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Conserved domains on  [gi|489737870|ref|WP_003641965|]
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MULTISPECIES: AraC family transcriptional regulator [Lactiplantibacillus]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 13303781)

helix-turn-helix domain-containing protein such as an AraC family transcriptional regulator, which controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_18 pfam12833
Helix-turn-helix domain;
199-278 7.98e-23

Helix-turn-helix domain;


:

Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 89.57  E-value: 7.98e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870  199 LAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLE-TDHKIEYIAMQCGFPNSKTFNRNFKSWKGMTPTDYRQ 277
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 489737870  278 A 278
Cdd:pfam12833  81 R 81
PRK13502 super family cl32883
HTH-type transcriptional activator RhaR;
30-277 1.26e-15

HTH-type transcriptional activator RhaR;


The actual alignment was detected with superfamily member PRK13502:

Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 75.09  E-value: 1.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870  30 APHWHQGIELNYLVSGTTLKfVTDGQTNEYRPGDLWTTNRRVVHSASGPTevDWVEFGIIidddFLQTQIPASANWQLTL 109
Cdd:PRK13502  32 AEHTHEFCELVMVWRGNGLH-VLNERPYRITRGDLFYIRAEDKHSYTSVN--DLVLQNII----YCPERLKLNVNWQAMI 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 110 NGAASSKTHPQ------AYADVRQQLVTI-HDLLTTPTTDLLRLQILshFYQLLVTLgQTFTVPLTATTVSPNLTLTDTV 182
Cdd:PRK13502 105 PGFQGAQWHPHwrlgsmGMNQARQVINQLeHESNGRDPLANEMAELL--FGQLVMTL-KRHRYATDDLPATSRETLLDKL 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 183 MTAINQHYAEPIDGNTLAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLETDHKIEYIAMQCGFPNSKTFNR 262
Cdd:PRK13502 182 ITALANSLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSV 261

                        250
                 ....*....|....*
gi 489737870 263 NFKSWKGMTPTDYRQ 277
Cdd:PRK13502 262 VFTRETGMTPSQWRH 276
 
Name Accession Description Interval E-value
HTH_18 pfam12833
Helix-turn-helix domain;
199-278 7.98e-23

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 89.57  E-value: 7.98e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870  199 LAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLE-TDHKIEYIAMQCGFPNSKTFNRNFKSWKGMTPTDYRQ 277
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 489737870  278 A 278
Cdd:pfam12833  81 R 81
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
199-276 8.26e-23

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 89.53  E-value: 8.26e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489737870   199 LAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLETDHKIEYIAMQCGFPNSKTFNRNFKSWKGMTPTDYR 276
Cdd:smart00342   7 LAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
199-281 2.23e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 93.31  E-value: 2.23e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 199 LAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLETDHKIEYIAMQCGFPNSKTFNRNFKSWKGMTPTDYRQA 278
Cdd:COG2207  174 LARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKR 253


                 ...
gi 489737870 279 YAR 281
Cdd:COG2207  254 LRA 256
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
152-277 8.71e-17

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 78.18  E-value: 8.71e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 152 FYQLLVTLGQ-TFTVPLTATTVSPNLtltdtVMTAINQHYAEPIDGNTLAEQFHVSLTTLNQQFNANVQLSVNRYLRLIR 230
Cdd:PRK13503 150 FMQLLVLLRKsSLQENGENSDARLNQ-----LLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLR 224

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 489737870 231 LMNARRLLLETDHKIEYIAMQCGFPNSKTFNRNFKSWKGMTPTDYRQ 277
Cdd:PRK13503 225 LLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPRDIRQ 271
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
30-277 1.26e-15

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 75.09  E-value: 1.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870  30 APHWHQGIELNYLVSGTTLKfVTDGQTNEYRPGDLWTTNRRVVHSASGPTevDWVEFGIIidddFLQTQIPASANWQLTL 109
Cdd:PRK13502  32 AEHTHEFCELVMVWRGNGLH-VLNERPYRITRGDLFYIRAEDKHSYTSVN--DLVLQNII----YCPERLKLNVNWQAMI 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 110 NGAASSKTHPQ------AYADVRQQLVTI-HDLLTTPTTDLLRLQILshFYQLLVTLgQTFTVPLTATTVSPNLTLTDTV 182
Cdd:PRK13502 105 PGFQGAQWHPHwrlgsmGMNQARQVINQLeHESNGRDPLANEMAELL--FGQLVMTL-KRHRYATDDLPATSRETLLDKL 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 183 MTAINQHYAEPIDGNTLAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLETDHKIEYIAMQCGFPNSKTFNR 262
Cdd:PRK13502 182 ITALANSLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSV 261

                        250
                 ....*....|....*
gi 489737870 263 NFKSWKGMTPTDYRQ 277
Cdd:PRK13502 262 VFTRETGMTPSQWRH 276
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
29-74 7.52e-06

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 43.68  E-value: 7.52e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 489737870  29 VAPHWHQGIELNYLVSGTtLKFVTDGQTNEYRPGDLWTTNRRVVHS 74
Cdd:COG1917   36 TPWHSHPGEELIYVLEGE-GEVEVGGEEYELKPGDVVFIPPGVPHA 80
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 31-73 1.93e-04

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 39.16  E-value: 1.93e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 489737870   31 PHWHQG-IELNYLVSGTtLKFVTDGQTNEYRPGDLWTTNRRVVH 73
Cdd:pfam07883  13 PHRHPGeDEFFYVLEGE-GELTVDGEEVVLKAGDSVYFPAGVPH 55
cupin_OxDC_N cd20304
Oxalate decarboxylase (OxDC), N-terminal cupin domain; This model represents the N-terminal ...
 32-92 4.62e-04

Oxalate decarboxylase (OxDC), N-terminal cupin domain; This model represents the N-terminal cupin domain of oxalate decarboxylase (OxDC; EC 4.1.1.2), a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues. Members of this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380438  Cd Length: 155  Bit Score: 39.90  E-value: 4.62e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489737870  32 HWHQGIELNYLVSGTTLKFVTD--GQT--NEYRPGDLWTTNRRVVHSASGpTEVDWVEFGIIIDD 92
Cdd:cd20304   47 HWHAAAEWAYVLSGRCRITAVDpeGRSfiDDVGPGDLWYFPRGHPHSIQG-LGPDGCEFLLVFDD 110
 
Name Accession Description Interval E-value
HTH_18 pfam12833
Helix-turn-helix domain;
199-278 7.98e-23

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 89.57  E-value: 7.98e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870  199 LAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLE-TDHKIEYIAMQCGFPNSKTFNRNFKSWKGMTPTDYRQ 277
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 489737870  278 A 278
Cdd:pfam12833  81 R 81
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
199-276 8.26e-23

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 89.53  E-value: 8.26e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489737870   199 LAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLETDHKIEYIAMQCGFPNSKTFNRNFKSWKGMTPTDYR 276
Cdd:smart00342   7 LAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
199-281 2.23e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 93.31  E-value: 2.23e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 199 LAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLETDHKIEYIAMQCGFPNSKTFNRNFKSWKGMTPTDYRQA 278
Cdd:COG2207  174 LARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKR 253


                 ...
gi 489737870 279 YAR 281
Cdd:COG2207  254 LRA 256
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 182-281 6.79e-22

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 93.30  E-value: 6.79e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 182 VMTAINQHYAEPIDGNTLAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLETDHKIEYIAMQCGFPNSKTFN 261
Cdd:COG4977  215 AQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHFR 294

                         90       100
                 ....*....|....*....|
gi 489737870 262 RNFKSWKGMTPTDYRQAYAR 281
Cdd:COG4977  295 RAFRRRFGVSPSAYRRRFRA 314
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
152-277 8.71e-17

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 78.18  E-value: 8.71e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 152 FYQLLVTLGQ-TFTVPLTATTVSPNLtltdtVMTAINQHYAEPIDGNTLAEQFHVSLTTLNQQFNANVQLSVNRYLRLIR 230
Cdd:PRK13503 150 FMQLLVLLRKsSLQENGENSDARLNQ-----LLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLR 224

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 489737870 231 LMNARRLLLETDHKIEYIAMQCGFPNSKTFNRNFKSWKGMTPTDYRQ 277
Cdd:PRK13503 225 LLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPRDIRQ 271
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 166-289 5.48e-16

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 77.02  E-value: 5.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 166 PLTATTVSPNLTLTDTVMTAINQHYAEPIDGNTLAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRlLLETDHKI 245
Cdd:COG2169   73 PDLAPGSPPRADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQ-LLQTGLSV 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 489737870 246 EYIAMQCGFPNSKTFNRNFKSWKGMTPTDYRQAYA--RYHRIDTSC 289
Cdd:COG2169  152 TDAAYAAGFGSLSRFYEAFKKLLGMTPSAYRRGGAgaAIRFAPTPC 197
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
30-277 1.26e-15

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 75.09  E-value: 1.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870  30 APHWHQGIELNYLVSGTTLKfVTDGQTNEYRPGDLWTTNRRVVHSASGPTevDWVEFGIIidddFLQTQIPASANWQLTL 109
Cdd:PRK13502  32 AEHTHEFCELVMVWRGNGLH-VLNERPYRITRGDLFYIRAEDKHSYTSVN--DLVLQNII----YCPERLKLNVNWQAMI 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 110 NGAASSKTHPQ------AYADVRQQLVTI-HDLLTTPTTDLLRLQILshFYQLLVTLgQTFTVPLTATTVSPNLTLTDTV 182
Cdd:PRK13502 105 PGFQGAQWHPHwrlgsmGMNQARQVINQLeHESNGRDPLANEMAELL--FGQLVMTL-KRHRYATDDLPATSRETLLDKL 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 183 MTAINQHYAEPIDGNTLAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLETDHKIEYIAMQCGFPNSKTFNR 262
Cdd:PRK13502 182 ITALANSLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSV 261

                        250
                 ....*....|....*
gi 489737870 263 NFKSWKGMTPTDYRQ 277
Cdd:PRK13502 262 VFTRETGMTPSQWRH 276
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
180-281 3.03e-15

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 74.17  E-value: 3.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 180 DTVMTAINQHYAEPIDGNTLAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLETDHKIEYIAMQCGFPNSKT 259
Cdd:PRK13501 179 DLIMSALQQSLGAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNY 258

                         90       100
                 ....*....|....*....|..
gi 489737870 260 FNRNFKSWKGMTPTDYRQAYAR 281
Cdd:PRK13501 259 FSAVFTREAGMTPRDYRQRFIR 280
ftrA PRK09393
transcriptional activator FtrA; Provisional
 182-281 2.07e-10

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 60.36  E-value: 2.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 182 VMTAINQHYAEPIDGNTLAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLETDHKIEYIAMQCGFPNSKTFN 261
Cdd:PRK09393 223 LIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESLR 302

                         90       100
                 ....*....|....*....|
gi 489737870 262 RNFKSWKGMTPTDYRQAYAR 281
Cdd:PRK09393 303 HHFRRRAATSPAAYRKRFGR 322
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
30-277 7.88e-10

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 58.57  E-value: 7.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870  30 APHWHQGIELNYLVSGTTLKFVTDGQTNEYRpGDLWTTNRRVVHSASGPTevDWVEFGIIidddFLQTQIPASANWQLTL 109
Cdd:PRK13500  62 AEHTHDFCELVIVWRGNGLHVLNDRPYRITR-GDLFYIHADDKHSYASVN--DLVLQNII----YCPERLKLNLDWQGAI 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 110 NGAASSKTHPQ------AYADVRQQLVTI-HDLLTTPTTDLLRLQILshFYQLLVTLGQ----TFTVPLTATTvspnlTL 178
Cdd:PRK13500 135 PGFSASAGQPHwrlgsvGMAQARQVIGQLeHESSQHVPFANEMAELL--FGQLVMLLNRhrytSDSLPPTSSE-----TL 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 179 TDTVMTAINQHYAEPIDGNTLAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLETDHKIEYIAMQCGFPNSK 258
Cdd:PRK13500 208 LDKLITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSN 287

                        250
                 ....*....|....*....
gi 489737870 259 TFNRNFKSWKGMTPTDYRQ 277
Cdd:PRK13500 288 YFSVVFTRETGMTPSQWRH 306
PRK10371 PRK10371
transcriptional regulator MelR;
181-278 8.52e-09

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 55.60  E-value: 8.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 181 TVMTAINQHYAEPIDGNTLAEqfHVSLTTLNQQ--FNANVQLSVNRYLRLIRLMNARRLLLETDHKIEYIAMQCGFPNSK 258
Cdd:PRK10371 195 QMLGFIAENYDQALTINDVAE--HVKLNANYAMgiFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSS 272

                         90       100
                 ....*....|....*....|
gi 489737870 259 TFNRNFKSWKGMTPTDYRQA 278
Cdd:PRK10371 273 RFYSTFGKYVGMSPQQYRKL 292
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
181-278 8.40e-08

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 49.54  E-value: 8.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 181 TVMTAINQHYAEPIDGNTLAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLETDHKIEYIAMQCGFPNSKTF 260
Cdd:PRK10219   9 TLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTF 88

                         90
                 ....*....|....*...
gi 489737870 261 NRNFKSWKGMTPTDYRQA 278
Cdd:PRK10219  89 SRVFRRQFDRTPSDYRHR 106
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 152-283 3.39e-06

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 47.61  E-value: 3.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 152 FYQLLVTLGQTFTVPLTATTVSPNLTltDTVMTAINQHYAEPIDGNTLAEQFHVSLTTLNQQFNANvQLSVNRYLRLIRL 231
Cdd:PRK09978 119 FALLSVFLEDEHFIPLLLNVLQPNMR--TRVCTVINNNIAHEWTLARIASELLMSPSLLKKKLREE-ETSYSQLLTECRM 195

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489737870 232 MNARRLLLETDHKIEYIAMQCGFPNSKTFNRNFKSWKGMTPTDYRQAYARYH 283
Cdd:PRK09978 196 QRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQERSAQGL 247
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
29-74 7.52e-06

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 43.68  E-value: 7.52e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 489737870  29 VAPHWHQGIELNYLVSGTtLKFVTDGQTNEYRPGDLWTTNRRVVHS 74
Cdd:COG1917   36 TPWHSHPGEELIYVLEGE-GEVEVGGEEYELKPGDVVFIPPGVPHA 80
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
181-283 9.59e-06

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 46.12  E-value: 9.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 181 TVMTAINQHYAEPIDGNTLAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLETDHKIEYIAMQCGFPNSKTF 260
Cdd:PRK10572 187 EACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYF 266

                         90       100
                 ....*....|....*....|...
gi 489737870 261 NRNFKSWKGMTPTDYRQAYARYH 283
Cdd:PRK10572 267 SRVFKKCTGASPSEFRARCEEKN 289
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 182-280 2.06e-05

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 45.02  E-value: 2.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 182 VMTAINQHYAEP-IDGNTLAEQFHVSLTTLNQQFnANVQLSVNRYLRLIRLM---NARRLLLEtDHKIEYIAMQCGFPNS 257
Cdd:PRK09685 202 VVALIDQSIQEEiLRPEWIAGELGISVRSLYRLF-AEQGLVVAQYIRNRRLDrcaDDLRPAAD-DEKITSIAYKWGFSDS 279

                         90       100
                 ....*....|....*....|...
gi 489737870 258 KTFNRNFKSWKGMTPTDYRQAYA 280
Cdd:PRK09685 280 SHFSTAFKQRFGVSPGEYRRKFR 302
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
181-276 7.51e-05

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 41.63  E-value: 7.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 181 TVMTAINQHYAEPIDGNTLAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLLETDHKIEYIAMQCGFPNSKTF 260
Cdd:PRK11511  13 SILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTL 92

                         90
                 ....*....|....*.
gi 489737870 261 NRNFKSWKGMTPTDYR 276
Cdd:PRK11511  93 TRTFKNYFDVPPHKYR 108
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 31-73 1.93e-04

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 39.16  E-value: 1.93e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 489737870   31 PHWHQG-IELNYLVSGTtLKFVTDGQTNEYRPGDLWTTNRRVVH 73
Cdd:pfam07883  13 PHRHPGeDEFFYVLEGE-GELTVDGEEVVLKAGDSVYFPAGVPH 55
PRK10130 PRK10130
HTH-type transcriptional regulator EutR;
191-280 2.01e-04

HTH-type transcriptional regulator EutR;


Pssm-ID: 182258 [Multi-domain]  Cd Length: 350  Bit Score: 42.21  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870 191 AEPIDGNTLAEQFHVSLTTLNQQFNANVQLSVNRYLRLIRLMNARRLLL---ETDHKIEYIAMQCGFpnsktfnrnfksW 267
Cdd:PRK10130 254 SEPVTVLDLCNQLHVSRRTLQNAFHAILGIGPNAWLKRIRLNAVRRELIspwSQSTTVKDAAMQWGF------------W 321

                         90
                 ....*....|....
gi 489737870 268 K-GMTPTDYRQAYA 280
Cdd:PRK10130 322 HlGQFATDYQQLFA 335
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 244-277 4.20e-04

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 37.13  E-value: 4.20e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 489737870  244 KIEYIAMQCGFpNSKTFNRNFKSWKGMTPTDYRQ 277
Cdd:pfam00165  10 TIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
cupin_OxDC_N cd20304
Oxalate decarboxylase (OxDC), N-terminal cupin domain; This model represents the N-terminal ...
 32-92 4.62e-04

Oxalate decarboxylase (OxDC), N-terminal cupin domain; This model represents the N-terminal cupin domain of oxalate decarboxylase (OxDC; EC 4.1.1.2), a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues. Members of this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380438  Cd Length: 155  Bit Score: 39.90  E-value: 4.62e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489737870  32 HWHQGIELNYLVSGTTLKFVTD--GQT--NEYRPGDLWTTNRRVVHSASGpTEVDWVEFGIIIDD 92
Cdd:cd20304   47 HWHAAAEWAYVLSGRCRITAVDpeGRSfiDDVGPGDLWYFPRGHPHSIQG-LGPDGCEFLLVFDD 110
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 18-156 5.23e-04

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 39.34  E-value: 5.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870   18 YYEHDPLTDINVAPHWHQGIELNYLVSGtTLKFVTDGQTNEYRPGDLWTTNRRVVHSASGPTEVDWVEFGIIIDDDFLQt 97
Cdd:pfam02311   5 EGIEARYPGHSFPPHVHDFYVIGYIERG-VGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPELLE- 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 489737870   98 QIPASANWQltlngaASSKTHPQAYADVRQQLVTIHdLLTTPTTDLLRLQILSHFYQLL 156
Cdd:pfam02311  83 RILADISIL------AGGPLPLLRDPELAALLRALF-RLLEEAGRSDDLLAEALLYQLL 134
cupin_BLL4011-like cd02235
Bradyrhizobium diazoefficiens BLL4011 and related proteins, cupin domain; This family includes ...
 5-81 8.22e-04

Bradyrhizobium diazoefficiens BLL4011 and related proteins, cupin domain; This family includes bacterial and fungal proteins homologous to BLL4011, a Bradyrhizobium diazoefficiens protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380363 [Multi-domain]  Cd Length: 100  Bit Score: 37.94  E-value: 8.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489737870   5 HETVQTIPRLPfkyyehdPltDINVAPHWHQGIELNYLVSGtTLKFVTDGQ-TNEYRPGDLWTTNRRVVHSA----SGPT 79
Cdd:cd02235   17 REVVQVRVEIP-------P--GAVAGRHTHPGEESGYVLEG-SLELEVDGQpPVTLKAGDSFFIPAGTVHNAknvgSGPA 86


                 ..
gi 489737870  80 EV 81
Cdd:cd02235   87 KL 88
OxdD COG2140
Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate ...
 31-94 1.84e-03

Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate transport and metabolism]; Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 441743 [Multi-domain]  Cd Length: 115  Bit Score: 37.25  E-value: 1.84e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489737870  31 PHWH-QGIELNYLVSG----TTLKFVTDGQTNEYRPGDLWTTNRRVVHSASGPTEVDwVEFGIIIDDDF 94
Cdd:COG2140   18 EHWHpNAAEWYYVLSGearmTVQDPPGRARTVDVGPGDVVYVPPGYGHYIINTGDEP-LVFLAVFDDDA 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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