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Conserved domains on  [gi|489742683|ref|WP_003646733|]
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MULTISPECIES: threonine/serine exporter family protein [Lactobacillus]

Protein Classification

threonine/serine exporter family protein( domain architecture ID 10581889)

threonine/serine exporter family protein similar to ThrE, a membrane protein involved in the export of threonine and serine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ThrE_2 pfam12821
Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the ...
 10-138 1.54e-44

Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.


:

Pssm-ID: 432807  Cd Length: 129  Bit Score: 142.66  E-value: 1.54e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489742683   10 NLVFAWLASVGFGLIINVPHRALVLCGVSGSAGWILYWLANRIGIGRLGSNLLGALCVGILGLVFARIKKCPVTVFNIPG 89
Cdd:pfam12821   1 QLIFAFIATLGFGILFNVPKRALFYAGIGGAVGWLVYLLLMHFGSSIALASFLAALAIGLLSEIFARRLKAPVTVFLVPG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 489742683   90 VVPLVPGVPAYQAVRAMVEGQLSDAEDLILRVAIVTIAIAMGFMLAQLM 138
Cdd:pfam12821  81 IIPLVPGGGAYNTMYYLVQGNYALAVSYGLETLFIAGAIALGLVLVSLI 129
 
Name Accession Description Interval E-value
ThrE_2 pfam12821
Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the ...
 10-138 1.54e-44

Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.


Pssm-ID: 432807  Cd Length: 129  Bit Score: 142.66  E-value: 1.54e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489742683   10 NLVFAWLASVGFGLIINVPHRALVLCGVSGSAGWILYWLANRIGIGRLGSNLLGALCVGILGLVFARIKKCPVTVFNIPG 89
Cdd:pfam12821   1 QLIFAFIATLGFGILFNVPKRALFYAGIGGAVGWLVYLLLMHFGSSIALASFLAALAIGLLSEIFARRLKAPVTVFLVPG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 489742683   90 VVPLVPGVPAYQAVRAMVEGQLSDAEDLILRVAIVTIAIAMGFMLAQLM 138
Cdd:pfam12821  81 IIPLVPGGGAYNTMYYLVQGNYALAVSYGLETLFIAGAIALGLVLVSLI 129
YjjB COG3610
Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];
2-150 1.22e-36

Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];


Pssm-ID: 442828  Cd Length: 150  Bit Score: 123.38  E-value: 1.22e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489742683   2 PFWLEIIVNLVFAWLASVGFGLIINVPHRALVLCGVSGSAGWILYWLANRIGIGRLGSNLLGALCVGILGLVFARIKKCP 81
Cdd:COG3610    1 DLLLPLLLQLLAAFVAAVGFAVLFNAPRRALLWAGLGGALGWLVYLLLLDLGLGPVLATFVAALVVGLLAELLARRLKAP 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489742683  82 VTVFNIPGVVPLVPGVPAYQAVRAMVEGQLSDAEDLILRVAIVTIAIAMGFMLAQLMGEIFFKTRNNRK 150
Cdd:COG3610   81 ATVFTVPGIIPLVPGSGAYRAMYALVEGDYLAALSNGLEALLIAGALAAGLLLGSLLARPRRRKRRLKR 149
PRK09917 PRK09917
threonine/serine exporter;
1-108 4.87e-10

threonine/serine exporter;


Pssm-ID: 182143  Cd Length: 157  Bit Score: 54.77  E-value: 4.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489742683   1 MPFWLEIIVNLVFAWLASVGFGLIINVPHRALVLCGVSGSAGWILYWLANRIGIGRLGSNLLGALCVGILGLVFARIKKC 80
Cdd:PRK09917   4 IEFLLALAQDMILAAIPAVGFAMVFNVPVRALRWCALLGAIGHGSRMLMMTSGLNIEWSTFMASMLVGTIGIQWSRWYLA 83

                         90       100
                 ....*....|....*....|....*...
gi 489742683  81 PVTVFNIPGVVPLVPGVPAYQAVRAMVE 108
Cdd:PRK09917  84 HPKVFTVAAVIPMFPGISAYTAMISAVK 111
 
Name Accession Description Interval E-value
ThrE_2 pfam12821
Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the ...
 10-138 1.54e-44

Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.


Pssm-ID: 432807  Cd Length: 129  Bit Score: 142.66  E-value: 1.54e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489742683   10 NLVFAWLASVGFGLIINVPHRALVLCGVSGSAGWILYWLANRIGIGRLGSNLLGALCVGILGLVFARIKKCPVTVFNIPG 89
Cdd:pfam12821   1 QLIFAFIATLGFGILFNVPKRALFYAGIGGAVGWLVYLLLMHFGSSIALASFLAALAIGLLSEIFARRLKAPVTVFLVPG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 489742683   90 VVPLVPGVPAYQAVRAMVEGQLSDAEDLILRVAIVTIAIAMGFMLAQLM 138
Cdd:pfam12821  81 IIPLVPGGGAYNTMYYLVQGNYALAVSYGLETLFIAGAIALGLVLVSLI 129
YjjB COG3610
Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];
2-150 1.22e-36

Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];


Pssm-ID: 442828  Cd Length: 150  Bit Score: 123.38  E-value: 1.22e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489742683   2 PFWLEIIVNLVFAWLASVGFGLIINVPHRALVLCGVSGSAGWILYWLANRIGIGRLGSNLLGALCVGILGLVFARIKKCP 81
Cdd:COG3610    1 DLLLPLLLQLLAAFVAAVGFAVLFNAPRRALLWAGLGGALGWLVYLLLLDLGLGPVLATFVAALVVGLLAELLARRLKAP 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489742683  82 VTVFNIPGVVPLVPGVPAYQAVRAMVEGQLSDAEDLILRVAIVTIAIAMGFMLAQLMGEIFFKTRNNRK 150
Cdd:COG3610   81 ATVFTVPGIIPLVPGSGAYRAMYALVEGDYLAALSNGLEALLIAGALAAGLLLGSLLARPRRRKRRLKR 149
PRK09917 PRK09917
threonine/serine exporter;
1-108 4.87e-10

threonine/serine exporter;


Pssm-ID: 182143  Cd Length: 157  Bit Score: 54.77  E-value: 4.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489742683   1 MPFWLEIIVNLVFAWLASVGFGLIINVPHRALVLCGVSGSAGWILYWLANRIGIGRLGSNLLGALCVGILGLVFARIKKC 80
Cdd:PRK09917   4 IEFLLALAQDMILAAIPAVGFAMVFNVPVRALRWCALLGAIGHGSRMLMMTSGLNIEWSTFMASMLVGTIGIQWSRWYLA 83

                         90       100
                 ....*....|....*....|....*...
gi 489742683  81 PVTVFNIPGVVPLVPGVPAYQAVRAMVE 108
Cdd:PRK09917  84 HPKVFTVAAVIPMFPGISAYTAMISAVK 111
ThrE pfam06738
Putative threonine/serine exporter; ThrE is a family of bacterial and Archaeal proteins that ...
 2-135 1.06e-06

Putative threonine/serine exporter; ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.


Pssm-ID: 461997  Cd Length: 241  Bit Score: 46.36  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489742683    2 PFWLeiivnLVFAW-LASVGFGLIINVPHRALVLCGVSGSAGWILYWLANRIGIGRLGSNLLGALCVGILGLVFARIKKC 80
Cdd:pfam06738 107 PRWL-----VVLAAgLASAAFALLFGGDWIDFLVAFLAGGLGGLLRLVLNRRGLNSFFFEAVAAFVASLLALLAVSLGLG 181

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 489742683   81 P-VTVFNIPGVVPLVPGVPAYQAVRAMVEGQLSDAEDLILRVAIVTIAIAMGFMLA 135
Cdd:pfam06738 182 InPDAIIIGSIMLLVPGLPLTNAVRDLIAGDLVSGLARLVEAILIALAIAFGIALA 237
YjjP COG2966
Uncharacterized membrane protein YjjP, DUF1212 family [Function unknown];
8-135 1.29e-06

Uncharacterized membrane protein YjjP, DUF1212 family [Function unknown];


Pssm-ID: 442206 [Multi-domain]  Cd Length: 409  Bit Score: 46.47  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489742683   8 IVNLVFAWLASVGFGLIINVPHRALVLCGVSGSAGWILYWLANRIGIGRLGSNLLGALCVGILGLVFAR--IKKCPVTVF 85
Cdd:COG2966  121 WLVVLAAGLAAAAFALLFGGGWLDFLVAFLAGALGGLLRRLLARRGLNPFFVEALAAFVATLIALLLARlgLGLNPDLII 200

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 489742683  86 nIPGVVPLVPGVPAYQAVRAMVEGQLSDAEDLILRVAIVTIAIAMGFMLA 135
Cdd:COG2966  201 -IGSILPLVPGVPLTNAVRDLIAGDLVSGLARLAEALLIALAIAFGVALA 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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