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Conserved domains on  [gi|489739500|ref|WP_003643584|]
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MULTISPECIES: LytTR family DNA-binding domain-containing protein [Lactiplantibacillus]

Protein Classification

LytR/AlgR family response regulator transcription factor( domain architecture ID 11461715)

LytR/AlgR family response regulator transcription factor with a signal receiver (REC) and a DNA-binding domain may be part of a two-component regulatory system

CATH:  3.40.50.2300|2.40.50.1020
Gene Ontology:  GO:0000160|GO:0000156|GO:0003677
PubMed:  11557134|27013338|18462668|31100988|20226724|16740923|12034833
SCOP:  4003632|4004734

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-232 1.21e-45

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 152.28  E-value: 1.21e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   1 MISVYICEDDPKQLQQIRQIITKVivdqqLDMSICLACQDPHELLDKVNAQQPQkaIYVLDIALnSDINGIQLASQIRDM 80
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEKY-----PDLEVVGEASNGEEALELLEEHKPD--LVFLDIQM-PGLDGFELARQLREL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500  81 GRRSKIIFITTHTELSLMVFQyqVEALDFILKDFPdslYERFSKVLHVAQDRFQ-----TDENDQDDYVQIKIGETVRSI 155
Cdd:COG3279   73 DPPPPIIFTTAYDEYALEAFE--VNAVDYLLKPID---EERLAKALEKAKERLEakaaaEASPEEKDRIFVKSGGKLVKI 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500 156 NVKSIIFFESStsPHKIVVHLDDGELEYYGLLKDVPDL--SPNFYRCHKSYVVNLKRIKSLDKHLRR-LTMANGEKVLCS 232
Cdd:COG3279  148 PLDDILYIEAE--GNYVKIHTKDKKYLVRKTLKELEEKlpPKQFFRVHRSYIVNLDKIKEIEKNFNGeVVLKNGEEIPVS 225
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-232 1.21e-45

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 152.28  E-value: 1.21e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   1 MISVYICEDDPKQLQQIRQIITKVivdqqLDMSICLACQDPHELLDKVNAQQPQkaIYVLDIALnSDINGIQLASQIRDM 80
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEKY-----PDLEVVGEASNGEEALELLEEHKPD--LVFLDIQM-PGLDGFELARQLREL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500  81 GRRSKIIFITTHTELSLMVFQyqVEALDFILKDFPdslYERFSKVLHVAQDRFQ-----TDENDQDDYVQIKIGETVRSI 155
Cdd:COG3279   73 DPPPPIIFTTAYDEYALEAFE--VNAVDYLLKPID---EERLAKALEKAKERLEakaaaEASPEEKDRIFVKSGGKLVKI 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500 156 NVKSIIFFESStsPHKIVVHLDDGELEYYGLLKDVPDL--SPNFYRCHKSYVVNLKRIKSLDKHLRR-LTMANGEKVLCS 232
Cdd:COG3279  148 PLDDILYIEAE--GNYVKIHTKDKKYLVRKTLKELEEKlpPKQFFRVHRSYIVNLDKIKEIEKNFNGeVVLKNGEEIPVS 225
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 2-132 8.60e-25

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 95.38  E-value: 8.60e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   2 ISVYICEDDPKQLQQIRQIITKVIVDQQLDMSICLACQdPHELLDKVNAQQPQKaIYVLDIAL-NSDINGIQLASQIRDM 80
Cdd:cd17533    1 MNIFILEDDKIQRVRLEEIIENILKIENIEYVIELTGK-TEELLEKIKERGKNG-IYFLDIDIkMEEKNGLEVAQKIRKY 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489739500  81 GRRSKIIFITTHTELSLMVFQYQVEALDFILKDFPDSLYE-RFSKVLHVAQDR 132
Cdd:cd17533   79 DPYAIIIFVTTHSEFAPLTFEYKVAALDFILKPLKLEEFKkRIEECIKYAQKN 131
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-121 5.47e-16

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 71.41  E-value: 5.47e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500    4 VYICEDDPKQLQQIRQIItkvivdQQLDMSICLAcQDPHELLDKVNAQQPQkaIYVLDIALnSDINGIQLASQIRDMGRR 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLL------EKEGYVVAEA-DDGKEALELLKEERPD--LILLDINM-PGMDGLELLKRIRRRDPT 70

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 489739500   84 SKIIFITTHTELSLMVFQYQVEALDFILKDF-PDSLYER 121
Cdd:pfam00072  71 TPVIILTAHGDEDDAVEALEAGADDFLSKPFdPDELLAA 109
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 150-232 4.14e-15

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 68.76  E-value: 4.14e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   150 ETVRSINVKSIIFFESStsPHKIVVHLDDGELEYYGLLKDVPDLSP--NFYRCHKSYVVNLKRIKSLDKHLR---RLTMA 224
Cdd:smart00850   1 GRIVLIPLDDILYIEAE--GNYVTVHTKDGTYLVRGTLKELEERLDpdNFFRIHRSYIVNLDHIKEIEPWFNgtyLLILK 78


                   ....*...
gi 489739500   225 NGEKVLCS 232
Cdd:smart00850  79 NGEEVPVS 86
PRK14084 PRK14084
DNA-binding response regulator;
60-232 1.67e-10

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 59.38  E-value: 1.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500  60 LDIALnSDINGIQLASQIRDMGRRSKIIFITTHTELSLMVFqyQVEALDFILKDFPDslyERFSKVLH-VAQDRFQTDEN 138
Cdd:PRK14084  52 LDINL-MDESGIELAAKIQKMKEPPAIIFATAHDQFAVKAF--ELNATDYILKPFEQ---KRIEQAVNkVRATKAKDDNN 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500 139 DQ----------DDYVQIKIGETVRSINVKSIIFFESSTSPHKIVVHLDDGE----LEYYGllKDVPDlsPNFYRCHKSY 204
Cdd:PRK14084 126 ASaiandmsanfDQSLPIEIDDKIHMLNQQDIIAIGVHNGITTIHTTNHKYEttepLNRYE--KRLNP--TYFIRIHRSY 201

                        170       180       190
                 ....*....|....*....|....*....|.
gi 489739500 205 VVNLKRIKSLDK---HLRRLTMANGEKVLCS 232
Cdd:PRK14084 202 IINKKHIKEVEQwfnYTYQVILTNGVKMQVS 232
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-232 1.21e-45

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 152.28  E-value: 1.21e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   1 MISVYICEDDPKQLQQIRQIITKVivdqqLDMSICLACQDPHELLDKVNAQQPQkaIYVLDIALnSDINGIQLASQIRDM 80
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEKY-----PDLEVVGEASNGEEALELLEEHKPD--LVFLDIQM-PGLDGFELARQLREL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500  81 GRRSKIIFITTHTELSLMVFQyqVEALDFILKDFPdslYERFSKVLHVAQDRFQ-----TDENDQDDYVQIKIGETVRSI 155
Cdd:COG3279   73 DPPPPIIFTTAYDEYALEAFE--VNAVDYLLKPID---EERLAKALEKAKERLEakaaaEASPEEKDRIFVKSGGKLVKI 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500 156 NVKSIIFFESStsPHKIVVHLDDGELEYYGLLKDVPDL--SPNFYRCHKSYVVNLKRIKSLDKHLRR-LTMANGEKVLCS 232
Cdd:COG3279  148 PLDDILYIEAE--GNYVKIHTKDKKYLVRKTLKELEEKlpPKQFFRVHRSYIVNLDKIKEIEKNFNGeVVLKNGEEIPVS 225
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 2-132 8.60e-25

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 95.38  E-value: 8.60e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   2 ISVYICEDDPKQLQQIRQIITKVIVDQQLDMSICLACQdPHELLDKVNAQQPQKaIYVLDIAL-NSDINGIQLASQIRDM 80
Cdd:cd17533    1 MNIFILEDDKIQRVRLEEIIENILKIENIEYVIELTGK-TEELLEKIKERGKNG-IYFLDIDIkMEEKNGLEVAQKIRKY 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489739500  81 GRRSKIIFITTHTELSLMVFQYQVEALDFILKDFPDSLYE-RFSKVLHVAQDR 132
Cdd:cd17533   79 DPYAIIIFVTTHSEFAPLTFEYKVAALDFILKPLKLEEFKkRIEECIKYAQKN 131
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-121 5.47e-16

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 71.41  E-value: 5.47e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500    4 VYICEDDPKQLQQIRQIItkvivdQQLDMSICLAcQDPHELLDKVNAQQPQkaIYVLDIALnSDINGIQLASQIRDMGRR 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLL------EKEGYVVAEA-DDGKEALELLKEERPD--LILLDINM-PGMDGLELLKRIRRRDPT 70

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 489739500   84 SKIIFITTHTELSLMVFQYQVEALDFILKDF-PDSLYER 121
Cdd:pfam00072  71 TPVIILTAHGDEDDAVEALEAGADDFLSKPFdPDELLAA 109
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 155-243 3.19e-15

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 69.16  E-value: 3.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500  155 INVKSIIFFESStsPHKIVVHLDDGELEYYGLLKDVPDL--SPNFYRCHKSYVVNLKRIKSLDK---HLRRLTMANGEKV 229
Cdd:pfam04397   6 VPIDDILYIEAE--DKYVTIHTANGEYLTRGTLKELEEKlpPDGFFRCHRSYLVNLNKIKEIDPdfnGTYELTLKNGEKI 83

                          90
                  ....*....|....
gi 489739500  230 LCSAQANRYLAKWL 243
Cdd:pfam04397  84 PVSRRYLKELKELL 97
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 150-232 4.14e-15

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 68.76  E-value: 4.14e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   150 ETVRSINVKSIIFFESStsPHKIVVHLDDGELEYYGLLKDVPDLSP--NFYRCHKSYVVNLKRIKSLDKHLR---RLTMA 224
Cdd:smart00850   1 GRIVLIPLDDILYIEAE--GNYVTVHTKDGTYLVRGTLKELEERLDpdNFFRIHRSYIVNLDHIKEIEPWFNgtyLLILK 78


                   ....*...
gi 489739500   225 NGEKVLCS 232
Cdd:smart00850  79 NGEEVPVS 86
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 3-112 4.65e-12

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 60.56  E-value: 4.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   3 SVYICEDDPKQLQQIRQIItkvivDQQLDMSICLACQDPHELLDKVNAQQPqkaiyvlDIALnSDIN-----GIQLASQI 77
Cdd:COG4753    1 KVLIVDDEPLIREGLKRIL-----EWEAGFEVVGEAENGEEALELLEEHKP-------DLVI-TDINmpgmdGLELLEAI 67

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 489739500  78 RDMGRRSKIIFITTHTELSLMVFQYQVEALDFILK 112
Cdd:COG4753   68 RELDPDTKIIILSGYSDFEYAQEAIKLGADDYLLK 102
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-142 2.12e-11

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 59.98  E-value: 2.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   1 MISVYICEDDPKQLQQIRQIITKVivdqqLDMSICLACQDPHELLDKVNAQQPQKAIyvLDIALnSDINGIQLASQIRDM 80
Cdd:COG4565    3 MIRVLIVEDDPMVAELLRRYLERL-----PGFEVVGVASSGEEALALLAEHRPDLIL--LDIYL-PDGDGLELLRELRAR 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489739500  81 GRRSKIIFITTHTELSLMVFQYQVEALDFILKDFPdslYERFSKVLHVAQDRFQTDENDQDD 142
Cdd:COG4565   75 GPDVDVIVITAARDPETVREALRAGVVDYLIKPFT---FERLREALERYLEYRRLLREDQEE 133
PRK14084 PRK14084
DNA-binding response regulator;
60-232 1.67e-10

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 59.38  E-value: 1.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500  60 LDIALnSDINGIQLASQIRDMGRRSKIIFITTHTELSLMVFqyQVEALDFILKDFPDslyERFSKVLH-VAQDRFQTDEN 138
Cdd:PRK14084  52 LDINL-MDESGIELAAKIQKMKEPPAIIFATAHDQFAVKAF--ELNATDYILKPFEQ---KRIEQAVNkVRATKAKDDNN 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500 139 DQ----------DDYVQIKIGETVRSINVKSIIFFESSTSPHKIVVHLDDGE----LEYYGllKDVPDlsPNFYRCHKSY 204
Cdd:PRK14084 126 ASaiandmsanfDQSLPIEIDDKIHMLNQQDIIAIGVHNGITTIHTTNHKYEttepLNRYE--KRLNP--TYFIRIHRSY 201

                        170       180       190
                 ....*....|....*....|....*....|.
gi 489739500 205 VVNLKRIKSLDK---HLRRLTMANGEKVLCS 232
Cdd:PRK14084 202 IINKKHIKEVEQwfnYTYQVILTNGVKMQVS 232
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-140 4.81e-10

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 58.82  E-value: 4.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   1 MISVYICEDDPKQLQQIRQIItkvivdQQLDMSiCLACQDPHELLDKVNAQQPQkaIYVLDIALnSDINGIQLASQIRDM 80
Cdd:COG2204    2 MARILVVDDDPDIRRLLKELL------ERAGYE-VETAASGEEALALLREEPPD--LVLLDLRM-PGMDGLELLRELRAL 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489739500  81 GRRSKIIFITTHTELSLMVFQYQVEALDFILKDF-PDSLYERFSKVLHVAQDRFQTDENDQ 140
Cdd:COG2204   72 DPDLPVILLTGYGDVETAVEAIKAGAFDYLTKPFdLEELLAAVERALERRRLRRENAEDSG 132
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 6-112 5.13e-10

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 54.93  E-value: 5.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   6 ICEDDPkqlqQIRQIITKVIVDQQLDmsiCLACQDPHELLDKVNAQQPQkaIYVLDIALnSDINGIQLASQIRDMGRRSK 85
Cdd:cd00156    2 IVDDDP----AIRELLKSLLEREGYE---VDTAADGEEALELLREERPD--LVLLDLMM-PGMDGLELLRKLRELPPDIP 71

                         90       100
                 ....*....|....*....|....*..
gi 489739500  86 IIFITTHTELSLMVFQYQVEALDFILK 112
Cdd:cd00156   72 VIVLTAKADEEDAVRALELGADDYLVK 98
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-133 1.16e-09

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 56.07  E-value: 1.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   1 MISVYICEDDPKQLQQIRQIITKVIVDqqldmsiCLACQDPHELLDKVNAQQPQkaIYVLDIALnSDINGIQLASQIRDM 80
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLEAAGYE-------VVEAADGEEALELLQEHRPD--LILLDLEM-PDMDGLELCRRLRAD 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489739500  81 GRRSK--IIFITTHTELSLMVFQYQVEALDFILKDF-PDSLYERFSKVLHVAQDRF 133
Cdd:COG3706   71 PRTADipIIFLTALDDEEDRARALEAGADDYLTKPFdPEELLARVDLVARYGGEEF 126
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 31-126 1.26e-09

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 54.47  E-value: 1.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500  31 DMSICLACQDPHELLDKVNAQQPQkaIYVLDIALnSDINGIQLASQIRDMGRRSKIIFITTHTELSLMVFqyQVEALDFI 110
Cdd:cd17532   23 DIEIVGEAENGEEALEAIEELKPD--VVFLDIQM-PGLDGLELAKKLSKLAKPPLIVFVTAYDEYAVEAF--ELNAVDYL 97

                         90
                 ....*....|....*.
gi 489739500 111 LKDFPDslyERFSKVL 126
Cdd:cd17532   98 LKPFSE---ERLAEAL 110
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 4-112 1.70e-09

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 54.27  E-value: 1.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   4 VYICEDDPKqlqqIRQIITKVIVDQQLDMSICLACQDPHELLDKVNAQQPqkaiyvlDIALnSDI-----NGIQLASQIR 78
Cdd:cd17536    1 VLIVDDEPL----IREGLKKLIDWEELGFEVVGEAENGEEALELIEEHKP-------DIVI-TDIrmpgmDGLELIEKIR 68

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 489739500  79 DMGRRSKIIFITTHTElslmvFQY-----QVEALDFILK 112
Cdd:cd17536   69 ELYPDIKIIILSGYDD-----FEYaqkaiRLGVVDYLLK 102
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-126 1.43e-08

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 53.42  E-value: 1.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   1 MISVYICEDDPkqlqQIRQIITKVIVDQQLDmsiCLACQDPHELLDKVNAQQPqkAIYVLDIALnSDINGIQLASQIRDM 80
Cdd:COG0745    1 MPRILVVEDDP----DIRELLADALEREGYE---VDTAADGEEALELLEEERP--DLILLDLML-PGMDGLEVCRRLRAR 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 489739500  81 GRRSKIIFITTHTELSLMVFQYQVEALDFILKDF-PDSLYERFSKVL 126
Cdd:COG0745   71 PSDIPIIMLTARDDEEDRVRGLEAGADDYLTKPFdPEELLARIRALL 117
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 4-130 6.80e-08

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 49.85  E-value: 6.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   4 VYICEDDPkqlqQIRQIITKVIvdQQLDMSICLACqDPHELLDKVNAQQPqkAIYVLDIALnSDINGIQLASQIRDMGRR 83
Cdd:COG0784    8 ILVVDDNP----DNRELLRRLL--ERLGYEVTTAE-DGAEALELLRAGPP--DLILLDINM-PGMDGLELLRRIRALPRL 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 489739500  84 S--KIIFITTHTELSLMVFQYQVEALDFILKDF-PDSLYERFSKVLHVAQ 130
Cdd:COG0784   78 PdiPIIALTAYADEEDRERALEAGADDYLTKPVdPEELLEALRRLLARAS 127
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 8-137 9.04e-07

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 48.24  E-value: 9.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   8 EDDPKQLQQIRQIITKVIVDqqldmsiCLACQDPHELLDKVNAQQPqkAIYVLDIALnSDINGIQLASQIRDM--GRRSK 85
Cdd:COG3437   13 DDDPENLELLRQLLRTLGYD-------VVTAESGEEALELLLEAPP--DLILLDVRM-PGMDGFELLRLLRADpsTRDIP 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489739500  86 IIFITTHTELSLMVFQYQVEALDFILKDF-PDSLYERFSKVLHVAQDRFQTDE 137
Cdd:COG3437   83 VIFLTALADPEDRERALEAGADDYLTKPFdPEELLARVRNALELRRLQRELDD 135
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 4-115 2.11e-06

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 45.58  E-value: 2.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   4 VYICEDDPKQLQQIRQIItkvivDQQLDMSICLACQDPHELLDKVNAQQPQkaIYVLDIALnSDINGIQLASQIRDMGRR 83
Cdd:cd17535    1 VLIVDDHPLVREGLRRLL-----ESEPDIEVVGEAADGEEALALLRELRPD--VVLMDLSM-PGMDGIEALRRLRRRYPD 72

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 489739500  84 SKIIFITTHTELslmvfQYQVEALD-----FILKDFP 115
Cdd:cd17535   73 LKVIVLTAHDDP-----EYVLRALKagaagYLLKDSS 104
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 3-114 2.17e-06

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 45.34  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   3 SVYICEDDpkqlQQIRQIITKVIVDQQLDmsiCLACQDPHELLDKVNAQQPQkaIYVLDIALnSDINGIQLASQIRDMGR 82
Cdd:cd19919    2 TVWIVDDD----SSIRWVLERALAGAGLT---VTSFENAQEALAALASSQPD--VLISDIRM-PGMDGLALLAQIKQRHP 71

                         90       100       110
                 ....*....|....*....|....*....|..
gi 489739500  83 RSKIIFITTHTELSLMVFQYQVEALDFILKDF 114
Cdd:cd19919   72 DLPVIIMTAHSDLDSAVSAYQGGAFEYLPKPF 103
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 4-97 1.85e-05

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 42.33  E-value: 1.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   4 VYICEDDPKQLQqirqiitkVIVDQQLDMS-ICLACQDPHELLDKVnAQQPQKAIYVLDIALNSDINGIQLASQIRDMGR 82
Cdd:cd18161    1 VLVVEDDPDVRR--------LTAEVLEDLGyTVLEAASGDEALDLL-ESGPDIDLLVTDVIMPGGMNGSQLAEEARRRRP 71

                         90
                 ....*....|....*
gi 489739500  83 RSKIIFITTHTELSL 97
Cdd:cd18161   72 DLKVLLTSGYAENAI 86
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 6-112 2.12e-05

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 42.01  E-value: 2.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   6 ICEDDPKqlqqIRQIITKVIVDQQLDmsiCLACQDPHELLDKVNAQQPQkaIYVLDIALnSDINGIQLASQIRDMGRRSK 85
Cdd:cd17574    2 VVEDDEE----IAELLSDYLEKEGYE---VDTAADGEEALELAREEQPD--LIILDVML-PGMDGFEVCRRLREKGSDIP 71

                         90       100
                 ....*....|....*....|....*..
gi 489739500  86 IIFITTHTELSLMVFQYQVEALDFILK 112
Cdd:cd17574   72 IIMLTAKDEEEDKVLGLELGADDYITK 98
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 4-116 6.70e-05

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 41.04  E-value: 6.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   4 VYICEDDPKQLQQIRQIITkvivdqqldmSICLACQ---DPHELLDKVNAQQPqkAIYVLDIALnSDINGIQLASQIRDM 80
Cdd:cd17537    3 VYVVDDDEAVRDSLAFLLR----------SVGLAVKtftSASAFLAAAPPDQP--GCLVLDVRM-PGMSGLELQDELLAR 69

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489739500  81 GRRSKIIFITTHTELSLMVFQYQVEALDFILKDFPD 116
Cdd:cd17537   70 GSNIPIIFITGHGDVPMAVEAMKAGAVDFLEKPFRD 105
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 2-126 2.10e-04

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 39.92  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   2 ISVYICEDDPKqLQQIRqiitKVIVDQQLDMSICLACQDPHELLDKVNAQQPQKAIyvLDIALnSDINGIQLASQIRDMG 81
Cdd:cd19925    1 INVLIVEDDPM-VAEIH----RAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLIL--LDIYL-PDGNGLDLLRELRAAG 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 489739500  82 RRSKIIFITTHTELSLMVFQYQVEALDFILKDFPdslYERFSKVL 126
Cdd:cd19925   73 HDVDVIVVTAANDVETVREALRLGVVDYLIKPFT---FERLRQRL 114
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 2-94 3.49e-04

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 39.31  E-value: 3.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   2 ISVYICEDDPKQLQQIRQIItkvivdQQLDMSICLACQDPHELLDKVNAQQPQKAIyvLDIALNSDINGIQLASQIRDMg 81
Cdd:cd17534    1 KKILIVEDEAIIALDLKEIL------ESLGYEVVGIADSGEEAIELAEENKPDLIL--MDINLKGDMDGIEAAREIREK- 71

                         90
                 ....*....|...
gi 489739500  82 RRSKIIFITTHTE 94
Cdd:cd17534   72 FDIPVIFLTAYSD 84
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 4-114 3.60e-04

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 41.39  E-value: 3.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   4 VYICEDDpkqlQQIRQIITKVIVDQQLDmsiCLACQDPHELLDKVNAQQPQkaIYVLDIALnSDINGIQLASQIRDMGRR 83
Cdd:PRK10923   6 VWVVDDD----SSIRWVLERALAGAGLT---CTTFENGNEVLEALASKTPD--VLLSDIRM-PGMDGLALLKQIKQRHPM 75

                         90       100       110
                 ....*....|....*....|....*....|.
gi 489739500  84 SKIIFITTHTELSLMVFQYQVEALDFILKDF 114
Cdd:PRK10923  76 LPVIIMTAHSDLDAAVSAYQQGAFDYLPKPF 106
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 4-126 6.35e-04

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 38.41  E-value: 6.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   4 VYICEDDPKQLQQIRQIITK---VIVDQQLDMSiclacqdphELLDKVNAQQPQkaIYVLDIALnSDINGIQLASQIRDM 80
Cdd:cd17542    3 VLIVDDAAFMRMMLKDILTKagyEVVGEAANGE---------EAVEKYKELKPD--LVTMDITM-PEMDGIEALKEIKKI 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 489739500  81 GRRSKIIFITTHTELSLMVFQYQVEALDFILKDF-PDSLYERFSKVL 126
Cdd:cd17542   71 DPNAKVIMCSAMGQEEMVKEAIKAGAKDFIVKPFqPERVLEAVEKVL 117
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 4-140 1.78e-03

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 37.47  E-value: 1.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500   4 VYICEDDPkqlqQIRQIITkvivdQQLDMS--ICLACQDPHELLDKVNAQQPqkAIYVLDIALnSDINGIQLASQIRDMG 81
Cdd:cd17549    1 VLLVDDDA----DVREALQ-----QTLELAgfRVRAFADAEEALAALSPDFP--GVVISDIRM-PGMDGLELLAQIRELD 68

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739500  82 RRSKIIFITTHTELSLMVFQYQVEALDFILKDFPDslyERFSKVLHVAQD-RFQTDENDQ 140
Cdd:cd17549   69 PDLPVILITGHGDVPMAVEAMRAGAYDFLEKPFDP---ERLLDVVRRALEkRRLVLENRR 125
fixJ PRK09390
response regulator FixJ; Provisional
 67-117 5.13e-03

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 36.90  E-value: 5.13e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489739500  67 DINGIQLASQIRDMGRRSKIIFITTHTELSLMVFQYQVEALDFILKDFPDS 117
Cdd:PRK09390  59 GIDGIELLRRLKARGSPLPVIVMTGHGDVPLAVEAMKLGAVDFIEKPFEDE 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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