|
Name |
Accession |
Description |
Interval |
E-value |
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
7-458 |
0e+00 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 517.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 7 YENKNILILGLGKSGFSVAKLLLKLGAKLTLNDKKDLSnDDRAAELDKLGVRVISGHHPVEIFDKekFDYLVKNPGIPYE 86
Cdd:COG0771 2 LKGKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAP-ELAAAELEAPGVEVVLGEHPEELLDG--ADLVVKSPGIPPD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 87 NPMVEKALKLNIPVITEPEIALNVSEAPYVCVTGSNGKTTTVMLTqrimdHHLSKNGG-HAYAVGNIGVPISEVVEKATN 165
Cdd:COG0771 79 HPLLKAARAAGIPVIGEIELAYRLSPAPIIAITGTNGKTTTTTLI-----GHILKAAGlRVAVGGNIGTPLLDLLLEPEP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 166 KDLLVVEMSSFQLLGVTDIKPKVAAIVDIYNNvHLDYHKTFDNYVEAKLRITQSQDQNDYFIANFDQKNILdRELKKTKA 245
Cdd:COG0771 154 PDVYVLELSSFQLETTPSLRPDVAVILNITPD-HLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDPLTR-ALAEEAKA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 246 KVQTFSETDK-TADYFIGDEYL-ESKDDHQIMKISDIKIPGIHNQQNCLVAIAISKLMGADDSDIQYALSTFTGATHRLQ 323
Cdd:COG0771 232 RVVPFSLKEPlEGGAGLEDGKLvDRASGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLE 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 324 YVMTYNDRKIYNDSKSTNIEAATVAIPSFKEPEVLIAGGLDRGFMFDSLVPLFKKHVKSIVLYGETKYLLADAARKAGIK 403
Cdd:COG0771 312 FVAEINGVRFINDSKATNPDATLAALESFDGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAGVP 391
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 489744569 404 dIVIVNTLQEAVPRAYELSEAGDVILFSPACASWDQFNTFEERGDFFVKFIKELK 458
Cdd:COG0771 392 -VVIVETMEEAVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVRELA 445
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
7-457 |
1.70e-135 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 397.42 E-value: 1.70e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 7 YENKNILILGLGKSGFSVAKLLLKLGAKLTLNDKKDLSN-DDRAAELDKLGVRVISGHHPVEifDKEKFDYLVKNPGIPY 85
Cdd:PRK14106 3 LKGKKVLVVGAGVSGLALAKFLKKLGAKVILTDEKEEDQlKEALEELGELGIELVLGEYPEE--FLEGVDLVVVSPGVPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 86 ENPMVEKALKLNIPVITEPEIALNVSEAPYVCVTGSNGKTTTVMLTQRImdhhLSKNGGHAYAVGNIGVPISEVVEKATN 165
Cdd:PRK14106 81 DSPPVVQAHKKGIEVIGEVELAYRFSKAPIVAITGTNGKTTTTTLLGEI----FKNAGRKTLVAGNIGYPLIDAVEEYGE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 166 KDLLVVEMSSFQLLGVTDIKPKVAAIVDIYNNvHLDYHKTFDNYVEAKLRITQSQDQNDYFIANFDQKNIldREL-KKTK 244
Cdd:PRK14106 157 DDIIVAEVSSFQLETIKEFKPKVGCILNITPD-HLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDPRT--RSLaKKAK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 245 AKVQTFSETDKTAD-YFI-GDEYLESKDDH--QIMKISDIKIPGIHNQQNCLVAIAISKLMGADDSDIQYALSTFTGATH 320
Cdd:PRK14106 234 ARVIFFSRKSLLEEgVFVkNGKIVISLGGKeeEVIDIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEH 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 321 RLQYVMTYNDRKIYNDSKSTNIEAATVAIPSFKEPEVLIAGGLDRGFMFDSLVPLFKKHVKSIVLYGETKYLLADAARKA 400
Cdd:PRK14106 314 RIEFVAEINGVKFINDSKGTNPDAAIKALEAYETPIVLIAGGYDKGSDFDEFAKAFKEKVKKLILLGETAQEIAEAARKY 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 489744569 401 GIKDIVIVNTLQEAVPRAYELSEAGDVILFSPACASWDQFNTFEERGDFFVKFIKEL 457
Cdd:PRK14106 394 GFDNILFAETLEEAVKKAYEIAKPGDVVLLSPACASWDMFKNFEERGRLFKELVLEL 450
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
11-455 |
1.52e-131 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 386.70 E-value: 1.52e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 11 NILILGLGKSGFSVAKLLLKLGAKLTLNDKKDLSNDDRAAELDKLGVRVISGHHpVEIFDKEKFDYLVKNPGIPYENPMV 90
Cdd:TIGR01087 1 KILILGLGKTGRAVARFLHKKGAEVTVTDLKPNEELEPSMGQLRLNEGSVLHTG-LHLEDLNNADLVVKSPGIPPDHPLV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 91 EKALKLNIPVITEPEIALNVSEAPYVCVTGSNGKTTTVMLTQrimdHHLSKNGGHAYAVGNIGVPISEVVEKaTNKDLLV 170
Cdd:TIGR01087 80 QAAAKRGIPVVGDIELFLRLVPLPVVAITGTNGKTTTTSLLY----HLLKAAGLKAFLGGNIGTPALEVLDQ-EGAELYV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 171 VEMSSFQLLGVTDIKPKVAAIVDIYNNvHLDYHKTFDNYVEAKLRITQSQDQNDYFIANFDQKnILDRELKKTKAKVQTF 250
Cdd:TIGR01087 155 LELSSFQLETTESLRPEIALILNISED-HLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDP-RFARLAQKSKAQVIWF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 251 SETdKTADYFIGDEyleskDDHQIMKISD--IKIPGIHNQQNCLVAIAISKLMGADDSDIQYALSTFTGATHRLQYVMTY 328
Cdd:TIGR01087 233 SVE-KDAERGLCIR-----DGGLYLKPNDleGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQK 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 329 NDRKIYNDSKSTNIEAATVAIPSFKEPEVLIAGGLDRGFMFDSLVPLFKKHVKSIVLYGETKYLLADAARKAGIkDIVIV 408
Cdd:TIGR01087 307 NGVHFYNDSKATNVHATLAALSAFDNPVILIVGGDDKGADFSPLAPAAAGKVKAVLAIGEDAAKIAPLLKEAGL-SVYLV 385
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 489744569 409 NTLQEAVPRAYELSEAGDVILFSPACASWDQFNTFEERGDFFVKFIK 455
Cdd:TIGR01087 386 ESLEEAVQAAREVASPGDVVLLSPACASFDQFKSYEERGEKFKELVR 432
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
118-297 |
1.54e-23 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 97.76 E-value: 1.54e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 118 VTGSNGKTTTVmltqRIMDHHLSKNGGHAYAVGN------------IGVP--ISEVVEKATnkDLLVVEMSSFQL---LG 180
Cdd:pfam08245 1 VTGTNGKTTTT----ELIAAILSLAGGVIGTIGTyigksgnttnnaIGLPltLAEMVEAGA--EYAVLEVSSHGLgegRL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 181 VTDIKPKVAAIvdiyNNV---HLDYHKTFDNYVEAKLRITQSQDQNDYFIANFDQK--NILDRELKKTKAKVQTFSEtDK 255
Cdd:pfam08245 75 SGLLKPDIAVF----TNIspdHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPygAFLIAKLKKAGVRVITYGI-EG 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 489744569 256 TADYFI--------GDEYLESKDDHQIMKISdIKIPGIHNQQNCLVAIAI 297
Cdd:pfam08245 150 EADLRAanielssdGTSFDLFTVPGGELEIE-IPLLGRHNVYNALAAIAA 198
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
49-429 |
8.53e-14 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 72.74 E-value: 8.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 49 AAELDKLGvrvisghHPVEIFD------KEKFDYLVKNPGIPYENPMVEKALKL---------NIPVITEPEIalnVSE- 112
Cdd:NF033197 13 ARELRGLG-------YDVDAVDvygkleKDDLFLLEEKGIISKKEAPFSDYDLViapvhcppdGKPFITHHEA---VGEi 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 113 ---------APYVCVTGSNGKTTTVMLTQRIMDHH----LSKNGGHAYAVGNIGVPIS-------EVVEKA-----TNKD 167
Cdd:NF033197 83 lkkkygripKKFIEITGVKGKTTTAELLAHILSDEyvllHTSRGTERYPEGELSNKGSitpasilNALELAeeigiDDYG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 168 LLVVEMSsfqlLGVTdikpkVAAIVDIYNNVHLDYH--KTFDNYVEAKLRITQSQDQNDYFIANFDQKNILDRELKKTKA 245
Cdd:NF033197 163 FLIFEVS----LGGT-----GAGDVGIITNILEDYPiaGGKRSASAAKLQSLKNAKVGSINVADLGIYINGKNKLVITVA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 246 KVQTFSetdktadyFIGDEYLESKDDHQIMKisdiKIPGIHNQQNCLVAIAISKLMGADDSDIQYALSTFTGATHRLQyV 325
Cdd:NF033197 234 GVEILS--------KYPLRFKYGNTEFEFNP----LLFGPHYRENSLFAIEAALNLGVDPEDIISALKGFKGLPGRMA-V 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 326 MTYNDRKIYNDSKS-TNIEAATVAIPSFKE---PEVLIAGGLDR----GFMFDSLVPLFKKHVKSIVlygETKYLLADAA 397
Cdd:NF033197 301 KKEGGVVIVDNINPgLNVKAIEYALDDALEllgDGTLVIGGDFGvvceEIDIDKLSEVLKKYRPKID---ILVGVGTELG 377
|
410 420 430
....*....|....*....|....*....|....*.
gi 489744569 398 R---KAGIKDIVIVN-TLQEAVPRAYELSEAGDVIL 429
Cdd:NF033197 378 KrlkKYLDKLEGYEAgTLEEGLDDARELTGEGNTLV 413
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
7-458 |
0e+00 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 517.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 7 YENKNILILGLGKSGFSVAKLLLKLGAKLTLNDKKDLSnDDRAAELDKLGVRVISGHHPVEIFDKekFDYLVKNPGIPYE 86
Cdd:COG0771 2 LKGKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAP-ELAAAELEAPGVEVVLGEHPEELLDG--ADLVVKSPGIPPD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 87 NPMVEKALKLNIPVITEPEIALNVSEAPYVCVTGSNGKTTTVMLTqrimdHHLSKNGG-HAYAVGNIGVPISEVVEKATN 165
Cdd:COG0771 79 HPLLKAARAAGIPVIGEIELAYRLSPAPIIAITGTNGKTTTTTLI-----GHILKAAGlRVAVGGNIGTPLLDLLLEPEP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 166 KDLLVVEMSSFQLLGVTDIKPKVAAIVDIYNNvHLDYHKTFDNYVEAKLRITQSQDQNDYFIANFDQKNILdRELKKTKA 245
Cdd:COG0771 154 PDVYVLELSSFQLETTPSLRPDVAVILNITPD-HLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDPLTR-ALAEEAKA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 246 KVQTFSETDK-TADYFIGDEYL-ESKDDHQIMKISDIKIPGIHNQQNCLVAIAISKLMGADDSDIQYALSTFTGATHRLQ 323
Cdd:COG0771 232 RVVPFSLKEPlEGGAGLEDGKLvDRASGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLE 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 324 YVMTYNDRKIYNDSKSTNIEAATVAIPSFKEPEVLIAGGLDRGFMFDSLVPLFKKHVKSIVLYGETKYLLADAARKAGIK 403
Cdd:COG0771 312 FVAEINGVRFINDSKATNPDATLAALESFDGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAGVP 391
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 489744569 404 dIVIVNTLQEAVPRAYELSEAGDVILFSPACASWDQFNTFEERGDFFVKFIKELK 458
Cdd:COG0771 392 -VVIVETMEEAVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVRELA 445
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
7-457 |
1.70e-135 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 397.42 E-value: 1.70e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 7 YENKNILILGLGKSGFSVAKLLLKLGAKLTLNDKKDLSN-DDRAAELDKLGVRVISGHHPVEifDKEKFDYLVKNPGIPY 85
Cdd:PRK14106 3 LKGKKVLVVGAGVSGLALAKFLKKLGAKVILTDEKEEDQlKEALEELGELGIELVLGEYPEE--FLEGVDLVVVSPGVPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 86 ENPMVEKALKLNIPVITEPEIALNVSEAPYVCVTGSNGKTTTVMLTQRImdhhLSKNGGHAYAVGNIGVPISEVVEKATN 165
Cdd:PRK14106 81 DSPPVVQAHKKGIEVIGEVELAYRFSKAPIVAITGTNGKTTTTTLLGEI----FKNAGRKTLVAGNIGYPLIDAVEEYGE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 166 KDLLVVEMSSFQLLGVTDIKPKVAAIVDIYNNvHLDYHKTFDNYVEAKLRITQSQDQNDYFIANFDQKNIldREL-KKTK 244
Cdd:PRK14106 157 DDIIVAEVSSFQLETIKEFKPKVGCILNITPD-HLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDPRT--RSLaKKAK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 245 AKVQTFSETDKTAD-YFI-GDEYLESKDDH--QIMKISDIKIPGIHNQQNCLVAIAISKLMGADDSDIQYALSTFTGATH 320
Cdd:PRK14106 234 ARVIFFSRKSLLEEgVFVkNGKIVISLGGKeeEVIDIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEH 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 321 RLQYVMTYNDRKIYNDSKSTNIEAATVAIPSFKEPEVLIAGGLDRGFMFDSLVPLFKKHVKSIVLYGETKYLLADAARKA 400
Cdd:PRK14106 314 RIEFVAEINGVKFINDSKGTNPDAAIKALEAYETPIVLIAGGYDKGSDFDEFAKAFKEKVKKLILLGETAQEIAEAARKY 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 489744569 401 GIKDIVIVNTLQEAVPRAYELSEAGDVILFSPACASWDQFNTFEERGDFFVKFIKEL 457
Cdd:PRK14106 394 GFDNILFAETLEEAVKKAYEIAKPGDVVLLSPACASWDMFKNFEERGRLFKELVLEL 450
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
11-455 |
1.52e-131 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 386.70 E-value: 1.52e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 11 NILILGLGKSGFSVAKLLLKLGAKLTLNDKKDLSNDDRAAELDKLGVRVISGHHpVEIFDKEKFDYLVKNPGIPYENPMV 90
Cdd:TIGR01087 1 KILILGLGKTGRAVARFLHKKGAEVTVTDLKPNEELEPSMGQLRLNEGSVLHTG-LHLEDLNNADLVVKSPGIPPDHPLV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 91 EKALKLNIPVITEPEIALNVSEAPYVCVTGSNGKTTTVMLTQrimdHHLSKNGGHAYAVGNIGVPISEVVEKaTNKDLLV 170
Cdd:TIGR01087 80 QAAAKRGIPVVGDIELFLRLVPLPVVAITGTNGKTTTTSLLY----HLLKAAGLKAFLGGNIGTPALEVLDQ-EGAELYV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 171 VEMSSFQLLGVTDIKPKVAAIVDIYNNvHLDYHKTFDNYVEAKLRITQSQDQNDYFIANFDQKnILDRELKKTKAKVQTF 250
Cdd:TIGR01087 155 LELSSFQLETTESLRPEIALILNISED-HLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDP-RFARLAQKSKAQVIWF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 251 SETdKTADYFIGDEyleskDDHQIMKISD--IKIPGIHNQQNCLVAIAISKLMGADDSDIQYALSTFTGATHRLQYVMTY 328
Cdd:TIGR01087 233 SVE-KDAERGLCIR-----DGGLYLKPNDleGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQK 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 329 NDRKIYNDSKSTNIEAATVAIPSFKEPEVLIAGGLDRGFMFDSLVPLFKKHVKSIVLYGETKYLLADAARKAGIkDIVIV 408
Cdd:TIGR01087 307 NGVHFYNDSKATNVHATLAALSAFDNPVILIVGGDDKGADFSPLAPAAAGKVKAVLAIGEDAAKIAPLLKEAGL-SVYLV 385
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 489744569 409 NTLQEAVPRAYELSEAGDVILFSPACASWDQFNTFEERGDFFVKFIK 455
Cdd:TIGR01087 386 ESLEEAVQAAREVASPGDVVLLSPACASFDQFKSYEERGEKFKELVR 432
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
51-430 |
8.18e-32 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 126.33 E-value: 8.18e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 51 ELDKLGVRVISGHHPVEIfdkEKFDYLVKNPGIPYENPMVEKALKLNIPVITEPE-IALNVSEAPYVCVTGSNGKTTTV- 128
Cdd:COG0773 44 RLEALGIPVFIGHDAENI---DDADLVVVSSAIPRDNPELVAARERGIPVLSRAEmLAELMRGKRSIAVAGTHGKTTTTs 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 129 MLTQrIMDHhlsknGGHA--YAVG----NIGVPIsevveKATNKDLLVVEM----SSFQLLgvtdiKPKVAAIvdiyNNV 198
Cdd:COG0773 121 MLAH-ILEE-----AGLDptFLIGgilnNFGTNA-----RLGDGDYFVAEAdesdGSFLHY-----SPDIAVV----TNI 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 199 ---HLDYHKTFDNYVEAKLRITQSQDQNDYFIANFDQKNiLDRELKKTKAKVQTFSeTDKTADYFIGDeyLESKDDHQIM 275
Cdd:COG0773 181 eadHLDIYGDLEAIKEAFHEFARNVPFYGLLVLCADDPG-LRELLPRCGRPVITYG-FSEDADYRAEN--IRIDGGGSTF 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 276 KIS---------DIKIPGIHNQQNCLVAIAISKLMGADDSDIQYALSTFTGATHRLQYVMTYNDRKIYNDS-------KS 339
Cdd:COG0773 257 DVLrrgeelgevELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFELKGEVGGVTVIDDYahhpteiAA 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 340 TnIEAATVAIPSFK-----EPevliaggldR-----GFMFDSLVPLFKK--HVksIVLY----------GETKYLLADAA 397
Cdd:COG0773 337 T-LAAAREKYPDRRlvavfQP---------HrysrtRDFLDEFAEALSLadEV--ILLDiyaarekpipGVSSEDLAEAI 404
|
410 420 430
....*....|....*....|....*....|...
gi 489744569 398 RKAGiKDIVIVNTLQEAVPRAYELSEAGDVILF 430
Cdd:COG0773 405 RKRG-KDVVYVPDLDELVEALAEIARPGDVVLT 436
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
89-430 |
3.76e-29 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 118.67 E-value: 3.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 89 MVEKALKLNIPVIT--EPEIAL--------NVSEAPYVCVTGSNGKTTTVMLTQRImdhhLSKNGGHAYAVGN----IGV 154
Cdd:COG0770 66 LVSRPLPADLPLIVvdDTLKALqqlaaahrARFNIPVIAITGSNGKTTTKEMLAAV----LSTKGKVLATPGNfnneIGV 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 155 PISevVEKATNK-DLLVVEM--SSF---QLLgvTDI-KPKVAAIvdiyNNV---HLDYHKTFDNYVEAKLRITQSQDQND 224
Cdd:COG0770 142 PLT--LLRLPEDhEFAVLEMgmNHPgeiAYL--ARIaRPDIAVI----TNIgpaHLEGFGSLEGIARAKGEIFEGLPPGG 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 225 YFIANFDQKnILDRELKKTKAKVQTFSeTDKTADYFIGDeyLESKDDHQIMKIS--------DIKIPGIHNQQNCLVAIA 296
Cdd:COG0770 214 VAVLNADDP-LLAALAERAKARVLTFG-LSEDADVRAED--IELDEDGTRFTLHtpggelevTLPLPGRHNVSNALAAAA 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 297 ISKLMGADDSDIQYALSTFTGATHRLQYVMTYNDRKIYNDSKSTNIEAATVAIPSFKEPE-----VLIAG-----GLDRG 366
Cdd:COG0770 290 VALALGLDLEEIAAGLAAFQPVKGRLEVIEGAGGVTLIDDSYNANPDSMKAALDVLAQLPgggrrIAVLGdmlelGEESE 369
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489744569 367 FMFDSLVPLFKK-HVKSIVLYGEtkyLLADAARKAGIKDIVIVNTLQEAVPRAYELSEAGDVILF 430
Cdd:COG0770 370 ELHREVGELAAElGIDRLFTVGE---LARAIAEAAGGERAEHFEDKEELLAALKALLRPGDVVLV 431
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
100-336 |
2.35e-24 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 105.16 E-value: 2.35e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 100 VITEPEIALNVSEAPYVC---------------------------VTGSNGKTTTVMLTQRImdhhLSKNGGHAYAVGNI 152
Cdd:COG0769 40 VVTEAPGALLAAGVPVIVvpdpraalallaaafyghpsqklkligVTGTNGKTTTTYLLAQI----LRALGKKTGLIGTV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 153 GVPISEVVEKATN-----KDL--------------LVVEMSSFQL-LG-VTDIKPKVAaivdIYNNV---HLDYHKTFDN 208
Cdd:COG0769 116 GNGIGGELIPSSLttpeaLDLqrllaemvdagvthVVMEVSSHALdQGrVDGVRFDVA----VFTNLtrdHLDYHGTMEA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 209 YVEAKLRITQSQDQNDYFIANFDQKNIlDRELKKTKAKVQTFSeTDKTADYFIGDeyLESKDDHQIMKIS--------DI 280
Cdd:COG0769 192 YFAAKARLFDQLGPGGAAVINADDPYG-RRLAAAAPARVITYG-LKADADLRATD--IELSADGTRFTLVtpggevevRL 267
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 489744569 281 KIPGIHNQQNCLVAIAISKLMGADDSDIQYALSTFTGATHRLQYVMTYNDRKIYND 336
Cdd:COG0769 268 PLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRMERVDGGQGPTVIVD 323
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
118-297 |
1.54e-23 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 97.76 E-value: 1.54e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 118 VTGSNGKTTTVmltqRIMDHHLSKNGGHAYAVGN------------IGVP--ISEVVEKATnkDLLVVEMSSFQL---LG 180
Cdd:pfam08245 1 VTGTNGKTTTT----ELIAAILSLAGGVIGTIGTyigksgnttnnaIGLPltLAEMVEAGA--EYAVLEVSSHGLgegRL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 181 VTDIKPKVAAIvdiyNNV---HLDYHKTFDNYVEAKLRITQSQDQNDYFIANFDQK--NILDRELKKTKAKVQTFSEtDK 255
Cdd:pfam08245 75 SGLLKPDIAVF----TNIspdHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPygAFLIAKLKKAGVRVITYGI-EG 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 489744569 256 TADYFI--------GDEYLESKDDHQIMKISdIKIPGIHNQQNCLVAIAI 297
Cdd:pfam08245 150 EADLRAanielssdGTSFDLFTVPGGELEIE-IPLLGRHNVYNALAAIAA 198
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
84-361 |
1.87e-16 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 81.16 E-value: 1.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 84 PYENPMVEKALKLNIPVITEPEIALNVSE---APYVCVTGSNGKTTTVMLTQRImdhhLSKNGGHAYAVGN----IGVPI 156
Cdd:TIGR01143 42 EVGPDNGLPQILVDDTLEALQALARAKRAkfsGKVIGITGSSGKTTTKEMLAAI----LSHKYKVFATPGNfnneIGLPL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 157 SeVVEKATNKDLLVVEMssfqllGV---------TDI-KPKVAAIvdiyNNV---HLDYHKTFDNYVEAKLRITQSQDQN 223
Cdd:TIGR01143 118 T-LLRAPGDHDYAVLEM------GAshpgeiaylAEIaKPDIAVI----TNIgpaHLEGFGSLEGIAEAKGEILQGLKEN 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 224 DYFIANFDQKNILDRELKKTKAKVQTFSETDK---TADYFIGDEYLESKDDHQIMKISDIKIP--GIHNQQNCLVAIAIS 298
Cdd:TIGR01143 187 GIAVINADDPAFADLAKRLPNRNILSFGFEGGdfvAKDISYSALGSTSFTLVAPGGEFEVSLPllGRHNVMNALAAAALA 266
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489744569 299 KLMGADDSDIQYALSTFTGATHRLQYVMTYNDRKIyNDSKSTNIEAATVAI---PSFKEPEVLIAG 361
Cdd:TIGR01143 267 LELGIPLEEIAEGLAELKLVKGRFEVQTKNGLTLI-DDTYNANPDSMRAALdalARFPGKKILVLG 331
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
118-325 |
1.92e-16 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 81.33 E-value: 1.92e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 118 VTGSNGKTTTVMLTQRIMDHHlsknGGHAYAVGNIGVPISEVVEKATN---------KDL----------LVVEMSSFQL 178
Cdd:PRK00139 100 VTGTNGKTTTAYLLAQILRLL----GEKTALIGTLGNGIGGELIPSGLttpdaldlqRLLaelvdagvtyAAMEVSSHAL 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 179 -LG-VTDIKPKVAaivdIYNNV---HLDYHKTFDNYVEAKLRITQSQDQndYFIANFDqknilDRELKKTKAKVQTFSET 253
Cdd:PRK00139 176 dQGrVDGLKFDVA----VFTNLsrdHLDYHGTMEDYLAAKARLFSELGL--AAVINAD-----DEVGRRLLALPDAYAVS 244
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489744569 254 DKTADYFIGDeyLESKDDHQIMKIS---DIKIPGIHNQQNCLVAIAISKLMGADDSDIQYALSTFTGATHRLQYV 325
Cdd:PRK00139 245 MAGADLRATD--VEYTDSGQTFTLVtevESPLIGRFNVSNLLAALAALLALGVPLEDALAALAKLQGVPGRMERV 317
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
49-429 |
8.53e-14 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 72.74 E-value: 8.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 49 AAELDKLGvrvisghHPVEIFD------KEKFDYLVKNPGIPYENPMVEKALKL---------NIPVITEPEIalnVSE- 112
Cdd:NF033197 13 ARELRGLG-------YDVDAVDvygkleKDDLFLLEEKGIISKKEAPFSDYDLViapvhcppdGKPFITHHEA---VGEi 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 113 ---------APYVCVTGSNGKTTTVMLTQRIMDHH----LSKNGGHAYAVGNIGVPIS-------EVVEKA-----TNKD 167
Cdd:NF033197 83 lkkkygripKKFIEITGVKGKTTTAELLAHILSDEyvllHTSRGTERYPEGELSNKGSitpasilNALELAeeigiDDYG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 168 LLVVEMSsfqlLGVTdikpkVAAIVDIYNNVHLDYH--KTFDNYVEAKLRITQSQDQNDYFIANFDQKNILDRELKKTKA 245
Cdd:NF033197 163 FLIFEVS----LGGT-----GAGDVGIITNILEDYPiaGGKRSASAAKLQSLKNAKVGSINVADLGIYINGKNKLVITVA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 246 KVQTFSetdktadyFIGDEYLESKDDHQIMKisdiKIPGIHNQQNCLVAIAISKLMGADDSDIQYALSTFTGATHRLQyV 325
Cdd:NF033197 234 GVEILS--------KYPLRFKYGNTEFEFNP----LLFGPHYRENSLFAIEAALNLGVDPEDIISALKGFKGLPGRMA-V 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 326 MTYNDRKIYNDSKS-TNIEAATVAIPSFKE---PEVLIAGGLDR----GFMFDSLVPLFKKHVKSIVlygETKYLLADAA 397
Cdd:NF033197 301 KKEGGVVIVDNINPgLNVKAIEYALDDALEllgDGTLVIGGDFGvvceEIDIDKLSEVLKKYRPKID---ILVGVGTELG 377
|
410 420 430
....*....|....*....|....*....|....*.
gi 489744569 398 R---KAGIKDIVIVN-TLQEAVPRAYELSEAGDVIL 429
Cdd:NF033197 378 KrlkKYLDKLEGYEAgTLEEGLDDARELTGEGNTLV 413
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
65-325 |
1.62e-13 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 72.81 E-value: 1.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 65 PVEIFDKEKFDYLVKNPGIPYENPMVEKAL-KLNIPVITEPEIALNVseapyVCVTGSNGKTTTVMLTQRImdhhLSKNG 143
Cdd:PRK11929 68 AAVLVEAEGEDQVAAADALVLPVADLRKALgELAARWYGRPSEQLSL-----VAVTGTNGKTSCAQLLAQL----LTRLG 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 144 GHAYAVGNIGVPISEVVEKATNK-------------------DLLVVEMSSFQL----LGVTDIkpkvaaIVDIYNNV-- 198
Cdd:PRK11929 139 KPCGSIGTLGARLDGRLIPGSLTtpdaiilhrilarmraagaDAVAMEASSHGLeqgrLDGLRI------AVAGFTNLtr 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 199 -HLDYHKTFDNYVEAKLRITQSQDQNDYFIANFDqknilDRELKKTKA------KVQTFSEtDKTADYFIGD-------E 264
Cdd:PRK11929 213 dHLDYHGTMQDYEEAKAALFSKLPGLGAAVINAD-----DPAAARLLAalprglKVGYSPQ-NAGADVQARDlratahgQ 286
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489744569 265 YLESKDDHQIMKIsDIKIPGIHNQQNCLVAIAISKLMGADDSDIQYALSTFTGATHRLQYV 325
Cdd:PRK11929 287 VFTLATPDGSYQL-VTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRMERV 346
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
118-326 |
1.68e-12 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 68.88 E-value: 1.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 118 VTGSNGKTTTVMLtqriMDHHLSKNGGHAYAVGNIGVPI---SEVVEKATN---------KDL----------LVVEMSS 175
Cdd:TIGR01085 90 VTGTNGKTTTTSL----IAQLLRLLGKKTGLIGTIGYRLggnDLIKNPAALttpealtlqSTLaemveagaqyAVMEVSS 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 176 FQLlgVTDIKPKVAAIVDIYNNV---HLDYHKTFDNYVEAKLRITQSQDQNDYFIANFDqkNILDRELKKTKAKVQTFSE 252
Cdd:TIGR01085 166 HAL--AQGRVRGVRFDAAVFTNLsrdHLDFHGTMENYFAAKASLFTELGLKRFAVINLD--DEYGAQFVKRLPKDITVSA 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 253 TDKTADYFIGDeyLESKDDHQIMKISDIKIP-------------GIHNQQNCLVAIAISK-LMGADDSDIQYALSTFTGA 318
Cdd:TIGR01085 242 ITQPADGRAQD--IKITDSGYSFEGQQFTFEtpageghlhtpliGRFNVYNLLAALATLLhLGGIDLEDIVAALEKFRGV 319
|
....*...
gi 489744569 319 THRLQYVM 326
Cdd:TIGR01085 320 PGRMELVD 327
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
114-361 |
1.09e-08 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 57.79 E-value: 1.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 114 PYVCVTGSNGKTTTVMLTQRIMDHHLSKNGGHAYAvGN----IGVPIS----------EVVEKATNKDLLVVEMSSFqll 179
Cdd:PRK11929 604 PVVAITGSNGKTTTKEMIAAILAAWQGEDRVLATE-GNfnneIGVPLTllrlraqhraAVFELGMNHPGEIAYLAAI--- 679
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 180 gvtdIKPKVAAIvdiyNNV---HLDYHKTFDNYVEAKLRITQSQDQNDYFIANFDQKNILDRELKKTKAKVQTF---SET 253
Cdd:PRK11929 680 ----AAPTVALV----TNAqreHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGARRVLRFglqPGA 751
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489744569 254 DKTADYFIGDEYLESKDD-----HQIMKISDIKIP--GIHNQQNCLVAIAISKLMGADDSDIQYALSTFTGATHRLQYVM 326
Cdd:PRK11929 752 DVYAEKIAKDISVGEAGGtrcqvVTPAGSAEVYLPliGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRR 831
|
250 260 270
....*....|....*....|....*....|....*....
gi 489744569 327 TYNDRKIYNDSKSTNIEAATVAIPSF----KEPEVLIAG 361
Cdd:PRK11929 832 LSCGTRIIDDTYNANPDSMRAAIDVLaelpNGPRALVLG 870
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
320-388 |
3.74e-04 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 39.25 E-value: 3.74e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489744569 320 HRLQYVMTYNDRKIYNDsKSTNIEAATVAIPSFKEPE----VLIAGG-LDRGFMFDSLVP-LFKKHVKSIVLYGE 388
Cdd:pfam02875 3 GRLEVVGENNGVLVIDD-YAHNPDAMEAALRALRNLFpgrlILVFGGmGDRDAEFHALLGrLAAALADVVILTGD 76
|
|
| |
