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Conserved domains on  [gi|489719289|ref|WP_003623405|]
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NADP-dependent phosphogluconate dehydrogenase [Lactobacillus delbrueckii]

Protein Classification

NADP(+)-dependent, decarboxylating phosphogluconate dehydrogenase( domain architecture ID 11483768)

NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate, as part of the oxidative branch of the pentose phosphate pathway

CATH:  3.40.50.720|1.20.5.320
EC:  1.1.1.44
Gene Ontology:  GO:0004616|GO:0050661|GO:0006098|GO:0046177
PubMed:  35234135|34709178|26479318
SCOP:  3000048

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
12-461 0e+00

NADP-dependent phosphogluconate dehydrogenase;


:

Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 744.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  12 MGKNLALNVRNHGFSVSGFSIDKPEVDALAK--YEDDKLKPCYTWEEFVDSLEKPRKILVQIMAGDPVDQTIQKLIPLLD 89
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAeeGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  90 KGDIIIDGGNSNFHDTNRRYHELKKHGLHFIGMGVSGGEEGALNGPALMPGGDKEAYEEAAPILTAMAAKTEDGRACVSY 169
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 170 IGPEGAGHYVKMVHNGMEYAIMQEISEVYDIMRKVAHKSNKEMADIFAEWDKGDLNAYLIEIASQVLRQKDDLTDDDVID 249
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDEETGKPLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 250 HILNVASYKGTGNWMLEDAIKLGAPITVVAEAVLARFMSKATT-REGKEVVYDGEVAS------DLIDNLGKAMYLAQIV 322
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDqRVAASKVLSGPAAKfegdkaEFIEDVRQALYASKIV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 323 AYAQGFQQLTMAAKAYDWELNYPAIAQNWEAGCIIHAKTLYHIEDAYADGKQLDNLFQDPYFAGVMEKNLPALRAVVKLA 402
Cdd:PRK09287 321 SYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVALA 400

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489719289 403 TEAGVPTPSFSAALNYLESIFNPSLPANMIQAQRDYFGAHTYYRNDREGVYHTEWYEEK 461
Cdd:PRK09287 401 VQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFFHTEWSEDG 459
 
Name Accession Description Interval E-value
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
12-461 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 744.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  12 MGKNLALNVRNHGFSVSGFSIDKPEVDALAK--YEDDKLKPCYTWEEFVDSLEKPRKILVQIMAGDPVDQTIQKLIPLLD 89
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAeeGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  90 KGDIIIDGGNSNFHDTNRRYHELKKHGLHFIGMGVSGGEEGALNGPALMPGGDKEAYEEAAPILTAMAAKTEDGRACVSY 169
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 170 IGPEGAGHYVKMVHNGMEYAIMQEISEVYDIMRKVAHKSNKEMADIFAEWDKGDLNAYLIEIASQVLRQKDDLTDDDVID 249
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDEETGKPLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 250 HILNVASYKGTGNWMLEDAIKLGAPITVVAEAVLARFMSKATT-REGKEVVYDGEVAS------DLIDNLGKAMYLAQIV 322
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDqRVAASKVLSGPAAKfegdkaEFIEDVRQALYASKIV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 323 AYAQGFQQLTMAAKAYDWELNYPAIAQNWEAGCIIHAKTLYHIEDAYADGKQLDNLFQDPYFAGVMEKNLPALRAVVKLA 402
Cdd:PRK09287 321 SYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVALA 400

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489719289 403 TEAGVPTPSFSAALNYLESIFNPSLPANMIQAQRDYFGAHTYYRNDREGVYHTEWYEEK 461
Cdd:PRK09287 401 VQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFFHTEWSEDG 459
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 1-457 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 695.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289   1 MQQFGVIGLSVMGKNLALNVRNHGFSVSGFSIDKPEVDALAK--YEDDKLKPCYTWEEFVDSLEKPRKILVQIMAGDPVD 78
Cdd:COG0362    2 KADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAehGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPVD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  79 QTIQKLIPLLDKGDIIIDGGNSNFHDTNRRYHELKKHGLHFIGMGVSGGEEGALNGPALMPGGDKEAYEEAAPILTAMAA 158
Cdd:COG0362   82 AVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIAA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 159 KTeDGRACVSYIGPEGAGHYVKMVHNGMEYAIMQEISEVYDIMRKVAHKSNKEMADIFAEWDKGDLNAYLIEIASQVLRQ 238
Cdd:COG0362  162 KV-DGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILRK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 239 KDDLTDDDVIDHILNVASYKGTGNWMLEDAIKLGAPITVVAEAVLARFMSK-ATTREGKEVVYDGEVAS-------DLID 310
Cdd:COG0362  241 KDPETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSAlKEERVAASKLLPGPEAApfegdkeAFIE 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 311 NLGKAMYLAQIVAYAQGFQQLTMAAKAYDWELNYPAIAQNWEAGCIIHAKTLYHIEDAYADGKQLDNLFQDPYFAGVMEK 390
Cdd:COG0362  321 DLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALKK 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489719289 391 NLPALRAVVKLATEAGVPTPSFSAALNYLESIFNPSLPANMIQAQRDYFGAHTYYRNDREGVYHTEW 457
Cdd:COG0362  401 AQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFFHTEW 467
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 3-459 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 588.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289    3 QFGVIGLSVMGKNLALNVRNHGFSVSGFSIDKPEVDA-LAKYEDDK-LKPCYTWEEFVDSLEKPRKILVQIMAGDPVDQT 80
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEfLAEEAKGKsIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289   81 IQKLIPLLDKGDIIIDGGNSNFHDTNRRYHELKKHGLHFIGMGVSGGEEGALNGPALMPGGDKEAYEEAAPILTAMAAKT 160
Cdd:TIGR00873  81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  161 eDGRACVSYIGPEGAGHYVKMVHNGMEYAIMQEISEVYDIMRKVAHKSNKEMADIFAEWDKGDLNAYLIEIASQVLRQKD 240
Cdd:TIGR00873 161 -DGEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  241 DLTDDDVIDhILNVASYKGTGNWMLEDAIKLGAPITVVAEAVLARFMS------KATTRE--GKEVVYDGEVASDLIDNL 312
Cdd:TIGR00873 240 EDGNPLVDK-ILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSslkeerVAASKVlpGPEAPKKGVDKEEFIEDV 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  313 GKAMYLAQIVAYAQGFQQLTMAAKAYDWELNYPAIAQNWEAGCIIHAKTLYHIEDAYADGKQLDNLFQDPYFAGVMEKNL 392
Cdd:TIGR00873 319 RQALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQ 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489719289  393 PALRAVVKLATEAGVPTPSFSAALNYLESIFNPSLPANMIQAQRDYFGAHTYYRNDREG--VYHTEWYE 459
Cdd:TIGR00873 399 SGWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNWTG 467
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 176-457 3.96e-145

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 416.08  E-value: 3.96e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  176 GHYVKMVHNGMEYAIMQEISEVYDIMRKVAHKSNKEMADIFAEWDKGDLNAYLIEIASQVLRQKDDLTDDDVIDHILNVA 255
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDPEDGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  256 SYKGTGNWMLEDAIKLGAPITVVAEAVLARFMSKATT-RE-------GKEVVYDGEVASDLIDNLGKAMYLAQIVAYAQG 327
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDeRVaaskvlpGPPPALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  328 FQQLTMAAKAYDWELNYPAIAQNWEAGCIIHAKTLYHIEDAYADGKQLDNLFQDPYFAGVMEKNLPALRAVVKLATEAGV 407
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 489719289  408 PTPSFSAALNYLESIFNPSLPANMIQAQRDYFGAHTYYRNDREGVYHTEW 457
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEGFFHTEW 290
 
Name Accession Description Interval E-value
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
12-461 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 744.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  12 MGKNLALNVRNHGFSVSGFSIDKPEVDALAK--YEDDKLKPCYTWEEFVDSLEKPRKILVQIMAGDPVDQTIQKLIPLLD 89
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAeeGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  90 KGDIIIDGGNSNFHDTNRRYHELKKHGLHFIGMGVSGGEEGALNGPALMPGGDKEAYEEAAPILTAMAAKTEDGRACVSY 169
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 170 IGPEGAGHYVKMVHNGMEYAIMQEISEVYDIMRKVAHKSNKEMADIFAEWDKGDLNAYLIEIASQVLRQKDDLTDDDVID 249
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDEETGKPLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 250 HILNVASYKGTGNWMLEDAIKLGAPITVVAEAVLARFMSKATT-REGKEVVYDGEVAS------DLIDNLGKAMYLAQIV 322
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDqRVAASKVLSGPAAKfegdkaEFIEDVRQALYASKIV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 323 AYAQGFQQLTMAAKAYDWELNYPAIAQNWEAGCIIHAKTLYHIEDAYADGKQLDNLFQDPYFAGVMEKNLPALRAVVKLA 402
Cdd:PRK09287 321 SYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVALA 400

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489719289 403 TEAGVPTPSFSAALNYLESIFNPSLPANMIQAQRDYFGAHTYYRNDREGVYHTEWYEEK 461
Cdd:PRK09287 401 VQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFFHTEWSEDG 459
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 1-457 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 695.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289   1 MQQFGVIGLSVMGKNLALNVRNHGFSVSGFSIDKPEVDALAK--YEDDKLKPCYTWEEFVDSLEKPRKILVQIMAGDPVD 78
Cdd:COG0362    2 KADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAehGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPVD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  79 QTIQKLIPLLDKGDIIIDGGNSNFHDTNRRYHELKKHGLHFIGMGVSGGEEGALNGPALMPGGDKEAYEEAAPILTAMAA 158
Cdd:COG0362   82 AVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIAA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 159 KTeDGRACVSYIGPEGAGHYVKMVHNGMEYAIMQEISEVYDIMRKVAHKSNKEMADIFAEWDKGDLNAYLIEIASQVLRQ 238
Cdd:COG0362  162 KV-DGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILRK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 239 KDDLTDDDVIDHILNVASYKGTGNWMLEDAIKLGAPITVVAEAVLARFMSK-ATTREGKEVVYDGEVAS-------DLID 310
Cdd:COG0362  241 KDPETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSAlKEERVAASKLLPGPEAApfegdkeAFIE 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 311 NLGKAMYLAQIVAYAQGFQQLTMAAKAYDWELNYPAIAQNWEAGCIIHAKTLYHIEDAYADGKQLDNLFQDPYFAGVMEK 390
Cdd:COG0362  321 DLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALKK 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489719289 391 NLPALRAVVKLATEAGVPTPSFSAALNYLESIFNPSLPANMIQAQRDYFGAHTYYRNDREGVYHTEW 457
Cdd:COG0362  401 AQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFFHTEW 467
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 3-459 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 588.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289    3 QFGVIGLSVMGKNLALNVRNHGFSVSGFSIDKPEVDA-LAKYEDDK-LKPCYTWEEFVDSLEKPRKILVQIMAGDPVDQT 80
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEfLAEEAKGKsIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289   81 IQKLIPLLDKGDIIIDGGNSNFHDTNRRYHELKKHGLHFIGMGVSGGEEGALNGPALMPGGDKEAYEEAAPILTAMAAKT 160
Cdd:TIGR00873  81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  161 eDGRACVSYIGPEGAGHYVKMVHNGMEYAIMQEISEVYDIMRKVAHKSNKEMADIFAEWDKGDLNAYLIEIASQVLRQKD 240
Cdd:TIGR00873 161 -DGEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  241 DLTDDDVIDhILNVASYKGTGNWMLEDAIKLGAPITVVAEAVLARFMS------KATTRE--GKEVVYDGEVASDLIDNL 312
Cdd:TIGR00873 240 EDGNPLVDK-ILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSslkeerVAASKVlpGPEAPKKGVDKEEFIEDV 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  313 GKAMYLAQIVAYAQGFQQLTMAAKAYDWELNYPAIAQNWEAGCIIHAKTLYHIEDAYADGKQLDNLFQDPYFAGVMEKNL 392
Cdd:TIGR00873 319 RQALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQ 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489719289  393 PALRAVVKLATEAGVPTPSFSAALNYLESIFNPSLPANMIQAQRDYFGAHTYYRNDREG--VYHTEWYE 459
Cdd:TIGR00873 399 SGWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNWTG 467
PTZ00142 PTZ00142
6-phosphogluconate dehydrogenase; Provisional
 1-457 1.43e-178

6-phosphogluconate dehydrogenase; Provisional


Pssm-ID: 240287 [Multi-domain]  Cd Length: 470  Bit Score: 508.17  E-value: 1.43e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289   1 MQQFGVIGLSVMGKNLALNVRNHGFSVSGFSIDKPEVD---ALAKYEDDKLKPCYTWEEFVDSLEKPRKILVQIMAGDPV 77
Cdd:PTZ00142   1 MSDIGLIGLAVMGQNLALNIASRGFKISVYNRTYEKTEefvKKAKEGNTRVKGYHTLEELVNSLKKPRKVILLIKAGEAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  78 DQTIQKLIPLLDKGDIIIDGGNSNFHDTNRRYHELKKHGLHFIGMGVSGGEEGALNGPALMPGGDKEAYEEAAPILTAMA 157
Cdd:PTZ00142  81 DETIDNLLPLLEKGDIIIDGGNEWYLNTERRIKRCEEKGILYLGMGVSGGEEGARYGPSLMPGGNKEAYDHVKDILEKCS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 158 AKTEDgRACVSYIGPEGAGHYVKMVHNGMEYAIMQEISEVYDIMRKVAHKSNKEMADIFAEWDKGDLNAYLIEIASQVLR 237
Cdd:PTZ00142 161 AKVGD-SPCVTYVGPGSSGHYVKMVHNGIEYGDMQLISESYKLMKHILGMSNEELSEVFNKWNEGILNSYLIEITAKILA 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 238 QKDDLTDDDVIDHILNVASYKGTGNWMLEDAIKLGAPITVVAEAVLARFMS----------KATTREGKEVVYDGEVASD 307
Cdd:PTZ00142 240 KKDDLGEEHLVDKILDIAGSKGTGKWTVQEALERGIPVPTMAASVDARNISalkeertkasSHLAGPNPANKTETEDKKY 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 308 LIDNLGKAMYLAQIVAYAQGFQQLTMAAKAYDWELNYPAIAQNWEAGCIIHAKTLYHIEDAYADGKQLDNLFQDPYFAGV 387
Cdd:PTZ00142 320 FIDDLKNALYCSKIISYTQGFFLIKEASKEFGWNLNLGEIARIWRGGCIIRAVFLDRIKNAFKKNPQLDLLFLDPDFNDE 399

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 388 MEKNLPALRAVVKLATEAGVPTPSFSAALNYLESIFNPSLPANMIQAQRDYFGAHTYYRNDREGVYHTEW 457
Cdd:PTZ00142 400 LKNKQPSWRKVVSMATKNGIPTPAFSASLAYYQMYRSQNLPANLVQAQRDYFGAHTYKRLDRPGAFHTNW 469
PLN02350 PLN02350
phosphogluconate dehydrogenase (decarboxylating)
 5-459 1.47e-166

phosphogluconate dehydrogenase (decarboxylating)


Pssm-ID: 215200 [Multi-domain]  Cd Length: 493  Bit Score: 478.44  E-value: 1.47e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289   5 GVIGLSVMGKNLALNVRNHGFSVSGFSIDKPEVDAL---AKYE-DDKLKPCYTWEEFVDSLEKPRKILVQIMAGDPVDQT 80
Cdd:PLN02350  10 GLAGLAVMGQNLALNIAEKGFPISVYNRTTSKVDETverAKKEgNLPLYGFKDPEDFVLSIQKPRSVIILVKAGAPVDQT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  81 IQKLIPLLDKGDIIIDGGNSNFHDTNRRYHELKKHGLHFIGMGVSGGEEGALNGPALMPGGDKEAYEEAAPILTAMAAKT 160
Cdd:PLN02350  90 IKALSEYMEPGDCIIDGGNEWYENTERRIKEAAEKGLLYLGMGVSGGEEGARNGPSLMPGGSFEAYKNIEDILEKVAAQV 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 161 EDGrACVSYIGPEGAGHYVKMVHNGMEYAIMQEISEVYDIMRKVAHKSNKEMADIFAEWDKGDLNAYLIEIASQVLRQKD 240
Cdd:PLN02350 170 DDG-PCVTYIGPGGAGNFVKMVHNGIEYGDMQLISEAYDVLKSVGGLSNEELAEVFAEWNKGELESFLIEITADIFSVKD 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 241 DLTDDDVIDHILNVASYKGTGNWMLEDAIKLGAPITVVAEAVLARFMS-KATTREGKEVVYDGEVASD------------ 307
Cdd:PLN02350 249 DKGDGYLVDKILDKTGMKGTGKWTVQQAAELSVAAPTIAASLDARYLSgLKEERVAAAKVFKEAGLEDilsadsgvdkkq 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 308 LIDNLGKAMYLAQIVAYAQGFQQLTMAAKAYDWELNYPAIAQNWEAGCIIHAKTLYHIEDAYADGKQLDNLFQDPYFAGV 387
Cdd:PLN02350 329 LIDDVRQALYASKICSYAQGMNLIRAKSVEKGWNLNLGELARIWKGGCIIRAVFLDRIKKAYDRNPDLASLLVDPEFAKE 408

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489719289 388 MEKNLPALRAVVKLATEAGVPTPSFSAALNYLESIFNPSLPANMIQAQRDYFGAHTYYRNDREGVYHTEWYE 459
Cdd:PLN02350 409 MVERQAAWRRVVSLAINAGISTPGMSASLAYFDTYRRARLPANLVQAQRDYFGAHTYERVDRPGSFHTEWTK 480
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 176-457 3.96e-145

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 416.08  E-value: 3.96e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  176 GHYVKMVHNGMEYAIMQEISEVYDIMRKVAHKSNKEMADIFAEWDKGDLNAYLIEIASQVLRQKDDLTDDDVIDHILNVA 255
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDPEDGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  256 SYKGTGNWMLEDAIKLGAPITVVAEAVLARFMSKATT-RE-------GKEVVYDGEVASDLIDNLGKAMYLAQIVAYAQG 327
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDeRVaaskvlpGPPPALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  328 FQQLTMAAKAYDWELNYPAIAQNWEAGCIIHAKTLYHIEDAYADGKQLDNLFQDPYFAGVMEKNLPALRAVVKLATEAGV 407
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 489719289  408 PTPSFSAALNYLESIFNPSLPANMIQAQRDYFGAHTYYRNDREGVYHTEW 457
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEGFFHTEW 290
YqeC COG1023
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];
3-288 1.36e-88

6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];


Pssm-ID: 440646 [Multi-domain]  Cd Length: 300  Bit Score: 272.35  E-value: 1.36e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289   3 QFGVIGLSVMGKNLALNVRNHGFSVSGFSIDKPEVDALAKyedDKLKPCYTWEEFVDSLEKPRKILVQIMAGDPVDQTIQ 82
Cdd:COG1023    2 QIGMIGLGKMGGNMARRLLRHGHEVVGYDRNPEAVAALAA---EGATGADSLEELVAKLPAPRVVWLMVPAGEITDQVIE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  83 KLIPLLDKGDIIIDGGNSNFHDTNRRYHELKKHGLHFIGMGVSGGEEGALNGPALMPGGDKEAYEEAAPILTAMAAKTED 162
Cdd:COG1023   79 ELAPLLEPGDIVIDGGNSNYKDDIRRAEELAEKGIHFVDVGTSGGVWGLENGYCLMIGGDKEAVERLEPIFKALAPGAEN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 163 GRAcvsYIGPEGAGHYVKMVHNGMEYAIMQEISEVYDIMRKVahKSNKEMADIFAEWDKGD-LNAYLIEIASQVLRQkdd 241
Cdd:COG1023  159 GYL---HCGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEAS--EFDLDLAEVAEVWRRGSvIRSWLLDLTADALAE--- 230

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 489719289 242 ltdddvIDHILNVASY---KGTGNWMLEDAIKLGAPITVVAEAVLARFMS 288
Cdd:COG1023  231 ------DPKLEGISGYvedSGEGRWTVEEAIELGVPAPVITAALFARFRS 274
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
3-288 3.09e-87

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 268.54  E-value: 3.09e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289   3 QFGVIGLSVMGKNLALNVRNHGFSVSGFSIDKPEVDALAKYEddkLKPCYTWEEFVDSLEKPRKILVQIMAGDPVDQTIQ 82
Cdd:PRK09599   2 QLGMIGLGRMGGNMARRLLRGGHEVVGYDRNPEAVEALAEEG---ATGADSLEELVAKLPAPRVVWLMVPAGEITDATID 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  83 KLIPLLDKGDIIIDGGNSNFHDTNRRYHELKKHGLHFIGMGVSGGEEGALNGPALMPGGDKEAYEEAAPILTAMAAKTED 162
Cdd:PRK09599  79 ELAPLLSPGDIVIDGGNSYYKDDIRRAELLAEKGIHFVDVGTSGGVWGLERGYCLMIGGDKEAVERLEPIFKALAPRAED 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289 163 GracVSYIGPEGAGHYVKMVHNGMEYAIMQEISEVYDIMRkvAHKSNKEMADIFAEWDKGD-LNAYLIEIASQVLRQKDd 241
Cdd:PRK09599 159 G---YLHAGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLE--ASRFDLDLAAVAEVWRRGSvIRSWLLDLTADALAEDP- 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489719289 242 ltdddvidhilNVASYK------GTGNWMLEDAIKLGAPITVVAEAVLARFMS 288
Cdd:PRK09599 233 -----------KLDEISgyvedsGEGRWTVEEAIDLAVPAPVIAAALFMRFRS 274
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 3-171 2.99e-60

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 194.23  E-value: 2.99e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289    3 QFGVIGLSVMGKNLALNVRNHGFSVSGFSIDKPEVDALAKYEddkLKPCYTWEEFVDSLekpRKILVQIMAGDPVDQTIQ 82
Cdd:pfam03446   1 KIGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEKVEELVAAG---AIAAASPAEFVAGL---DVVITMVPAGAAVDAVIF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289   83 K--LIPLLDKGDIIIDGGNSNFHDTNRRYHELKKHGLHFIGMGVSGGEEGALNGP-ALMPGGDKEAYEEAAPILTAMAak 159
Cdd:pfam03446  75 GegLLPGLKPGDIIIDGSTSSPEDARRRAKELKEKGLHFLDAPVSGGEAGAENGTlSIMVGGDEEAFERVKPILEAMG-- 152

                         170
                  ....*....|..
gi 489719289  160 tedgrACVSYIG 171
Cdd:pfam03446 153 -----ACVTYIG 159
gnd_rel TIGR00872
6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) ...
 3-289 3.18e-54

6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) of bacterial and eukaryotic 6-phosphogluconate dehydrogenases but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle. In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273313 [Multi-domain]  Cd Length: 298  Bit Score: 183.12  E-value: 3.18e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289    3 QFGVIGLSVMGKNLALNVRNHGFSVSGFSIDKPEVDALAKYEDDKLKPCYtweEFVDSLEKPRKILVQIMAGdPVDQTIQ 82
Cdd:TIGR00872   2 QLGLIGLGRMGANIVRRLAKRGHDCVGYDHDQDAVKAMKEDRTTGVANLR---ELSQRLSAPRVVWVMVPHG-IVDAVLE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289   83 KLIPLLDKGDIIIDGGNSNFHDTNRRYHELKKHGLHFIGMGVSGGEEGALNGPALMPGGDKEAYEEAAPILTAMAAKtED 162
Cdd:TIGR00872  78 ELAPTLEKGDIVIDGGNSYYKDSLRRYKLLKEKGIHLLDCGTSGGVWGRERGYCFMIGGDGEAFARAEPLFADVAPE-EQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  163 GRAcvsYIGPEGAGHYVKMVHNGMEYAIMQEISEVYDIMRKVAHKSN-KEMADIfaeWDKGD-LNAYLIEIASQVLRQkd 240
Cdd:TIGR00872 157 GYL---YCGPCGSGHFVKMVHNGIEYGMMAAIAEGFEILRNSQFDFDiPEVARV---WRRGSvIRSWLLDLTAIAFRE-- 228

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 489719289  241 dltdDDVIDHILNVASYKGTGNWMLEDAIKLGAPITVVAEAVLARFMSK 289
Cdd:TIGR00872 229 ----SPDLAEFSGRVSDSGEGRWTVIAAIDLGVPAPVIATSLQSRFASR 273
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 1-196 1.07e-22

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 97.49  E-value: 1.07e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289   1 MQQFGVIGLSVMGKNLALNVRNHGFSVSGFSIDKPEVDALAkyeDDKLKPCYTWEEFVDSLEkprkiLVQIMAGDP--VD 78
Cdd:COG2084    1 MMKVGFIGLGAMGAPMARNLLKAGHEVTVWNRTPAKAEALV---AAGARVAASPAEAAAAAD-----VVITMLPDDaaVE 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  79 QTI---QKLIPLLDKGDIIIDGGNSNFHDTNRRYHELKKHGLHFIGMGVSGGEEGALNGP-ALMPGGDKEAYEEAAPILT 154
Cdd:COG2084   73 EVLlgeDGLLAALRPGAVVVDMSTISPETARELAAAAAARGVRYLDAPVSGGPAGAEAGTlTIMVGGDEAAFERARPVLE 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 489719289 155 AMAAKtedgracVSYIGPEGAGHYVKMVHNGMEYAIMQEISE 196
Cdd:COG2084  153 AMGKR-------IVHVGDAGAGQAAKLANNLLLAGTMAALAE 187
garR PRK11559
tartronate semialdehyde reductase; Provisional
 1-181 2.75e-13

tartronate semialdehyde reductase; Provisional


Pssm-ID: 183197 [Multi-domain]  Cd Length: 296  Bit Score: 70.08  E-value: 2.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289   1 MQQFGVIGLSVMGKNLALNVRNHGFSVSGFSIDKPEVDALAKYEDDKLKPCYTWEEFVDslekprkILVQIMAGDPVDQT 80
Cdd:PRK11559   2 TMKVGFIGLGIMGKPMSKNLLKAGYSLVVYDRNPEAVAEVIAAGAETASTAKAVAEQCD-------VIITMLPNSPHVKE 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  81 I----QKLIPLLDKGDIIIDggNSNFHDTNRR--YHELKKHGLHFIGMGVSGGEEGALNGP-ALMPGGDKEAYEEAAPIL 153
Cdd:PRK11559  75 ValgeNGIIEGAKPGTVVID--MSSIAPLASReiAAALKAKGIEMLDAPVSGGEPKAIDGTlSVMVGGDKAIFDKYYDLM 152

                        170       180
                 ....*....|....*....|....*...
gi 489719289 154 TAMAAKtedgracVSYIGPEGAGHYVKM 181
Cdd:PRK11559 153 KAMAGS-------VVHTGDIGAGNVTKL 173
PRK15461 PRK15461
sulfolactaldehyde 3-reductase;
1-190 4.35e-07

sulfolactaldehyde 3-reductase;


Pssm-ID: 185358 [Multi-domain]  Cd Length: 296  Bit Score: 51.40  E-value: 4.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289   1 MQQFGVIGLSVMGKNLALNVRNHGFSVSGFSIDKPEVDALAkyeDDKLKPCYTWEEFVDSLEkprKILVQIMAGDPVDQT 80
Cdd:PRK15461   1 MAAIAFIGLGQMGSPMASNLLKQGHQLQVFDVNPQAVDALV---DKGATPAASPAQAAAGAE---FVITMLPNGDLVRSV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  81 I---QKLIPLLDKGDIIIDGGNSNFHDTNRRYHELKKHGLHFIGMGVSGGEEGALNGPAL-MPGGDKEAYEEAAPILTAM 156
Cdd:PRK15461  75 LfgeNGVCEGLSRDALVIDMSTIHPLQTDKLIADMQAKGFSMMDVPVGRTSDNAITGTLLlLAGGTAEQVERATPILMAM 154

                        170       180       190
                 ....*....|....*....|....*....|....
gi 489719289 157 aaktedGRACVSYIGPeGAGHYVKMVHNGMEYAI 190
Cdd:PRK15461 155 ------GNELINAGGP-GMGIRVKLINNYMSIAL 181
PLN02858 PLN02858
fructose-bisphosphate aldolase
 2-183 1.68e-06

fructose-bisphosphate aldolase


Pssm-ID: 215463 [Multi-domain]  Cd Length: 1378  Bit Score: 50.62  E-value: 1.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289    2 QQFGVIGLSVMGKNLALNVRNHGFSVSGFSIDKPevdALAKYEDDKLKPCYTWEEfvdsLEKPRKILVQIMAGDpvDQTI 81
Cdd:PLN02858  325 KRIGFIGLGAMGFGMASHLLKSNFSVCGYDVYKP---TLVRFENAGGLAGNSPAE----VAKDVDVLVIMVANE--VQAE 395

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289   82 QKL------IPLLDKG-DIIIDGGNSNFHDTN-RRYHELKKHGLHFIGMGVSGGEEGALNGP-ALMPGGDKEAYEEAAPI 152
Cdd:PLN02858  396 NVLfgdlgaVSALPAGaSIVLSSTVSPGFVIQlERRLENEGRDIKLVDAPVSGGVKRAAMGTlTIMASGTDEALKSAGSV 475

                         170       180       190
                  ....*....|....*....|....*....|...
gi 489719289  153 LTAMAAKTedgracvsYI--GPEGAGHYVKMVH 183
Cdd:PLN02858  476 LSALSEKL--------YVikGGCGAGSGVKMVN 500
PRK15059 PRK15059
2-hydroxy-3-oxopropionate reductase;
3-196 1.63e-05

2-hydroxy-3-oxopropionate reductase;


Pssm-ID: 185019 [Multi-domain]  Cd Length: 292  Bit Score: 46.55  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289   3 QFGVIGLSVMGKNLALNVRNHGFSVSGFSIDkPEVDALAKYEDDKLKPCYTWEEFVDslekprkiLVQIMAGDP--VDQT 80
Cdd:PRK15059   2 KLGFIGLGIMGTPMAINLARAGHQLHVTTIG-PVADELLSLGAVSVETARQVTEASD--------IIFIMVPDTpqVEEV 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489719289  81 I---QKLIPLLDKGDIIIDGGNSNFHDTNRRYHELKKHGLHFIGMGVSGGEEGALNGP-ALMPGGDKEAYEEAAPILTAM 156
Cdd:PRK15059  73 LfgeNGCTKASLKGKTIVDMSSISPIETKRFARQVNELGGDYLDAPVSGGEIGAREGTlSIMVGGDEAVFERVKPLFELL 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 489719289 157 AAKtedgracVSYIGPEGAGHYVKMVHNGMEYAIMQEISE 196
Cdd:PRK15059 153 GKN-------ITLVGGNGDGQTCKVANQIIVALNIEAVSE 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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