGTKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKDEknRELVTVVQNDGVLGGK 158
Cdd:PRK09206 79 -GGNdVSLKAGQTFTFTTDKSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITG--NEVICKVLNNGDLGEN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 159 KGVNAPGVAINLPGITEKDSDDIRFGLDNGINFIAASFVRKPQDVLDIRELLEEKNALNVQIFPKIESQEGIDNIDDILK 238
Cdd:PRK09206 156 KGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGENIQIISKIENQEGLNNFDEILE 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 239 VSDGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGES 318
Cdd:PRK09206 236 ASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGES 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 319 ANGDYPVESVAAMARIDEYTEAAMMDQDAFALKeySNKN-VTEAVGQSVAHTARNLGVKTIVAATESGYTARMISKYRPK 397
Cdd:PRK09206 316 AKGKYPLEAVSIMATICERTDRVMNSRLESNND--NRKLrITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPD 393
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489661007 398 ADILAITFSEKTQRGLMVNWGVYPIIAEKPANTDAMFDLATKKAQDLGFAKEGDLILITAGVPVgESGTTNVMKVQLI 475
Cdd:PRK09206 394 ATILALTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGALV-PSGTTNTASVHVL 470
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
1-342 |
1.09e-180 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 513.45 E-value: 1.09e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 1 MKKTKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHEAEKITGKTVGIMLDTKGAEIRTTLEDTP 80
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 81 NGKIDFHTGDKVRISMDASLKG--TKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKDEKNReLVTVVQNDGVLGGK 158
Cdd:pfam00224 81 KKDIELKAGDEMIVSTDAKYKGacDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKT-LVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 159 KGVNAPGVAINLPGITEKDSDDIRFGLDNGINFIAASFVRKPQDVLDIRELLEEKNaLNVQIFPKIESQEGIDNIDDILK 238
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAG-KNIQIIAKIENQEGVNNFDEILE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 239 VSDGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGES 318
Cdd:pfam00224 239 ATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 318
|
330 340
....*....|....*....|....
gi 489661007 319 ANGDYPVESVAAMARIDEYTEAAM 342
Cdd:pfam00224 319 AKGNYPVEAVRMMHEICLEAEKAL 342
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
2-480 |
1.37e-166 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 482.50 E-value: 1.37e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 2 KKTKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHEAEKITGKTVGIMLDTKGAEIRttLEDTPN 81
Cdd:PRK06247 5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLR--LGRFAD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 82 GKIDFHTGDKVRISMDASLkGTKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKDEKnrELVTVVQNDGVLGGKKGV 161
Cdd:PRK06247 83 GKVQLANGQTFRLDVDDAP-GDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGD--DVVCRVVEGGPVSDRKGV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 162 NAPGVAINLPGITEKDSDDIRFGLDNGINFIAASFVRKPQDVLDIRELLEEKnalnVQIFPKIESQEGIDNIDDILKVSD 241
Cdd:PRK06247 160 SLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGR----VPVMAKIEKPQAIDRLEAIVEASD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 242 GLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGESANG 321
Cdd:PRK06247 236 AIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 322 DYPVESVAAMARIDEYTEAammDQDAFAL----KEYSNKNVTEAVGQSVAHTARNLGVKTIVAATESGYTARMISKYRPK 397
Cdd:PRK06247 316 KYPVEAVRTMARIIRQVER---DPTYPPLihaqRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPP 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 398 ADILAITFSEKTQRGLMVNWGVYPIIAEKPANTDAMFDLATKKAQDLGFAKEGDLILITAGVPVGESGTTNVMKVQLIGS 477
Cdd:PRK06247 393 LPILALTPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYIGE 472
|
...
gi 489661007 478 KLV 480
Cdd:PRK06247 473 DDV 475
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
2-472 |
9.48e-150 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 440.95 E-value: 9.48e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 2 KKTKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHEAEKITGKTVGIMLDTKGAEIRT-TLEDtp 80
Cdd:PLN02461 21 PKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTgFLKD-- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 81 nGK-IDFHTGDKVRISMDASLKGTKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKDEKNRELVTVVQNDGVLGGKK 159
Cdd:PLN02461 99 -GKpVQLKQGQEITITTDYSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEAGTVRCRCENSAMLGERK 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 160 GVNAPGVAINLPGITEKDSDDI-RFGLDNGINFIAASFVRKPQDVLDIRELLEEkNALNVQIFPKIESQEGIDNIDDILK 238
Cdd:PLN02461 178 NVNLPGVVVDLPTLTEKDKEDIlQWGVPNKIDFIALSFVRKGSDLVEVRKVLGE-HAKSILLISKVENQEGLDNFDDILA 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 239 VSDGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGES 318
Cdd:PLN02461 257 ESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGET 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 319 ANGDYPVESVAAMARIDEYTEAA---------MMDQDAFALkeysnkNVTEAVGQSVAHTARNLGVKTIVAATESGYTAR 389
Cdd:PLN02461 337 AAGAYPELAVKTMARICREAEASldygalfkeIMRSAPLPM------SPLESLASSAVRTANKVKASLIVVLTRGGTTAR 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 390 MISKYRPKADILAI------------TFSEKTQ-RGLMVNWGVYPIIAEKPA------NTDAMFDLATKKAQDLGFAKEG 450
Cdd:PLN02461 411 LVAKYRPAVPILSVvvpeittdsfdwSCSDEAPaRHSLIYRGLIPVLAEGSAkatdseSTEEILEAAIEHAKKKGLCKPG 490
|
490 500
....*....|....*....|..
gi 489661007 451 DLIlitagVPVGESGTTNVMKV 472
Cdd:PLN02461 491 DSV-----VALHRIGGASVIKI 507
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
269-588 |
2.35e-147 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 427.78 E-value: 2.35e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 269 KCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGESANGDYPVESVAAMARIDEYTEAAMMDQDAF 348
Cdd:COG3848 1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 349 ALK-EYSNKNVTEAVGQSVAHTARNLGVKTIVAATESGYTARMISKYRPKADILAITFSEKTQRGLMVNWGVYPIIAEKP 427
Cdd:COG3848 81 VPRaKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEES 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 428 ANTDAMFDLATKKAQDLGFAKEGDLILITAGVPVGESGTTNVMKVQLIGSKLVQGSGVGDESTIGKAVIASNAQEAAAKM 507
Cdd:COG3848 161 ASTDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVVGDVLAKGQGIGRGSVTGKAVVARSAEEALEKF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 508 QKGDILVVKTTDKDYLPAIEKAAALVVETGGLTSHAAVVGIAMGIPVVVGAENATSVISDGQIITVDSRRGIIYKGATNA 587
Cdd:COG3848 241 EEGDILVVPSTDAEFVPAIEKAAGIITEEGGLTSHAAIVGLELGIPVIVGAEGATEILKDGQVVTVDAERGVVYRGAVNV 320
|
.
gi 489661007 588 L 588
Cdd:COG3848 321 L 321
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
2-472 |
4.41e-143 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 424.17 E-value: 4.41e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 2 KKTKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHEA-EKITGKTVGIMLDTKGAEIRTTLedTP 80
Cdd:PTZ00066 38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAaKARPNANLGILLDTKGPEIRTGF--LK 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 81 NGK-IDFHTGDKVRISMDASLKGTKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKDEKNreLVTVVQNDGVLGGKK 159
Cdd:PTZ00066 116 NHKpITLKEGQTLKITTDYTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDY--IITKVLNNATIGERK 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 160 GVNAPGVAINLPGITEKDSDDI-RFGLDNGINFIAASFVRKPQDVLDIRELLEEKnALNVQIFPKIESQEGIDNIDDILK 238
Cdd:PTZ00066 194 NMNLPGVKVELPVIGEKDKNDIlNFAIPMGCDFIALSFVQSADDVRLCRQLLGER-GRHIKIIPKIENIEGLINFDEILA 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 239 VSDGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGES 318
Cdd:PTZ00066 273 ESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGET 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 319 ANGDYPVESVAAMARIDEYTEAAMMDQDAFALKEYSNK---NVTEAVGQSVAHTARNLGVKTIVAATESGYTARMISKYR 395
Cdd:PTZ00066 353 ANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPtpvSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYR 432
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489661007 396 PKADILAITFSEKTQRGLMVNWGVYPIIAEKPANTDAMFDLATKKAQDLGFAKEGDLILITAGVPVGESGTTNVMKV 472
Cdd:PTZ00066 433 PSCTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNLMKV 509
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
29-455 |
2.22e-108 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 332.79 E-value: 2.22e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 29 NVFRFNFSHGDHEEHLARMNMVHEAEKITGKTVGIMLDTKGAEIRTTLedTPNGKIDFHTGDKVRISMDASL--KGTKEK 106
Cdd:PTZ00300 2 SVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGL--FVGGEAVMERGATCYVTTDPAFadKGTKDK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 107 VAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKdEKNRELVTVVQNDGVLGGKKGVNAPGVAINLPGITEKDSDDIRFGLD 186
Cdd:PTZ00300 80 FYIDYQNLSKVVRPGGYIYIDDGILILHVQSH-EDEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 187 NGINFIAASFVRKPQDVLDIRELLEEKNAlNVQIFPKIESQEGIDNIDDILKVSDGLMVARGDMGVEIPFEHVPIVQKRL 266
Cdd:PTZ00300 159 QGVDMIFASFIRSAEQVGEVRKALGAKGG-DIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKIL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 267 IKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGESANGDYPVESVAAMARIDEYTEAAMMDQD 346
Cdd:PTZ00300 238 ISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 347 AF-ALKEYSN--KNVTEAVGQSVAHTARNLGVKTIVAATESGYTARMISKYRPKADILAITFSEKTQRGLMVNWGVYPII 423
Cdd:PTZ00300 318 FFnSIKKLQPipMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVF 397
|
410 420 430
....*....|....*....|....*....|....*..
gi 489661007 424 --AEKPANTDAMFD---LATKKAQDLGFAKEGDLILI 455
Cdd:PTZ00300 398 fdAERLGHDEGKEQrvaMGVGFAKSKGYVQSGDLMVV 434
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
2-473 |
4.23e-107 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 333.82 E-value: 4.23e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 2 KKTKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHE-AEKITGKTVGIMLDTKGAEIRTTleDTP 80
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEyNAQSKDNVIAIMLDTKGPEVRSG--DLP 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 81 NgKIDFHTGDKVRISMDASLkGTKEKVAVTYPGLYDDTHVGGHVLFDDGLidMKITEKDEKNRELVTVVQNDGVLGGKKG 160
Cdd:PLN02623 188 Q-PIMLEEGQEFTFTIKRGV-STEDCVSVNYDDFVNDVEVGDMLLVDGGM--MSLAVKSKTSDSVKCEVVDGGELKSRRH 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 161 VNAPGVAINLPGITEKDSDDIRFGLDNGINFIAASFVRKPQDVLDIRELLEEKNAlNVQIFPKIESQEGIDNIDDILKVS 240
Cdd:PLN02623 264 LNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNA-DIHVIVKIESADSIPNLHSIITAS 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 241 DGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGESAN 320
Cdd:PLN02623 343 DGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAH 422
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 321 GDYPVESVAAMARIDEYTEAAMMDQDAFA-LKEYSNKNVTEAVGQSVAHTARNLGVKTIVaATESGYTARMISKYRPKAD 399
Cdd:PLN02623 423 GKFPLKAVKVMHTVALRTEATLPEGTTPPnLGQAFKNHMSEMFAFHATMMANTLGTSIIV-FTRTGFMAILLSHYRPSGT 501
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489661007 400 ILAITFSEKTQRGLMVNWGVYPIIAEKPANTDAMFDLATKKAQDLGFAKEGDLI-LITAGV-PVGESGTTN---VMKVQ 473
Cdd:PLN02623 502 IFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVaLVQSGRqPIWRSESTHhiqVRKVQ 580
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
4-472 |
7.90e-93 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 295.04 E-value: 7.90e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 4 TKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHEAEKITGKTVGIMLDTKGAEIRttLEDTPNGK 83
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQ--VINKTEKP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 84 IDFHTGDKVRISMDASLKGTKEKVAVTYPGLYD-----DTHVGGHVLFDDGLIDMKITEKDE-KNRELVTVVQNDGVLGG 157
Cdd:PLN02765 108 ISLKAGNTVTLTPDQSKEASSEVLPINFPGLAKavkpgDTIFVGQYLFTGSETTSVWLEVDEvKGDDVVCTVKNSATLAG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 158 KK-GVNAPGVAINLPGITEKDSDDIR-FGLDNGINFIAASFVRKPQDVLDIRELLEEKNALNVQIFPKIESQEGIDNIDD 235
Cdd:PLN02765 188 SLfTLHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSQTQIFAKIENVEGLTHFDE 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 236 ILKVSDGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITaTQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLS 315
Cdd:PLN02765 268 ILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGADAILLG 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 316 GESANGDYPVESVAAMARIDEYTEaAMMDQDAFALK--EYSNKNVT--EAVGQSVAHTARNLGVKTIVAATESGYTARMI 391
Cdd:PLN02765 347 AETLRGLYPVETISTVGRICAEAE-KVFNQDLYFKKtvKYVGEPMShlESIASSAVRAAIKVKASVIIVFTSSGRAARLI 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 392 SKYRPKADILAI------------TFSEKTQ-RGLMVNWGVYPIIAE-------KPANTDAMFDLATKKAQDLGFAKEGD 451
Cdd:PLN02765 426 AKYRPTMPVLSVviprlktnqlkwSFTGAFQaRQCLIVRGLFPMLADprhsaesTSATNESVLKVALDHGKAAGVIKSHD 505
|
490 500
....*....|....*....|.
gi 489661007 452 LILITAGVpvgesGTTNVMKV 472
Cdd:PLN02765 506 RVVVCQKV-----GDSSVVKI 521
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
7-352 |
2.69e-90 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 282.60 E-value: 2.69e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 7 VSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVheaeKITGKTVGIMLDTKGAEIRttLEDTPNGKIDF 86
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLV----KSLDDSIKILGDVQGPKIR--LGEIKGEQITL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 87 HTGDKVrISMDASLKGTKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMkITEKDEKNReLVTVVQNDGVLGGKKGVNAPGV 166
Cdd:PRK06739 80 QAGDSF-ILHTQPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVEL-IVEKVSTDK-IETKVKTGGNISSHKGVNLPGA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 167 AINLPGITEKDSDDIRFGLDNGINFIAASFVRKPQDVLDIRELLEEKNALNVQIFPKIESQEGIDNIDDILKVSDGLMVA 246
Cdd:PRK06739 157 IVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPNLIAKIETMEAIENFQDICKEADGIMIA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 247 RGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAVFDGTDATMLSGESANGDYPVE 326
Cdd:PRK06739 237 RGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIE 316
|
330 340
....*....|....*....|....*.
gi 489661007 327 SVAAMARIDEYTEAAMMDqDAFALKE 352
Cdd:PRK06739 317 SVSTLRLVSEFAEHVKKD-GPFVMKD 341
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
1-455 |
6.00e-86 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 276.24 E-value: 6.00e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 1 MKKTKIVSTLGPASNTTDIIVKLIEAGANVFRFNFSHGDHEEHLARMNMVHEAEKITGKTVGIMLDTKGAEIRTTLEDTP 80
Cdd:PLN02762 24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLGGA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 81 ------NGKIDFHTgdkVRiSMDASLKgtKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEK---DEKNR----ELVT 147
Cdd:PLN02762 104 ssakaeDGEEWTFT---VR-KFDGSRP--EFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKigpDVKCKctdpGLLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 148 VVQN-----DGVLGGKKgvNApgvaiNLPGITEKDSDDIRFGLDNGINFIAASFVRKPQDVLDIRELLEEKNA-LNVQIF 221
Cdd:PLN02762 178 PRANltfwrDGSLVRER--NA-----MLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRdSDIGVI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 222 PKIESQEGIDNIDDILKVSDGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDV 301
Cdd:PLN02762 251 AKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADV 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 302 ANAVFDGTDATMLSGESANGDYPVESVAAM----ARIDEYTEAAMMdQDAFALKEYS---NKNVTEAVGQSVAHTARNLG 374
Cdd:PLN02762 331 SEAVRQRADALMLSGESAMGLYPEKALSVLrsvsLRMELWSREEKR-HEALELPQLSsslSDRISEEICNSAAKMANNLG 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 375 VKTIVAATESGYTARMISKYRPKADILAITFSEKTQRGLMVNWGVYPIIAE----KPANTDAMFDLATKKaqdlGFAKEG 450
Cdd:PLN02762 410 VDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDfsddMESNLNKTFSLLKAR----GMIKSG 485
|
....*
gi 489661007 451 DLILI 455
Cdd:PLN02762 486 DLVIA 490
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
4-334 |
3.06e-51 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 183.68 E-value: 3.06e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 4 TKIVSTL-GPASNTTDIIVKLIEAGANVFRFNFSHgDHEEHLARM-NMVHEAEKITGKTVGIMLDTKGAEIRTTLEDTPN 81
Cdd:PRK08187 135 TRIMVTLpSEAADDPDFVLRLAERGMDCARINCAH-DDPAAWQAMiGHLRQAERATGRRCKILMDLAGPKIRTGAVAGPL 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 82 GKIDFHTGDKVRISMDASLKGTKE---KVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKDEKNREL-VTVVQNDGV-LG 156
Cdd:PRK08187 214 GKTRLYTGDRLALVAQGPPRRIDEehfQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLeVTHARPKGLkLK 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 157 GKKGVNAPGVAINLPGITEKDSDDIRFGLDNGiNFIAASFVRKPQDVLDIRELLEEKNALNVQ---IFPKIESQEGIDNI 233
Cdd:PRK08187 294 PEKGLNFPDTALDLPALTEKDRADLDFVARHA-DLVGYSFVQSPGDVEALQAALAARRPDDWRklgLVLKIETPRAVANL 372
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 234 DDIL-----KVSDGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQENPRPTRAEVNDVANAvfDG 308
Cdd:PRK08187 373 PELIvqaagRQPFGVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA--AR 450
|
330 340
....*....|....*....|....*.
gi 489661007 309 TDATMLSgesaNGDYPVESVAAMARI 334
Cdd:PRK08187 451 AECVMLN----KGPYLVEAVTFLDDL 472
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
360-472 |
6.32e-47 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 159.95 E-value: 6.32e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 360 EAVGQSVAHTARNLGVKTIVAATESGYTARMISKYRPKADILAITFSEKTQRGLMVNWGVYPIIAEKPANTDAMFDLATK 439
Cdd:pfam02887 1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVK 80
|
90 100 110
....*....|....*....|....*....|...
gi 489661007 440 KAQDLGFAKEGDLILITAGVPVGESGTTNVMKV 472
Cdd:pfam02887 81 VAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKV 113
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
69-334 |
1.06e-36 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 144.71 E-value: 1.06e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 69 GAEIRTTLEDTP--NGKIDFHTGDKVRISMD------ASLKGTKEKVAVTYPGLYDDTHVGGHVLFDDGLIDMKITEKDE 140
Cdd:PRK14725 316 GRHDSTRVGGLPpvEQKLRLKVGDRLVLTRDdapgdpAQGDAPPARISCTLPEAFRAARVGERVWFDDGKIGAVVVKVEA 395
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 141 knRELVTVVQNDGVLGGK----KGVNAPGVAINLPGITEKDSDDIRFGLDNGiNFIAASFVRKPQDVLDIRELLEEKNAL 216
Cdd:PRK14725 396 --DEVELRITHARPGGSKlkagKGINLPDSHLPLPALTDKDLEDLAFVAKHA-DIVALSFVRSPEDVRLLLDALEKLGAD 472
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 217 NVQIFPKIESQEGIDNIDDIL-------KVsdGLMVARGDMGVEIPFEHVPIVQKRLIKKCNSLGKPVITATQMLDSMQE 289
Cdd:PRK14725 473 DLGVVLKIETRRAFENLPRILleamrhpRF--GVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAK 550
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 489661007 290 NPRPTRAEVNDVANAVfdGTDATMLSgesaNGDYPVESVAAMARI 334
Cdd:PRK14725 551 KGLPSRAEITDAAMAL--RAECVMLN----KGPHIVEAVRVLDDI 589
|
|
| PpsA |
COG0574 |
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and ... |
471-580 |
2.57e-26 |
|
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Phosphoenolpyruvate synthase/pyruvate phosphate dikinase is part of the Pathway/BioSystem: Gluconeogenesis
Pssm-ID: 440339 [Multi-domain] Cd Length: 455 Bit Score: 112.23 E-value: 2.57e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 471 KVQLIGSKLVQGSGVGDESTIGKAVIASNAQEAAaKMQKGDILVVKTTDKDYLPAIEKAAALVVETGGLTSHAAVVGIAM 550
Cdd:COG0574 346 KAKEEGEVLAKGLPASPGAASGKVVFIADEAELA-RFQEGVILVRDETDPDDVPGMKAAAGIVTERGGMTSHAAIVAREL 424
|
90 100 110
....*....|....*....|....*....|
gi 489661007 551 GIPVVVGAENATSVISDGQIITVDSRRGII 580
Cdd:COG0574 425 GIPAVVGCGDATRVLKDGDEITVDGTTGEV 454
|
|
| PRK06464 |
PRK06464 |
phosphoenolpyruvate synthase; Validated |
479-584 |
5.79e-26 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235809 [Multi-domain] Cd Length: 795 Bit Score: 112.92 E-value: 5.79e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 479 LVQGSGVGDESTIGKAVIASNAQEAAaKMQKGDILVVKTTDKDYLPAIEKAAALVVETGGLTSHAAVVGIAMGIPVVVGA 558
Cdd:PRK06464 356 LVEGRAIGPGIGSGKVRVILDISEMD-KVQPGDVLVTDMTDPDWEPVMKRASAIVTNRGGRTCHAAIIARELGIPAVVGT 434
|
90 100
....*....|....*....|....*....
gi 489661007 559 ENATSVISDGQIITV---DSRRGIIYKGA 584
Cdd:PRK06464 435 GNATEVLKDGQEVTVscaEGDTGYVYEGL 463
|
|
| PEP-utilizers |
pfam00391 |
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain ... |
506-578 |
9.58e-26 |
|
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it.
Pssm-ID: 459796 [Multi-domain] Cd Length: 73 Bit Score: 100.56 E-value: 9.58e-26
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489661007 506 KMQKGDILVVKTTDKDYLPAIEKAAALVVETGGLTSHAAVVGIAMGIPVVVGAENATSVISDGQIITVDSRRG 578
Cdd:pfam00391 1 KLPEGVILVAPDTTPSDTAGLDKAAGIVTERGGMTSHAAIVARELGIPAVVGVGDATILLKEGDLVTVDGSTG 73
|
|
| PEP_synth |
TIGR01418 |
phosphoenolpyruvate synthase; Also called pyruvate,water dikinase and PEP synthase. The member ... |
439-586 |
2.12e-25 |
|
phosphoenolpyruvate synthase; Also called pyruvate,water dikinase and PEP synthase. The member from Methanococcus jannaschii contains a large intein. This enzyme generates phosphoenolpyruvate (PEP) from pyruvate, hydrolyzing ATP to AMP and releasing inorganic phosphate in the process. The enzyme shows extensive homology to other enzymes that use PEP as substrate or product. This enzyme may provide PEP for gluconeogenesis, for PTS-type carbohydrate transport systems, or for other processes. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273612 [Multi-domain] Cd Length: 786 Bit Score: 111.37 E-value: 2.12e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 439 KKAQDLGFAKEGDL--ILITAGVP--VGESGT-TNVMKVQLIGSK---LVQGSGVGDESTIGKAVIASNAQEAAaKMQKG 510
Cdd:TIGR01418 307 GRPMDIEWAKDGFDgeIFIVQARPetVQSRKKkENVEERYELKGKgkvLVTGRAAGPGIASGKVKVIFDLKEMD-KFEEG 385
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489661007 511 DILVVKTTDKDYLPAIEKAAALVVETGGLTSHAAVVGIAMGIPVVVGAENATSVISDGQIITVDSRR---GIIYKGATN 586
Cdd:TIGR01418 386 DILVTDMTDPDWEPAMKRASAIVTNEGGMTCHAAIVARELGIPAVVGTGDATKTLKDGMEVTVDCAEgdtGYVYAGKLE 464
|
|
| PRK08296 |
PRK08296 |
hypothetical protein; Provisional |
492-580 |
1.59e-16 |
|
hypothetical protein; Provisional
Pssm-ID: 181362 Cd Length: 603 Bit Score: 82.78 E-value: 1.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 492 GKAVIASNAQEAAaKMQKGDILVVKTTDKDYLPAIEKAAALVVETGGLTSHAAVVGIAMGIPVVVGAENATSVISDGQII 571
Cdd:PRK08296 512 GPARVIRSADELS-EVQEGEILVCPVTSPSWAPIFAKIKATVTDIGGVMSHAAIVCREYGLPAVVGTGNATKRIKTGQRL 590
|
....*....
gi 489661007 572 TVDSRRGII 580
Cdd:PRK08296 591 RVDGTKGVV 599
|
|
| PRK06241 |
PRK06241 |
phosphoenolpyruvate synthase; Validated |
492-580 |
2.45e-16 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235751 [Multi-domain] Cd Length: 871 Bit Score: 82.63 E-value: 2.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 492 GKAVIASNAQEAaaKMQKGDILVVKTTDKDYLPAIEKAAALVVETGGLTSHAAVVGIAMGIPVVVGAENATSVISDGQII 571
Cdd:PRK06241 780 GRARVILNPEDA--DLEKGDILVTAFTDPGWTPLFVSIKGLVTEVGGLMTHGAVIAREYGIPAVVGVENATKLIKDGQRI 857
|
....*....
gi 489661007 572 TVDSRRGII 580
Cdd:PRK06241 858 RVDGTEGYV 866
|
|
| PRK05878 |
PRK05878 |
pyruvate phosphate dikinase; Provisional |
492-584 |
2.43e-14 |
|
pyruvate phosphate dikinase; Provisional
Pssm-ID: 235635 [Multi-domain] Cd Length: 530 Bit Score: 75.94 E-value: 2.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 492 GKAVIASNAQEAAAKMQKGDILVVKTTDKDYLPAIEKAAALVVETGGLTSHAAVVGIAMGIPVVVGAENATSVISDGQII 571
Cdd:PRK05878 363 GTAYTDVDEALDAADRGEPVILVRDHTRPDDVHGMLAAQGIVTEVGGATSHAAVVSRELGRVAVVGCGAGVAAALAGKEI 442
|
90
....*....|...
gi 489661007 572 TVDSRRGIIYKGA 584
Cdd:PRK05878 443 TVDGYEGEVRQGV 455
|
|
| PRK05865 |
PRK05865 |
sugar epimerase family protein; |
474-580 |
2.61e-11 |
|
sugar epimerase family protein;
Pssm-ID: 235630 [Multi-domain] Cd Length: 854 Bit Score: 66.61 E-value: 2.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661007 474 LIGSKLVQGSGVGDESTIGKAVIASnaQEAAAKMQKGDILVVKTTDKDYLPAIEKAAALVVETGGLTSHAAVVGIAMGIP 553
Cdd:PRK05865 730 LAAGDTLRGVGVCGGRVRGRVRIVR--PETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFP 807
|
90 100
....*....|....*....|....*..
gi 489661007 554 VVVGAENATSVISDGQIITVDSRRGII 580
Cdd:PRK05865 808 CVVDAQGATRFLPPGALVEVDGATGEI 834
|
|
| PtsA |
COG1080 |
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate ... |
527-581 |
7.05e-11 |
|
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism];
Pssm-ID: 440698 [Multi-domain] Cd Length: 571 Bit Score: 64.71 E-value: 7.05e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 489661007 527 EKAAALVVETGGLTSHAAVVGIAMGIPVVVGAENATSVISDGQIITVDSRRGIIY 581
Cdd:COG1080 173 SRVAGFVTDLGGRTSHTAILARSLGIPAVVGLGDALLLVKDGDLVIVDGDAGVVI 227
|
|
| HpcH |
COG3836 |
2-keto-3-deoxy-L-rhamnonate aldolase RhmA [Carbohydrate transport and metabolism]; |
224-277 |
8.34e-06 |
|
2-keto-3-deoxy-L-rhamnonate aldolase RhmA [Carbohydrate transport and metabolism];
Pssm-ID: 443047 [Multi-domain] Cd Length: 237 Bit Score: 47.41 E-value: 8.34e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489661007 224 IESQEGIDNIDDILKVS--DGLMVARGD----MGVEIPFEHvPIVQ---KRLIKKCNSLGKPV 277
Cdd:COG3836 148 IETAEAVENLDEIAAVPgvDGVFIGPADlsasLGHPGQPDH-PEVQaaiERVIAAARAAGKPA 209
|
|
| PRK11061 |
PRK11061 |
phosphoenolpyruvate--protein phosphotransferase; |
527-581 |
7.86e-05 |
|
phosphoenolpyruvate--protein phosphotransferase;
Pssm-ID: 182937 [Multi-domain] Cd Length: 748 Bit Score: 45.76 E-value: 7.86e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 489661007 527 EKAAALVVETGGLTSHAAVVGIAMGIPVVVGAENATSVISDGQIItVDSRRGIIY 581
Cdd:PRK11061 341 DRLAGVVVRDGAANSHAAILVRALGIPTVMGADIQPSLLHQRLLI-VDGYRGELL 394
|
|
| PRK11377 |
PRK11377 |
dihydroxyacetone kinase subunit M; Provisional |
537-580 |
6.66e-03 |
|
dihydroxyacetone kinase subunit M; Provisional
Pssm-ID: 183108 [Multi-domain] Cd Length: 473 Bit Score: 39.35 E-value: 6.66e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 489661007 537 GGLTSHAAVVGIAMGIPVVVGAENATSVISDGQIITVDSRRGII 580
Cdd:PRK11377 426 GSPLSHSAIIARELGIGWICQQGEKLYAIQPEETLTLDVKTQRL 469
|
|
| |
