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Conserved domains on  [gi|489667713|ref|WP_003571992|]
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glucosamine-6-phosphate deaminase [Lacticaseibacillus paracasei]

Protein Classification

glucosamine-6-phosphate deaminase( domain architecture ID 10105361)

glucosamine-6-phosphate deaminase catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and an ammonium ion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 11-233 3.36e-128

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


:

Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 361.42  E-value: 3.36e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  11 EAGKYAFDLIKQGM-DNGAKVLGLATGSTPVTMYKAMVNSD----VDFSNMTSINLDEYVGLAPDNDQSYRYFMQSNLFD 85
Cdd:cd01399    2 EMSEAAAELIAELIrEKPPAVLGLATGSTPLGVYEELIELHkeggLSFSNVTTFNLDEYVGLPPDHPQSYHYFMRENLFD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  86 KKPFKE--TFVPNGLAKDPEEETTRYNKVIAD-HPIDIQVLGIGRNGHIGFNEPGSPFDAETRKVPLTQSTIDANARFFA 162
Cdd:cd01399   82 HIDIKPenIHIPDGNAADLEAECRRYEALIAEaGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQANARFFD 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489667713 163 SEDDVPRYAYSMGIGSILKSKKILLLAFGENKADAVKKMIEGPVTNDVPASALQKHSDVVVILDKAAASKL 233
Cdd:cd01399  162 GDEDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
 
Name Accession Description Interval E-value
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 11-233 3.36e-128

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 361.42  E-value: 3.36e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  11 EAGKYAFDLIKQGM-DNGAKVLGLATGSTPVTMYKAMVNSD----VDFSNMTSINLDEYVGLAPDNDQSYRYFMQSNLFD 85
Cdd:cd01399    2 EMSEAAAELIAELIrEKPPAVLGLATGSTPLGVYEELIELHkeggLSFSNVTTFNLDEYVGLPPDHPQSYHYFMRENLFD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  86 KKPFKE--TFVPNGLAKDPEEETTRYNKVIAD-HPIDIQVLGIGRNGHIGFNEPGSPFDAETRKVPLTQSTIDANARFFA 162
Cdd:cd01399   82 HIDIKPenIHIPDGNAADLEAECRRYEALIAEaGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQANARFFD 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489667713 163 SEDDVPRYAYSMGIGSILKSKKILLLAFGENKADAVKKMIEGPVTNDVPASALQKHSDVVVILDKAAASKL 233
Cdd:cd01399  162 GDEDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-234 4.51e-117

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 334.05  E-value: 4.51e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713   1 MDVKIFDNDTE----AGKYAFDLIKQGM-DNGAKVLGLATGSTPVTMYKAMV----NSDVDFSNMTSINLDEYVGLAPDN 71
Cdd:COG0363    2 MRVIIFPDAEElaaaAAERAAERIAEAIaEKGRAVLGLAGGSTPLGLYEELArlhkEGGLDWSRVHVFNLDEYVGLPPDH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  72 DQSYRYFMQSNLFDKKPFKE--TFVPNGLAKDPEEETTRYNKVIADHP-IDIQVLGIGRNGHIGFNEPGSPFDAET-RKV 147
Cdd:COG0363   82 PQSNRRFMREALLDHVDIPPenIHIPDGEAEDPEAAAARYEALIAEAGgIDLQLLGIGEDGHIAFNFPGSPFLSETdRVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713 148 PLTQSTIDANARFFASEDDVPRYAYSMGIGSILKSKKILLLAFGENKADAVKKMIEGPVTNDVPASALQKHSDVVVILDK 227
Cdd:COG0363  162 TLDESTRQANARFFGSIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWFLDE 241


                 ....*..
gi 489667713 228 AAASKLS 234
Cdd:COG0363  242 AAASLLT 248
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-236 1.87e-107

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 310.22  E-value: 1.87e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713   1 MDVKIFDNDTEAGKYAFDLIKQGMDN------GAKVLGLATGSTPVTMYKAMV----NSDVDFSNMTSINLDEYVGLAPD 70
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAflptkeRPFVLGLATGSSPLETYKALIelhkAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  71 NDQSYRYFMQSNLFDK--KPFKETFVPNGLAKDPEEETTRYNKVIADH-PIDIQVLGIGRNGHIGFNEPGSPFDAETRKV 147
Cdd:PRK00443  81 HPESYRYFMRENFFDHvdIPPENINLLNGNAPDPEAECRRYEEKIKSAgGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713 148 PLTQSTIDANARFFASE-DDVPRYAYSMGIGSILKSKKILLLAFGENKADAVKKMIEGPVTNDVPASALQKHSDVVVILD 226
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDiEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                        250
                 ....*....|
gi 489667713 227 KAAASKLSKK 236
Cdd:PRK00443 241 EAAASELKVK 250
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-236 6.50e-85

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 253.20  E-value: 6.50e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713    1 MDVKIFDNDTEAGKYAFDLIKQGMDNGAK------VLGLATGSTPVTMYKAMV----NSDVDFSNMTSINLDEYVGLAPD 70
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPtaarpfVLGLPTGGTPIGTYKQLIelhqAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713   71 NDQSYRYFMQSNLF---DKKPfKETFVPNGLAKDPEEETTRYNKVIADH-PIDIQVLGIGRNGHIGFNEPGSPFDAETRK 146
Cdd:TIGR00502  81 HPESYHSFMHNNFFqhiDIKP-ENINILNGNAPDLEAECRRYEEKIRSYgGIDLFMGGIGPDGHIAFNEPGSSLTSRTRI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  147 VPLTQSTIDANARFFASE-DDVPRYAYSMGIGSILKSKKILLLAFGENKADAVKKMIEGPVTNDVPASALQKHSDVVVIL 225
Cdd:TIGR00502 160 KTLTEDTIQANSRFFEGDvNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVC 239

                         250
                  ....*....|.
gi 489667713  226 DKAAASKLSKK 236
Cdd:TIGR00502 240 DENATQELKVK 250
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
31-223 2.70e-16

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 74.97  E-value: 2.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713   31 LGLATGSTPVTMYKAMVNS--DVDFSNmtsINL---DE-YVglAPDNDQS-YRyFMQSNLFDKKPF-KETFVP-NGLAKD 101
Cdd:pfam01182  30 LALSGGSTPKPLYELLAAApaRLDWSR---VHVfwgDErCV--PPDDPDSnYG-MAREALLSHVPIpASNVHPiPASAAD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  102 PEEETTRYNKVIADHP-------IDIQVLGIGRNGHI--GFnePGSPFDAETRK--VPLTQSTIDANARffaseddvpry 170
Cdd:pfam01182 104 PEEAAAAYEAELRELLpdlelpvFDLVLLGMGPDGHTasLF--PGSPALEETDRlvVAVTDSPKPPPER----------- 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489667713  171 aYSMGIGSILKSKKILLLAFGENKADAVKKMIEGPVTnDVPASALQKHSDVVV 223
Cdd:pfam01182 171 -ITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPD-PLPAALVRPGAGETV 221
 
Name Accession Description Interval E-value
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 11-233 3.36e-128

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 361.42  E-value: 3.36e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  11 EAGKYAFDLIKQGM-DNGAKVLGLATGSTPVTMYKAMVNSD----VDFSNMTSINLDEYVGLAPDNDQSYRYFMQSNLFD 85
Cdd:cd01399    2 EMSEAAAELIAELIrEKPPAVLGLATGSTPLGVYEELIELHkeggLSFSNVTTFNLDEYVGLPPDHPQSYHYFMRENLFD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  86 KKPFKE--TFVPNGLAKDPEEETTRYNKVIAD-HPIDIQVLGIGRNGHIGFNEPGSPFDAETRKVPLTQSTIDANARFFA 162
Cdd:cd01399   82 HIDIKPenIHIPDGNAADLEAECRRYEALIAEaGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQANARFFD 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489667713 163 SEDDVPRYAYSMGIGSILKSKKILLLAFGENKADAVKKMIEGPVTNDVPASALQKHSDVVVILDKAAASKL 233
Cdd:cd01399  162 GDEDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-234 4.51e-117

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 334.05  E-value: 4.51e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713   1 MDVKIFDNDTE----AGKYAFDLIKQGM-DNGAKVLGLATGSTPVTMYKAMV----NSDVDFSNMTSINLDEYVGLAPDN 71
Cdd:COG0363    2 MRVIIFPDAEElaaaAAERAAERIAEAIaEKGRAVLGLAGGSTPLGLYEELArlhkEGGLDWSRVHVFNLDEYVGLPPDH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  72 DQSYRYFMQSNLFDKKPFKE--TFVPNGLAKDPEEETTRYNKVIADHP-IDIQVLGIGRNGHIGFNEPGSPFDAET-RKV 147
Cdd:COG0363   82 PQSNRRFMREALLDHVDIPPenIHIPDGEAEDPEAAAARYEALIAEAGgIDLQLLGIGEDGHIAFNFPGSPFLSETdRVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713 148 PLTQSTIDANARFFASEDDVPRYAYSMGIGSILKSKKILLLAFGENKADAVKKMIEGPVTNDVPASALQKHSDVVVILDK 227
Cdd:COG0363  162 TLDESTRQANARFFGSIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWFLDE 241


                 ....*..
gi 489667713 228 AAASKLS 234
Cdd:COG0363  242 AAASLLT 248
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-236 1.87e-107

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 310.22  E-value: 1.87e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713   1 MDVKIFDNDTEAGKYAFDLIKQGMDN------GAKVLGLATGSTPVTMYKAMV----NSDVDFSNMTSINLDEYVGLAPD 70
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAflptkeRPFVLGLATGSSPLETYKALIelhkAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  71 NDQSYRYFMQSNLFDK--KPFKETFVPNGLAKDPEEETTRYNKVIADH-PIDIQVLGIGRNGHIGFNEPGSPFDAETRKV 147
Cdd:PRK00443  81 HPESYRYFMRENFFDHvdIPPENINLLNGNAPDPEAECRRYEEKIKSAgGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713 148 PLTQSTIDANARFFASE-DDVPRYAYSMGIGSILKSKKILLLAFGENKADAVKKMIEGPVTNDVPASALQKHSDVVVILD 226
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDiEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                        250
                 ....*....|
gi 489667713 227 KAAASKLSKK 236
Cdd:PRK00443 241 EAAASELKVK 250
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-236 6.50e-85

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 253.20  E-value: 6.50e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713    1 MDVKIFDNDTEAGKYAFDLIKQGMDNGAK------VLGLATGSTPVTMYKAMV----NSDVDFSNMTSINLDEYVGLAPD 70
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPtaarpfVLGLPTGGTPIGTYKQLIelhqAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713   71 NDQSYRYFMQSNLF---DKKPfKETFVPNGLAKDPEEETTRYNKVIADH-PIDIQVLGIGRNGHIGFNEPGSPFDAETRK 146
Cdd:TIGR00502  81 HPESYHSFMHNNFFqhiDIKP-ENINILNGNAPDLEAECRRYEEKIRSYgGIDLFMGGIGPDGHIAFNEPGSSLTSRTRI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  147 VPLTQSTIDANARFFASE-DDVPRYAYSMGIGSILKSKKILLLAFGENKADAVKKMIEGPVTNDVPASALQKHSDVVVIL 225
Cdd:TIGR00502 160 KTLTEDTIQANSRFFEGDvNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVC 239

                         250
                  ....*....|.
gi 489667713  226 DKAAASKLSKK 236
Cdd:TIGR00502 240 DENATQELKVK 250
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-236 3.23e-77

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 233.11  E-value: 3.23e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713   1 MDVKIFDNDTEAGKYAFD-LIKQGMDNGAK-----VLGLATGSTPVTMYKAMV----NSDVDFSNMTSINLDEYVGLAPD 70
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNyIIKRINDFKPTsdrpfVLGLPTGSTPLPTYQELIrayrEGRVSFSNVVTFNMDEYVGLPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  71 NDQSYRYFMQSNLFDKKPFKETFVP--NGLAKDPEEETTRY-NKVIADHPIDIQVLGIGRNGHIGFNEPGSPFDAETRKV 147
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHilNGTAPDLEEECRRYeEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713 148 PLTQSTIDANARFFASE-DDVPRYAYSMGIGSILKSKKILLLAFGENKADAVKKMIEGPVTNDVPASALQKHSDVVVILD 226
Cdd:PTZ00285 161 SLNQETIDANARFFGNDiSKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240

                        250
                 ....*....|
gi 489667713 227 KAAASKLSKK 236
Cdd:PTZ00285 241 EDATLELKVK 250
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 3-233 5.13e-75

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 239.16  E-value: 5.13e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713   3 VKIFDNDTEAGKYAF----DLIKQGMDNGAK-VLGLATGSTPVTMYKAMV----NSDVDFSNMTSINLDEYVGLAPDNDQ 73
Cdd:PRK02122  30 TDIFESSEEASRAVAqeiaTLIRERQAEGKPcVLGLATGSSPIGVYAELIrmhrEEGLSFKNVITFNLDEYYPMQPDSLQ 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  74 SYRYFMQSNLFDKK--PFKETFVPNG-LAKDPEEETTR-YNKVIADHP-IDIQVLGIGRNGHIGFNEPGSPFDAETRKVP 148
Cdd:PRK02122 110 SYHRFMKENLFDHVdiPPENIHIPDGtIPKEEIDEYCRdYEEKIEAAGgIDFQLLGIGRTGHIGFNEPGSGRNSRTRLVT 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713 149 LTQSTIDANARFFASEDDVPRYAYSMGIGSILKSKKILLLAFGENKADAVKKMIEGPVTNDVPASALQKHSDVVVILDKA 228
Cdd:PRK02122 190 LDHITRRDAASDFFGEENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYLQEHPNATFVLDLA 269


                 ....*
gi 489667713 229 AASKL 233
Cdd:PRK02122 270 AASEL 274
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 12-227 4.61e-35

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 124.56  E-value: 4.61e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  12 AGKYAFDLIKQgmdNGAKVLGLATGSTPVTMYKAMVN----SDVDFSNMTSINLDEYVGLAPDNDQSYRYFMQSNLFdkK 87
Cdd:PRK09762  16 ASEYLLAVIRS---KPDAVICLATGATPLLTYHYLVEkihqQQVDVSQLTFVKLDEWVDLPLTMPGTCETFLQQHIV--Q 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  88 PF---KETFVP-NGLAKDpEEETTRYNKVIADH-PIDIQVLGIGRNGHIGFNEPGSPFDAETRKVPLTQSTIDANARFFA 162
Cdd:PRK09762  91 PLglrEDQLISfRSEEIN-ETECERVTNLIARKgGLDLCVLGLGKNGHLGLNEPGESLQPACHISQLDARTQQHEMLKTA 169

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489667713 163 SEDdvPRYAYSMGIGSILKSKKILLLAFGENKADAVKKMIEGPVTNDVPASALQKHSDVVVILDK 227
Cdd:PRK09762 170 GRP--VTRGITLGLKDILNAREVLLLVTGEGKQDATERFLTAKVSTAIPASFLWLHSNFICLIDR 232
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
31-235 3.15e-31

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 114.85  E-value: 3.15e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  31 LGLATGSTPVTMYKAM---VNSDVDFSNMTSINLDEyvgLAPDNDQSYRYFMqSNLfdKKPFketFVPnglAKDPEEETT 107
Cdd:PRK12358  32 LAITAGSTPKGMYEYLitlVKGKAWYDNVHYYNFDE---IPFRGKEGEGVTI-TNL--RNLF---FTP---AGIKEENIH 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713 108 RYN---------KVIADHPIDIQVLGIGRNGHIGFNEPG-SPFDAETRKVPLTQSTIDANARFFASED--DVPRYAYSMG 175
Cdd:PRK12358 100 KLTidnyrehdqKLARDGGLDLVVLGLGADGHFCGNLPGtTHFHDETVEVPIQGEMVDIVAHGELGGDfsLVPDSYVTMG 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713 176 IGSILKSKKILLLAFGENKADAVKKMIEGPVTNDVPASALQKHSDVVVILDKAAASKLSK 235
Cdd:PRK12358 180 PKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHPNLTVILDEAAAAELAL 239
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 31-225 4.28e-21

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 87.62  E-value: 4.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  31 LGLATGSTPVTMYKAMVNSD-VDFSNMTsINL-DE-YVglAPDNDQSYrYFM-QSNLFDKKPFKETFVP--NGlAKDPEE 104
Cdd:cd01400   27 LALSGGSTPKPLYELLAAAPaLDWSKVH-VFLgDErCV--PPDDPDSN-YRLaREALLSHVAIPAANIHpiPT-ELGPED 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713 105 ETTRYNKVIADH-----PIDIQVLGIGRNGHIG--FnePGSPFDAETRKVPLTqstidanARFFASEDDVPRYaySMGIG 177
Cdd:cd01400  102 AAAAYEKELRALfggvpPFDLVLLGMGPDGHTAslF--PGHPALLEETDRLVV-------AVTDSPKPPPERI--TLTLP 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 489667713 178 SILKSKKILLLAFGENKADAVKKMIEGPVTNDVPASALQKHSDVVVIL 225
Cdd:cd01400  171 VLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPGEVLWF 218
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
31-223 2.70e-16

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 74.97  E-value: 2.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713   31 LGLATGSTPVTMYKAMVNS--DVDFSNmtsINL---DE-YVglAPDNDQS-YRyFMQSNLFDKKPF-KETFVP-NGLAKD 101
Cdd:pfam01182  30 LALSGGSTPKPLYELLAAApaRLDWSR---VHVfwgDErCV--PPDDPDSnYG-MAREALLSHVPIpASNVHPiPASAAD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  102 PEEETTRYNKVIADHP-------IDIQVLGIGRNGHI--GFnePGSPFDAETRK--VPLTQSTIDANARffaseddvpry 170
Cdd:pfam01182 104 PEEAAAAYEAELRELLpdlelpvFDLVLLGMGPDGHTasLF--PGSPALEETDRlvVAVTDSPKPPPER----------- 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489667713  171 aYSMGIGSILKSKKILLLAFGENKADAVKKMIEGPVTnDVPASALQKHSDVVV 223
Cdd:pfam01182 171 -ITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPD-PLPAALVRPGAGETV 221
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 30-126 6.94e-09

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 53.51  E-value: 6.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489667713  30 VLGLATGSTPVTMYKAMVNSD--VDFSNMTSINLDEYVGLaPDNDQSYRYFMQSNLFD--KKPFKETFVPNGLAKDPEEE 105
Cdd:cd00458   23 VIGLGTGSTPAYFYKLLGEKLkrGEISDIVGFPTDERYVP-LDSDQSNFRQAKLLAFEhdIIPASNVHYVDTSLPIEKAC 101

                         90       100
                 ....*....|....*....|..
gi 489667713 106 TTRYNKVI-ADHPIDIQVLGIG 126
Cdd:cd00458  102 EKYEREILdQVDAIDLAVDGAG 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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