|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
8-390 |
7.74e-166 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 469.52 E-value: 7.74e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 8 TSLGLYMNYFVHGMALIIIAQNIDFLSQKWHTDLAGAAGVVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFFYIVFLG 87
Cdd:cd17396 1 TALGLYFNYFVHGMGVIILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 88 GILLSPNTIIAYMFGISAGIANSFLDTGTYPALMEAYPKKAASANIIVKAFVQSGQFLLPFMIAFILANNLWYGWSFIVL 167
Cdd:cd17396 81 GILFSPNLIIAYVFALLAGAANSFLDTGTYPALMEAFPKASGSANILVKAFVSFGQFLLPFIIAFLAANNLWYGWSFIVP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 168 IVILLINLLYTLTRTFPPMTVGKPLDVAELAEEKKQKFHFSIDEICLILFGFVAQTLLYIMSQWIAKYGSEVIHMTDDAS 247
Cdd:cd17396 161 AAVLVLNALLLLKLSFPPQTVTAANTKQKEIPVKREKPKFLIEGIALILIGFTSTATFYLFSQWMPKYGSAVAGMGEAES 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 248 RLLVSYASVGAIICVCVTFVLGNRGVRTLHILITYVTMTMLISFTLFAFPSEIVCIVGAFLLGYFSAGGIIQLGLTLLAE 327
Cdd:cd17396 241 LKLISYYSMGSLVCVFITAVLLKRYVRPIWILVLYPIISLLALFVLYLVPSPDVCILGAFVIGFFAAGGVLQLGLTLMAE 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489819559 328 VSARGKGFVTSLYTIAEGIAVFIIPLIAAAI-SRIDIAAIFLLNAGIALFGLALLMIVFTRKKK 390
Cdd:cd17396 321 FFPKGKGKVTGIYMIASSLANFVIPLITGIIaSAIGIAYIFLFDFGIALLGLLLAIFVFIRYRK 384
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
12-385 |
9.31e-27 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 109.72 E-value: 9.31e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 12 LYMNYFVHGMALIIIAQNIDFLSQKWHTDLAGAAGVVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFFYIVFLGGILL 91
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 92 SPNTIIAYMFGISAGIANSFLDTGTYPALMEAYPKKAASANIIVKAFVQSGQFLLPFMIAFILANNLWYGWSFIVLIVIL 171
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 172 LINLLYTLTRTFPPM-TVGKPLDVAELAEEKKQKFHFSIDEICLILFGFVAQTLLYIMSQWIAKYGSEVIHMTDDASRLL 250
Cdd:cd17333 161 LLLAILILLTLFPELpSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 251 VSYASVGAIICV-CVTFVLGNRGVRTLhiLITYVTMTMLISFTLFAFPSEIVCIVGAFLLGyFSAGGIIQLGLTLLAEVS 329
Cdd:cd17333 241 LSGFWVGITIGRlLGGPISRRIKPHTL--LVLSGSGALLGLLILLLAPTLVVGLVATALLG-LFMAALFPTILSLGISNL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 489819559 330 ARGKGFVTSLYTIAEGIAVFIIPLIAAAI-SRIDIAAIFLLnaGIALFGLALLMIVF 385
Cdd:cd17333 318 PYAKGKGTSVLLAAGSIGGAIIPFIMGFIaEAVGIQTAMLL--ITILYAIIFVLALL 372
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
2-390 |
3.50e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 79.51 E-value: 3.50e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 2 KNKYLSTSLGLYMNYFVHGMALIIIAQNIDFLSQKWHTDLAGAAGVVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFF 81
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 82 YIVFLGGILLSPNTIIAYMFGISAGIANSFLDTGTYPALMEAYPKKAASANIIVKAFVQSGQFLLPFMIAFILANNLWYG 161
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 162 W--SFIVLIVILLINLLYTLTRTFPPMTVGKPLDVAELAEEKKQKFHFSIDEICLILFGFVAqtLLYIMSQWIAKYGSEV 239
Cdd:COG0738 163 WhlPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVG--AEGAIGDWLPLYLKDV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 240 IHMTDDASRLLVSYASVGAII-CVCVTFVLGNRGVRTLhiLITYVTMTMLISFTLFAFPSEIVCIVGAFLLGyFSAGGII 318
Cdd:COG0738 241 LGLSEATAALGLSLFWGGMTIgRFLGGFLLKRFGPVRL--LRLSALLAAVGLLLALLAPGPWLALIGLALVG-LGLSLMF 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489819559 319 QLGLTLLAEVSARGKGFVTSLYTIAEGIAVFIIPLIAAAIS-RIDIAAIFLLnaGIALFGLALLMIVFTRKKK 390
Cdd:COG0738 318 PTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLAdAFGLRAAFLV--PLVCYLLILLLALALKRKR 388
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-384 |
1.49e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 65.14 E-value: 1.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 12 LYMNYFVHGMALIIIAQNIDFLSQKWHTDLAGAAGVVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFFYIVFLGGILL 91
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 92 SPNTIIAYMFGISAGIANSFLDTGTYPALMEAYPKKAASANIIVKAFVQSGQFLLPFMIAFILANNLWYGWSFIVLIVIL 171
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 172 LINLLYTLTRTFPPMTVGKPLDVAELAEEKKQKFHFSI-----DEICLILFGFVAQTLLYIMSQWIAKYGSEVIHMTDDA 246
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRvlknpGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 247 SRLLVSYASVGAIICVCVTFVLGNRGVRTLHILITYVTMTMLISFTLFAFPSEIVCIVGAFLLGYFSAGGIIQLGLTLLA 326
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 489819559 327 EVSARGKGFVTSLYTIAEGIAVFIIPLIAAAISRIDIAAIFLLNAGIALFGLALLMIV 384
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
12-352 |
4.33e-11 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 63.59 E-value: 4.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 12 LYMNYFVHGMALIIIAQNI-DFLSQKWHTDLAGAAGVVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFFYIVFLGGIL 90
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 91 LSPNTIIAYMFGISAGIANSFLDTGTYPALMEAYPKKA-ASANIIVKAFVQSGQFLLPFMIAFILANNLWYGWSFIVLIV 169
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 170 ILLINLLYTLTRTFPPMTVGKPLDVAELAEEKKQKFHFSIDEICLILFGFVAQTLLYIMSQWIAKYGSEVIHMTDDASRL 249
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 250 LVSYASVGAIICVCVTFVLGNRGVRTLHILITYVTMTMLISFTLFAFPSEIVCIVGAFLLGYFSAGGIIQLGLTLLAEVS 329
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 489819559 330 ARGK-GFVTSLYTIAEGIAVFIIP 352
Cdd:pfam07690 321 PKEErGTASGLYNTAGSLGGALGP 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-390 |
6.90e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 59.88 E-value: 6.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 16 YFVHGMALIIIAQNIDFLSQKWHTDLAGAAGVVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFFYIVFLGGILLSPNT 95
Cdd:COG2271 19 YFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSF 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 96 IIAYMFGISAGIANSFLDTGTYPALMEAYPKKA-ASANIIVKAFVQSGQFLLPFMIAFILANNLWyGWSFIVLIVILLIN 174
Cdd:COG2271 99 WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKErGRALGIFNAGGPLGGALAPPLLGWLLAAFGW-RAAFLILGLPGLLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 175 LLYTLtrtfppmtvgkpldvaelaeekkqkfhfsideICLILFGFVAQTLLYIMSQWIAKYGSEVIHMTDDASRLLVSYA 254
Cdd:COG2271 178 ALLRF--------------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 255 SVGAIICVCVTFVLGNR-GVRTLHILITYVTMTMLISFTLFAFPSEIVCIVGAFLLGYFSAGGIIQLGLTLLAEVSARGK 333
Cdd:COG2271 226 FLAGIVGSLLGGWLSDRlGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKAR 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 489819559 334 GFVTSL-YTIAEGIAVFIIPLIAAAISRIDIAAIFLLNAGIALFGLALLMIVFTRKKK 390
Cdd:COG2271 306 GTASGLvNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
10-347 |
3.03e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.06 E-value: 3.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 10 LGLYMNYFVHGMALIIIAQNIDFLSQKWHTDLAGAAGVVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFFYIVFLGGI 89
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 90 LLSPNTIIAYMFGISAGIANSFLDTGTYPALMEAYPKKAASANIIVKAFVQSGQFLLPFMIAFILANNLWYGWSFIVLIV 169
Cdd:COG2814 93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 170 ILLINLLYTLTRTFPPMTVGKPLDVAELAEEKKQKFHFSideicLILFGFVAQTLLYIMSQWIAKYGSEVIHMTDDASRL 249
Cdd:COG2814 173 LALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLL-----LLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 250 LVSYASVGAIICVCVTFVLGNRGVRTLHILITYVtmTMLISFTLFAFPSEIVCIVGAFLLGYFSAGGIIQLGLTLLAE-V 328
Cdd:COG2814 248 LLALFGLGGVLGALLAGRLADRFGRRRLLLIGLL--LLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAElA 325
|
330
....*....|....*....
gi 489819559 329 SARGKGFVTSLYTIAEGIA 347
Cdd:COG2814 326 PPEARGRASGLYNSAFFLG 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
12-385 |
6.80e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.20 E-value: 6.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 12 LYMNYFVHGMALIIIAQNIDFLSQKWHTDLAGAAGVVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFFYIVFLGGILL 91
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 92 SPNT---IIAYMFgisAGIANSFLDTGTYPALMEAYPKKAASANI-IVKAFVQSGQFLLPFMIAFILAnnlWYGWSFIVL 167
Cdd:cd17325 81 ATSYwqlLLARFL---QGLASAAVWPAAMALIADIAPPEERGRAMgIFSSAIGLGFLIGPLLGGLLAD---ALGYRAPFL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 168 IVILLINLLYTLTRTFPPMTVGKPLDVAELAEEKKQKFHFSIDEICLILFG---FVAQTLLYIMSQWIAKYGSEVIHMTD 244
Cdd:cd17325 155 VCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFlaiFVLAFAFGALEPFLPLYAAELGGLSP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 245 DASRLLVSYASVGAIICVCVTFVLGNRGVRTLHILITYVTMTmlISFTLFAFPSEIVCIVGAFLLGYFSAGGIIQLGLTL 324
Cdd:cd17325 235 AQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA--VALLLLPLATSFWLLLLLLALLGLGLGLVFPATLAL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489819559 325 LAE-VSARGKGFVTSLYTIAEGIAVFIIPLIAAAIS-RIDIAAIFLLNAGIALFGLALLMIVF 385
Cdd:cd17325 313 LADiVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYdAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
1-321 |
7.67e-08 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 53.78 E-value: 7.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 1 MKNKYLSTSLGlYMNYFVHGMALIIIAQNIDFLSQKWHTDLAGAAGVVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVF 80
Cdd:PRK03699 2 NSNRIKLTWIS-FLSYALTGALVIVTGMVMGPIAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 81 FYIVFLGGILLSPN--TIIAYMF--GISAGIansFLDTGTYPALMEAYPKKAASANIIVKAFVQSGQFLLPFMIAFILAN 156
Cdd:PRK03699 81 LMILAVAGLMFSHSlaLFSIAMFvlGVVSGI---TMSIGTFLITHVYEGKQRGSRLLFTDSFFSMAGMIFPIIAAYLLAR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 157 NLWYGWSFIVLIVILLINLLYTLTRTFPpmTVGKPLDVAElAEEKKQKFHFSIDEICLILFGFVAQtlLYIMSQWIAKYG 236
Cdd:PRK03699 158 SIEWYWVYACIGLVYVAIFILTLFSEFP--ALGKHAPKAD-KPVAKEKWGIGVLFLAIAALLYILA--QLTFISWVPEYA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 237 SEVIHM-TDDASRLLVSYASVGAIICVCVTFVLgnRGVRTLHILITYVTMTMLISFTLFAFPSEIVCIVGAFLLGYFSAG 315
Cdd:PRK03699 233 QKKFGMsLEDAGNLVSNFWMAYMVGMWIFSFIV--RFFDLQRILTVLAGLALVLMYLFVNTDDPSHLLYAILGLGFFSSA 310
|
....*....
gi 489819559 316 ---GIIQLG 321
Cdd:PRK03699 311 iytTIITLG 319
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
13-382 |
2.43e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 52.22 E-value: 2.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 13 YMNYFVHGMALIIIAQNIDflsqkWHTDLAGAAGVVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFFYIVFLGGILLS 92
Cdd:cd17316 12 AYDFFLIGFVAPVLAAEFS-----LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 93 PNTIIAYMFGISAGIANSFLDTGTYPALMEAYPKKAASANIIVKAFVQSGQFLLPFMIAFILANNL--WYGWSFIVLIVI 170
Cdd:cd17316 87 PTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgDWGWRILFLIGA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 171 LLINLLYTLTRTFppmtvgkpldvaelaeekkqkfhfsideICLILFGFVAQTLLYIMSQWIAKYGSEVIHMTDDASRLL 250
Cdd:cd17316 167 LPALLALLLRRRT----------------------------LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLY 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 251 VSYASVGAIICVCVTFVLGNRGVRTLHILITYVTMTMLISFTLFAFPSEIVCIVGAFLLGYFSAGGIIQLGLTLLAE--- 327
Cdd:cd17316 219 LLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAElfp 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 489819559 328 --VSARGKGFVTSLYTIAEGIAVFIIPLIaaAISRIDIAAIFLLNAGIALFGLALLM 382
Cdd:cd17316 299 teVRATGVGLSYNLGRLGGGGAPPLIALL--LASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
33-384 |
3.91e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 51.42 E-value: 3.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 33 LSQKWHTDLAGAAGVVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFFYIVFLGGILLSPNTIIAYMFGISAGIANSFL 112
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 113 DTGTYPALMEAYP-KKAASANIIVKAFVQSGQFLLPFMIAFILAnnLWYGWSFIVLIVILLINLLYTLTRTFPPMTVGKP 191
Cdd:cd17474 105 GPLALTLIGDLFEgGERAKAMGLYEAALGLGIAVGPLLGGLLAA--ISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 192 LDVAELAEEKKQKFHFSideicLILFGFVAQTLLYIMSQWIAkYGSEVIHMTDDASRLLVSYASVGAIICVCVT-FVLGN 270
Cdd:cd17474 183 SSATKLRDLKKALRGRG-----LLTFLVSAFLYFFLYFAFLT-YLPFLLELLYGISPIIIGLLFAGWSVLLALGsLFVGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 271 RGVRTLHILITYVT--MTMLISFTLFAFPSEIVCIVGAFLLGYFSAGGIIQLGLTLLAEVSARG-KGFVTSLYTIAEGIA 347
Cdd:cd17474 257 LLKKRFGARRILVIglLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEeRGTASSLYNFVRFLG 336
|
330 340 350
....*....|....*....|....*....|....*...
gi 489819559 348 VFIIPLIAAAISRI-DIAAIFLLNAGIALFGLALLMIV 384
Cdd:cd17474 337 QAVGPLLFGLLLEIfGLSAPFLVGAAIALAAAVLLALL 374
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
32-390 |
3.95e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 48.34 E-value: 3.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 32 FLSQKWHTDLAGAAGVVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFFYIVFLGGILLSPNTIIAYMFGISAGIANSF 111
Cdd:COG2223 30 PLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 112 LDTGTYPALMEAYPK-KAASANIIVKAFVQSGQFLLPFMIAFILAnnlWYGWSFIVLIVILLINLLYTLTRTF-----PP 185
Cdd:COG2223 110 SFAVGIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIA---AFGWRNAFLILGILLLVVAVLAWLFlrdppAG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 186 MTVGKPLDVAELAEEKKQKfhfsiDEICLILFGFVAQTLLYIMSQWIAKYGSEVIHMTDDASRLLVSYASVGAIICVCVT 265
Cdd:COG2223 187 AAAAAKASLRDQLEALRDP-----RFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 266 FVLGNR--GVRTLhiLITYVTMTMLISFTLFAFPSEIVCIVGAFLLGYFSAGGIIQLGLTLLAEVSARGKGFVTSLYTIA 343
Cdd:COG2223 262 GWLSDRigGRRVL--LIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAA 339
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 489819559 344 EGIAVFIIPLIAAAISRI--DIAAIFLLNAGIALFGLALLMIVFTRKKK 390
Cdd:COG2223 340 GGLGGFLGPLLFGALLDAtgSYTAAFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-164 |
6.15e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 47.50 E-value: 6.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 10 LGLYMNYFVHGMALIIIAQNIDFLSQKWHTDLAGAAGVVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFFYIVFLGGI 89
Cdd:COG0477 17 LALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLC 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489819559 90 LLSPNTIIAYMFGISAGIANSFLDTGTYPALMEAYPKKAASANIIVKAFVQSGQFLLPFMIAFILANNLWYGWSF 164
Cdd:COG0477 97 GLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
16-164 |
8.10e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 44.49 E-value: 8.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 16 YFVHGMALI-IIAQNIDFLSQKWHTDLAGAAGVVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFFYIVFLGGILLSPN 94
Cdd:COG2223 214 YFGTFGSFIgFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG 293
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489819559 95 TIIAYMFGISAGIANSFLDTGTYPALMEAY-PKKAASANI-IVKAFVQSGQFLLPFMIAFILANNLWYGWSF 164
Cdd:COG2223 294 SLWLFLVLFLLLGLALGGGNGAVFALVPDIfPTKNAGAVYgLVGAAGGLGGFLGPLLFGALLDATGSYTAAF 365
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
32-382 |
1.08e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.08 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 32 FLSQKWHTDLAGAAGVVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFFYIVFLGGILLSPNTIIAYMFGISAGIANSF 111
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 112 LDTGTYPALMEAYPKKAASANIIVKAFVQSGQFLLPFMIAFILANNLWYGWSFIVLIVILLINLLYTLTRTFPPMTVGKP 191
Cdd:cd17478 101 FHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 192 LDVAELAEEKKQKFHFSIDEICLILF-GFVAQTLLYIMSQWIAKYGSEVIHMTDDASRLLVSyASVGAIICVcvtfVLGN 270
Cdd:cd17478 181 AAKSSARSTLKGVWRALLLLLIIVFLrSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFA-GAIGTLIGG----PLSD 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 271 RGVRTLHILITYVTMTmlISFTLFAFPSEIVCIVGAFLLGyFSAGGIIQLGLTLLAEVSARGKGFVTSLY-TIAEGIAVF 349
Cdd:cd17478 256 RFGRRRVIIASLLLAA--PFLLLFLLTPGIWSYILLVLAG-FLLFASFPVTVVLAQELLPGNVGLASGLMmGLSFGLGGI 332
|
330 340 350
....*....|....*....|....*....|...
gi 489819559 350 IIPLIAAAISRIDIAAIFLLNAGIALFGLALLM 382
Cdd:cd17478 333 GAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
44-153 |
3.56e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 42.18 E-value: 3.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 44 AAGVVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFFYIVFLGGILLSPN-TIIAYMFGISaGIANSFLDTGTYPALME 122
Cdd:cd17317 27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSyELFLVLRFLV-GVTSAGIFTVGFVLGME 105
|
90 100 110
....*....|....*....|....*....|..
gi 489819559 123 AYPKKAAS-ANIIVKAFVQSGQFLLPFMIAFI 153
Cdd:cd17317 106 IVGPKYRSfVGILFGLFWALGYMLLALLAYLI 137
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
25-108 |
2.40e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 39.86 E-value: 2.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 25 IIAQNIDFLSQKWHTDLAGAAGVVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFFYIVFLGGILLSPNTIIAYMFGIS 104
Cdd:cd17359 19 VINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARII 98
|
....
gi 489819559 105 AGIA 108
Cdd:cd17359 99 GGLA 102
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
47-382 |
3.90e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.11 E-value: 3.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 47 VVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFFYIVFLGGILLSPNTIIAYMFGISAGIANSFLDTGTYPALMEAYPK 126
Cdd:cd17489 36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 127 KAASANIIVKAFVQSGQFLLPFMIAFILANNLWYGWSFIVLIVILLINLLYtltrtFPPMTVGKPLDVAELAEEKKQKFH 206
Cdd:cd17489 116 SRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLL-----VFLVKDPPPVAAEEAEAGTRAFRR 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 207 FSIDEICLILFGFVAQTLLY-IMSQWIAKYGSEVIHmtDDASRLLVSYAsVGAIICVCVTFVLGNRGVRTLHILITYVTM 285
Cdd:cd17489 191 LVEKKVLPPALILFLASIAYgAISTFLPLYAAERGI--SNAGLFFTVYA-IALLLSRPFSGKLSDRKGPKTVIIPGLLLL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 286 TmlISFTLFAF-PSEIVCIVGAFLLGYfsAGGIIQLGLTLLA--EVSARGKGFVTSLYTIAEGIAVFIIPLIAAAI-SRI 361
Cdd:cd17489 268 A--LGLLLLSFaGSPWMLLLAAVLYGL--GFGLLFPALQALAvdLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVaELF 343
|
330 340
....*....|....*....|.
gi 489819559 362 DIAAIFLLNAGIALFGLALLM 382
Cdd:cd17489 344 GYRAMFLLAAVVVLLALVLYI 364
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
47-111 |
6.53e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 38.41 E-value: 6.53e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489819559 47 VVSSFGIGKLLAVFISGRLSDKFGRKLSVILGVFFYIVFLGGILLSPNTIIAYMF-------GISAGIANSF 111
Cdd:pfam00083 51 IVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLivgrvlvGIGVGGASVL 122
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
44-385 |
8.83e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 37.98 E-value: 8.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 44 AAGVVSSFGIGKLLAVFISGRLSDKFGRK-----LSVILGVFFYIVFLGGILLSPNTIIAYMFGISAGIANSFLDTGTYP 118
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRrllilADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 119 ALMEAYPKKA-ASANIIVKAFVQSGQFLLPFMIAFILA-NNLWYGWSFIVLIVILLINLLYTLTRTFPPMTVGKPLDVAE 196
Cdd:cd06173 116 LLPELVPKEQlVRANALNSLATQLARIIGPALGGLLVAlLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 197 LAEEKKQKFHFSIDEICLILFGFVAQTLLYIMSQWIAKYGSEVIHMTDDASRLLVSYASVGAIICVCVTFVLGNRgVRTL 276
Cdd:cd06173 196 DLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKR-RRRG 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819559 277 HILITYVTMTMLISFTLFAFPSEIVCIVGAFLLGYFSAGGIIQLGLTLLAEVSARGKGFVTSLYTIAEGIAVFIIPLIAA 356
Cdd:cd06173 275 RLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAG 354
|
330 340
....*....|....*....|....*....
gi 489819559 357 AISRIDIAAIFLLNAGIALFGLALLMIVF 385
Cdd:cd06173 355 LLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| |
