|
Name |
Accession |
Description |
Interval |
E-value |
| obgE |
PRK12297 |
GTPase CgtA; Reviewed |
1-431 |
0e+00 |
|
GTPase CgtA; Reviewed
Pssm-ID: 237046 [Multi-domain] Cd Length: 424 Bit Score: 729.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 1 MFVDQVKVDVKAGNGGNGMVAFRREKFVPNggpaggdggrggSVVLQADEGLRTLMDFRYTRKFKAAAGGNGMIKQMTGR 80
Cdd:PRK12297 1 MFIDQAKIYVKAGDGGDGMVSFRREKYVPKggpdggdggkggSVIFVADEGLRTLLDFRYKRHFKAENGENGMGKNMHGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 81 SAKDTIIKVPLGTTVTDAETGELIGDIVNKDQRLVVAKGGRGGRGNIHFASAKNPAPEIAENGEPGDELTIRMELKVLAD 160
Cdd:PRK12297 81 NGEDLIIKVPVGTVVKDAETGEVIADLVEPGQEVVVAKGGRGGRGNAHFATSTNQAPRIAENGEPGEERELRLELKLLAD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 161 VGLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLDDGRDFVMADLPGLIEGAANGVGLGIQFLRHIERTRVI 240
Cdd:PRK12297 161 VGLVGFPNVGKSTLLSVVSNAKPKIANYHFTTLVPNLGVVETDDGRSFVMADIPGLIEGASEGVGLGHQFLRHIERTRVI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 241 LHLIDMSGVEENDPFEDYHKINHELTSYDPDLLKRPQIVVATKMDMPDAEANLEDFKAKLAtddtlpntPAVYPVSSITQ 320
Cdd:PRK12297 241 VHVIDMSGSEGRDPIEDYEKINKELKLYNPRLLERPQIVVANKMDLPEAEENLEEFKEKLG--------PKVFPISALTG 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 321 QGLKALLAKTADLLDTTPQFPIKGVDDLKHRDYT-TEADADFSIDNPEPGLFVLSGDKLERLFKMTNLDHEESLMRFARQ 399
Cdd:PRK12297 313 QGLDELLYAVAELLEETPEFPLEEEEVEEEVYYKfEEEEKDFTITRDEDGVFVVSGEKIERLFKMTNFNRDESLRRFARQ 392
|
410 420 430
....*....|....*....|....*....|..
gi 489740498 400 LRGMGVDDALRAAGAKNDDTIQILDYSFQFMD 431
Cdd:PRK12297 393 LRKMGVDDALREAGAKDGDTVRIGDFEFEFVD 424
|
|
| Obg |
COG0536 |
GTPase involved in cell partioning and DNA repair [Cell cycle control, cell division, ... |
2-349 |
0e+00 |
|
GTPase involved in cell partioning and DNA repair [Cell cycle control, cell division, chromosome partitioning, Replication, recombination, and repair];
Pssm-ID: 440302 [Multi-domain] Cd Length: 343 Bit Score: 560.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 2 FVDQVKVDVKAGNGGNGMVAFRREKFVPNggpaggdggrggSVVLQADEGLRTLMDFRYTRKFKAAAGGNGMIKQMTGRS 81
Cdd:COG0536 1 FVDEAKIYVKAGDGGNGCVSFRREKYVPKggpdggdggrggDVILVADENLNTLLDFRYKRHFKAENGENGMGKNRTGKN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 82 AKDTIIKVPLGTTVTDAETGELIGDIVNKDQRLVVAKGGRGGRGNIHFASAKNPAPEIAENGEPGDELTIRMELKVLADV 161
Cdd:COG0536 81 GEDLVIKVPVGTVVKDAETGEVLADLTEDGQRVVVAKGGRGGLGNAHFKSSTNRAPRFAEPGEPGEERWLRLELKLLADV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 162 GLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLDDGRDFVMADLPGLIEGAANGVGLGIQFLRHIERTRVIL 241
Cdd:COG0536 161 GLVGLPNAGKSTLLSAVSAAKPKIADYPFTTLVPNLGVVRVGDGRSFVIADIPGLIEGASEGAGLGHRFLRHIERTRVLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 242 HLIDMSGVEENDPFEDYHKINHELTSYDPDLLKRPQIVVATKMDMPDAEAnLEDFKAKLATDDtLPntpaVYPVSSITQQ 321
Cdd:COG0536 241 HVVDAAPLDGRDPVEDYEIIRNELEAYSPELAEKPRIVVLNKIDLLDAEE-LEELKAELEKLG-GP----VFPISAVTGE 314
|
330 340
....*....|....*....|....*...
gi 489740498 322 GLKALLAKTADLLDTTPQFPIKGVDDLK 349
Cdd:COG0536 315 GLDELLYALAELLEELRAEEAEEEEEVE 342
|
|
| Obg_CgtA |
TIGR02729 |
Obg family GTPase CgtA; This model describes a univeral, mostly one-gene-per-genome ... |
2-334 |
0e+00 |
|
Obg family GTPase CgtA; This model describes a univeral, mostly one-gene-per-genome GTP-binding protein that associates with ribosomal subunits and appears to play a role in ribosomal RNA maturation. This GTPase, related to the nucleolar protein Obg, is designated CgtA in bacteria. Mutations in this gene are pleiotropic, but it appears that effects on cellular functions such as chromosome partition may be secondary to the effect on ribosome structure. Recent work done in Vibrio cholerae shows an essential role in the stringent response, in which RelA-dependent ability to synthesize the alarmone ppGpp is required for deletion of this GTPase to be lethal. [Protein synthesis, Other]
Pssm-ID: 274271 [Multi-domain] Cd Length: 328 Bit Score: 537.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 2 FVDQVKVDVKAGNGGNGMVAFRREKFVPNGGPAGGDGGRGGSVVLQADEGLRTLMDFRYTRKFKAAAGGNGMIKQMTGRS 81
Cdd:TIGR02729 1 FVDEAKIFVKAGDGGNGCVSFRREKYVPKGGPDGGDGGRGGSVILEADENLNTLLDFRYQRHFKAENGENGMGKNRTGKS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 82 AKDTIIKVPLGTTVTDAETGELIGDIVNKDQRLVVAKGGRGGRGNIHFASAKNPAPEIAENGEPGDELTIRMELKVLADV 161
Cdd:TIGR02729 81 GEDLVIKVPVGTVVYDADTGELLADLTEPGQRFLVAKGGRGGLGNAHFKSSTNRAPRFATPGEPGEERWLRLELKLLADV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 162 GLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLDDGRDFVMADLPGLIEGAANGVGLGIQFLRHIERTRVIL 241
Cdd:TIGR02729 161 GLVGLPNAGKSTLISAVSAAKPKIADYPFTTLVPNLGVVRVDDGRSFVIADIPGLIEGASEGAGLGHRFLKHIERTRVLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 242 HLIDMSGVEENDPFEDYHKINHELTSYDPDLLKRPQIVVATKMDMPDAEaNLEDFKAKLATDDTLPntpaVYPVSSITQQ 321
Cdd:TIGR02729 241 HLIDISPEDGSDPVEDYEIIRNELKKYSPELAEKPRIVVLNKIDLLDEE-ELEELLKELKKELGKP----VFPISALTGE 315
|
330
....*....|...
gi 489740498 322 GLKALLAKTADLL 334
Cdd:TIGR02729 316 GLDELLDALAELL 328
|
|
| obgE |
PRK12299 |
GTPase CgtA; Reviewed |
1-339 |
2.26e-177 |
|
GTPase CgtA; Reviewed
Pssm-ID: 237048 [Multi-domain] Cd Length: 335 Bit Score: 498.44 E-value: 2.26e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 1 MFVDQVKVDVKAGNGGNGMVAFRREKFVPnggpaggdggrggSVVLQADEGLRTLMDFRYTRKFKAAAGGNGMIKQMTGR 80
Cdd:PRK12299 1 KFIDEAKIYVKAGDGGNGCVSFRREKFIPfggpdggdggrggSVILEADENLNTLIDFRYKRHFKAENGENGMGRNRTGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 81 SAKDTIIKVPLGTTVTDAETGELIGDIVNKDQRLVVAKGGRGGRGNIHFASAKNPAPEIAENGEPGDELTIRMELKVLAD 160
Cdd:PRK12299 81 SGKDLVLKVPVGTQIYDADTGELIADLTEHGQRFLVAKGGKGGLGNAHFKSSTNRAPRYATPGEPGEERWLRLELKLLAD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 161 VGLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLDDGRDFVMADLPGLIEGAANGVGLGIQFLRHIERTRVI 240
Cdd:PRK12299 161 VGLVGLPNAGKSTLISAVSAAKPKIADYPFTTLHPNLGVVRVDDYKSFVIADIPGLIEGASEGAGLGHRFLKHIERTRLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 241 LHLIDMSGVeenDPFEDYHKINHELTSYDPDLLKRPQIVVATKMDMPDAEANLEDFKAKLATDDTLPntpaVYPVSSITQ 320
Cdd:PRK12299 241 LHLVDIEAV---DPVEDYKTIRNELEKYSPELADKPRILVLNKIDLLDEEEEREKRAALELAALGGP----VFLISAVTG 313
|
330
....*....|....*....
gi 489740498 321 QGLKALLAKTADLLDTTPQ 339
Cdd:PRK12299 314 EGLDELLRALWELLEEARR 332
|
|
| obgE |
PRK12298 |
GTPase CgtA; Reviewed |
1-339 |
5.02e-153 |
|
GTPase CgtA; Reviewed
Pssm-ID: 237047 [Multi-domain] Cd Length: 390 Bit Score: 438.92 E-value: 5.02e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 1 MFVDQVKVDVKAGNGGNGMVAFRREKFVPNGGPAGGDGGRGGSVVLQADEGLRTLMDFRYTRKFKAAAGGNGMIKQMTGR 80
Cdd:PRK12298 2 KFVDEAKIRVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVYLEADENLNTLIDYRFERHFRAERGQNGQGRDCTGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 81 SAKDTIIKVPLGTTVTDAETGELIGDIVNKDQRLVVAKGGRGGRGNIHFASAKNPAPEIAENGEPGDELTIRMELKVLAD 160
Cdd:PRK12298 82 RGKDITIKVPVGTRVIDADTGEVIGDLTEHGQRLLVAKGGWHGLGNTRFKSSVNRAPRQKTPGTPGEERELKLELKLLAD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 161 VGLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLDDGRDFVMADLPGLIEGAANGVGLGIQFLRHIERTRVI 240
Cdd:PRK12298 162 VGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVRVDDERSFVVADIPGLIEGASEGAGLGIRFLKHLERCRVL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 241 LHLIDMSGVEENDPFEDYHKINHELTSYDPDLLKRPQIVVATKMDMPDAEANLEDFKAKLatdDTLPNTPAVYPVSSITQ 320
Cdd:PRK12298 242 LHLIDIAPIDGSDPVENARIIINELEKYSPKLAEKPRWLVFNKIDLLDEEEAEERAKAIV---EALGWEGPVYLISAASG 318
|
330
....*....|....*....
gi 489740498 321 QGLKALLAKTADLLDTTPQ 339
Cdd:PRK12298 319 LGVKELCWDLMTFIEENPR 337
|
|
| obgE |
PRK12296 |
GTPase CgtA; Reviewed |
2-422 |
1.30e-130 |
|
GTPase CgtA; Reviewed
Pssm-ID: 237045 [Multi-domain] Cd Length: 500 Bit Score: 385.76 E-value: 1.30e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 2 FVDQVKVDVKAGNGGNGMVAFRREKFVPNGGPAGGDGGRGGSVVLQADEGLRTLMDFRYTRKFKAAAGGNGMIKQMTGRS 81
Cdd:PRK12296 4 FVDRVVLHVKAGDGGNGCASVHREKFKPLGGPDGGNGGRGGSVVLVVDPQVTTLLDFHFRPHRKATNGKPGMGDNRDGAA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 82 AKDTIIKVPLGTTVTDaETGELIGDIVNKDQRLVVAKGGRGGRGNIHFASAKNPAPEIAENGEPGDELTIRMELKVLADV 161
Cdd:PRK12296 84 GEDLVLPVPDGTVVLD-EDGEVLADLVGAGTRFVAAAGGRGGLGNAALASKARKAPGFALLGEPGEERDLVLELKSVADV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 162 GLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLDDGRdFVMADLPGLIEGAANGVGLGIQFLRHIERTRVIL 241
Cdd:PRK12296 163 GLVGFPSAGKSSLISALSAAKPKIADYPFTTLVPNLGVVQAGDTR-FTVADVPGLIPGASEGKGLGLDFLRHIERCAVLV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 242 HLIDMSGVEEN-DPFEDYHKINHELTSYDP---------DLLKRPQIVVATKMDMPDAEANLEDFKAKLATDDtLPntpa 311
Cdd:PRK12296 242 HVVDCATLEPGrDPLSDIDALEAELAAYAPaldgdlglgDLAERPRLVVLNKIDVPDARELAEFVRPELEARG-WP---- 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 312 VYPVSSITQQGLKALLAKTADLLD-----------TTPQFPIKGVDDlkhRDYTTEADADfsidnpEPGLFVLSGDKLER 380
Cdd:PRK12296 317 VFEVSAASREGLRELSFALAELVEearaaepeaepTRIVIRPKAVDD---AGFTVERDGD------GEGGFRVRGEKPER 387
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 489740498 381 LFKMTNLDHEESLMRFARQLRGMGVDDALRAAGAKNDDTIQI 422
Cdd:PRK12296 388 WVRQTDFDNDEAVGYLADRLARLGVEDELLKAGARPGDAVTI 429
|
|
| Obg |
cd01898 |
Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress ... |
159-334 |
3.61e-94 |
|
Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins conserved from bacteria to humans. The E. coli homolog, ObgE is believed to function in ribosomal biogenesis. Members of the subfamily contain two equally and highly conserved domains, a C-terminal GTP binding domain and an N-terminal glycine-rich domain.
Pssm-ID: 206685 [Multi-domain] Cd Length: 170 Bit Score: 280.46 E-value: 3.61e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 159 ADVGLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLDDGRDFVMADLPGLIEGAANGVGLGIQFLRHIERTR 238
Cdd:cd01898 1 ADVGLVGLPNAGKSTLLSAISNAKPKIADYPFTTLVPNLGVVRVDDGRSFVIADIPGLIEGASEGKGLGHRFLRHIERTR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 239 VILHLIDMSGveENDPFEDYHKINHELTSYDPDLLKRPQIVVATKMDMPDAEANLEDFKAKLATDDTLPntpaVYPVSSI 318
Cdd:cd01898 81 VLLHVIDLSG--EDDPVEDYETIRNELEAYNPGLAEKPRIVVLNKIDLLDAEERFEKLKELLKELKGKK----VFPISAL 154
|
170
....*....|....*.
gi 489740498 319 TQQGLKALLAKTADLL 334
Cdd:cd01898 155 TGEGLDELLKKLAKLL 170
|
|
| GTP1_OBG |
pfam01018 |
GTP1/OBG; The N-terminal domain of Swiss:P20964 has the OBG fold, which is formed by three ... |
3-157 |
1.90e-76 |
|
GTP1/OBG; The N-terminal domain of Swiss:P20964 has the OBG fold, which is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich these regions form six left-handed collagen-like helices packed and H-bonded together.
Pssm-ID: 460027 [Multi-domain] Cd Length: 155 Bit Score: 234.55 E-value: 1.90e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 3 VDQVKVDVKAGNGGNGMVAFRREKFVPNGGPAGGDGGRGGSVVLQADEGLRTLMDFRYTRKFKAAAGGNGMIKQMTGRSA 82
Cdd:pfam01018 1 VDRAKIKVKAGDGGNGCVSFRREKYVPKGGPDGGDGGRGGDVILVADENLNTLLDFRYKRHFKAENGENGGGKNCHGKNG 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489740498 83 KDTIIKVPLGTTVTDAETGELIGDIVNKDQRLVVAKGGRGGRGNIHFASAKNPAPEIAENGEPGDELTIRMELKV 157
Cdd:pfam01018 81 EDLIIKVPVGTVVKDAETGEVLADLTEPGQRVLVAKGGRGGRGNAHFKTSTNQAPRFAEPGEPGEERWLELELKL 155
|
|
| Obg_like |
cd01881 |
Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; ... |
162-334 |
9.43e-53 |
|
Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; The Obg-like subfamily consists of five well-delimited, ancient subfamilies, namely Obg, DRG, YyaF/YchF, Ygr210, and NOG1. Four of these groups (Obg, DRG, YyaF/YchF, and Ygr210) are characterized by a distinct glycine-rich motif immediately following the Walker B motif (G3 box). Obg/CgtA is an essential gene that is involved in the initiation of sporulation and DNA replication in the bacteria Caulobacter and Bacillus, but its exact molecular role is unknown. Furthermore, several OBG family members possess a C-terminal RNA-binding domain, the TGS domain, which is also present in threonyl-tRNA synthetase and in bacterial guanosine polyphosphatase SpoT. Nog1 is a nucleolar protein that might function in ribosome assembly. The DRG and Nog1 subfamilies are ubiquitous in archaea and eukaryotes, the Ygr210 subfamily is present in archaea and fungi, and the Obg and YyaF/YchF subfamilies are ubiquitous in bacteria and eukaryotes. The Obg/Nog1 and DRG subfamilies appear to form one major branch of the Obg family and the Ygr210 and YchF subfamilies form another branch. No GEFs, GAPs, or GDIs for Obg have been identified.
Pssm-ID: 206668 [Multi-domain] Cd Length: 167 Bit Score: 174.12 E-value: 9.43e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 162 GLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLDDGRDFVMADLPGLIEGAANGVGLGIQFLRHIERTRVIL 241
Cdd:cd01881 1 GLVGLPNVGKSTLLSALTSAKVEIASYPFTTLEPNVGVFEFGDGVDIQIIDLPGLLDGASEGRGLGEQILAHLYRSDLIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 242 HLIDMSGVEENDPFEDYHKINHELTSYDPDLLKRPQIVVATKMDMPDAEANLEDFKAKLAtddtlpNTPAVYPVSSITQQ 321
Cdd:cd01881 81 HVIDASEDCVGDPLEDQKTLNEEVSGSFLFLKNKPEMIVANKIDMASENNLKRLKLDKLK------RGIPVVPTSALTRL 154
|
170
....*....|...
gi 489740498 322 GLKALLAKTADLL 334
Cdd:cd01881 155 GLDRVIRTIRKLL 167
|
|
| MMR_HSR1 |
pfam01926 |
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ... |
160-283 |
3.19e-28 |
|
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.
Pssm-ID: 460387 [Multi-domain] Cd Length: 113 Bit Score: 107.32 E-value: 3.19e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 160 DVGLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLdDGRDFVMADLPGLIEGAANGVGLGIQFLRHIErTRV 239
Cdd:pfam01926 1 RVALVGRPNVGKSTLINALTGAKAIVSDYPGTTRDPNEGRLEL-KGKQIILVDTPGLIEGASEGEGLGRAFLAIIE-ADL 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 489740498 240 ILHLIDMSgveendpfEDYHKINHELTSYDPDlLKRPQIVVATK 283
Cdd:pfam01926 79 ILFVVDSE--------EGITPLDEELLELLRE-NKKPIILVLNK 113
|
|
| Obg_CgtA_exten |
TIGR03595 |
Obg family GTPase CgtA, C-terminal extension; CgtA (see model TIGR02729) is a broadly ... |
361-429 |
2.24e-26 |
|
Obg family GTPase CgtA, C-terminal extension; CgtA (see model TIGR02729) is a broadly conserved member of the obg family of GTPases associated with ribosome maturation. This model represents a unique C-terminal domain found in some but not all sequences of CgtA. This region is preceded, and may be followed, by a region of low-complexity sequence.
Pssm-ID: 274668 [Multi-domain] Cd Length: 69 Bit Score: 101.04 E-value: 2.24e-26
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489740498 361 FSIDNPEPGLFVLSGDKLERLFKMTNLDHEESLMRFARQLRGMGVDDALRAAGAKNDDTIQILDYSFQF 429
Cdd:TIGR03595 1 FEIERDGDGVFVVSGKKIERWVAKTPFNNDEALRRFARKLKKLGVEDALRKAGAKAGDTVRIGDFEFEW 69
|
|
| DUF1967 |
pfam09269 |
Domain of unknown function (DUF1967); Members of this family contain a four-stranded beta ... |
363-429 |
2.91e-26 |
|
Domain of unknown function (DUF1967); Members of this family contain a four-stranded beta sheet and three alpha helices flanked by an additional beta strand. They are predominantly found in the bacterial GTP-binding protein Obg, and are still functionally uncharacterized.
Pssm-ID: 462733 [Multi-domain] Cd Length: 67 Bit Score: 100.52 E-value: 2.91e-26
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489740498 363 IDNPEPGLFVLSGDKLERLFKMTNLDHEESLMRFARQLRGMGVDDALRAAGAKNDDTIQILDYSFQF 429
Cdd:pfam09269 1 IEEDEEGVFVVEGPKIERLVRMTNFDNEESLRRFQRVLKKLGVEDALRKAGAKEGDTVRIGDFEFEY 67
|
|
| Ygr210 |
cd01899 |
Ygr210 GTPase; Ygr210 is a member of Obg-like family and present in archaea and fungi. They ... |
161-412 |
9.39e-23 |
|
Ygr210 GTPase; Ygr210 is a member of Obg-like family and present in archaea and fungi. They are characterized by a distinct glycine-rich motif immediately following the Walker B motif. The Ygr210 and YyaF/YchF subfamilies appear to form one major branch of the Obg-like family. Among eukaryotes, the Ygr210 subfamily is represented only in fungi. These fungal proteins form a tight cluster with their archaeal orthologs, which suggests the possibility of horizontal transfer from archaea to fungi.
Pssm-ID: 206686 [Multi-domain] Cd Length: 318 Bit Score: 98.07 E-value: 9.39e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 161 VGLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGM--VRLD------------------DGRDFV---MADLPGLI 217
Cdd:cd01899 1 IGLVGKPNVGKSTFFNAATLADVEIANYPFTTIDPNVGVgyVRVEcpckelgvscnprygkciDGKRYVpveLIDVAGLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 218 EGAANGVGLGIQFLRHIERTRVILHLIDMSG----------VEENDPFEDYHKINHELTS-------------------- 267
Cdd:cd01899 81 PGAHEGKGLGNQFLDDLRDADVLIHVVDASGgtdaegngveTGGYDPLEDIEFLENEIDMwiygilernwekivrkakae 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 268 ------------------------------YDPDL-----------------LKRPQIVVATKMDMPDAEANLEdfKAKL 300
Cdd:cd01899 161 ktdivealseqlsgfgvnedvviealeeleLPADLskwddedllrlarelrkRRKPMVIAANKADIPDAEENIS--KLRL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 301 ATDDtlpntPAVYPVSSITQQGLKalLAKTADLLDTTPqfpikgvddlkhrdytteADADFSIDNPEPglfvLSGDKLER 380
Cdd:cd01899 239 KYPD-----EIVVPTSAEAELALR--RAAKQGLIKYVP------------------GDSDFEITDEDG----LSDKQREA 289
|
330 340 350
....*....|....*....|....*....|..
gi 489740498 381 LFKMtnldHEESLMRFArqlrGMGVDDALRAA 412
Cdd:cd01899 290 LENI----RDEVLDRFG----STGVQEALNAA 313
|
|
| DRG |
cd01896 |
Developmentally Regulated GTP-binding protein (DRG); The developmentally regulated GTP-binding ... |
159-231 |
1.68e-21 |
|
Developmentally Regulated GTP-binding protein (DRG); The developmentally regulated GTP-binding protein (DRG) subfamily is an uncharacterized member of the Obg family, an evolutionary branch of GTPase superfamily proteins. GTPases act as molecular switches regulating diverse cellular processes. DRG2 and DRG1 comprise the DRG subfamily in eukaryotes. In view of their widespread expression in various tissues and high conservation among distantly related species in eukaryotes and archaea, DRG proteins may regulate fundamental cellular processes. It is proposed that the DRG subfamily proteins play their physiological roles through RNA binding.
Pssm-ID: 206683 [Multi-domain] Cd Length: 233 Bit Score: 92.61 E-value: 1.68e-21
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489740498 159 ADVGLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLDDGRdFVMADLPGLIEGAANGVGLGIQFL 231
Cdd:cd01896 1 ARVALVGFPSVGKSTLLSKLTNTKSEVAAYEFTTLTCVPGVMEYKGAK-IQLLDLPGIIEGASDGKGRGRQVI 72
|
|
| Era_like |
cd00880 |
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ... |
162-334 |
5.17e-21 |
|
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.
Pssm-ID: 206646 [Multi-domain] Cd Length: 161 Bit Score: 89.23 E-value: 5.17e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 162 GLVGFPSVGKSTLLSVVTSAKPKI-AAYHFTTLVPNLGMVRLDDGRDFVMADLPGLIEGAANGVGLGIQFLRHIERTRVI 240
Cdd:cd00880 1 AIFGRPNVGKSSLLNALLGQNVGIvSPIPGTTRDPVRKEWELLPLGPVVLIDTPGLDEEGGLGRERVEEARQVADRADLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 241 LHLIDmSGVEENDPFEDYHKINheltsydpdLLKRPQIVVATKMDMPDAEANLEDFK-AKLATDDTLPntpaVYPVSSIT 319
Cdd:cd00880 81 LLVVD-SDLTPVEEEAKLGLLR---------ERGKPVLLVLNKIDLVPESEEEELLReRKLELLPDLP----VIAVSALP 146
|
170
....*....|....*
gi 489740498 320 QQGLKALLAKTADLL 334
Cdd:cd00880 147 GEGIDELRKKIAELL 161
|
|
| Rbg1 |
COG1163 |
Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis]; |
159-227 |
7.48e-20 |
|
Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis];
Pssm-ID: 440777 [Multi-domain] Cd Length: 368 Bit Score: 90.24 E-value: 7.48e-20
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489740498 159 ADVGLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLDDGRdFVMADLPGLIEGAANGVGLG 227
Cdd:COG1163 64 ATVVLVGFPSVGKSTLLNKLTNAKSEVGAYEFTTLDVVPGMLEYKGAK-IQILDVPGLIEGAASGKGRG 131
|
|
| PRK09602 |
PRK09602 |
translation-associated GTPase; Reviewed |
161-344 |
2.00e-19 |
|
translation-associated GTPase; Reviewed
Pssm-ID: 236584 [Multi-domain] Cd Length: 396 Bit Score: 89.48 E-value: 2.00e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 161 VGLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGM--VRLD------------------DGRDFV---MADLPGLI 217
Cdd:PRK09602 4 IGLVGKPNVGKSTFFNAATLADVEIANYPFTTIDPNVGVayVRVEcpckelgvkcnprngkciDGTRFIpveLIDVAGLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 218 EGAANGVGLGIQFLRHIERTRVILHLIDMSG----------VEENDPFEDYHKINHELT--------------------- 266
Cdd:PRK09602 84 PGAHEGRGLGNQFLDDLRQADALIHVVDASGstdeegnpvePGSHDPVEDIKFLEEELDmwiygileknwekfsrkaqae 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 267 -------------------------------SYDPD-------------LLKR--PQIVVATKMDMPDAEANLEdfkaKL 300
Cdd:PRK09602 164 kfdieealaeqlsglgineehvkealrelglPEDPSkwtdedllelareLRKIskPMVIAANKADLPPAEENIE----RL 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 489740498 301 ATDDTLPntpaVYPVSSITQQGLKAllAKTADLLDTTP---QFPIKG 344
Cdd:PRK09602 240 KEEKYYI----VVPTSAEAELALRR--AAKAGLIDYIPgdsDFEILG 280
|
|
| Nog1 |
COG1084 |
GTP-binding protein, GTP1/Obg family [General function prediction only]; |
165-341 |
3.57e-16 |
|
GTP-binding protein, GTP1/Obg family [General function prediction only];
Pssm-ID: 440701 [Multi-domain] Cd Length: 330 Bit Score: 79.11 E-value: 3.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 165 GFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLDDGRdFVMADLPGL----------IEGAAngvglgIQFLRHI 234
Cdd:COG1084 167 GYPNVGKSSLVSKVTSAKPEIASYPFTTKGIIVGHFERGHGR-YQVIDTPGLldrplserneIERQA------ILALKHL 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 235 erTRVILHLIDMSGveendpfEDYHKINHELTSYDP--DLLKRPQIVVATKMDMPDAEANLEDFKAklatddtlpntpAV 312
Cdd:COG1084 240 --ADVILFLFDPSE-------TCGYSLEEQLNLLEEirSLFDVPVIVVINKIDLSDEEELKEAEEE------------AD 298
|
170 180
....*....|....*....|....*....
gi 489740498 313 YPVSSITQQGLKALLAKTADLLDTTPQFP 341
Cdd:COG1084 299 IKISALTGEGVDELLDELIEALEEEPELP 327
|
|
| YchF |
cd01900 |
YchF GTPase; YchF is a member of the Obg family, which includes four other subfamilies of ... |
161-265 |
8.40e-16 |
|
YchF GTPase; YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated with the ribosome. Several members of the family, including YchF, possess the TGS domain related to the RNA-binding proteins. Experimental data and genomic analysis suggest that YchF may be part of a nucleoprotein complex and may function as a GTP-dependent translational factor.
Pssm-ID: 206687 [Multi-domain] Cd Length: 274 Bit Score: 77.11 E-value: 8.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 161 VGLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLDDGR------------------DFVmaDLPGLIEGAAN 222
Cdd:cd01900 1 IGIVGLPNVGKSTLFNALTKSNAEAANYPFCTIEPNVGIVPVPDERldklaeivkpkkivpatiEFV--DIAGLVKGASK 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 489740498 223 GVGLGIQFLRHIERTRVILHLI------DMSGVEEN-DPFEDYHKINHEL 265
Cdd:cd01900 79 GEGLGNKFLSHIREVDAIAHVVrcfeddDITHVEGSvDPVRDIEIINTEL 128
|
|
| PTZ00258 |
PTZ00258 |
GTP-binding protein; Provisional |
161-265 |
1.63e-15 |
|
GTP-binding protein; Provisional
Pssm-ID: 240334 [Multi-domain] Cd Length: 390 Bit Score: 77.68 E-value: 1.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 161 VGLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLDDGR-----DFV-----------MADLPGLIEGAANGV 224
Cdd:PTZ00258 24 MGIVGLPNVGKSTTFNALCKQQVPAENFPFCTIDPNTARVNVPDERfdwlcKHFkpksivpaqldITDIAGLVKGASEGE 103
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 489740498 225 GLGIQFLRHIERTRVILHLI------DMSGVEEN-DPFEDYHKINHEL 265
Cdd:PTZ00258 104 GLGNAFLSHIRAVDGIYHVVrafedeDITHVEGEiDPVRDLEIISSEL 151
|
|
| NOG |
cd01897 |
Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in ... |
163-335 |
2.73e-15 |
|
Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in eukaryotes ranging from trypanosomes to humans. NOG1 is functionally linked to ribosome biogenesis and found in association with the nuclear pore complexes and identified in many preribosomal complexes. Thus, defects in NOG1 can lead to defects in 60S biogenesis. The S. cerevisiae NOG1 gene is essential for cell viability, and mutations in the predicted G motifs abrogate function. It is a member of the ODN family of GTP-binding proteins that also includes the bacterial Obg and DRG proteins.
Pssm-ID: 206684 [Multi-domain] Cd Length: 167 Bit Score: 73.36 E-value: 2.73e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 163 LVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLDDGRdFVMADLPGL----------IEGAAngvglgIQFLR 232
Cdd:cd01897 5 IAGYPNVGKSSLVNKLTRAKPEVAPYPFTTKSLFVGHFDYKYLR-WQVIDTPGIldrpleerntIEMQA------ITALA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 233 HIerTRVILHLIDMSG-----VEENdpFEDYHKINheltsydpDLLKRPQIVVATKMDMPDAEANLEDFKAKLATDDtlp 307
Cdd:cd01897 78 HL--RAAVLFFIDPSEtcgysIEEQ--LSLFKEIK--------PLFNKPVIVVLNKIDLLTEEDLSEIEKELEKEGE--- 142
|
170 180
....*....|....*....|....*...
gi 489740498 308 ntpAVYPVSSITQQGLKALLAKTADLLD 335
Cdd:cd01897 143 ---EVIKISTLTEEGVDELKNKACELLL 167
|
|
| Ras_like_GTPase |
cd00882 |
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ... |
162-329 |
7.13e-15 |
|
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.
Pssm-ID: 206648 [Multi-domain] Cd Length: 161 Bit Score: 71.72 E-value: 7.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 162 GLVGFPSVGKSTLLSVVTSAKPKI-AAYHFTTLVPNLGMVRLD-DGRDFVMADLPGLIEGaaNGVGLGIQFLRHIERTRV 239
Cdd:cd00882 1 VVVGRGGVGKSSLLNALLGGEVGEvSDVPGTTRDPDVYVKELDkGKVKLVLVDTPGLDEF--GGLGREELARLLLRGADL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 240 ILHLIDMSgveeNDPFEDYHKINHELTSYDPDLlkrPQIVVATKMDMPDAEANLEDFKAKLAtdDTLPNTPaVYPVSSIT 319
Cdd:cd00882 79 ILLVVDST----DRESEEDAKLLILRRLRKEGI---PIILVGNKIDLLEEREVEELLRLEEL--AKILGVP-VFEVSAKT 148
|
170
....*....|
gi 489740498 320 QQGLKALLAK 329
Cdd:cd00882 149 GEGVDELFEK 158
|
|
| HflX |
cd01878 |
HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment ... |
161-334 |
3.75e-10 |
|
HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual biological functions of these GTPases remain unclear. HflX is widespread, but not universally represented in all three superkingdoms.
Pssm-ID: 206666 [Multi-domain] Cd Length: 204 Bit Score: 59.40 E-value: 3.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 161 VGLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLDDGRDFVMADLpgliegaangVGlgiqFLRHI------ 234
Cdd:cd01878 44 VALVGYTNAGKSTLFNALTGADVLAEDQLFATLDPTTRRIKLPGGREVLLTDT----------VG----FIRDLphqlve 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 235 ------ERTR---VILHLIDMS--GVEENdpFEDYHKINHELtsydpDLLKRPQIVVATKMDMPDAEANLEDFkaklatd 303
Cdd:cd01878 110 afrstlEEVAeadLLLHVVDASdpDREEQ--IETVEEVLKEL-----GADDIPIILVLNKIDLLDDEELEERL------- 175
|
170 180 190
....*....|....*....|....*....|.
gi 489740498 304 dtLPNTPAVYPVSSITQQGLKALLAKTADLL 334
Cdd:cd01878 176 --RAGRPDAVFISAKTGEGLDLLKEAIEELL 204
|
|
| small_GTP |
TIGR00231 |
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ... |
161-326 |
1.20e-09 |
|
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]
Pssm-ID: 272973 [Multi-domain] Cd Length: 162 Bit Score: 57.00 E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 161 VGLVGFPSVGKSTLLSVVTSAKPKI-AAYHFTTLVPNLGMVRLD-DGRDFVMADLPGLIEGAANGVGLGIQFLRHIERTR 238
Cdd:TIGR00231 4 IVIVGHPNVGKSTLLNSLLGNKGSItEYYPGTTRNYVTTVIEEDgKTYKFNLLDTAGQEDYDAIRRLYYPQVERSLRVFD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 239 VILHLIDMsgveENDPFEDYHKINHELTSydpdllKRPQIVVATKMDMPDAeanleDFKAKLATDDTLPNTPAVYPVSSI 318
Cdd:TIGR00231 84 IVILVLDV----EEILEKQTKEIIHHADS------GVPIILVGNKIDLKDA-----DLKTHVASEFAKLNGEPIIPLSAE 148
|
....*...
gi 489740498 319 TQQGLKAL 326
Cdd:TIGR00231 149 TGKNIDSA 156
|
|
| YihA_EngB |
cd01876 |
YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli ... |
161-334 |
7.88e-09 |
|
YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and consists of the GTPase domain only (some of the eukaryotic homologs contain an N-terminal extension of about 120 residues that might be involved in organellar targeting). Homologs of yihA are found in most Gram-positive and Gram-negative pathogenic bacteria, with the exception of Mycobacterium tuberculosis. The broad-spectrum nature of YihA and its essentiality for cell viability in bacteria make it an attractive antibacterial target.
Pssm-ID: 206665 [Multi-domain] Cd Length: 170 Bit Score: 54.82 E-value: 7.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 161 VGLVGFPSVGKSTLLSVVTSAK--PKIAAYHFTTLVPNLGMVrlddGRDFVMADLPGLieGAANG--------VGLGIQF 230
Cdd:cd01876 2 VAFAGRSNVGKSSLINALTNRKklARTSKTPGRTQLINFFNV----GDKFRLVDLPGY--GYAKVskevrekwGKLIEEY 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 231 LRHIERTRVILHLIDmsgveendpfedyhkINHELTSYDPDLL------KRPQIVVATKMDM---PDAEANLEDFKAKLA 301
Cdd:cd01876 76 LENRENLKGVVLLID---------------ARHGPTPIDLEMLefleelGIPFLIVLTKADKlkkSELAKVLKKIKEELN 140
|
170 180 190
....*....|....*....|....*....|...
gi 489740498 302 TDDTLPNtpaVYPVSSITQQGLKALLAKTADLL 334
Cdd:cd01876 141 LFNILPP---VILFSSKKGTGIDELRALIAEWL 170
|
|
| PRK11058 |
PRK11058 |
GTPase HflX; Provisional |
161-327 |
1.70e-08 |
|
GTPase HflX; Provisional
Pssm-ID: 182934 [Multi-domain] Cd Length: 426 Bit Score: 56.26 E-value: 1.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 161 VGLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLDDGRDFVMADLPGLIEGAANgvGLGIQFLRHIERTR-- 238
Cdd:PRK11058 200 VSLVGYTNAGKSTLFNRITEARVYAADQLFATLDPTLRRIDVADVGETVLADTVGFIRHLPH--DLVAAFKATLQETRqa 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 239 -VILHLIDMSGVEENDPFEDYHKINHELTSYDPdllkrPQIVVATKMDMpdaeanLEDFKAKLATDDTlpNTPAVYPVSS 317
Cdd:PRK11058 278 tLLLHVVDAADVRVQENIEAVNTVLEEIDAHEI-----PTLLVMNKIDM------LDDFEPRIDRDEE--NKPIRVWLSA 344
|
170
....*....|
gi 489740498 318 ITQQGLKALL 327
Cdd:PRK11058 345 QTGAGIPLLF 354
|
|
| HflX |
COG2262 |
50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]; ... |
161-334 |
2.04e-08 |
|
50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441863 [Multi-domain] Cd Length: 419 Bit Score: 55.86 E-value: 2.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 161 VGLVGFPSVGKSTLLSVVTSA----KPKIaayhFTTLVPNLGMVRLDDGRDFVMADLpgliegaangVGlgiqFLRH--- 233
Cdd:COG2262 202 VALVGYTNAGKSTLFNRLTGAdvlaEDKL----FATLDPTTRRLELPDGRPVLLTDT----------VG----FIRKlph 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 234 ---------IERTR---VILHLIDMS--GVEENdpFEDYHKINHELtsydpDLLKRPQIVVATKMDMPDAEAnLEDFKAK 299
Cdd:COG2262 264 qlveafrstLEEVReadLLLHVVDASdpDFEEQ--IETVNEVLEEL-----GADDKPIILVFNKIDLLDDEE-LERLRAG 335
|
170 180 190
....*....|....*....|....*....|....*
gi 489740498 300 LatddtlpntPAVYPVSSITQQGLKALLAKTADLL 334
Cdd:COG2262 336 Y---------PDAVFISAKTGEGIDELLEAIEERL 361
|
|
| Era |
cd04163 |
E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is ... |
161-334 |
5.96e-07 |
|
E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly by chaperoning the 16S rRNA. It also contacts several assembly elements of the 30S subunit. Era couples cell growth with cytokinesis and plays a role in cell division and energy metabolism. Homologs have also been found in eukaryotes. Era contains two domains: the N-terminal GTPase domain and a C-terminal domain KH domain that is critical for RNA binding. Both domains are important for Era function. Era is functionally able to compensate for deletion of RbfA, a cold-shock adaptation protein that is required for efficient processing of the 16S rRNA.
Pssm-ID: 206726 [Multi-domain] Cd Length: 168 Bit Score: 49.00 E-value: 5.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 161 VGLVGFPSVGKSTLL-SVV------TSAKPKiaayhfTTLVPNLGMVRLDDGRdFVMADLPGLIEGAANgvgLGIQFLRH 233
Cdd:cd04163 6 VAIIGRPNVGKSTLLnALVgqkisiVSPKPQ------TTRNRIRGIYTDDDAQ-IIFVDTPGIHKPKKK---LGERMVKA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 234 IERT----RVILHLIDMSgveendpfedyhkinHELTSYDPDLL------KRPQIVVATKMDMPDAEANLEDFKAKLatd 303
Cdd:cd04163 76 AWSAlkdvDLVLFVVDAS---------------EWIGEGDEFILellkksKTPVILVLNKIDLVKDKEDLLPLLEKL--- 137
|
170 180 190
....*....|....*....|....*....|.
gi 489740498 304 DTLPNTPAVYPVSSITQQGLKALLAKTADLL 334
Cdd:cd04163 138 KELHPFAEIFPISALKGENVDELLEYIVEYL 168
|
|
| EngB |
COG0218 |
GTP-binding protein EngB required for normal cell division [Cell cycle control, cell division, ... |
169-334 |
9.19e-07 |
|
GTP-binding protein EngB required for normal cell division [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 439988 [Multi-domain] Cd Length: 194 Bit Score: 48.91 E-value: 9.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 169 VGKSTLLSVV--------TSAKP-KiaayhfTTLVpNLgmVRLDDGRDFVmaDLPG----------------LIEgaang 223
Cdd:COG0218 34 VGKSSLINALtnrkklarTSKTPgK------TQLI-NF--FLINDKFYLV--DLPGygyakvskaekekwqkLIE----- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 224 vglgiQFLRHIERTRVILHLIDmsgveendpfedyhkINHELTSYDPDLL------KRPQIVVATKMD---MPDAEANLE 294
Cdd:COG0218 98 -----DYLEGRENLKGVVLLID---------------IRHPPKELDLEMLewldeaGIPFLIVLTKADklkKSELAKQLK 157
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 489740498 295 DFKAKLATDdtlPNTPAVYPVSSITQQGLKALLAKTADLL 334
Cdd:COG0218 158 AIKKALGKD---PAAPEVILFSSLKKEGIDELRAAIEEWL 194
|
|
| Era |
COG1159 |
GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis]; |
161-340 |
2.41e-06 |
|
GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis];
Pssm-ID: 440773 [Multi-domain] Cd Length: 290 Bit Score: 48.83 E-value: 2.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 161 VGLVGFPSVGKSTLL-SVV------TSAKPKiaayhfTTLVPNLGMVRLDDGRdFVMADLPGLiegaangvglgiqflrH 233
Cdd:COG1159 6 VAIVGRPNVGKSTLLnALVgqkvsiVSPKPQ------TTRHRIRGIVTREDAQ-IVFVDTPGI----------------H 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 234 IERTR-----------------VILHLIDMSgvEENDPFEDYhkINHELTSydpdlLKRPQIVVATKMDMPDAEAnLEDF 296
Cdd:COG1159 63 KPKRKlgrrmnkaawsaledvdVILFVVDAT--EKIGEGDEF--ILELLKK-----LKTPVILVINKIDLVKKEE-LLPL 132
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 489740498 297 KAKLAtdDTLPNTpAVYPVSSITQQGLKALLAKTADLLDTTPQF 340
Cdd:COG1159 133 LAEYS--ELLDFA-EIVPISALKGDNVDELLDEIAKLLPEGPPY 173
|
|
| MnmE |
COG0486 |
tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal ... |
163-334 |
1.76e-04 |
|
tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal structure and biogenesis]; tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440253 [Multi-domain] Cd Length: 448 Bit Score: 43.51 E-value: 1.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 163 LVGFPSVGKSTLL--------SVVTSakpkIAAyhfTTlvpnlgmvrlddgRDFvmadlpglIEGAANGVGLGIQF---- 230
Cdd:COG0486 218 IVGRPNVGKSSLLnallgeerAIVTD----IAG---TT-------------RDV--------IEERINIGGIPVRLidta 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 231 -LRH---------IERTR-------VILHLIDMSGVEENDPFEDYHKINHeltsydpdllkRPQIVVATKMDMPDAEAnl 293
Cdd:COG0486 270 gLREtedevekigIERAReaieeadLVLLLLDASEPLTEEDEEILEKLKD-----------KPVIVVLNKIDLPSEAD-- 336
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 489740498 294 edfkaklATDDTLPNTPAVYpVSSITQQGLKALLAKTADLL 334
Cdd:COG0486 337 -------GELKSLPGEPVIA-ISAKTGEGIDELKEAILELV 369
|
|
| trmE |
PRK05291 |
tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE; |
163-334 |
3.76e-04 |
|
tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;
Pssm-ID: 235392 [Multi-domain] Cd Length: 449 Bit Score: 42.41 E-value: 3.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 163 LVGFPSVGKSTLL--------SVVTSakpkIAAyhfTTlvpnlgmvrlddgRDFvmadlpglIEGAANGVGLGIQF---- 230
Cdd:PRK05291 220 IAGRPNVGKSSLLnallgeerAIVTD----IAG---TT-------------RDV--------IEEHINLDGIPLRLidta 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 231 -LRH---------IERTR-------VILHLIDMSGVEENDPFEDYHKINHEltsydpdllkrPQIVVATKMDMPDAEanl 293
Cdd:PRK05291 272 gIREtddevekigIERSReaieeadLVLLVLDASEPLTEEDDEILEELKDK-----------PVIVVLNKADLTGEI--- 337
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 489740498 294 edfkaklatDDTLPNTPAVYPVSSITQQGLKALLAKTADLL 334
Cdd:PRK05291 338 ---------DLEEENGKPVIRISAKTGEGIDELREAIKELA 369
|
|
| FeoB |
cd01879 |
Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) ... |
163-335 |
1.52e-03 |
|
Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.
Pssm-ID: 206667 [Multi-domain] Cd Length: 159 Bit Score: 38.98 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 163 LVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGMVRLdDGRDFVMADLPGLI--------EGAANgvglgiQFLRHi 234
Cdd:cd01879 2 LVGNPNVGKTTLFNALTGARQKVGNWPGVTVEKKEGEFKL-GGKEIEIVDLPGTYsltpysedEKVAR------DFLLG- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 235 ERTRVILHLIDMSGVEENDPfedyhkinheLTSydpDLL--KRPQIVVATKMDmpdaEANLEDFK---AKLATDDTLPnt 309
Cdd:cd01879 74 EEPDLIVNVVDATNLERNLY----------LTL---QLLelGLPVVVALNMID----EAEKRGIKidlDKLSELLGVP-- 134
|
170 180
....*....|....*....|....*.
gi 489740498 310 paVYPVSSITQQGLKALLAKTADLLD 335
Cdd:cd01879 135 --VVPTSARKGEGIDELLDAIAKLAE 158
|
|
| trmE |
cd04164 |
trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in ... |
163-334 |
1.61e-03 |
|
trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase domain that forms a canonical Ras-like fold. It functions a molecular switch GTPase, and apparently uses a conformational change associated with GTP hydrolysis to promote the tRNA modification reaction, in which the conserved cysteine in the C-terminal domain is thought to function as a catalytic residue. In bacteria that are able to survive in extremely low pH conditions, TrmE regulates glutamate-dependent acid resistance.
Pssm-ID: 206727 [Multi-domain] Cd Length: 159 Bit Score: 39.01 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 163 LVGFPSVGKSTLL--------SVVTSakpkIAAyhfTTlvpnlgmvrlddgRDFVMADLpgLIEGaangvgLGIQF---- 230
Cdd:cd04164 8 IAGKPNVGKSSLLnalagrdrAIVSD----IAG---TT-------------RDVIEEEI--DLGG------IPVRLidta 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 231 -LRH---------IERTR-------VILHLIDMSGVEENDPFEDYHKINheltsydpdllKRPQIVVATKMDMPDAEANL 293
Cdd:cd04164 60 gLREtedeiekigIERAReaieeadLVLLVVDASEGLDEEDLEILELPA-----------KKPVIVVLNKSDLLSDAEGI 128
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 489740498 294 EDfkaklatddtlPNTPAVYPVSSITQQGLKALLAKTADLL 334
Cdd:cd04164 129 SE-----------LNGKPIIAISAKTGEGIDELKEALLELA 158
|
|
| Gem1 |
COG1100 |
GTPase SAR1 family domain [General function prediction only]; |
161-334 |
1.81e-03 |
|
GTPase SAR1 family domain [General function prediction only];
Pssm-ID: 440717 [Multi-domain] Cd Length: 177 Bit Score: 39.19 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 161 VGLVGFPSVGKSTLLSVVTSAKPKIAAYhfttLVPNlG------MVRLDDG-RDFVMADLPGLIEGAAngvgLGIQFLRH 233
Cdd:COG1100 6 IVVVGTGGVGKTSLVNRLVGDIFSLEKY----LSTN-GvtidkkELKLDGLdVDLVIWDTPGQDEFRE----TRQFYARQ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 234 IERTRVILHLIDMSGVEENDPFEDYHKINHELtsydpdLLKRPQIVVATKMDMPDAE--ANLEDFKAKLATDdtlpNTPA 311
Cdd:COG1100 77 LTGASLYLFVVDGTREETLQSLYELLESLRRL------GKKSPIILVLNKIDLYDEEeiEDEERLKEALSED----NIVE 146
|
170 180
....*....|....*....|...
gi 489740498 312 VYPVSSITQQGLKALLAKTADLL 334
Cdd:COG1100 147 VVATSAKTGEGVEELFAALAEIL 169
|
|
| HSR1_MMR1 |
cd01857 |
A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC ... |
161-217 |
3.35e-03 |
|
A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC class I region and is highly homologous to a putative GTP-binding protein, MMR1 from mouse. These proteins represent a new subfamily of GTP-binding proteins that has only eukaryote members. This subfamily shows a circular permutation of the GTPase signature motifs so that the C-terminal strands 5, 6, and 7 (strand 6 contains the G4 box with sequence NKXD) are relocated to the N-terminus.
Pssm-ID: 206750 [Multi-domain] Cd Length: 140 Bit Score: 37.60 E-value: 3.35e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489740498 161 VGLVGFPSVGKSTLL-SVVTSAKPKIAAY-----HFTTLVpnlgmvrLDDGrdFVMADLPGLI 217
Cdd:cd01857 85 IGLVGYPNVGKSSLInALVGSKKVSVSSTpgktkHFQTIF-------LEPG--ITLCDCPGLV 138
|
|
| PRK04213 |
PRK04213 |
GTP-binding protein EngB; |
156-285 |
8.67e-03 |
|
GTP-binding protein EngB;
Pssm-ID: 179790 [Multi-domain] Cd Length: 201 Bit Score: 37.20 E-value: 8.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489740498 156 KVLADVGLVGFPSVGKSTLLSVVTSAKPKIAAYHFTTLVPNLGmvrldDGRDFVMADLPGLieGAANGVGLGIQ------ 229
Cdd:PRK04213 7 DRKPEIVFVGRSNVGKSTLVRELTGKKVRVGKRPGVTRKPNHY-----DWGDFILTDLPGF--GFMSGVPKEVQekikde 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489740498 230 FLRHIE----RTRVILHLID-MSGVEENDPFEDYHKINHELTSYD-PDLLKRPQIVVATKMD 285
Cdd:PRK04213 80 IVRYIEdnadRILAAVLVVDgKSFIEIIERWEGRGEIPIDVEMFDfLRELGIPPIVAVNKMD 141
|
|
| SelB |
cd04171 |
SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; ... |
271-339 |
9.38e-03 |
|
SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; SelB is an elongation factor needed for the co-translational incorporation of selenocysteine. Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin. In bacteria, the C-terminal part of SelB recognizes this hairpin, while the N-terminal part binds GTP and tRNA in analogy with elongation factor Tu (EF-Tu). It specifically recognizes the selenocysteine charged tRNAsec, which has a UCA anticodon, in an EF-Tu like manner. This allows insertion of selenocysteine at in-frame UGA stop codons. In E. coli SelB binds GTP, selenocysteyl-tRNAsec, and a stem-loop structure immediately downstream of the UGA codon (the SECIS sequence). The absence of active SelB prevents the participation of selenocysteyl-tRNAsec in translation. Archaeal and animal mechanisms of selenocysteine incorporation are more complex. Although the SECIS elements have different secondary structures and conserved elements between archaea and eukaryotes, they do share a common feature. Unlike in E. coli, these SECIS elements are located in the 3' UTRs. This group contains bacterial SelBs, as well as, one from archaea.
Pssm-ID: 206734 [Multi-domain] Cd Length: 170 Bit Score: 36.81 E-value: 9.38e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489740498 271 DLLKRPQIVVA-TKMDMPD---AEANLEDFKAKLATDDtLPNTPaVYPVSSITQQGLKALLAKTADLLDTTPQ 339
Cdd:cd04171 99 ELLGIKKGLVVlTKADLVDedrLELVEEEILELLAGTF-LADAP-IFPVSSVTGEGIEELKNYLDELAEPQSK 169
|
|
| |
