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Conserved domains on  [gi|489745453|ref|WP_003649479|]
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MULTISPECIES: RNA-binding S4 domain-containing protein [Lactobacillus]

Protein Classification

RNA-binding S4 domain-containing protein( domain architecture ID 10003114)

RNA-binding S4 domain-containing protein

Gene Ontology:  GO:0003723
PubMed:  10093218

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HslR COG1188
Ribosomal 50S subunit-recycling heat shock protein, contains S4 domain [Translation, ribosomal ...
 1-80 6.40e-30

Ribosomal 50S subunit-recycling heat shock protein, contains S4 domain [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440801  Cd Length: 120  Bit Score: 102.22  E-value: 6.40e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489745453   1 MRIDKFLKVSRLVKRRTVAKEMADQGRVKVNDRVVKSSYDVKVGDVIEIGFGTKQLKARVLDLRE-TTKKAEASDLYELI 79
Cdd:COG1188    5 MRLDKWLWAARFFKTRSLAAEACDGGRVRVNGQRAKPSREVKVGDVLTIRQGGRERVVRVLALSErRGPAPEAQLLYEEL 84


                 .
gi 489745453  80 D 80
Cdd:COG1188   85 T 85
 
Name Accession Description Interval E-value
HslR COG1188
Ribosomal 50S subunit-recycling heat shock protein, contains S4 domain [Translation, ribosomal ...
 1-80 6.40e-30

Ribosomal 50S subunit-recycling heat shock protein, contains S4 domain [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440801  Cd Length: 120  Bit Score: 102.22  E-value: 6.40e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489745453   1 MRIDKFLKVSRLVKRRTVAKEMADQGRVKVNDRVVKSSYDVKVGDVIEIGFGTKQLKARVLDLRE-TTKKAEASDLYELI 79
Cdd:COG1188    5 MRLDKWLWAARFFKTRSLAAEACDGGRVRVNGQRAKPSREVKVGDVLTIRQGGRERVVRVLALSErRGPAPEAQLLYEEL 84


                 .
gi 489745453  80 D 80
Cdd:COG1188   85 T 85
S4 cd00165
S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, ...
 1-49 1.75e-09

S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized functional similarity between these three protein classes.


Pssm-ID: 238095 [Multi-domain]  Cd Length: 70  Bit Score: 48.78  E-value: 1.75e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 489745453  1 MRIDKFLKVSRLVKRRTVAKEMADQGRVKVNDRVV-KSSYDVKVGDVIEI 49
Cdd:cd00165   1 MRLDKILARLGLAPSRSEARQLIKHGHVLVNGKVVtKPSYKVKPGDVIEV 50
S4 pfam01479
S4 domain; The S4 domain is a small domain consisting of 60-65 amino acid residues that was ...
 1-47 3.91e-09

S4 domain; The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation. The S4 domain probably mediates binding to RNA.


Pssm-ID: 396182 [Multi-domain]  Cd Length: 48  Bit Score: 47.49  E-value: 3.91e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 489745453   1 MRIDKFLKVSRLVKRRTVAKEMADQGRVKVNDRVVKS-SYDVKVGDVI 47
Cdd:pfam01479  1 RRLDKVLARLGLASSRSQARQLIEHGRVLVNGKVVKDpSYRVKPGDEI 48
S4 smart00363
S4 RNA-binding domain;
1-54 6.36e-08

S4 RNA-binding domain;


Pssm-ID: 214638 [Multi-domain]  Cd Length: 60  Bit Score: 44.51  E-value: 6.36e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 489745453    1 MRIDKFLKVSRLVKRRTVAKEMADQGRVKVNDRVV-KSSYDVKVGDVIEIGFGTK 54
Cdd:smart00363  1 RRLDKFLARLGLAPSRSQARRLIEQGRVKVNGKKVtKPSYIVKPGDVISVRGKEL 55
PRK10348 PRK10348
ribosome-associated heat shock protein Hsp15; Provisional
 1-77 2.13e-05

ribosome-associated heat shock protein Hsp15; Provisional


Pssm-ID: 182397  Cd Length: 133  Bit Score: 39.62  E-value: 2.13e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489745453   1 MRIDKFLKVSRLVKRRTVAKEMADQGRVKVNDRVVKSSYDVKVGDVIEIGFGTKQLKARVLDLRETTKKA-EASDLYE 77
Cdd:PRK10348   9 VRLDKWLWAARFYKTRALAREMIEGGKVHYNGQRSKPSKIVELNATLTLRQGNDERTVIVKAITEQRRPAsEAALLYE 86
 
Name Accession Description Interval E-value
HslR COG1188
Ribosomal 50S subunit-recycling heat shock protein, contains S4 domain [Translation, ribosomal ...
 1-80 6.40e-30

Ribosomal 50S subunit-recycling heat shock protein, contains S4 domain [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440801  Cd Length: 120  Bit Score: 102.22  E-value: 6.40e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489745453   1 MRIDKFLKVSRLVKRRTVAKEMADQGRVKVNDRVVKSSYDVKVGDVIEIGFGTKQLKARVLDLRE-TTKKAEASDLYELI 79
Cdd:COG1188    5 MRLDKWLWAARFFKTRSLAAEACDGGRVRVNGQRAKPSREVKVGDVLTIRQGGRERVVRVLALSErRGPAPEAQLLYEEL 84


                 .
gi 489745453  80 D 80
Cdd:COG1188   85 T 85
S4 cd00165
S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, ...
 1-49 1.75e-09

S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized functional similarity between these three protein classes.


Pssm-ID: 238095 [Multi-domain]  Cd Length: 70  Bit Score: 48.78  E-value: 1.75e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 489745453  1 MRIDKFLKVSRLVKRRTVAKEMADQGRVKVNDRVV-KSSYDVKVGDVIEI 49
Cdd:cd00165   1 MRLDKILARLGLAPSRSEARQLIKHGHVLVNGKVVtKPSYKVKPGDVIEV 50
S4 pfam01479
S4 domain; The S4 domain is a small domain consisting of 60-65 amino acid residues that was ...
 1-47 3.91e-09

S4 domain; The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation. The S4 domain probably mediates binding to RNA.


Pssm-ID: 396182 [Multi-domain]  Cd Length: 48  Bit Score: 47.49  E-value: 3.91e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 489745453   1 MRIDKFLKVSRLVKRRTVAKEMADQGRVKVNDRVVKS-SYDVKVGDVI 47
Cdd:pfam01479  1 RRLDKVLARLGLASSRSQARQLIEHGRVLVNGKVVKDpSYRVKPGDEI 48
S4 smart00363
S4 RNA-binding domain;
1-54 6.36e-08

S4 RNA-binding domain;


Pssm-ID: 214638 [Multi-domain]  Cd Length: 60  Bit Score: 44.51  E-value: 6.36e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 489745453    1 MRIDKFLKVSRLVKRRTVAKEMADQGRVKVNDRVV-KSSYDVKVGDVIEIGFGTK 54
Cdd:smart00363  1 RRLDKFLARLGLAPSRSQARRLIEQGRVKVNGKKVtKPSYIVKPGDVISVRGKEL 55
RsuA COG1187
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ...
 1-49 1.62e-05

Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ribosomal structure and biogenesis]; Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440800 [Multi-domain]  Cd Length: 226  Bit Score: 40.40  E-value: 1.62e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 489745453   1 MRIDKFLKVSRLVKRRtVAKEMADQGRVKVNDRVVKS-SYDVKVGDVIEI 49
Cdd:COG1187    3 MRLQKFLANAGVGSRR-EAEELIEAGRVTVNGKVVTElGTKVDPGDEVTV 51
PRK10348 PRK10348
ribosome-associated heat shock protein Hsp15; Provisional
 1-77 2.13e-05

ribosome-associated heat shock protein Hsp15; Provisional


Pssm-ID: 182397  Cd Length: 133  Bit Score: 39.62  E-value: 2.13e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489745453   1 MRIDKFLKVSRLVKRRTVAKEMADQGRVKVNDRVVKSSYDVKVGDVIEIGFGTKQLKARVLDLRETTKKA-EASDLYE 77
Cdd:PRK10348   9 VRLDKWLWAARFYKTRALAREMIEGGKVHYNGQRSKPSKIVELNATLTLRQGNDERTVIVKAITEQRRPAsEAALLYE 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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