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Conserved domains on  [gi|489818986|ref|WP_003722799|]
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GNAT family N-acetyltransferase [Listeria monocytogenes]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11450351)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
13-144 1.95e-49

Predicted N-acyltransferase, GNAT family [General function prediction only];


:

Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 154.96  E-value: 1.95e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818986  13 QAALKIRNDVFVVEQRVDPALEWDEFDEidSVVMFVDYaEDGTPLATGRFR-EKDGYGKVERICTQKVARGTGSGRRIME 91
Cdd:COG2153    5 YDALALRREVFVVEQGVPPYLELDGKDE--DARHLLAY-DDGELVATARLLpPGDGEAKIGRVAVLPEYRGQGLGRALME 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489818986  92 AIESEAKSRGLTTLKLGAQVTAIPFYEKLGYETCSGLFLDAGIEHKDMKKTLT 144
Cdd:COG2153   82 AAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAGIPHIDMRKPLS 134
 
Name Accession Description Interval E-value
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
13-144 1.95e-49

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 154.96  E-value: 1.95e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818986  13 QAALKIRNDVFVVEQRVDPALEWDEFDEidSVVMFVDYaEDGTPLATGRFR-EKDGYGKVERICTQKVARGTGSGRRIME 91
Cdd:COG2153    5 YDALALRREVFVVEQGVPPYLELDGKDE--DARHLLAY-DDGELVATARLLpPGDGEAKIGRVAVLPEYRGQGLGRALME 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489818986  92 AIESEAKSRGLTTLKLGAQVTAIPFYEKLGYETCSGLFLDAGIEHKDMKKTLT 144
Cdd:COG2153   82 AAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAGIPHIDMRKPLS 134
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 46-143 7.15e-16

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 69.22  E-value: 7.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818986   46 MFVdyAEDGTPLAtGRFREKDGyGKVERICTQKVARGTGSGRRIMEAIESEAKSRG--LTTLKLGAQVTAIPFYEKLGYE 123
Cdd:pfam13673  33 FFV--AFEGGQIV-GVIALRDR-GHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGikLSELTVNASPYAVPFYEKLGFR 108

                          90       100
                  ....*....|....*....|
gi 489818986  124 TCSGLFLDAGIEHKDMKKTL 143
Cdd:pfam13673 109 ATGPEQEFNGIRFVPMEKEL 128
PRK10314 PRK10314
GNAT family N-acetyltransferase;
14-141 6.55e-05

GNAT family N-acetyltransferase;


Pssm-ID: 182373 [Multi-domain]  Cd Length: 153  Bit Score: 40.60  E-value: 6.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818986  14 AALKIRNDVFVVEQRVdPALEWDEFDEIDSVVMFVDYaEDGTPLATGRFREKDGYGK---VERICTQKVARGTGSGRRIM 90
Cdd:PRK10314  19 ALLQLRCAVFVVEQNC-PYQDIDGDDLTGDNRHILGW-KNDELVAYARILKSDDDLEpvvIGRVIVSEALRGEKVGQQLM 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489818986  91 E-AIESEAKSRGLTTLKLGAQVTAIPFYEKLGYETCSGLFLDAGIEHKDMKK 141
Cdd:PRK10314  97 SkTLESCTRHWPDKPVYLGAQAHLQNFYQSFGFIPVTEVYEEDGIPHIGMAR 148
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 52-107 2.13e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 37.26  E-value: 2.13e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489818986  52 EDGTPLATGRFR---EKDGYGKVERICTQKVARGTGSGRRIMEAIESEAKSRGLTTLKL 107
Cdd:cd04301    6 DDGEIVGFASLSpdgSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
 
Name Accession Description Interval E-value
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
13-144 1.95e-49

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 154.96  E-value: 1.95e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818986  13 QAALKIRNDVFVVEQRVDPALEWDEFDEidSVVMFVDYaEDGTPLATGRFR-EKDGYGKVERICTQKVARGTGSGRRIME 91
Cdd:COG2153    5 YDALALRREVFVVEQGVPPYLELDGKDE--DARHLLAY-DDGELVATARLLpPGDGEAKIGRVAVLPEYRGQGLGRALME 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489818986  92 AIESEAKSRGLTTLKLGAQVTAIPFYEKLGYETCSGLFLDAGIEHKDMKKTLT 144
Cdd:COG2153   82 AAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAGIPHIDMRKPLS 134
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 46-143 7.15e-16

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 69.22  E-value: 7.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818986   46 MFVdyAEDGTPLAtGRFREKDGyGKVERICTQKVARGTGSGRRIMEAIESEAKSRG--LTTLKLGAQVTAIPFYEKLGYE 123
Cdd:pfam13673  33 FFV--AFEGGQIV-GVIALRDR-GHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGikLSELTVNASPYAVPFYEKLGFR 108

                          90       100
                  ....*....|....*....|
gi 489818986  124 TCSGLFLDAGIEHKDMKKTL 143
Cdd:pfam13673 109 ATGPEQEFNGIRFVPMEKEL 128
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 36-123 7.09e-13

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 61.61  E-value: 7.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818986  36 DEFDEIDSVVMFVDYAEDGTPLATGRFREKDG-YGKVERICTQKVARGTGSGRRIMEAIESEAKSRGLTTLKLG---AQV 111
Cdd:COG0454   25 KAMEGSLAGAEFIAVDDKGEPIGFAGLRRLDDkVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDtldGNP 104

                         90
                 ....*....|..
gi 489818986 112 TAIPFYEKLGYE 123
Cdd:COG0454  105 AAIRFYERLGFK 116
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 52-143 7.80e-13

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 61.16  E-value: 7.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818986  52 EDGTPLATGRFRE-KDGYGKVERICTQKVARGTGSGRRIMEAIESEAKSRGLTTLKLGAQVTAIPFYEKLGYETCSGLFL 130
Cdd:COG1246   35 EDGEIVGCAALHPlDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSAAIHFYEKLGFEEIDKEDL 114

                         90
                 ....*....|....*..
gi 489818986 131 DAGIEHKD----MKKTL 143
Cdd:COG1246  115 PYAKVWQRdsvvMEKDL 131
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 13-122 6.37e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 58.68  E-value: 6.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818986   13 QAALKIRNDVFVVEQRVDPALEWDEFDEIDSVVMFVDYaEDGTPLATGRFR---EKDGYGKVERICTQKVARGTGSGRRI 89
Cdd:pfam00583   2 EALYELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAE-EDGELVGFASLSiidDEPPVGEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 489818986   90 MEAIESEAKSRGLTTLKLGAQVT---AIPFYEKLGY 122
Cdd:pfam00583  81 LQALLEWARERGCERIFLEVAADnlaAIALYEKLGF 116
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 58-144 1.23e-11

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 56.97  E-value: 1.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818986  58 ATGRFREKDGYGKVERICTQKVARGTGSGRRIMEAIESEAKSRGLTTLKLGAQVT---AIPFYEKLGYETCSGLFLDAGI 134
Cdd:COG0456    3 ALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDneaAIALYEKLGFEEVGERPNYYGD 82

                         90
                 ....*....|
gi 489818986 135 EHKDMKKTLT 144
Cdd:COG0456   83 DALVMEKELA 92
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
52-143 5.16e-10

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 53.94  E-value: 5.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818986  52 EDGTPLATGRFREKDGYGKVERICTQKVA-----RGTGSGRRIMEAIESEAKSRGLTTLKLGAQVTAIPFYEKLGYETCS 126
Cdd:COG3153   46 DDGEIVGHVALSPVDIDGEGPALLLGPLAvdpeyRGQGIGRALMRAALEAARERGARAVVLLGDPSLLPFYERFGFRPAG 125

                         90
                 ....*....|....*..
gi 489818986 127 GLFLDAGIEHKDMKKTL 143
Cdd:COG3153  126 ELGLTLGPDEVFLAKEL 142
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 42-123 7.79e-10

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 52.07  E-value: 7.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818986   42 DSVVMFVdYAEDGTPLATGRFREKDGYGKVE--RICTQKVARGTGSGRRIMEAIESEAKSRGLTTLKLGAQVTAIPFYEK 119
Cdd:pfam13508   1 PGGRFFV-AEDDGKIVGFAALLPLDDEGALAelRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAAAFYEK 79


                  ....
gi 489818986  120 LGYE 123
Cdd:pfam13508  80 LGFE 83
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
52-124 2.40e-08

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 49.99  E-value: 2.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818986  52 EDGTPLAT---GRFREKDGYGKV--ERICTQKVARGTGSGRRIMEAIESEAKSRGLTTLKLGAQVT---AIPFYEKLGYE 123
Cdd:COG1247   59 EDGEVVGFaslGPFRPRPAYRGTaeESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADneaSIALYEKLGFE 138


                 .
gi 489818986 124 T 124
Cdd:COG1247  139 E 139
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
56-123 3.42e-08

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 47.98  E-value: 3.42e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489818986  56 PLATGRFR-EKDGYGKVERICTQKVARGTGSGRRIMEAIESEAKSRGLTTLKL---GAQVTAIPFYEKLGYE 123
Cdd:COG3393    2 LVAMAGVRaESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLyvdADNPAARRLYERLGFR 73
PRK10314 PRK10314
GNAT family N-acetyltransferase;
14-141 6.55e-05

GNAT family N-acetyltransferase;


Pssm-ID: 182373 [Multi-domain]  Cd Length: 153  Bit Score: 40.60  E-value: 6.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818986  14 AALKIRNDVFVVEQRVdPALEWDEFDEIDSVVMFVDYaEDGTPLATGRFREKDGYGK---VERICTQKVARGTGSGRRIM 90
Cdd:PRK10314  19 ALLQLRCAVFVVEQNC-PYQDIDGDDLTGDNRHILGW-KNDELVAYARILKSDDDLEpvvIGRVIVSEALRGEKVGQQLM 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489818986  91 E-AIESEAKSRGLTTLKLGAQVTAIPFYEKLGYETCSGLFLDAGIEHKDMKK 141
Cdd:PRK10314  97 SkTLESCTRHWPDKPVYLGAQAHLQNFYQSFGFIPVTEVYEEDGIPHIGMAR 148
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 52-107 2.13e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 37.26  E-value: 2.13e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489818986  52 EDGTPLATGRFR---EKDGYGKVERICTQKVARGTGSGRRIMEAIESEAKSRGLTTLKL 107
Cdd:cd04301    6 DDGEIVGFASLSpdgSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
PLN02706 PLN02706
glucosamine 6-phosphate N-acetyltransferase
 42-122 8.29e-04

glucosamine 6-phosphate N-acetyltransferase


Pssm-ID: 178308 [Multi-domain]  Cd Length: 150  Bit Score: 37.38  E-value: 8.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489818986  42 DSVVMFVDYAEDGTPLATGR-FREKD---GYGKV---ERICTQKVARGTGSGRRIMEAIESEAKSRGLTTLKLGAQVTAI 114
Cdd:PLN02706  52 DHLICVIEDAASGRIIATGSvFVERKfirNCGKVghiEDVVVDSAARGKGLGKKIIEALTEHARSAGCYKVILDCSEENK 131


                 ....*...
gi 489818986 115 PFYEKLGY 122
Cdd:PLN02706 132 AFYEKCGY 139
PRK03624 PRK03624
putative acetyltransferase; Provisional
 80-124 1.13e-03

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 36.83  E-value: 1.13e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 489818986  80 ARGTGSGRRIMEAIESEAKSRGLttLKLGAQV-----TAIPFYEKLGYET 124
Cdd:PRK03624  80 FRGRGIGRALVARLEKKLIARGC--PKINLQVredndAVLGFYEALGYEE 127
PTZ00330 PTZ00330
acetyltransferase; Provisional
 69-125 1.75e-03

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 36.36  E-value: 1.75e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489818986  69 GKVERICTQKVARGTGSGRRIMEAIESEAKSRGLTTLKLGAQVTAIPFYEKLGYETC 125
Cdd:PTZ00330  83 GHIEDVVVDPSYRGQGLGRALISDLCEIARSSGCYKVILDCTEDMVAFYKKLGFRAC 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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