|
Name |
Accession |
Description |
Interval |
E-value |
| pgi |
PRK14097 |
glucose-6-phosphate isomerase; Provisional |
1-448 |
0e+00 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 184504 Cd Length: 448 Bit Score: 912.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 1 MTHIKFDYSKALRFFEERELDYLEPAVKAAHDSLHNGTGAGNDALGWINLPTDYDKEEFARIKKATEKIHSDSDVLIVIG 80
Cdd:PRK14097 1 MTHIKFDYSKALSFVGEHELEYLQPQVKAAHQTLHNGTGAGNDFLGWLDLPENYDKEEFARIKKAAEKIKSDSDVLVVIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 81 IGGSYLGARAAIETLNHSFYNVLEKGARKTPQVFFAGNSISSSYLHDLIEVVGDRDFSVNVISKSGTTTEPAIAFRVFKE 160
Cdd:PRK14097 81 IGGSYLGARAAIEFLNHSFYNLLPKEQRKAPQIIFAGNSISSTYLADLLEYLKDKDFSINVISKSGTTTEPAIAFRIFKE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 161 LLIKKYGEEGAKKRIYATTDKAKGALKTLSDNEGYETFVVPDDVGGRFSVLTAVGLLPIAVSGVDIDALMNGAAAASKDF 240
Cdd:PRK14097 161 LLEKKYGKEEAKKRIYATTDKAKGALKTLADAEGYETFVIPDDVGGRFSVLTAVGLLPIAVAGIDIDALMKGAADARKDY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 241 DKPELKNNIAYQYAAARNVLYRKGKVTELLISYEPGLQYFNEWWKQLFGESEGKDKKGIYPSSANFSTDLHSIGQYIQDG 320
Cdd:PRK14097 241 SSSDLSENPAYQYAAVRNILYRKGYTTEILVNYEPSLQYFSEWWKQLFGESEGKDQKGIFPASANFSTDLHSLGQYIQEG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 321 RRNLFETVIKVDKPRHNLTINKEDVDLDGLNYLAGETVDFVNTKAFEGTLLAHTDGEVPNFVVEVPELDAYTFGYLVYFF 400
Cdd:PRK14097 321 RRNLFETVIKVEKPRKDLTIPEDEEDLDGLNYLAGKTVDFVNKKAFEGTLLAHTDGGVPNIVVNIPELDEYTFGYLVYFF 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 489818579 401 EKAVAISGYLNGVNPFDQPGVEAYKANMFALLGKPGFEDKKAELEKRL 448
Cdd:PRK14097 401 EKACAISGYLLGVNPFDQPGVEAYKKNMFALLGKPGFEELKAELEARL 448
|
|
| Pgi |
COG0166 |
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate ... |
3-449 |
0e+00 |
|
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate isomerase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439936 Cd Length: 484 Bit Score: 553.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 3 HIKFDYSKAlrFFEERELDYLEPAVKA--AHDSLHNGTGAGNDA-----LGWINLP------TDYDKEEFARIKKATEKI 69
Cdd:COG0166 22 GLLLDYSKN--RITDETLELLLELAEEeeAREALFAGEKINPTEgravlHGALRLPeagedvMPEVREELARIKAFAEKV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 70 HS--DSDVLIVIGIGGSYLGARAAIETLNHSFynvlekgaRKTPQVFFaGNSISSSYLHDLIEVVGDRDFSVNVISKSGT 147
Cdd:COG0166 100 RTgkRITDVVNIGIGGSDLGPRAVIEALKPYF--------RDGPRVHF-VSNVDPDYLAELLAGLDPETTLFIVISKSGT 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 148 TTEPAIAFRVFKELLIKKyGEEGAKKRIYATTDKAkGALKTLSDNEGYETFVVPDDVGGRFSVLTAVGLLPIAVSGVDID 227
Cdd:COG0166 171 TQETLTNARVAREWLEKA-GGEDAAKHFVAVTDNA-GALRAFGIDEGYNTFPFPDWVGGRYSVLSAVGLLPAAAIGIDFE 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 228 ALMNGAAAASKDFDKPELKNNIAYQYAAARNVL-YRKGKVTELLISYEPGLQYFNEWWKQLFGESEGKDK--------KG 298
Cdd:COG0166 249 ELLAGAHAMDEHFRTAPLEENPPVLLALLGIWYrNFKGAETEAVLPYDQRLERFPAWLQQLWMESNGKSVdrdgnpvgYG 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 299 IYPSSANFSTDLHSIGQYIQDGRRNLFETVIKVDKPRHNLTiNKEDVDLDGLNYLAGETVDFVNTKAFEGTLLAHTDGEV 378
Cdd:COG0166 329 TGPVGEPGTTDQHSFGQLLHQGTRDIPVTFIAVAEPHHDIP-DLLLANLQGLALLAGKTLDEVLALAAEATPHALFPGNR 407
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489818579 379 PNFVVEVPELDAYTFGYLVYFFEKAVAISGYLNGVNPFDQPGVEAYKANMFALLGKPGFEDKKAE--LEKRLN 449
Cdd:COG0166 408 PSNTILLPKLTPYTLGALIALYEHAVFVQGVLWGINPFDQPGVELGKKLAFALLGKLGGEEAAAGdsTEALLK 480
|
|
| SIS_PGI_1 |
cd05015 |
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification ... |
56-221 |
3.82e-55 |
|
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF). Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.
Pssm-ID: 240146 Cd Length: 158 Bit Score: 180.41 E-value: 3.82e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 56 KEEFARIKKATEKIHS--DSDVLIVIGIGGSYLGARAAIETLNHSFYnvlekgarKTPQVFFAGNsISSSYLHDLIEVVG 133
Cdd:cd05015 1 RAELERIKEFAEKVRSgkKITDVVVIGIGGSDLGPRAVYEALKPYFK--------GGLRLHFVSN-VDPDDLAELLKKLD 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 134 DRDFSVNVISKSGTTTEPAIAFRVFKELLIKKYGEEgAKKRIYATTDKAKGALKTLsDNEGYETFVVPDDVGGRFSVLTA 213
Cdd:cd05015 72 PETTLFIVISKSGTTLETLANARLAREWLEEAGGDD-LAKHFVAITDNGSGLLKKA-GIEGLNTFEIPDWVGGRFSVLSS 149
|
....*...
gi 489818579 214 VGLLPIAV 221
Cdd:cd05015 150 VGGLPLAL 157
|
|
| PGI |
pfam00342 |
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of ... |
56-422 |
3.11e-24 |
|
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate.
Pssm-ID: 395271 Cd Length: 487 Bit Score: 104.86 E-value: 3.11e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 56 KEEFARIKKATEKIHSDSDV---------LIVIGIGGSYLGARAAIETLNHSfynvlekgARKTPQVFFAGNsISSSYLH 126
Cdd:pfam00342 70 NAVLAKMKSFSERVRSGEWKgytgkaitdVVNIGIGGSDLGPVMVTEALKPY--------SGRDLDVHFVSN-VDGTHIA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 127 DLIEVVGDRDFSVNVISKSGTTTEPAIAFRVFKELLIKKYGEEGA-KKRIYATTDKAKGALKTLSDNEgyETFVVPDDVG 205
Cdd:pfam00342 141 EVLKKLNPETTLFIVASKTFTTAETMTNAESAKEWLLKALKDDSAvAKHFIALSTNAEKVEEFGIDTK--NMFEFWDWVG 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 206 GRFSVLTAVGLlPIAVS-GVDI-DALMNGAAAASKDFDKPELKNNIAYQYAAArNVLYRK--GKVTELLISYEPGLQYFN 281
Cdd:pfam00342 219 GRYSLWSAIGL-PIALSiGFENfQQLLEGAHAMDKHFLSAPPEKNIPVLLALL-GVWYNNffGAQTHAILPYDQYLHRFP 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 282 EWWKQLFGESEGK--DKKGIYpssANFSTDL-----------HSIGQYIQDGRRNL---FETVIKVDKPR----HNLTIN 341
Cdd:pfam00342 297 AYLQQLDMESNGKyvTRDGVL---VDHQTGPiifgepgtngqHAFYQLIHQGTRLIpcdFIGAVQSQNPEngdhHKILLS 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 342 KEDVDLDGLNYlaGETVDFVN---TKAFEGTLLAHT--DGEVPNFVVEVPELDAYTFGYLVYFFEKAVAISGYLNGVNPF 416
Cdd:pfam00342 374 NFFAQTEALMV--GKSPEEVRkelAAADVEHLIPHKtfTGNRPSNSILVQKLTPATLGALIAMYEHKIFVQGAIWGINSF 451
|
....*.
gi 489818579 417 DQPGVE 422
Cdd:pfam00342 452 DQWGVE 457
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| pgi |
PRK14097 |
glucose-6-phosphate isomerase; Provisional |
1-448 |
0e+00 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 184504 Cd Length: 448 Bit Score: 912.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 1 MTHIKFDYSKALRFFEERELDYLEPAVKAAHDSLHNGTGAGNDALGWINLPTDYDKEEFARIKKATEKIHSDSDVLIVIG 80
Cdd:PRK14097 1 MTHIKFDYSKALSFVGEHELEYLQPQVKAAHQTLHNGTGAGNDFLGWLDLPENYDKEEFARIKKAAEKIKSDSDVLVVIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 81 IGGSYLGARAAIETLNHSFYNVLEKGARKTPQVFFAGNSISSSYLHDLIEVVGDRDFSVNVISKSGTTTEPAIAFRVFKE 160
Cdd:PRK14097 81 IGGSYLGARAAIEFLNHSFYNLLPKEQRKAPQIIFAGNSISSTYLADLLEYLKDKDFSINVISKSGTTTEPAIAFRIFKE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 161 LLIKKYGEEGAKKRIYATTDKAKGALKTLSDNEGYETFVVPDDVGGRFSVLTAVGLLPIAVSGVDIDALMNGAAAASKDF 240
Cdd:PRK14097 161 LLEKKYGKEEAKKRIYATTDKAKGALKTLADAEGYETFVIPDDVGGRFSVLTAVGLLPIAVAGIDIDALMKGAADARKDY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 241 DKPELKNNIAYQYAAARNVLYRKGKVTELLISYEPGLQYFNEWWKQLFGESEGKDKKGIYPSSANFSTDLHSIGQYIQDG 320
Cdd:PRK14097 241 SSSDLSENPAYQYAAVRNILYRKGYTTEILVNYEPSLQYFSEWWKQLFGESEGKDQKGIFPASANFSTDLHSLGQYIQEG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 321 RRNLFETVIKVDKPRHNLTINKEDVDLDGLNYLAGETVDFVNTKAFEGTLLAHTDGEVPNFVVEVPELDAYTFGYLVYFF 400
Cdd:PRK14097 321 RRNLFETVIKVEKPRKDLTIPEDEEDLDGLNYLAGKTVDFVNKKAFEGTLLAHTDGGVPNIVVNIPELDEYTFGYLVYFF 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 489818579 401 EKAVAISGYLNGVNPFDQPGVEAYKANMFALLGKPGFEDKKAELEKRL 448
Cdd:PRK14097 401 EKACAISGYLLGVNPFDQPGVEAYKKNMFALLGKPGFEELKAELEARL 448
|
|
| Pgi |
COG0166 |
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate ... |
3-449 |
0e+00 |
|
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate isomerase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439936 Cd Length: 484 Bit Score: 553.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 3 HIKFDYSKAlrFFEERELDYLEPAVKA--AHDSLHNGTGAGNDA-----LGWINLP------TDYDKEEFARIKKATEKI 69
Cdd:COG0166 22 GLLLDYSKN--RITDETLELLLELAEEeeAREALFAGEKINPTEgravlHGALRLPeagedvMPEVREELARIKAFAEKV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 70 HS--DSDVLIVIGIGGSYLGARAAIETLNHSFynvlekgaRKTPQVFFaGNSISSSYLHDLIEVVGDRDFSVNVISKSGT 147
Cdd:COG0166 100 RTgkRITDVVNIGIGGSDLGPRAVIEALKPYF--------RDGPRVHF-VSNVDPDYLAELLAGLDPETTLFIVISKSGT 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 148 TTEPAIAFRVFKELLIKKyGEEGAKKRIYATTDKAkGALKTLSDNEGYETFVVPDDVGGRFSVLTAVGLLPIAVSGVDID 227
Cdd:COG0166 171 TQETLTNARVAREWLEKA-GGEDAAKHFVAVTDNA-GALRAFGIDEGYNTFPFPDWVGGRYSVLSAVGLLPAAAIGIDFE 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 228 ALMNGAAAASKDFDKPELKNNIAYQYAAARNVL-YRKGKVTELLISYEPGLQYFNEWWKQLFGESEGKDK--------KG 298
Cdd:COG0166 249 ELLAGAHAMDEHFRTAPLEENPPVLLALLGIWYrNFKGAETEAVLPYDQRLERFPAWLQQLWMESNGKSVdrdgnpvgYG 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 299 IYPSSANFSTDLHSIGQYIQDGRRNLFETVIKVDKPRHNLTiNKEDVDLDGLNYLAGETVDFVNTKAFEGTLLAHTDGEV 378
Cdd:COG0166 329 TGPVGEPGTTDQHSFGQLLHQGTRDIPVTFIAVAEPHHDIP-DLLLANLQGLALLAGKTLDEVLALAAEATPHALFPGNR 407
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489818579 379 PNFVVEVPELDAYTFGYLVYFFEKAVAISGYLNGVNPFDQPGVEAYKANMFALLGKPGFEDKKAE--LEKRLN 449
Cdd:COG0166 408 PSNTILLPKLTPYTLGALIALYEHAVFVQGVLWGINPFDQPGVELGKKLAFALLGKLGGEEAAAGdsTEALLK 480
|
|
| PRK00973 |
PRK00973 |
glucose-6-phosphate isomerase; Provisional |
4-447 |
6.54e-109 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 179193 [Multi-domain] Cd Length: 446 Bit Score: 329.26 E-value: 6.54e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 4 IKFDYSKALRF-----FEERELDYLEPAVKAAHDSLHNGTGAGNdaLGWINLPTDYDKEEFARIKKATEkihsDSDVLIV 78
Cdd:PRK00973 3 LKFDFSNVFEPnigggISIEDIESVKEKITSAVENLMEKEPNGE--LGFLELPYDRSLDSYEELKEWSK----NFDNVVV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 79 IGIGGSYLGARAAIETLNHSFYNVLEKGARKTPQVFFAGNSiSSSYLHDLIEVVGDRDFSVNVISKSGTTTEPAIAFRVF 158
Cdd:PRK00973 77 LGIGGSALGNLALHYALNPLNWNELSKEERNGPRVFVLDNV-DPEKTASILDVIDLEKTLFNVISKSGNTAETLANYLII 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 159 KELLiKKYGEeGAKKRIYATTDKAKGALKTLSDNEGYETFVVPDDVGGRFSVLTAVGLLPIAVSGVDIDALMNGAAAASK 238
Cdd:PRK00973 156 RGIL-EKLGL-DPKKHLVFTTDPEKGKLKKIAEKEGYRTLEIPENVGGRFSVLTPVGLAPAAALGIDIEELLEGAKEMDK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 239 DFDKPELKNNIAYQYAAARNVLYRKGKVTELLISYEPGLQYFNEWWKQLFGESEGKDKKGIYPSSANFSTDLHSIGQYIQ 318
Cdd:PRK00973 234 ICEKEDIFKNPALLNALIHYLYYNRGKNISVMMPYSERLKYFGDWYRQLWAESLGKKGVGQTPVKALGATDQHSQLQLYM 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 319 DGRRNLFETVIKVDKPRHNLTINKEDVDLDGLNYLAGETVDFVNTKAFEGTLLAHTDGEVPNFVVEVPELDAYTFGYLVY 398
Cdd:PRK00973 314 EGPKDKIITFLKVEKYRRDVEIPYEYEDIEELSYLGGHKLSELINSEQKGTEIALTENGRPNVKITLDELNEYTVGQLFY 393
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 489818579 399 FFEKAVAISGYLNGVNPFDQPGVEAYKANMFALLGKPGFEDKKAELEKR 447
Cdd:PRK00973 394 MYEMQTAFMGELLNINAFDQPGVELGKKITYALLGRSGYEEEKKEIEKK 442
|
|
| SIS_PGI_1 |
cd05015 |
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification ... |
56-221 |
3.82e-55 |
|
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF). Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.
Pssm-ID: 240146 Cd Length: 158 Bit Score: 180.41 E-value: 3.82e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 56 KEEFARIKKATEKIHS--DSDVLIVIGIGGSYLGARAAIETLNHSFYnvlekgarKTPQVFFAGNsISSSYLHDLIEVVG 133
Cdd:cd05015 1 RAELERIKEFAEKVRSgkKITDVVVIGIGGSDLGPRAVYEALKPYFK--------GGLRLHFVSN-VDPDDLAELLKKLD 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 134 DRDFSVNVISKSGTTTEPAIAFRVFKELLIKKYGEEgAKKRIYATTDKAKGALKTLsDNEGYETFVVPDDVGGRFSVLTA 213
Cdd:cd05015 72 PETTLFIVISKSGTTLETLANARLAREWLEEAGGDD-LAKHFVAITDNGSGLLKKA-GIEGLNTFEIPDWVGGRFSVLSS 149
|
....*...
gi 489818579 214 VGLLPIAV 221
Cdd:cd05015 150 VGGLPLAL 157
|
|
| SIS_PGI_2 |
cd05016 |
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification ... |
267-431 |
1.16e-54 |
|
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF). Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.
Pssm-ID: 240147 Cd Length: 164 Bit Score: 179.33 E-value: 1.16e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 267 TELLISYEPGLQYFNEWWKQLFGESEGKDKK--------GIYPSSANFSTDLHSIGQYIQDGRRNLFETVIKVDKPRHnl 338
Cdd:cd05016 2 THALLPYSQRLERFPAWLQQLDMESNGKSVTrdgedyptGPIPWGAPGTNDQHSFFQLIHQGTKDKPVDFIAVKKPQN-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 339 tinkedvdlDGLNYLAGETVDFVNTKAFEGTLLAH-TDGEVPNFVVEVPELDAYTFGYLVYFFEKAVAISGYLNGVNPFD 417
Cdd:cd05016 80 ---------DVLDYLAGKTLHDLLLANCLATREALmFPGGRPSNTIVLPELTPYTLGALLALYEHKTAVQGALLGINPFD 150
|
170
....*....|....
gi 489818579 418 QPGVEAYKANMFAL 431
Cdd:cd05016 151 QPGVELGKKLAKKI 164
|
|
| PRK03868 |
PRK03868 |
glucose-6-phosphate isomerase; Provisional |
42-425 |
2.40e-49 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 235168 Cd Length: 410 Bit Score: 173.20 E-value: 2.40e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 42 NDALGWINLP---TDYdKEEFARIKKATEKIhsdSDVlIVIGIGGSYLGARAAietlnHSFYNVLEKGARKtpqVFFAGN 118
Cdd:PRK03868 29 SGEIGYYHLPdqsTSL-IEESLKFVKDKESI---KNI-VVIGIGGSSLGVKAI-----YSFLKNEKNNKKE---LHFLEN 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 119 SISSSYLHDLIEVvgDRDFSVN-VISKSGTTTEPaiaFRVFKeLLIKKYG-EEGAKKRIYATTDKAKgALKTLSDNEGYE 196
Cdd:PRK03868 96 TDPISINKTLSKI--NLENTLFiVISKSGTTIET---ISIFK-YLLSHFKlDQELKKNFLFITDPDS-KLEQFAKENNIK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 197 TFVVPDDVGGRFSVLTAVGLLPIAVSGVDIDALMNGAAAASKDF--DKPELKNNIAYQYAAARNvlyrKGKVTeLLISYE 274
Cdd:PRK03868 169 CFNIPKNVGGRFSVLSAVGIVPLALCGYDIKALLEGAKACKDSFfeQKEDHILKKAYFYATHKN----AYNIN-VLFSYS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 275 PGLQYFNEWWKQLFGESEGKDKK-----GIYPSSANFSTDLHSIGQYIQDGRRNLFETVIKVDKPRHNLTInkEDVDLDG 349
Cdd:PRK03868 244 DALKGFNDWYVQLWGESLGKKQGyktrvGLTPIGLIGSRDQHSFLQLIMEGPRDKTVTFIKIKDFQNAPKI--PNISLKG 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 350 LnylagETVDFVNTKAF--------EGTLLAHTDGEVPNFVVEVPELDAYTFGYLVYFFEKAVAISGYLNGVNPFDQPGV 421
Cdd:PRK03868 322 L-----ESLDFVNGVSFnelinaqcDATMEALIAEDIPVDVITLEKLDEFSIGYLIYYYELLTSAVGKMLGINTYDQPGV 396
|
....
gi 489818579 422 EAYK 425
Cdd:PRK03868 397 EVGK 400
|
|
| pgi |
PRK14096 |
glucose-6-phosphate isomerase; Provisional |
57-434 |
4.59e-35 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 237609 [Multi-domain] Cd Length: 528 Bit Score: 136.55 E-value: 4.59e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 57 EEFARIKKATEKIHSD----------SDVLIvIGIGGSYLGARAAIETLnhsfynvleKGARKTPQVFFAGNS----ISS 122
Cdd:PRK14096 89 ETLAQIEAFAAKVHSGtikppngekfTDVLW-IGIGGSALGPQFVAEAL---------QPNSDGLNIHFIDNTdpdgIDR 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 123 SyLHDLievvGDRDFS--VNVISKSGTTTEPAIAFRVFKELLiKKYGEEGAKKRIYATTDKAKgaLKTLSDNEGY-ETFV 199
Cdd:PRK14096 159 V-LAEL----GDRLATtlVVVISKSGGTPETRNGMLEAKAAY-EAAGLDFASHAVAITMKGSK--LDQLAQSEGWlARFP 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 200 VPDDVGGRFSVLTAVGLLPIAVSGVDIDALMNGAAAASKDFDKPELKNNIAYQYAAArnvLYR----KGKVTELLISYEP 275
Cdd:PRK14096 231 MWDWVGGRTSETSAVGLLPAALQGIDIRAFLAGAKQMDEATRVPDLKNNPAALLALA---WYYagdgKGKKDMVVLPYKD 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 276 GLQYFNEWWKQLFGESEGKDK----------------KGiypssanfSTDLHSIGQYIQDGRRNLFETVIKVDKPRHNLT 339
Cdd:PRK14096 308 RLLLFSRYLQQLVMESLGKELdldgnvvhqgiavygnKG--------STDQHAYVQQLRDGVDNFFVTFIEVLEDRQGSS 379
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 340 INKEDVDLDGlNYLAGetvdFvntkaFEGTLLAHTDGEVPNFVVEVPELDAYTFGYLVYFFEKAVAISGYLNGVNPFDQP 419
Cdd:PRK14096 380 IEVEPGVTSG-DYLSG----F-----LQGTRQALYENGRQSITITIPEVNPRTLGALIALFERAVGLYASLVNINAYHQP 449
|
410
....*....|....*...
gi 489818579 420 GVEAYK---ANMFALLGK 434
Cdd:PRK14096 450 GVEAGKkaaAAILDLQKK 467
|
|
| PLN02649 |
PLN02649 |
glucose-6-phosphate isomerase |
61-426 |
8.28e-29 |
|
glucose-6-phosphate isomerase
Pssm-ID: 215351 [Multi-domain] Cd Length: 560 Bit Score: 118.99 E-value: 8.28e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 61 RIKKATEKIHSDsdvLIVIGIGGSYLGARAAIETLNHsfYNVLEKGARKTpQVFFAGNSisssylhDLIEVvgDRDFS-- 138
Cdd:PLN02649 138 KWKGATGKRFTN---VVSIGIGGSFLGPLFVHEALAT--DPEALKSAKGR-KLRFLANV-------DPVDI--ARQIAql 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 139 ------VNVISKSGTTTEPAIAFRVFKELLIKKYGEEGAKKRIYATTDKAKGALKTLSDNEGYetFVVPDDVGGRFSVLT 212
Cdd:PLN02649 203 dpettlVVVVSKTFTTAETMLNARTVRKWLRDALGGLAVAKHMVAVSTNLLLVNKFGIDPWNA--FPFWDWVGGRYSVCS 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 213 AVGLLPIAVS-GVD-IDALMNGAAAASKDFDKPELKNNIAYQYAA----ARNVLYRKGKVtelLISYEPGLQYFNEWWKQ 286
Cdd:PLN02649 281 AVGLLPLSLQyGFDvVEEFLEGAASMDEHFRTAPLKENIPVLLGLlsvwNSSFLGYPARA---ILPYSQALLKFAPHIQQ 357
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 287 LFGESEGK--DKKGI---YPSS-ANF----STDLHSIGQYIQDGRrNLFETVIKVDKPRHNLTI-NKEDVDL-DGL--NY 352
Cdd:PLN02649 358 LDMESNGKgvDLDGNplpVNTGeIDFgepgTNGQHSFYQLIHQGR-NIPCDFIGVVRSQQPVHLwLGEGVSNhDELmsNF 436
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 353 LA-------GETVDFVNTKAFEGTLLAHT--DGEVPNFVVEVPELDAYTFGYLVYFFEKAVAISGYLNGVNPFDQPGVEA 423
Cdd:PLN02649 437 FAqpdalayGKTPEQLRAEGVPEELIPHKvfAGNRPSLSILLPELTAYTVGQLLALYEHRVAVQGFIWNINSFDQWGVEL 516
|
...
gi 489818579 424 YKA 426
Cdd:PLN02649 517 GKA 519
|
|
| PRK09533 |
PRK09533 |
bifunctional transaldolase/phosoglucose isomerase; Validated |
21-425 |
2.89e-27 |
|
bifunctional transaldolase/phosoglucose isomerase; Validated
Pssm-ID: 236551 [Multi-domain] Cd Length: 948 Bit Score: 115.07 E-value: 2.89e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 21 DYLEPAVKAAHDSL-HNGT--------------GAGNDALGWINLPTDY-----DKEEFARIKKAtEKIhsdSDVLiVIG 80
Cdd:PRK09533 388 ADLAKAVAAALEAWrADGKirrlwardasvwtgADEAKWLGWLDIVEDElahlaEYEAFAEEVRA-EGF---TDAV-VLG 462
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 81 IGGSYLGAraaiETLNHSFynvlekgarktpqvffaGNSISSSYLH-----DLIEVVGDRDfSVN-------VISKSGTT 148
Cdd:PRK09533 463 MGGSSLGP----EVLAETF-----------------GQRDGFPKLHvldstDPAQVRALEA-AVDlartlfiVSSKSGGT 520
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 149 TEPAIAFRVFKELLIKKYGEEgAKKRIYATTDKAKgALKTLSDNEGY-ETFVVPDDVGGRFSVLTAVGLLPIAVSGVDID 227
Cdd:PRK09533 521 LEPNIFKDYFFARVKEVLGAK-AGRHFVAVTDPGS-SLEKVAKEDGFrKIFHGDPDIGGRYSVLSPFGLVPAAAAGIDVR 598
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 228 ALMNGA--AAASKDFDKPELkNNIAYQYAAARNVLYRKG--KVTellISYEPGLQYFNEWWKQLFGESEGKDKKGIYPSS 303
Cdd:PRK09533 599 ALLDSAlaMVRSCGPSVPPA-DNPGVQLGLALGVAATQGrdKVT---IVASPAIADFGAWAEQLIAESTGKEGKGLIPID 674
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 304 ANfstDLHSIGQYIQDgrrNLFetvikvdkprhnltinkedVDLDglnyLAGETVDfvntkAFEGTLLAHTDGEVPnfVV 383
Cdd:PRK09533 675 GE---PLGDPAVYGND---RVF-------------------VYLR----LAGEADA-----AQDAALAALEAAGHP--VV 718
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 489818579 384 EVPELDAYTFGYLVYFFEKAVAISGYLNGVNPFDQPGVEAYK 425
Cdd:PRK09533 719 RIVLDSAEQLGQEFFRWEMATAVAGAVLGINPFDQPDVEASK 760
|
|
| pgi |
PRK14095 |
glucose-6-phosphate isomerase; Provisional |
56-434 |
1.32e-24 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 237608 Cd Length: 533 Bit Score: 106.25 E-value: 1.32e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 56 KEEFARIKKATEKIHSDSDV---------LIVIGIGGSYLGARAaietlnhsFYNVLEKGARKTPQVFFagnsISSSYLH 126
Cdd:PRK14095 125 KRELERLAEFLKKVRSGEIKnsngkkfttVVQIGIGGSDLGPKA--------LYLALKNYAKKDKRVHF----ISNVDPD 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 127 DLIEVVGDRDFS---VNVISKSGTTTEPAiafrVFKELLIKKYGEEG--AKKRIYATTdkAKGAlkTLSDNEGY-ETFVV 200
Cdd:PRK14095 193 DAAEVLSEIDLAktlFIVVSKSGTTLETA----ANEEFVRDALKKAGldYKKHFIAVT--SEGS--PMDDESGYlEVFHM 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 201 PDDVGGRFSVLTAVGLLPIAVS-GVDI-DALMNGAAAASKDFDKPELKNNIAYQYAA----ARNVLyrkGKVTELLISYE 274
Cdd:PRK14095 265 WDSIGGRFSSTSMVGGVVLGFAfGFEVfKEFLKGAAAMDKAALNPNIRENLPLLAALigiwNRNFL---GYPTTAVIPYS 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 275 PGLQYFNEWWKQLFGESEGK--DKKGIypsSANFSTD-----------LHSIGQYIQDGrrnlfETVIKVD--KPRHNLT 339
Cdd:PRK14095 342 QALERFPAHLQQLDMESNGKsvNRFGE---PINFKTGpiiwgepgtngQHSFFQLLHQG-----TDIVPVEfiGFKESQL 413
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 340 inKEDVDLDG-------LNYLAGETVDFV----NT---KAFEgtllahtdGEVPNFVVEVPELDAYTFGYLVYFFEKAVA 405
Cdd:PRK14095 414 --GQDIVIQGstsqqklFANLIAQIIALAcgkeNTnpnKNFK--------GNRPSSLLVAKQLTPYTLGALLAHYENKVM 483
|
410 420
....*....|....*....|....*....
gi 489818579 406 ISGYLNGVNPFDQPGVEaykanmfalLGK 434
Cdd:PRK14095 484 FQGFCWNINSFDQEGVQ---------LGK 503
|
|
| PGI |
pfam00342 |
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of ... |
56-422 |
3.11e-24 |
|
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate.
Pssm-ID: 395271 Cd Length: 487 Bit Score: 104.86 E-value: 3.11e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 56 KEEFARIKKATEKIHSDSDV---------LIVIGIGGSYLGARAAIETLNHSfynvlekgARKTPQVFFAGNsISSSYLH 126
Cdd:pfam00342 70 NAVLAKMKSFSERVRSGEWKgytgkaitdVVNIGIGGSDLGPVMVTEALKPY--------SGRDLDVHFVSN-VDGTHIA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 127 DLIEVVGDRDFSVNVISKSGTTTEPAIAFRVFKELLIKKYGEEGA-KKRIYATTDKAKGALKTLSDNEgyETFVVPDDVG 205
Cdd:pfam00342 141 EVLKKLNPETTLFIVASKTFTTAETMTNAESAKEWLLKALKDDSAvAKHFIALSTNAEKVEEFGIDTK--NMFEFWDWVG 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 206 GRFSVLTAVGLlPIAVS-GVDI-DALMNGAAAASKDFDKPELKNNIAYQYAAArNVLYRK--GKVTELLISYEPGLQYFN 281
Cdd:pfam00342 219 GRYSLWSAIGL-PIALSiGFENfQQLLEGAHAMDKHFLSAPPEKNIPVLLALL-GVWYNNffGAQTHAILPYDQYLHRFP 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 282 EWWKQLFGESEGK--DKKGIYpssANFSTDL-----------HSIGQYIQDGRRNL---FETVIKVDKPR----HNLTIN 341
Cdd:pfam00342 297 AYLQQLDMESNGKyvTRDGVL---VDHQTGPiifgepgtngqHAFYQLIHQGTRLIpcdFIGAVQSQNPEngdhHKILLS 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 342 KEDVDLDGLNYlaGETVDFVN---TKAFEGTLLAHT--DGEVPNFVVEVPELDAYTFGYLVYFFEKAVAISGYLNGVNPF 416
Cdd:pfam00342 374 NFFAQTEALMV--GKSPEEVRkelAAADVEHLIPHKtfTGNRPSNSILVQKLTPATLGALIAMYEHKIFVQGAIWGINSF 451
|
....*.
gi 489818579 417 DQPGVE 422
Cdd:pfam00342 452 DQWGVE 457
|
|
| PTZ00430 |
PTZ00430 |
glucose-6-phosphate isomerase; Provisional |
61-422 |
1.28e-23 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 185612 Cd Length: 552 Bit Score: 103.56 E-value: 1.28e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 61 RIKKATEKIHSDS---------DVLIVIGIGGSYLGARAAIETLNHSFYNVLekgARKTPQVFFAGNsISSSYLHDLIEV 131
Cdd:PTZ00430 121 RIKKFSDKIRSGEilgstgkklKNVICIGIGGSYLGTEFVYEALRTYGEARE---ASKGRKLRFLAN-VDPIDVRRATEG 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 132 VGDRDFSVNVISKSGTTTEPAIAFRVFKELLIKKYGEEGA-KKRIYATTDKAKGALK-TLSDNEgyeTFVVPDDVGGRFS 209
Cdd:PTZ00430 197 LDPEETLVVIISKTFTTAETMLNAKTVRQWLLDNIKSKEAlSKHLCAVSTNLKLTSEfGIPDEN---VFGFWDWVGGRFS 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 210 VLTAVGLLPIAVS-GVD-IDALMNGAAAASKDFDKPELKNNIAyqyaaarnVL------YR---KGKVTELLISYEPGLQ 278
Cdd:PTZ00430 274 VTSAVGILPLSIQfGYDiVQQFLNGCHDMDEHFRTAPLEENLP--------VLlgltsfYNstfLGYNCVAILPYCQALL 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 279 YFNEWWKQLFGESEGKdKKGIYPSSANFSTDL-----------HSIGQYIQDGRRNLFETV--IKVDKPRHnltINKEDV 345
Cdd:PTZ00430 346 KFPAHVQQLLMESNGK-SVTLDGNTLDYNTGEiyfgepgtngqHSFYQLLHQGRVVPSEFIgfAKSQNPIK---LLGEPV 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 346 D------------LDGLNYlaGETVDFVNTKAFEGTLLAHT--DGEVPNFVVEVPELDAYTFGYLVYFFEKAVAISGYLN 411
Cdd:PTZ00430 422 SnhdelmsnffaqPDALAF--GKTYEELEKEGVPEELIPHKvfPGNRPSLLLLFPELNPYTIGQLLALYEHRTVVEGFLW 499
|
410
....*....|.
gi 489818579 412 GVNPFDQPGVE 422
Cdd:PTZ00430 500 NINSFDQWGVE 510
|
|
| pgi |
PRK00179 |
glucose-6-phosphate isomerase; Reviewed |
57-434 |
2.77e-13 |
|
glucose-6-phosphate isomerase; Reviewed
Pssm-ID: 234679 Cd Length: 548 Bit Score: 71.74 E-value: 2.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 57 EEFARIKKATEKIHSDS----------DVlIVIGIGGSYLGARAAIETLNHsfYnvlekgARKTPQVFFAGNsISSSYLH 126
Cdd:PRK00179 120 AVLARMKAFAEAVRSGEwkgytgkaitDV-VNIGIGGSDLGPVMVTEALRP--Y------ADPGLRVHFVSN-VDGAHLA 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 127 DLIevvgdRDFS-----VNVISKSGTTTEPAIAFRVFKELLIKKYGEEGAKKRIYA--TTDKAK-GALKTLSDNegyeTF 198
Cdd:PRK00179 190 ETL-----KKLDpettlFIVASKTFTTQETLTNAHSARDWFLAAGGDEAAVAKHFVavSTNAEAvAEFGIDPDN----MF 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 199 VVPDDVGGRFSVLTAVGlLPIAVS-GVD-IDALMNGAAAASKDFDKPELKNNIAYQYAAA----RNVLyrkGKVTELLIS 272
Cdd:PRK00179 261 GFWDWVGGRYSLWSAIG-LSIALAiGPDnFEELLAGAHAMDEHFRTAPLEKNLPVLLALIgvwyRNFF---GAQSHAVLP 336
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 273 YEPGLQYFNEWWKQLFGESEGK--DKKGiypSSANFST-----------DLHSIGQYIQDGRRnlfetVIKVD-----KP 334
Cdd:PRK00179 337 YDQYLHRFPAYLQQLEMESNGKsvDRDG---TPVDYQTgpiiwgepgtnGQHAFFQLLHQGTK-----LVPADfiapaQP 408
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 335 RHNLTI--------------------NKEDV--DLDGLNYLAGETVDFVNTKAFEG-----TLLAhtdgevpnfvvevPE 387
Cdd:PRK00179 409 HNPLGDhhdlllancfaqtealmfgkTAEEVraELRAKGLDEAEAEELAPHKVFPGnrpstTILL-------------DR 475
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 489818579 388 LDAYTFGYLVYFFEKAVAISGYLNGVNPFDQPGVEaykanmfalLGK 434
Cdd:PRK00179 476 LTPFTLGALIALYEHKVFVQGVIWGINSFDQWGVE---------LGK 513
|
|
| SIS_TAL_PGI |
cd05798 |
SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the ... |
265-425 |
1.51e-12 |
|
SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a C-terminal PGI domain. TAL catalyzes the reversible conversion of sedoheptulose-7-phosphate (S7P) and glyceraldehyde-3-phosphate (G3P), to fructose-6-phosphate (F6P) and erythrose-4-phosphate (E4P). PGI catalyzes the reversible isomerization of F6P to glucose-6-phosphate (G6P). It has been suggested for Gluconobacter oxydans TAL_PGI that this enzyme generates E4P and G6P directly from S7P and G3P. G. oxydans TAL_PGI contributes to increased xylitol production from D-arabitol. As xylitol is an alternative natural sweetner to sucrose, the microbial conversion of D-arabitol to xylitol is of interest to food and pharmaceutical industries.
Pssm-ID: 240224 [Multi-domain] Cd Length: 129 Bit Score: 64.40 E-value: 1.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 265 KVTellISYEPGLQYFNEWWKQLFGESEGKDKKGIYPssanfsTDLHSIGQYIQDGRRNLFetvikvdkprhnltinked 344
Cdd:cd05798 2 KVT---IIASPGIASLGAWLEQLIAESTGKEGKGIIP------VDGEPLGDPAVYGDDRVF------------------- 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 345 VDLdglnYLAGETVDfvntkAFEGTLLAHTDGEVPnfVVEVPELDAYTFGYLVYFFEKAVAISGYLNGVNPFDQPGVEAY 424
Cdd:cd05798 54 VYL----RLAGEADA-----DQEEALLALEAAGHP--VIRIDLDDAYDLGQEFFRWEMATAVAGAVLGINPFDQPDVEAS 122
|
.
gi 489818579 425 K 425
Cdd:cd05798 123 K 123
|
|
| SIS |
cd04795 |
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
76-166 |
1.26e-05 |
|
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.
Pssm-ID: 240112 [Multi-domain] Cd Length: 87 Bit Score: 43.52 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818579 76 LIVIGIGGSYLGARAAIETLNHSFynvlekgarkTPQVFFAGNSISssyLHDLIEVVGDRDFSVNVISKSGTTTEPAIAF 155
Cdd:cd04795 1 IFVIGIGGSGAIAAYFALELLELT----------GIEVVALIATEL---EHASLLSLLRKGDVVIALSYSGRTEELLAAL 67
|
90
....*....|.
gi 489818579 156 RVFKELLIKKY 166
Cdd:cd04795 68 EIAKELGIPVI 78
|
|
| |
