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Conserved domains on  [gi|489806939|ref|WP_003710810|]
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replication initiation protein [Ligilactobacillus salivarius]

Protein Classification

replication initiation protein( domain architecture ID 10470872)

replication initiation protein is essential for plasmid DNA replication

CATH:  1.10.10.10
Gene Ontology:  GO:0006270|GO:0003887
SCOP:  4000166

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rep_3 pfam01051
Initiator Replication protein; This protein is an initiator of plasmid replication. RepB ...
 19-169 8.60e-20

Initiator Replication protein; This protein is an initiator of plasmid replication. RepB possesses nicking-closing (topoisomerase I) like activity. It is also able to perform a strand transfer reaction on ssDNA that contains its target. This family also includes RepA which is an E.coli protein involved in plasmid replication. The RepA protein binds to DNA repeats that flank the repA gene.


:

Pssm-ID: 460042  Cd Length: 218  Bit Score: 82.33  E-value: 8.60e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489806939   19 KEVRYDNELNRIPIGFmNESEQNIFFAILSQVKETSERKTKLSFTqIRELAS----FQKTSNKELIKSLDNMTTKLASLN 94
Cdd:pfam01051   3 ELVVKSNDLIEAAYKL-TLVELRLFFLLLSKIKDKDTDFVEYEIS-ISDYALkfgvNSEGAYKQLKEALERLMKKDFEIR 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489806939   95 VRIHNQQQIIKFTLFptFQIDGDQQTLTVAVNEDFRYIVNDLAKGFvTNFDIEEFTSIKSKYAKTAFRLAREHEN 169
Cdd:pfam01051  81 DDEEDGGVIEVLFLW--VGIIISAGKVEIEFSPDLKPYLLELKKNF-TQYELKEFLKLKSKYSIRLYELLKQYRS 152
 
Name Accession Description Interval E-value
Rep_3 pfam01051
Initiator Replication protein; This protein is an initiator of plasmid replication. RepB ...
 19-169 8.60e-20

Initiator Replication protein; This protein is an initiator of plasmid replication. RepB possesses nicking-closing (topoisomerase I) like activity. It is also able to perform a strand transfer reaction on ssDNA that contains its target. This family also includes RepA which is an E.coli protein involved in plasmid replication. The RepA protein binds to DNA repeats that flank the repA gene.


Pssm-ID: 460042  Cd Length: 218  Bit Score: 82.33  E-value: 8.60e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489806939   19 KEVRYDNELNRIPIGFmNESEQNIFFAILSQVKETSERKTKLSFTqIRELAS----FQKTSNKELIKSLDNMTTKLASLN 94
Cdd:pfam01051   3 ELVVKSNDLIEAAYKL-TLVELRLFFLLLSKIKDKDTDFVEYEIS-ISDYALkfgvNSEGAYKQLKEALERLMKKDFEIR 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489806939   95 VRIHNQQQIIKFTLFptFQIDGDQQTLTVAVNEDFRYIVNDLAKGFvTNFDIEEFTSIKSKYAKTAFRLAREHEN 169
Cdd:pfam01051  81 DDEEDGGVIEVLFLW--VGIIISAGKVEIEFSPDLKPYLLELKKNF-TQYELKEFLKLKSKYSIRLYELLKQYRS 152
 
Name Accession Description Interval E-value
Rep_3 pfam01051
Initiator Replication protein; This protein is an initiator of plasmid replication. RepB ...
 19-169 8.60e-20

Initiator Replication protein; This protein is an initiator of plasmid replication. RepB possesses nicking-closing (topoisomerase I) like activity. It is also able to perform a strand transfer reaction on ssDNA that contains its target. This family also includes RepA which is an E.coli protein involved in plasmid replication. The RepA protein binds to DNA repeats that flank the repA gene.


Pssm-ID: 460042  Cd Length: 218  Bit Score: 82.33  E-value: 8.60e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489806939   19 KEVRYDNELNRIPIGFmNESEQNIFFAILSQVKETSERKTKLSFTqIRELAS----FQKTSNKELIKSLDNMTTKLASLN 94
Cdd:pfam01051   3 ELVVKSNDLIEAAYKL-TLVELRLFFLLLSKIKDKDTDFVEYEIS-ISDYALkfgvNSEGAYKQLKEALERLMKKDFEIR 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489806939   95 VRIHNQQQIIKFTLFptFQIDGDQQTLTVAVNEDFRYIVNDLAKGFvTNFDIEEFTSIKSKYAKTAFRLAREHEN 169
Cdd:pfam01051  81 DDEEDGGVIEVLFLW--VGIIISAGKVEIEFSPDLKPYLLELKKNF-TQYELKEFLKLKSKYSIRLYELLKQYRS 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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