|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09263 |
PRK09263 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
5-717 |
0e+00 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236436 [Multi-domain] Cd Length: 711 Bit Score: 1341.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 5 YTQIKKRDGRIVDFDASKISTAITKAAESVaklapsdVLTIDHLTDTVTAKIRDRY--HDDVEIAEIQTVVEQTLIAAEK 82
Cdd:PRK09263 2 MPKVIKRDGRKVPFDSEKIKNAIEKAAKAV-------EVDDEDYCATVAAEIASRVegRDEVDIEEIQDAVENQLMAGPY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 83 YNWAEAYTEYRLKRDLARKQKQDVNYNVSRLVNR-DESVVNENANKDSRVFSTQRDLTAGAVAKAIGLK-MLPPAVANAH 160
Cdd:PRK09263 75 KALARAYIEYRHDRDIAREKATDLNEEIRGLIEQsNEAVLNENANKDSKVFSTQRDLLAGIVSKHYALRhLLPRDVVNAH 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 161 LRGDIHWHDLDYTPFMAETNCCLIDFDYMLNHGFSIGNAEVEPAHSIQVAVTQMTQIIANVASSQYGGCSSDRTDQVLAP 240
Cdd:PRK09263 155 EKGDIHYHDLDYSPFFPMFNCCLIDLKGMLTNGFKIGNAEIESPKSIQTATAVTAQIIAQVASSQYGGCTINRIDEVLAP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 241 FAEKNYQKHLREFGSVIDDPaKLEALAVKQTKKDIYDALQTLEYQVNTLYSTQGQTPFVTVGFGLGTSWIEREIQKDILK 320
Cdd:PRK09263 235 YAEKSYEKHLKDAEEWVIEE-KAEAYARARTEKEIYDAMQSLEYEINTLHTSNGQTPFVTLGFGLGTSWESRLIQKAILR 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 321 IRILGLGKERRTAIFPKLVFTLKRGLNLKPEDPNYDIKQLAIECATKRMYPDVVSYDTIKRLTGSFKAPMGCRSFLQGWT 400
Cdd:PRK09263 314 NRIAGLGKERKTAIFPKLVFAIKDGLNLKPGDPNYDIKQLALECATKRMYPDILNYDKIVELTGSFKTPMGCRSFLQGWK 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 401 DpKTGKEVNAGRMNLGVITVNLPRIAMEANGDKAKFWKIFEERMRICKEGLLYKVERTKQATPESAPILYKYGAFGHKLA 480
Cdd:PRK09263 394 D-ENGEEVHDGRNNLGVVTLNLPRIALEAKGDEDKFWEILDERLELAKKALMTRIERLKGAKPRVAPILYMYGAFGVRLK 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 481 DTDSIDDLFKNGRATVSLGYIGLYEVGTVFYGSAWEKNPDAKAFSVSIVKALDDHCKAWEKQYGYHFSVYGTPSESLTDT 560
Cdd:PRK09263 473 ADDDVDELFKNGRATISLGYIGLYETINALYGGSWEVNPEAKAFALAIVKRMKDACDQWKKETGYGFSLYSTPSESLTDR 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 561 FCRADTKKFGIVKDITDKEYYTNSFHYDVRKSPTPFEKLDFEKDYPQYSAGGFIHYCEYPNLKQNPKALEAVWDYAYDKI 640
Cdd:PRK09263 553 FCRLDTEKFGVIPGITDKGYYTNSFHYDVRKKVNPFEKLDFEKPYPPLASGGFIHYCEYPNLQHNLKALEAVWDYSYDRV 632
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489668735 641 GYLGTNTPIDQCFKCGFKGEFTATAKGYQCPECGNHDPATCDVVKRLCGYLGNPNKRPMVHGRQEEIIHRKKHITFS 717
Cdd:PRK09263 633 GYLGTNTPIDECYECGFTGEFECTEKGFTCPKCGNHDPKTVSVTRRTCGYLGNPDARPFNHGRQEEIKRRVKHMSGG 709
|
|
| NrdD |
COG1328 |
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; ... |
6-703 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Anaerobic ribonucleoside-triphosphate reductase is part of the Pathway/BioSystem: Thymidylate biosynthesis
Pssm-ID: 440939 [Multi-domain] Cd Length: 671 Bit Score: 893.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 6 TQIKKRDGRIVDFDASKISTAITKAAESVAKlAPSDVLTIDHLTDTVTAKIRDRYHDD-VEIAEIQTVVEQTLIAAEKYN 84
Cdd:COG1328 3 LKVIKRDGRVVPFDPEKIANAIKKAAKAVGG-EDRDEELAEEIADEVEKELERLGGGGtITVEEIQDIVEKVLMESGHPE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 85 WAEAYTEYRLKRDLARKQKQDVNYNVSRLVNRDESVVNENANKdSRVFSTQRDLTAGAVAKAIGL-KMLPPAVANAHLRG 163
Cdd:COG1328 82 VAKAYILYREQRTRLREARTTLVDDIELLDEYDDWRVNENANK-SYSFSTQRDLIAGEVSKEYALnKILPPEVADAHRNG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 164 DIHWHDLDYTPFMaeTNCCLIDFDYMLNHGFSIGNAEVEPAHSIQVAVTQMTQIIANVASSQYGGCSSDRTDQVLAPFAE 243
Cdd:COG1328 161 DIHIHDLDYLPRM--TNCCLWDLRDLLKNGFNGGNGKVEPPKHIQTALAQMAQIIATVQSEQAGGQAFSRFDTYLAPYVR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 244 KNyqkhlrefgsviddpaKLEalavKQTKKDIYDALQTLEYQVNTLYSTQGQTPFVTVGFGLGT----SWIEREIQKDIL 319
Cdd:COG1328 239 KD----------------KLE----GKTYKEIKQAMQSLEYNLNTLPSRRGQTPFTSITFGLGTpedfSWEMRMINKAIL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 320 KIRILGLGkERRTAIFPKLVFTLKRGLNLKPEDPNYDIKQLAIECATKRMYPDVVSYDTIKRL-TGSFKAPMGCRSFLQG 398
Cdd:COG1328 299 EVRIEGDG-EGRTFIFPKLIFNITEGFNWEPEDPNYDLLQLAFECTAKRGYPYFLNYDNSDELyKGSFKRSMGCRLFLDG 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 399 WtdpKTGKEVNAGRMNLGVITVNLPRIAMEANGDKAKFWKIFEERMRICKEGLLYKVERTKQ-ATPESAPILYKYGAFGH 477
Cdd:COG1328 378 W---ENGEELNRGRGNLGVVTLNLPRIAYEAKGDEEKFFEILDERLDLAKEALEIKRKRLQKlAKAGLAPILYQTGAYLG 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 478 KLADTDSIDDLFKNGRATvsLGYIGLYEVGTVFYGSAWEKNPDAKAFSVSIVKALDDHCKAWEKQYGYHFSVYGTPSESL 557
Cdd:COG1328 455 RLKPDDSIDELFKNGFST--IGYIGLNEMLLNFTGKHHIESEEAKAFALEILKHMRERADEWQEETGYLYSLYATPAESL 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 558 TDTFCRADTKKFGIVKDITDKEYYTNSFHYDVRKSPTPFEKLDFEKDYPQYSAGGFIHYCEYPNLKQNPKALEAVWDYAY 637
Cdd:COG1328 533 TYRFAKLDKKRFGDIIGVTDKPYYTNSFHLPVRKTIDPFEKLDFEDEYQPLYTGGTISYVELGELQPNPEALEAVVRYAY 612
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489668735 638 D--KIGYLGTNTPIDQCFKCGFKGEFTATakgyqCPECGNHDpaTCDVVKRLCGYLGnpNKRPMVHGR 703
Cdd:COG1328 613 DnyRIGYLGINPPFDICPKCGYLGGEHDE-----CPKCGNED--TVEVIRRTCGYLG--NVQPWNDGK 671
|
|
| NRDD |
pfam13597 |
Anaerobic ribonucleoside-triphosphate reductase; |
124-713 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase;
Pssm-ID: 463930 [Multi-domain] Cd Length: 554 Bit Score: 694.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 124 NANKDSRVFSTQRDLTAGAVAKAIGLK-MLPPAVANAHLRGDIHWHDLDYTPFMAeTNCCLIDFDYMLNHGFSIGNAEVE 202
Cdd:pfam13597 1 NANKDSYSPSGQRLYIAGEVSKDYALRkLLPPEIADAHEEGDIHIHDLDYYALRT-PYCCGIDLRDLLENGFVTGNGVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 203 PAHSIQVAVTQMTQIIANVASSQYGGCSSDRTDQVLAPFAEKNYQKHLRefgsviddpaklealavKQTKKDIYDALQTL 282
Cdd:pfam13597 80 PPKHIETACAQAVNILATVQNEQAGGQAFSSFDTYLAPFVRKDYEKHLK-----------------GLTYKEVKQAMQAF 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 283 EYQVNTLYSTQG-QTPFVTVGFGLGTSWIERE----IQKDILKIRILGLGKERRTAIFPKLVFTLKRGLNLKPEDPNYDI 357
Cdd:pfam13597 143 VYNLNTMPSRRGgQTPFTNINLGLDTPKEGRDemdmIIKALLEVMLEGDGNGGTPFTFPIPIYKLKEGFNWDEGDPNYDL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 358 KQLAIECATKRMYPDVVSYDTIKRLTGSFKAPMGCRSFLQGWTDPKTGkevNAGRMNLGVITVNLPRIAMEANGDKAKFW 437
Cdd:pfam13597 223 FELAFECTAKRGYPYFSNFDSDLLPGDGYVASMGCRLRLDLRPNRKRF---GGLRGNIGVVTINLPRIAYEAAGDEDKFF 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 438 KIFEERMRICKEGLLYKVERTKQATPE-SAPILYKYGAFghkladtdsiddlfKNGRATVSLGYIGLYEVGTVFYGSAWE 516
Cdd:pfam13597 300 ELLDERLELAKEALLIRREVLKKLLAKgLLPFLMGEGYL--------------RGGNHTLTIGFIGLNEALKALTGKHHG 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 517 KNPDAKAFSVSIVKALDDHCKAWEKQYGYHFSVYGTPSESLTDTFCRADTKKFGIVKDITDKEYYTNSFHYDVRKSPTPF 596
Cdd:pfam13597 366 ESEEAKEFALKILKHMREKADEWKEETGLNFSLEATPAESLSYRFAKLDKKRFGEIKGVTDKPYYTNSFHVPVDYTIDAF 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 597 EKLDFEKDYPQYSAGGFIHYCEYPNLKQNPKALEAVWDYAYD-KIGYLGTNTPIDQCFKCGFKGEFtatakgYQCPECGN 675
Cdd:pfam13597 446 EKLKLEAPFQPLTTGGHISHVELGEAQPNPEALEKLVRIAYDtGIGYFSINPPIDVCPDCGYTGEI------EECPNCGN 519
|
570 580 590
....*....|....*....|....*....|....*...
gi 489668735 676 HDPaTCDVVKRLCGYLGNPNKrpMVHGRQEEIIHRKKH 713
Cdd:pfam13597 520 HDE-KVEVIRRITGYLRPVSD--WNKGKQAELKDRVKH 554
|
|
| RNR_III |
cd01675 |
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
123-693 |
0e+00 |
|
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in strict or facultative anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). The class III enzyme from phage T4 consists of two subunits, this model covers the larger subunit which contains the active and allosteric sites.
Pssm-ID: 153084 [Multi-domain] Cd Length: 555 Bit Score: 610.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 123 ENANKDSRVFSTQRDLTAGAVAKAIGLKMLPPAVANAHLRGDIHWHDLDYTPFMaeTNCCLIDFDYMLNHGFSIGNAEVE 202
Cdd:cd01675 1 ENANVDSSPGSTMKDLAAGIVKKYYLLKILPKEIARAHLNGDIHIHDLDYLPLT--PYCCGWDLRPLLEKGFTTGNGIIE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 203 PAHSIQVAVTQMTQIIANVASSQYGGCSSDRTDQVLAPFAEKNYQKHLREFgsviddpaklealavkqTKKDIYDALQTL 282
Cdd:cd01675 79 PPKHLSSALGHIVNFLGTVQNEQAGGQAFPEFDTYLAPFVRKDYLKYRLTA-----------------TRKEIKQAMQGF 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 283 EYQVNTLYSTQGQTPFVTVGFGL-------------------GTSWIEREIQKDILKIRILGLGKeRRTAIFPKLVFTLK 343
Cdd:cd01675 142 IYNLNTLSRRGGQTPFTNITLGLvcpkdlefegggepvftygDTDKEARMIQKAFLEVRLEGDAK-GRPFTFPIPTFNVT 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 344 RGLNLkpeDPNYDIKQLAIECATKRMYPDVVSYDTIKRLTGSfKAPMGCRSFLQGW--TDPKTGKEVNAGRMNLGVITVN 421
Cdd:cd01675 221 EGFNL---DPNYDLKELAFECAAKRGYPYFLNFDNSDNVPGD-VRAMGCRLFLDKNelKRGGGLEGSGDGTGNIGVVTIN 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 422 LPRIAMEANGDKAKFWKIFEERMRICKEGLLYKVERTKQATPESAPILYKYGAFGHKLadtdsiddLFKNGRATVSLGYI 501
Cdd:cd01675 297 LPRIAYEARGDEEKFFELLDEYLELAKDALEIRRKRLKEALARGLPPLYQEGLGGGKL--------LFILKRHTLTIGFI 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 502 GLYEVGTVFYGSAWEKNPDAKAFSVSIVKALDDHCKAWEKQYGYHFSVYGTPSESLTDTFCRADTKKFG-IVKDITDKEY 580
Cdd:cd01675 369 GLNEAAEALTGKGIGESEEAREFGIRILEHIRERADEFKEETGLLYSVEATPAESLAYRFAKKDRKKYGdIIPGVTDKPY 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 581 YTNSFHYDVRKSPTPFEKLDFEKDYPQYSAGGFIHYCEYPNLKQNPKALEAVWDYAYDK-IGYLGTNTPIDQCFKCGFKG 659
Cdd:cd01675 449 YTNSFHVPVYEDIDPFEKIDIEAKLHPLTTGGHILHIELGEAKPNPEALEALVKKAAKRgVIYFGINTPIDICNDCGYIG 528
|
570 580 590
....*....|....*....|....*....|....
gi 489668735 660 EFTatakGYQCPECGNHDpatCDVVKRLCGYLGN 693
Cdd:cd01675 529 EGE----GFKCPKCGSED---VEVISRITGYLGP 555
|
|
| NrdD |
TIGR02487 |
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive ... |
122-713 |
0e+00 |
|
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive (anaerobic, class III) ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centered radical, a C-terminal zinc binding site, and a set of conserved active site cysteines and asparagines. This enzyme requires an activating component, NrdG, a radical-SAM domain containing enzyme (TIGR02491). Together the two form an alpha-2/beta-2 heterodimer. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274159 [Multi-domain] Cd Length: 579 Bit Score: 600.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 122 NENANKDSRVFSTQRDLTAGAVAKAIGLK-MLPPAVANAHLRGDIHWHDLDYtPFMAETNCCLIDFDYMLNHGFSIGNAE 200
Cdd:TIGR02487 1 NENANMDSPTPSTQRKLIASEVSKDYALLhLLPKDIARAHLNGDIHIHDLDY-ALTLTTNCCLHDLRNLLKYGFRTGNIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 201 VEPAHSIQVAVTQMTQIIANVASSQYGGCSSDRTDQVLAPFAEKNYQKHLREFGSVIDDPAKLEALAVKQTKKDIYDALQ 280
Cdd:TIGR02487 80 SKPPKHIDVALNHIVNILQSLQNEQYGGQSFPEFDTLLAPYIEKTNLKHRKVLQQLQLLLFEATEYAARRTFTDVTQAMQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 281 TLEYQVNTLYSTQGQTPFVTVGFGLGTSWIEREIQKDILKIRILGLGKeRRTAIFPKLVFTLKRGLNLKPEDPnYDIKQL 360
Cdd:TIGR02487 160 GPEYNPNTLHSAGGQTPFESIGYGTETSKEGRMIAKALLDVRMEGDGK-GEPFIFPKIIFKVREGFNWDEPDP-YDLFEL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 361 AIECATKRMYPDVVSYDTIKRLTGSFKAPMGCRSFLQGWTDpKTGKEVNAGRMNLGVITVNLPRIAMEANGDKAKFWKIF 440
Cdd:TIGR02487 238 AFECAAKRGYPYFLNLDPEDNVKEDVRYPMGCRTFLSPNEN-GDGEESYIGRGNIGVTSINLPRIAYKSRGDEEEFFEEL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 441 EERMRICKEGLLYKVERTKQATPESAPILYKYGAFGHKLADTDSIDDLFKNGraTVSLGYIGLYEVGTVFYGSAWEKNPD 520
Cdd:TIGR02487 317 DEYLEIAKEALEIRREYLKKMLAKDLPPMYSQGGWDGGNLLDESVEEILKSG--TNSIGFIGLNEALVALTGKHLHEEEE 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 521 AKAFSVSIVKALDDHCKAWEKQYGYHFSVYGTPSESLTDTFCRADTKKFGIVKDITDKEYYTNSFHYDVRKSPTPFEKLD 600
Cdd:TIGR02487 395 ARELAIRILEFIRDKADEFKKETGLNYSVYATPAESLCGRFAKKDREEFGEIPGVTDKPYYTNSFHVPVYEDVNLGEKID 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 601 FEKDYPQYSAGGFIHYCEYPNLKQNPKALEAVWDYAYD-KIGYLGTNTPIDQCFKCGFKGEFTAtakgYQCPECGNHDpa 679
Cdd:TIGR02487 475 IEAPFHPLTNGGHITYIELDEAIPDPEALKDITKKAMKnGIGYFGINPPVDVCEDCGYTGEGLN----DKCPKCGSHD-- 548
|
570 580 590
....*....|....*....|....*....|....
gi 489668735 680 tCDVVKRLCGYLGnpNKRPMVHGRQEEIIHRKKH 713
Cdd:TIGR02487 549 -IEVISRITGYLG--PVENWNDGKQAEFKDRKKH 579
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09263 |
PRK09263 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
5-717 |
0e+00 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236436 [Multi-domain] Cd Length: 711 Bit Score: 1341.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 5 YTQIKKRDGRIVDFDASKISTAITKAAESVaklapsdVLTIDHLTDTVTAKIRDRY--HDDVEIAEIQTVVEQTLIAAEK 82
Cdd:PRK09263 2 MPKVIKRDGRKVPFDSEKIKNAIEKAAKAV-------EVDDEDYCATVAAEIASRVegRDEVDIEEIQDAVENQLMAGPY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 83 YNWAEAYTEYRLKRDLARKQKQDVNYNVSRLVNR-DESVVNENANKDSRVFSTQRDLTAGAVAKAIGLK-MLPPAVANAH 160
Cdd:PRK09263 75 KALARAYIEYRHDRDIAREKATDLNEEIRGLIEQsNEAVLNENANKDSKVFSTQRDLLAGIVSKHYALRhLLPRDVVNAH 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 161 LRGDIHWHDLDYTPFMAETNCCLIDFDYMLNHGFSIGNAEVEPAHSIQVAVTQMTQIIANVASSQYGGCSSDRTDQVLAP 240
Cdd:PRK09263 155 EKGDIHYHDLDYSPFFPMFNCCLIDLKGMLTNGFKIGNAEIESPKSIQTATAVTAQIIAQVASSQYGGCTINRIDEVLAP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 241 FAEKNYQKHLREFGSVIDDPaKLEALAVKQTKKDIYDALQTLEYQVNTLYSTQGQTPFVTVGFGLGTSWIEREIQKDILK 320
Cdd:PRK09263 235 YAEKSYEKHLKDAEEWVIEE-KAEAYARARTEKEIYDAMQSLEYEINTLHTSNGQTPFVTLGFGLGTSWESRLIQKAILR 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 321 IRILGLGKERRTAIFPKLVFTLKRGLNLKPEDPNYDIKQLAIECATKRMYPDVVSYDTIKRLTGSFKAPMGCRSFLQGWT 400
Cdd:PRK09263 314 NRIAGLGKERKTAIFPKLVFAIKDGLNLKPGDPNYDIKQLALECATKRMYPDILNYDKIVELTGSFKTPMGCRSFLQGWK 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 401 DpKTGKEVNAGRMNLGVITVNLPRIAMEANGDKAKFWKIFEERMRICKEGLLYKVERTKQATPESAPILYKYGAFGHKLA 480
Cdd:PRK09263 394 D-ENGEEVHDGRNNLGVVTLNLPRIALEAKGDEDKFWEILDERLELAKKALMTRIERLKGAKPRVAPILYMYGAFGVRLK 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 481 DTDSIDDLFKNGRATVSLGYIGLYEVGTVFYGSAWEKNPDAKAFSVSIVKALDDHCKAWEKQYGYHFSVYGTPSESLTDT 560
Cdd:PRK09263 473 ADDDVDELFKNGRATISLGYIGLYETINALYGGSWEVNPEAKAFALAIVKRMKDACDQWKKETGYGFSLYSTPSESLTDR 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 561 FCRADTKKFGIVKDITDKEYYTNSFHYDVRKSPTPFEKLDFEKDYPQYSAGGFIHYCEYPNLKQNPKALEAVWDYAYDKI 640
Cdd:PRK09263 553 FCRLDTEKFGVIPGITDKGYYTNSFHYDVRKKVNPFEKLDFEKPYPPLASGGFIHYCEYPNLQHNLKALEAVWDYSYDRV 632
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489668735 641 GYLGTNTPIDQCFKCGFKGEFTATAKGYQCPECGNHDPATCDVVKRLCGYLGNPNKRPMVHGRQEEIIHRKKHITFS 717
Cdd:PRK09263 633 GYLGTNTPIDECYECGFTGEFECTEKGFTCPKCGNHDPKTVSVTRRTCGYLGNPDARPFNHGRQEEIKRRVKHMSGG 709
|
|
| NrdD |
COG1328 |
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; ... |
6-703 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Anaerobic ribonucleoside-triphosphate reductase is part of the Pathway/BioSystem: Thymidylate biosynthesis
Pssm-ID: 440939 [Multi-domain] Cd Length: 671 Bit Score: 893.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 6 TQIKKRDGRIVDFDASKISTAITKAAESVAKlAPSDVLTIDHLTDTVTAKIRDRYHDD-VEIAEIQTVVEQTLIAAEKYN 84
Cdd:COG1328 3 LKVIKRDGRVVPFDPEKIANAIKKAAKAVGG-EDRDEELAEEIADEVEKELERLGGGGtITVEEIQDIVEKVLMESGHPE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 85 WAEAYTEYRLKRDLARKQKQDVNYNVSRLVNRDESVVNENANKdSRVFSTQRDLTAGAVAKAIGL-KMLPPAVANAHLRG 163
Cdd:COG1328 82 VAKAYILYREQRTRLREARTTLVDDIELLDEYDDWRVNENANK-SYSFSTQRDLIAGEVSKEYALnKILPPEVADAHRNG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 164 DIHWHDLDYTPFMaeTNCCLIDFDYMLNHGFSIGNAEVEPAHSIQVAVTQMTQIIANVASSQYGGCSSDRTDQVLAPFAE 243
Cdd:COG1328 161 DIHIHDLDYLPRM--TNCCLWDLRDLLKNGFNGGNGKVEPPKHIQTALAQMAQIIATVQSEQAGGQAFSRFDTYLAPYVR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 244 KNyqkhlrefgsviddpaKLEalavKQTKKDIYDALQTLEYQVNTLYSTQGQTPFVTVGFGLGT----SWIEREIQKDIL 319
Cdd:COG1328 239 KD----------------KLE----GKTYKEIKQAMQSLEYNLNTLPSRRGQTPFTSITFGLGTpedfSWEMRMINKAIL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 320 KIRILGLGkERRTAIFPKLVFTLKRGLNLKPEDPNYDIKQLAIECATKRMYPDVVSYDTIKRL-TGSFKAPMGCRSFLQG 398
Cdd:COG1328 299 EVRIEGDG-EGRTFIFPKLIFNITEGFNWEPEDPNYDLLQLAFECTAKRGYPYFLNYDNSDELyKGSFKRSMGCRLFLDG 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 399 WtdpKTGKEVNAGRMNLGVITVNLPRIAMEANGDKAKFWKIFEERMRICKEGLLYKVERTKQ-ATPESAPILYKYGAFGH 477
Cdd:COG1328 378 W---ENGEELNRGRGNLGVVTLNLPRIAYEAKGDEEKFFEILDERLDLAKEALEIKRKRLQKlAKAGLAPILYQTGAYLG 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 478 KLADTDSIDDLFKNGRATvsLGYIGLYEVGTVFYGSAWEKNPDAKAFSVSIVKALDDHCKAWEKQYGYHFSVYGTPSESL 557
Cdd:COG1328 455 RLKPDDSIDELFKNGFST--IGYIGLNEMLLNFTGKHHIESEEAKAFALEILKHMRERADEWQEETGYLYSLYATPAESL 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 558 TDTFCRADTKKFGIVKDITDKEYYTNSFHYDVRKSPTPFEKLDFEKDYPQYSAGGFIHYCEYPNLKQNPKALEAVWDYAY 637
Cdd:COG1328 533 TYRFAKLDKKRFGDIIGVTDKPYYTNSFHLPVRKTIDPFEKLDFEDEYQPLYTGGTISYVELGELQPNPEALEAVVRYAY 612
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489668735 638 D--KIGYLGTNTPIDQCFKCGFKGEFTATakgyqCPECGNHDpaTCDVVKRLCGYLGnpNKRPMVHGR 703
Cdd:COG1328 613 DnyRIGYLGINPPFDICPKCGYLGGEHDE-----CPKCGNED--TVEVIRRTCGYLG--NVQPWNDGK 671
|
|
| NRDD |
pfam13597 |
Anaerobic ribonucleoside-triphosphate reductase; |
124-713 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase;
Pssm-ID: 463930 [Multi-domain] Cd Length: 554 Bit Score: 694.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 124 NANKDSRVFSTQRDLTAGAVAKAIGLK-MLPPAVANAHLRGDIHWHDLDYTPFMAeTNCCLIDFDYMLNHGFSIGNAEVE 202
Cdd:pfam13597 1 NANKDSYSPSGQRLYIAGEVSKDYALRkLLPPEIADAHEEGDIHIHDLDYYALRT-PYCCGIDLRDLLENGFVTGNGVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 203 PAHSIQVAVTQMTQIIANVASSQYGGCSSDRTDQVLAPFAEKNYQKHLRefgsviddpaklealavKQTKKDIYDALQTL 282
Cdd:pfam13597 80 PPKHIETACAQAVNILATVQNEQAGGQAFSSFDTYLAPFVRKDYEKHLK-----------------GLTYKEVKQAMQAF 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 283 EYQVNTLYSTQG-QTPFVTVGFGLGTSWIERE----IQKDILKIRILGLGKERRTAIFPKLVFTLKRGLNLKPEDPNYDI 357
Cdd:pfam13597 143 VYNLNTMPSRRGgQTPFTNINLGLDTPKEGRDemdmIIKALLEVMLEGDGNGGTPFTFPIPIYKLKEGFNWDEGDPNYDL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 358 KQLAIECATKRMYPDVVSYDTIKRLTGSFKAPMGCRSFLQGWTDPKTGkevNAGRMNLGVITVNLPRIAMEANGDKAKFW 437
Cdd:pfam13597 223 FELAFECTAKRGYPYFSNFDSDLLPGDGYVASMGCRLRLDLRPNRKRF---GGLRGNIGVVTINLPRIAYEAAGDEDKFF 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 438 KIFEERMRICKEGLLYKVERTKQATPE-SAPILYKYGAFghkladtdsiddlfKNGRATVSLGYIGLYEVGTVFYGSAWE 516
Cdd:pfam13597 300 ELLDERLELAKEALLIRREVLKKLLAKgLLPFLMGEGYL--------------RGGNHTLTIGFIGLNEALKALTGKHHG 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 517 KNPDAKAFSVSIVKALDDHCKAWEKQYGYHFSVYGTPSESLTDTFCRADTKKFGIVKDITDKEYYTNSFHYDVRKSPTPF 596
Cdd:pfam13597 366 ESEEAKEFALKILKHMREKADEWKEETGLNFSLEATPAESLSYRFAKLDKKRFGEIKGVTDKPYYTNSFHVPVDYTIDAF 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 597 EKLDFEKDYPQYSAGGFIHYCEYPNLKQNPKALEAVWDYAYD-KIGYLGTNTPIDQCFKCGFKGEFtatakgYQCPECGN 675
Cdd:pfam13597 446 EKLKLEAPFQPLTTGGHISHVELGEAQPNPEALEKLVRIAYDtGIGYFSINPPIDVCPDCGYTGEI------EECPNCGN 519
|
570 580 590
....*....|....*....|....*....|....*...
gi 489668735 676 HDPaTCDVVKRLCGYLGNPNKrpMVHGRQEEIIHRKKH 713
Cdd:pfam13597 520 HDE-KVEVIRRITGYLRPVSD--WNKGKQAELKDRVKH 554
|
|
| RNR_III |
cd01675 |
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
123-693 |
0e+00 |
|
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in strict or facultative anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). The class III enzyme from phage T4 consists of two subunits, this model covers the larger subunit which contains the active and allosteric sites.
Pssm-ID: 153084 [Multi-domain] Cd Length: 555 Bit Score: 610.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 123 ENANKDSRVFSTQRDLTAGAVAKAIGLKMLPPAVANAHLRGDIHWHDLDYTPFMaeTNCCLIDFDYMLNHGFSIGNAEVE 202
Cdd:cd01675 1 ENANVDSSPGSTMKDLAAGIVKKYYLLKILPKEIARAHLNGDIHIHDLDYLPLT--PYCCGWDLRPLLEKGFTTGNGIIE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 203 PAHSIQVAVTQMTQIIANVASSQYGGCSSDRTDQVLAPFAEKNYQKHLREFgsviddpaklealavkqTKKDIYDALQTL 282
Cdd:cd01675 79 PPKHLSSALGHIVNFLGTVQNEQAGGQAFPEFDTYLAPFVRKDYLKYRLTA-----------------TRKEIKQAMQGF 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 283 EYQVNTLYSTQGQTPFVTVGFGL-------------------GTSWIEREIQKDILKIRILGLGKeRRTAIFPKLVFTLK 343
Cdd:cd01675 142 IYNLNTLSRRGGQTPFTNITLGLvcpkdlefegggepvftygDTDKEARMIQKAFLEVRLEGDAK-GRPFTFPIPTFNVT 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 344 RGLNLkpeDPNYDIKQLAIECATKRMYPDVVSYDTIKRLTGSfKAPMGCRSFLQGW--TDPKTGKEVNAGRMNLGVITVN 421
Cdd:cd01675 221 EGFNL---DPNYDLKELAFECAAKRGYPYFLNFDNSDNVPGD-VRAMGCRLFLDKNelKRGGGLEGSGDGTGNIGVVTIN 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 422 LPRIAMEANGDKAKFWKIFEERMRICKEGLLYKVERTKQATPESAPILYKYGAFGHKLadtdsiddLFKNGRATVSLGYI 501
Cdd:cd01675 297 LPRIAYEARGDEEKFFELLDEYLELAKDALEIRRKRLKEALARGLPPLYQEGLGGGKL--------LFILKRHTLTIGFI 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 502 GLYEVGTVFYGSAWEKNPDAKAFSVSIVKALDDHCKAWEKQYGYHFSVYGTPSESLTDTFCRADTKKFG-IVKDITDKEY 580
Cdd:cd01675 369 GLNEAAEALTGKGIGESEEAREFGIRILEHIRERADEFKEETGLLYSVEATPAESLAYRFAKKDRKKYGdIIPGVTDKPY 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 581 YTNSFHYDVRKSPTPFEKLDFEKDYPQYSAGGFIHYCEYPNLKQNPKALEAVWDYAYDK-IGYLGTNTPIDQCFKCGFKG 659
Cdd:cd01675 449 YTNSFHVPVYEDIDPFEKIDIEAKLHPLTTGGHILHIELGEAKPNPEALEALVKKAAKRgVIYFGINTPIDICNDCGYIG 528
|
570 580 590
....*....|....*....|....*....|....
gi 489668735 660 EFTatakGYQCPECGNHDpatCDVVKRLCGYLGN 693
Cdd:cd01675 529 EGE----GFKCPKCGSED---VEVISRITGYLGP 555
|
|
| NrdD |
TIGR02487 |
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive ... |
122-713 |
0e+00 |
|
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive (anaerobic, class III) ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centered radical, a C-terminal zinc binding site, and a set of conserved active site cysteines and asparagines. This enzyme requires an activating component, NrdG, a radical-SAM domain containing enzyme (TIGR02491). Together the two form an alpha-2/beta-2 heterodimer. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274159 [Multi-domain] Cd Length: 579 Bit Score: 600.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 122 NENANKDSRVFSTQRDLTAGAVAKAIGLK-MLPPAVANAHLRGDIHWHDLDYtPFMAETNCCLIDFDYMLNHGFSIGNAE 200
Cdd:TIGR02487 1 NENANMDSPTPSTQRKLIASEVSKDYALLhLLPKDIARAHLNGDIHIHDLDY-ALTLTTNCCLHDLRNLLKYGFRTGNIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 201 VEPAHSIQVAVTQMTQIIANVASSQYGGCSSDRTDQVLAPFAEKNYQKHLREFGSVIDDPAKLEALAVKQTKKDIYDALQ 280
Cdd:TIGR02487 80 SKPPKHIDVALNHIVNILQSLQNEQYGGQSFPEFDTLLAPYIEKTNLKHRKVLQQLQLLLFEATEYAARRTFTDVTQAMQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 281 TLEYQVNTLYSTQGQTPFVTVGFGLGTSWIEREIQKDILKIRILGLGKeRRTAIFPKLVFTLKRGLNLKPEDPnYDIKQL 360
Cdd:TIGR02487 160 GPEYNPNTLHSAGGQTPFESIGYGTETSKEGRMIAKALLDVRMEGDGK-GEPFIFPKIIFKVREGFNWDEPDP-YDLFEL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 361 AIECATKRMYPDVVSYDTIKRLTGSFKAPMGCRSFLQGWTDpKTGKEVNAGRMNLGVITVNLPRIAMEANGDKAKFWKIF 440
Cdd:TIGR02487 238 AFECAAKRGYPYFLNLDPEDNVKEDVRYPMGCRTFLSPNEN-GDGEESYIGRGNIGVTSINLPRIAYKSRGDEEEFFEEL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 441 EERMRICKEGLLYKVERTKQATPESAPILYKYGAFGHKLADTDSIDDLFKNGraTVSLGYIGLYEVGTVFYGSAWEKNPD 520
Cdd:TIGR02487 317 DEYLEIAKEALEIRREYLKKMLAKDLPPMYSQGGWDGGNLLDESVEEILKSG--TNSIGFIGLNEALVALTGKHLHEEEE 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 521 AKAFSVSIVKALDDHCKAWEKQYGYHFSVYGTPSESLTDTFCRADTKKFGIVKDITDKEYYTNSFHYDVRKSPTPFEKLD 600
Cdd:TIGR02487 395 ARELAIRILEFIRDKADEFKKETGLNYSVYATPAESLCGRFAKKDREEFGEIPGVTDKPYYTNSFHVPVYEDVNLGEKID 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 601 FEKDYPQYSAGGFIHYCEYPNLKQNPKALEAVWDYAYD-KIGYLGTNTPIDQCFKCGFKGEFTAtakgYQCPECGNHDpa 679
Cdd:TIGR02487 475 IEAPFHPLTNGGHITYIELDEAIPDPEALKDITKKAMKnGIGYFGINPPVDVCEDCGYTGEGLN----DKCPKCGSHD-- 548
|
570 580 590
....*....|....*....|....*....|....
gi 489668735 680 tCDVVKRLCGYLGnpNKRPMVHGRQEEIIHRKKH 713
Cdd:TIGR02487 549 -IEVISRITGYLG--PVENWNDGKQAEFKDRKKH 579
|
|
| PRK07111 |
PRK07111 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
6-703 |
9.16e-147 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 235937 [Multi-domain] Cd Length: 735 Bit Score: 445.93 E-value: 9.16e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 6 TQIKKRDGRIVDFDASKISTAITKAAESVAKLapSDVLTIDHLTDTVTAKIRDRYHDDVEIAEIQTVVEQTLIAAEKYNW 85
Cdd:PRK07111 3 LYIVKRDGREVPFDEEKITNAIFKAAEAVGGE--LDESEAIELTQKVIKYLEEKYKEEVTVEDIQDLVEKVLIENGHAET 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 86 AEAYTEYRLKRDLARKQKqdvnynvSRLVNRDESVVN----ENANKDSRVFSTQRDLTAGAVAKAIGLK-MLPPAVANAH 160
Cdd:PRK07111 81 AKAYILYRAERTRIREIK-------SDLMKAIEEIGNdtdrENANVSGNTPSGKMLRIASESNKDYYNLyLLPKELAKAH 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 161 LRGDIHWHDLDYtpFMAETNCCLIDFDYMLNHGFSIGNAEVEPAHSIQVAVTQMTQIIANVASSQYGGCSSDRTDQVLAP 240
Cdd:PRK07111 154 ENGDIHIHDLDF--YNLTTTCLQIDLKKLLERGFNTGHGYIREPKRIESAAALACIILQSNQNDMHGGQSIPNFDNDMAP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 241 FAEKNYQKHLRE----------------------------------FGSVIDDPAKLEALAVKQTKKDIYDALQTLEYQV 286
Cdd:PRK07111 232 FVEKTFRRHRKEilekllelgvgeevdekeslneeeellllllaldFNIAKKAQEKADELAEKETRKRTYQAMEGFIHNL 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 287 NTLYSTQG-QTPFVTVGFGLGTSWIEREIQKDILKIRILGLGK-ErrTAIFPKLVFTLKRGLNLKPEDPNYDIKQLAIEC 364
Cdd:PRK07111 312 NTMHSRAGaQVPFSSINYGTDTSPEGRMVCENLLLATEKGLGKgE--TPIFPIQIFRVKEGVNYNEEDPNYDLFKLACRV 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 365 ATKRMYPDVVSYDTikrltgSFKAP-------------MGCRSFLQGwtdPKTGKEVNAGRMNLGVITVNLPRIAMEANG 431
Cdd:PRK07111 390 AAKRLFPNFSFLDA------PFNKEyydkgrpptevatMGCRTRVMS---NVNGEEGTKGRGNLSFTTINLPRLAIEAKK 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 432 DKAKFWKIFEERMRICKEGLL--YKVERTKQAtpESAPILYKYGAF--GHKLADTDSIDDLFKNGraTVSLGYIGLYEVG 507
Cdd:PRK07111 461 DIDKFFELLDERLELAIEQLLhrYEVQKTLKV--KDFPFLMGQGLWkgSENLGPDDSIEPVLKQG--TLGIGFIGLAETL 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 508 TVFYGSAWEKNPDAKAFSVSIVKALDDHCKAWEKQYGYHFSVYGTPSESLTDTFCRADTKKFGIVKDITDKEYYTNSFHY 587
Cdd:PRK07111 537 VALTGKHHGESEEAQELGLKIVSHMRDFCDEYKEEYKLNYSLLATPAEGLSGRFIKMDRKKFGEIKGVTDKEYYTNSFHV 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 588 DVRKSPTPFEKLDFEKDYPQYSAGGFIHYCE---YPnlKQNPKALEAVwDYAYDK--IGYLGTNTPIDQCFKCGFKGeft 662
Cdd:PRK07111 617 PVYYPISIFEKIEIEAPYHKLTNGGHISYVEldgDP--SKNVEAFEII-VKAMKNtnIGYGSINHPVDRCPVCGYLG--- 690
|
730 740 750 760
....*....|....*....|....*....|....*....|....*.
gi 489668735 663 atAKGYQCPECGNHDpatCDVVKRLCGYLG-----NPNKRPMVHGR 703
Cdd:PRK07111 691 --VIEDKCPKCGSTN---IQRIRRITGYLGtldrfNSAKKAERRDR 731
|
|
| PRK14704 |
PRK14704 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
117-713 |
6.15e-99 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 184798 [Multi-domain] Cd Length: 618 Bit Score: 317.90 E-value: 6.15e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 117 DESVVNENANKDSRVFSTQRDLTAGAVAKAIGLKML-PPAVANAHLRGDIHWHDLDYTPfMAETNCCLIDFDYMLNHGFS 195
Cdd:PRK14704 23 EQDLMQENANVDGRSPMGVMGTFASESAKYYAVENLlSDQVKKAINENILYPHDLDFYA-TGTTTCSQIPLAQMLANGFH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 196 IGNAEVEPAHSIQVAVTQMTQIIANVASSQYGGCSSDRTDQVLAPFAEKNYQKHLREFGSVIDDPAKLEALAVKQTKKDI 275
Cdd:PRK14704 102 TGHGHMRQPQDIKSALALSSIIFQANQNMQHGGQSFALFDVDLAPYVRKTVERHKKRLQSYPLTKEQIEEFAWKETENDT 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 276 YDALQTLEYQVNTLYSTQG-QTPFVTVGFGLGTSWIEREIQKDILKIRILGLGKERrTAIFPKLVFTLKRGLNLKPEDPN 354
Cdd:PRK14704 182 YQACEAFIHNSNSMHSRGGgQVPFISINYGTDTSKEGRLLIKQLLKATQAGLGKGE-TPIFPIQIFKMKKGVNFEESDPN 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 355 YDIKQLAIECATKRMYPDVVSYDT---IKRLTGSFK---APMGCRSFLQGwtdPKTGKEVNAGRMNLGVITVNLPRIAMe 428
Cdd:PRK14704 261 YDLFELALETTAERLFPNFSFLDApfnAVHYDGRPEsevCYMGCRTRVMS---NIHGEETAIGRGNLSFTSINLVKLAL- 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 429 ANGDKAKFWKIFEERMRICKEGLLYKVERTKQATPESAPILYKYGAF--GHKLADTDSIDDLFKNGraTVSLGYIGLYEV 506
Cdd:PRK14704 337 ISGSKEAFFEALNYYLDLGIKQLLERFEYQCTKRARDFRFLYSQGVWrgGEKLQPEDSVASILKQG--TLSLGFIGLAEC 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 507 GTVFYGSAWEKNPDAKAFSVSIVKALDDHCKAWEKQYGYHFSVYGTPSESLTDTFCRADTKKFGIVKDITDKEYYTNSFH 586
Cdd:PRK14704 415 LVALTGKHHGEDEESWKLGYEIISFMRDRMDKATEEHELNFSVIATPAEGLSGKFVKKDREEFGVISGITNHNYYTNSFH 494
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 587 YDVRKSPTPFEKLDFEKDYPQYSAGGFIHYCEYP-NLKQNPKALEA-VWDYAYDKIGYLGTNTPIDQCFKCGFKGEFtat 664
Cdd:PRK14704 495 IPVYYNIQAINKIRLEGPFHALCNGGHITYIELDgAAMHNKKALKQiVQAMAEHGVGYGSINHPVDRCKCCSYHGVI--- 571
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 489668735 665 akGYQCPECGNHDPATCDVVKRLCGYLGNPNKRPMVHGRQEEiIHRKKH 713
Cdd:PRK14704 572 --GNECPSCGNEDEANIERIRRITGYLVGDMSKWNSAKRSEE-MDRVKH 617
|
|
| PRK08270 |
PRK08270 |
ribonucleoside triphosphate reductase; |
6-686 |
9.37e-38 |
|
ribonucleoside triphosphate reductase;
Pssm-ID: 236212 [Multi-domain] Cd Length: 656 Bit Score: 150.00 E-value: 9.37e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 6 TQIKKRDGRIVDFDASKISTAITKAAESVAKlapSDVLTIDHLTDTVTAKIRDryHDDVEIAEIQTVVEQTLIAAEKYNW 85
Cdd:PRK08270 3 TKIIKRDGRIVPFDAEKITEAIAKAFKATGE---FDPSEAERLALRVIEKLED--EDIPSVEEIQDIVEKVLIEAGYFKT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 86 AEAYTEYRLKRDLARKQKQ---DVNYNVSRLVNRDESVVNENANKDsrvFSTQrDL---TAGAVAKAIGL-KMLPPAVAN 158
Cdd:PRK08270 78 AKAYILYREQHARLRNDKKtllDVEDTVDEYLDREDWRVNENSNMG---YSLQ-GLilnISGKVTANYWLnKVYPPEIGE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 159 AHLRGDIHWHDLDY-TPFmaetnCCLIDFDYMLNHGFS--IGNAEVEPAHSIQVAVTQMtqiiANV--------ASSQyg 227
Cdd:PRK08270 154 AHRNGDLHIHDLDMlSGY-----CAGWSLRDLLLEGFNgvPGKVESKPPKHFRSALGQI----VNFlgtlqnewAGAQ-- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 228 GCSSdrTDQVLAPFAEKNyqkhlrefgsviddpaKLEALAVKQtkkdiydALQTLEYQVNTLYSTQGQTPFVTVGFglgt 307
Cdd:PRK08270 223 AFSS--FDTYLAPFVRKD----------------GLSYKEVKQ-------AIQEFVFNLNVPSRWGFQTPFTNLTF---- 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 308 SWIEREIQKDilKIRILGlGKErrtaifpkLVFTLKrglNLKPE---------------D----------PNYDIkqlai 362
Cdd:PRK08270 274 DLTVPEDLKD--QPVIIG-GEE--------MDFTYG---DFQKEmdminrafievmlegDangrvftfpiPTYNI----- 334
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 363 ecaTKRMYPDVVSYDTIKRLTGSFKAP-----------------MGCRsfLQ--------------GwTDPKTGkevnag 411
Cdd:PRK08270 335 ---TKDFDWDSENADLLFEMTAKYGLPyfqnfinsdlkpedvrsMCCR--LQldlrelrkrggglfG-SAELTG------ 402
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 412 rmNLGVITVNLPRIAMEANgDKAKFWKIFEERMRICKEGLLYK---VER-TKQAtpesapiLYKYGAF--GHkladtdsi 485
Cdd:PRK08270 403 --SIGVVTINLPRLGYLSK-DEEEFFARLDELMDLAKDSLEIKrkvIERlTDKG-------LYPYTKRylGT-------- 464
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 486 ddlFKNGRATvsLGYIGLYEVGTVFYGsaweKN---PDAKAFSVSIVKALDDHCKAWEKQYGYHFSVYGTPSESLTDTFC 562
Cdd:PRK08270 465 ---LRNHFST--IGLNGMNEACLNFLG----KDittEEGRAFALRVLDHMRERLVEFQEETGNLYNLEATPAEGTTYRLA 535
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 563 RADTKKFgivKDI-----TDKEYYTNSFHYDVRKSPTPFEKLDFEKDY-PQYSAGGFIH-YceypnLKQNPKALEAVWDY 635
Cdd:PRK08270 536 KEDKKRY---PDIitagtDEEPYYTNSTQLPVGYTDDPFEALELQDELqTKYTGGTVFHlY-----LGEAISDAEACKKL 607
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489668735 636 A------YdKIGYLgTNTP---IdqCFKCGF-KGEFtatakgYQCPECGnhdpATCDVVKR 686
Cdd:PRK08270 608 VkkalenY-RLPYI-TITPtfsI--CPKHGYlSGEH------EFCPKCG----EETEVYSR 654
|
|
| Gly_radical |
pfam01228 |
Glycine radical; |
589-695 |
1.45e-37 |
|
Glycine radical;
Pssm-ID: 426140 [Multi-domain] Cd Length: 106 Bit Score: 135.37 E-value: 1.45e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 589 VRKSPTPFEKLDFEKDYPQYSAGGFIHY-CEYPNLKQNPKALEAVWDYaYDKIGYLGTNTPIDQCFKCGFKGEFTATAKg 667
Cdd:pfam01228 1 VAPGISPSHGADFEGPTAVLNSVGKIDYeVELDGISLNQKFLPAVLGY-YDEEGYANLNTLIDTYFEGGHHLQFNVVDR- 78
|
90 100
....*....|....*....|....*...
gi 489668735 668 YQCPECGNHDPATCDVVKRLCGYLGNPN 695
Cdd:pfam01228 79 ETLPDAQKHPEKYPDLTVRVSGYSANFV 106
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
159-638 |
5.12e-32 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 128.80 E-value: 5.12e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 159 AHLRGDIHWHDLDYtPFmaeTNCCLIDFDYMLNHGFSIGNaevEPAHSIQVAVTQMTQIIANVASSQ-YGGCSSDRTDQV 237
Cdd:cd00576 7 AVKSGVITVGRPDL-PF---TGCVLVDYGDSLDPGIKGVN---ETAKSINEAIQKTYQIIALAASNQnGGGVSFARASSI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 238 LAPFAEKNYQKHlrefgsviddpaklealavKQTKKDIYDALQTLEYQVNTLYSTQGQTPFVTVGFGLGTSWIEREIQKD 317
Cdd:cd00576 80 LSPYGSRDYAKG-------------------SGTETDAVEAADAFNLALKEVGQGNGRTGAATGFIGGVHKGKGDKISQE 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 318 ILKIRIlGLGKERRTAIFPKLVFTLKRGLNLKpEDPNYDIKQLAIECATKRMYPDVVSydtikrltgsfkapmgcrsflq 397
Cdd:cd00576 141 FLNLAL-ANGGEGIPLNFPNLSVRVSSDKPGI-LVKAVELKQLIAEEARKTGSPGIFN---------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 398 gwtdpktgkevnaGRMNLGViTVNLPRIAMEA-NGDKAKFWKIFEERMRICKEGL----LYKVERTKQATpesapilyky 472
Cdd:cd00576 197 -------------DELCNLV-SLNLARIMEKAiNGSMDVVLEELEELAFLAVRALdcviDSHDERIPTIE---------- 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 473 gafghkladtdsiddLFKNGRATVSLGYIG----LYEVGTVFYGSaweknPDAKAFSVSIVKALDDHCKAWEKQYGYHFS 548
Cdd:cd00576 253 ---------------LGGDERRTVGLGIAGvadlLIKLGLEKVGD-----PEADDLAAELVDQLKKHLVKATNERGFNFL 312
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 549 VYGTPSESltdtfcradtkkfgivkdITDKEYYTNSFH-------YDVRKSPTPFEKLDFEKDYPQYSAGGFIHYCEYPN 621
Cdd:cd00576 313 LGLSPSES------------------NSSGAPATNGVSpsrg*iaIVLNGDIGPEESLASVAILQFYADNGISDTITIPD 374
|
490
....*....|....*..
gi 489668735 622 LKQNPKALEAVWDYAYD 638
Cdd:cd00576 375 SATNLDQLLAVIDGAAA 391
|
|
| ATP-cone |
pfam03477 |
ATP cone domain; |
7-97 |
1.85e-21 |
|
ATP cone domain;
Pssm-ID: 397513 [Multi-domain] Cd Length: 86 Bit Score: 88.86 E-value: 1.85e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 7 QIKKRDGRIVDFDASKISTAITKAAESVAKlapsdvlTIDHLTDTVTAKIRDRYHDDVEIAEIQTVVEQTLIAAEKYNWA 86
Cdd:pfam03477 2 KVIKRDGRREPFDKEKIRRAIEKACEKSPD-------QADELASEVEEELEKSLEDGISTEEIQDLVEKTLAEHPDYAVA 74
|
90
....*....|.
gi 489668735 87 EAYTEYRLKRD 97
Cdd:pfam03477 75 RAYILYRNLRK 85
|
|
| PRK08579 |
PRK08579 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
121-711 |
9.04e-17 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236303 [Multi-domain] Cd Length: 625 Bit Score: 84.42 E-value: 9.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 121 VNENANKdsrvFSTQRDLTAGAVAKAIG---LKMLPPAVANAHLRGDIHWHDLDYTPFMAEtnCCLIDFDYMLNHGFSIG 197
Cdd:PRK08579 24 VNENANR----YPGPTGFFAYVLEEALKeslVSLLPEPGLEAHFSGDIYIHKLPYSLYIPY--CTGHSISRLLEKGLKTP 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 198 NAEVEPAHSIQVAVTQmtqiIAN--VASSQY--GGCSSDRTDQVLAPFAEKNyqkhlrefgsviddpaKLEALAVKQTkk 273
Cdd:PRK08579 98 TIISRPARHFDTFVDH----VANylITMQHYftGAQAFSSVEWYAGPFIRKD----------------GLDYRKIKQN-- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 274 diydaLQTLEYQVNTLYSTQGQTPF--VTVGFGLGTSWIERE-IQKDILKIRILGLGKERRTAIFPKLVFTLKRGLNL-K 349
Cdd:PRK08579 156 -----IQRLVYNLNYPSRVGMQTPFtnFTVTLDAPKKMLEGDyAVYDGKKVGPLGEYEEEAKLFLLALTEVLREGDALgQ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 350 P----------------EDPnyDIKQLAIECATKR-----MYPDVVSYD---------TIKR--LTGSFKAPMGCRSFLQ 397
Cdd:PRK08579 231 PftfpiptlmttakmlwDDP--EVFEAVFTTAAKRgsfywLNTRVVDPDasyamccriNIDKneLMYAFGVGGKSRRDLE 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 398 GWTDpKTGKEVNAGRM-----------NLGVITVNLPRIAMEANGDKAKFWKIFEERMRICKEGLLY---KVERTKQATP 463
Cdd:PRK08579 309 DAEE-EYLEKLEKQRFgglwampditgSVNVTTVNLPRIALEARGDDDKFWELYEERLELVRITLDWfreRYVKLLKTYP 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 464 ESAPILYKY-GAFGHKLADTdsiddlfkngratvsLGYIGLYEVGTVFYGS----------AWEKnpdAKAFSVSIVKAL 532
Cdd:PRK08579 388 EMYSMIKEYlEEFPSSHFNT---------------IGIIGLPEAAAIYLGEpklwtegsrrDWLE---AAELMKKMVEFA 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 533 DDHCKAWEKQYGYHFSVYGTPSESLTDTFCRADTKKFGIVKDIT---DKEYYTNSF--HYDvrkSPTPFEKLDFEKDYPQ 607
Cdd:PRK08579 450 VEKAREWMKETGTPWNVEEVPGESAAAKLAIKDLKLFPELREYLsdpENPIYSTSIapYYG---PLELWDRIEIEEKVQQ 526
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 608 YSAGG-----FIHycEYPnlkqNPKALEAV-----------WDYaydkigylgtnTP-IDQCFKCGfkgeftATAKGY-- 668
Cdd:PRK08579 527 EFTGGvmmhiFLG--EEP----DPEALAKLtkrimntklvyWSY-----------TPaITVCNKCG------RSTTGLyt 583
|
650 660 670 680
....*....|....*....|....*....|....*....|....*.
gi 489668735 669 QCPECGNHDpatCDVVKRLCGYLgnpnkRPMVH---GRQEEIIHRK 711
Cdd:PRK08579 584 RCPRCGSED---VEVWSRIIGYY-----RPLKNwnpYRKKEFWLRK 621
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
7-106 |
1.87e-11 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 67.47 E-value: 1.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 7 QIKKRDGRIVDFDASKISTAITKAAESVAKLAPSDVltIDHLTDTVTAKIRDRYHDD--VEIAEIQTVVEQTLIAAEKYN 84
Cdd:PRK12364 2 EIIKRNGTTEPYDREKIEVAIRKAFASVGKPISDEI--IYSLVAEVERFIKEKYPNGhnVSVEEIQDLVEKTLMEHGHYA 79
|
90 100
....*....|....*....|..
gi 489668735 85 WAEAYTEYRLKRDLARKQKQDV 106
Cdd:PRK12364 80 EVKSYILYRAQRTEKRKAREQI 101
|
|
| PRK08271 |
PRK08271 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
408-713 |
2.44e-11 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 181342 [Multi-domain] Cd Length: 623 Bit Score: 66.96 E-value: 2.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 408 VNAGRMNlgVITVNLPRIAMEANgDKAKFWKIFEERMRICKEGLLYKVERTKQATPESAPILYKYGAFghkladtdSIDD 487
Cdd:PRK08271 346 VNTGSIN--VITINLPRIAQEAR-DRDDFLEILRERVDKIHKYQLAYREIMEERIAAGMLPLYDAGFI--------SLDK 414
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 488 LFkngratVSLGYIGLYEVGTvFYGSAWEKNPDAKAFSVSIVKALDDHCKAWEKQYGYHFSVYGTPSESLTDTFCRADTK 567
Cdd:PRK08271 415 QF------LTIGINGMVEAAE-FMGLTVGYNEEYKDFVQEVLKVIYEANEKASKEYGFTFNTEFVPAENLGVKLAKWDRE 487
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 568 -KFGIvkditDKEYYtNSFHYDVR-KSPTPFEKLDFE-KDYPQYSAGGFIHYC---EYPNLKQNPKALEAVwdyAYDKIG 641
Cdd:PRK08271 488 dGYGV-----PRQCY-NSYSYVVEdANTDALDKFKLHgKELDKYLSGGSALHLnldERLSEEGYRKLLNIA---AKTGCN 558
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489668735 642 YLGTNTPIDQCFKCGfkgeftATAKGY--QCPECGNHDpatCDVVKRLCGYL---GNPNKrpmvhGRQEEIIHRKKH 713
Cdd:PRK08271 559 YFAFNVKITICNDCH------HIDKRTgkRCPICGSEN---IDYYTRVIGYLkrvSAFSK-----VRQKEYPRRHYH 621
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
7-105 |
1.98e-10 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 64.21 E-value: 1.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 7 QIKKRDGRIVDFDASKISTAITKAAESV--AKLAPSDVL--TIDHLTDTVTAKIRDRYHD--DVEIAEIQTVVEQTLIAA 80
Cdd:PRK07207 35 KVIRRNGSVVPFEPSKIAVAMTKAFLAVegGQAAASARVreTVEQLTEQVVRALVRRRPSggTFHIEDIQDQVELALMRS 114
|
90 100
....*....|....*....|....*
gi 489668735 81 EKYNWAEAYTEYRLKRDLARKQKQD 105
Cdd:PRK07207 115 GEHKVARAYVLYREKRAQERAAEAE 139
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
7-104 |
4.62e-10 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 62.95 E-value: 4.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 7 QIKKRDGRIVDFDASKISTAITKAAESVAKLAPSDVltiDHLTDTVTAKIRDRYHDDVEiaEIQTVVEQTLIAAEKYNW- 85
Cdd:PRK06406 6 EVIKRDGTVVPFDKKKIAMAIYKAMLSVKNGSMEDA---EELTDKVVERLKKYERPTVE--QIQDIVEKVLMTKKINGKd 80
|
90 100
....*....|....*....|...
gi 489668735 86 ----AEAYTEYRLKRDLARKQKQ 104
Cdd:PRK06406 81 ftdvAKSYILYREKRRKIREEKE 103
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
8-106 |
4.38e-09 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 59.96 E-value: 4.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 8 IKKRDGRIVDFDASKISTAITKAAESVAK---LAPSDVLT-IDHLTDTVTAKIRDRY--HDDVEIAEIQTVVEQTLIAAE 81
Cdd:PRK12365 120 VIRRDGTVVHFNPMKISAALEKAFRATDKiegMTPSSVLEeINALTQNIVEEILECCsqEDRIDIEKIQDIVEQQLMVVG 199
|
90 100
....*....|....*....|....*
gi 489668735 82 KYNWAEAYTEYRLKRDLARKQKQDV 106
Cdd:PRK12365 200 HYDVAKNYILYREARARVRDNKEED 224
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
7-118 |
1.15e-08 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 59.01 E-value: 1.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489668735 7 QIKKRDGRIVDFDASKISTAITKAAESVAKlapSDVLTIDHLTDTVTAKIRDRYHDDV-EIAEIQTVVEQTLIAAEKYNW 85
Cdd:PRK08332 5 KVMKRDGRIVPFDESRIRWAVQRAMWEVGV---RDEKKLDEVVKRIVQRINELYDGKIpHIENIQDIVELELMRAGLFEV 81
|
90 100 110
....*....|....*....|....*....|...
gi 489668735 86 AEAYTEYRLKRDLARKQKQdvnynvsRLVNRDE 118
Cdd:PRK08332 82 AKAYILYRKKKAEIREEKK-------RILNKKE 107
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