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Conserved domains on  [gi|489819678|ref|WP_003723488|]
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MULTISPECIES: STAS domain-containing protein [Listeria]

Protein Classification

STAS domain-containing protein( domain architecture ID 10162406)

STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain-containing protein similar to Bacillus subtilis stressosome complex proteins RsbS, RsbRB, and RsbRC, which function in the environmental signaling branch of the general stress response

CATH:  3.30.750.24
Gene Ontology:  GO:0043856|GO:0006355
PubMed:  10662676|22116355
SCOP:  4003567

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
STAS_RsbR_RsbS_like cd07041
Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex ...
 162-269 5.20e-31

Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.


:

Pssm-ID: 132912  Cd Length: 109  Bit Score: 111.39  E-value: 5.20e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819678 162 STPVISITDKLAILPLMGRVDRERAEKLSEITANKCVHLGVEQLCIDLSGITYFDDALGEMLTNLVTMLKLLGVEAFISG 241
Cdd:cd07041    1 STPIIPVWDGVLVLPLIGDLDDERAEQLQERLLEAISRRRARGVIIDLTGVPVIDSAVARHLLRLARALRLLGARTILTG 80

                         90       100
                 ....*....|....*....|....*....
gi 489819678 242 IQPKMAQQINRVDLNLS-IPAYHSLKAVL 269
Cdd:cd07041   81 IRPEVAQTLVELGIDLSgIRTAATLQQAL 109
 
Name Accession Description Interval E-value
STAS_RsbR_RsbS_like cd07041
Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex ...
 162-269 5.20e-31

Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.


Pssm-ID: 132912  Cd Length: 109  Bit Score: 111.39  E-value: 5.20e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819678 162 STPVISITDKLAILPLMGRVDRERAEKLSEITANKCVHLGVEQLCIDLSGITYFDDALGEMLTNLVTMLKLLGVEAFISG 241
Cdd:cd07041    1 STPIIPVWDGVLVLPLIGDLDDERAEQLQERLLEAISRRRARGVIIDLTGVPVIDSAVARHLLRLARALRLLGARTILTG 80

                         90       100
                 ....*....|....*....|....*....
gi 489819678 242 IQPKMAQQINRVDLNLS-IPAYHSLKAVL 269
Cdd:cd07041   81 IRPEVAQTLVELGIDLSgIRTAATLQQAL 109
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 166-248 1.51e-10

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 56.79  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819678 166 ISITDKLAILPLMGRVDRERAEKLSEiTANKCVHLGVEQLCIDLSGITYFDDALGEMLTNLVTMLKLLGVEAFISGIQPK 245
Cdd:COG1366    4 VEVRDGVLVLPLIGELDAARAPELRE-ALLEALETGARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPA 82


                 ...
gi 489819678 246 MAQ 248
Cdd:COG1366   83 VAR 85
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 164-266 1.82e-04

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 39.90  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819678  164 PVISITDKLAILPLMGRVDRERAEKLSEITANKCVHLGVEQLCIDLSGITYFDDALGEMLTNLVTMLKLLGVEAFISGIQ 243
Cdd:pfam01740   2 PEAEEIPGILILRLDGPLDFANAESLRERLLRALEEGEIKHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPS 81

                          90       100
                  ....*....|....*....|...
gi 489819678  244 PKMAQQINRVDLNLSIPAYHSLK 266
Cdd:pfam01740  82 PEVARTLEKTGLDDIIKIFPTVA 104
 
Name Accession Description Interval E-value
STAS_RsbR_RsbS_like cd07041
Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex ...
 162-269 5.20e-31

Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.


Pssm-ID: 132912  Cd Length: 109  Bit Score: 111.39  E-value: 5.20e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819678 162 STPVISITDKLAILPLMGRVDRERAEKLSEITANKCVHLGVEQLCIDLSGITYFDDALGEMLTNLVTMLKLLGVEAFISG 241
Cdd:cd07041    1 STPIIPVWDGVLVLPLIGDLDDERAEQLQERLLEAISRRRARGVIIDLTGVPVIDSAVARHLLRLARALRLLGARTILTG 80

                         90       100
                 ....*....|....*....|....*....
gi 489819678 242 IQPKMAQQINRVDLNLS-IPAYHSLKAVL 269
Cdd:cd07041   81 IRPEVAQTLVELGIDLSgIRTAATLQQAL 109
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 166-248 1.51e-10

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 56.79  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819678 166 ISITDKLAILPLMGRVDRERAEKLSEiTANKCVHLGVEQLCIDLSGITYFDDALGEMLTNLVTMLKLLGVEAFISGIQPK 245
Cdd:COG1366    4 VEVRDGVLVLPLIGELDAARAPELRE-ALLEALETGARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPA 82


                 ...
gi 489819678 246 MAQ 248
Cdd:COG1366   83 VAR 85
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 164-266 1.82e-04

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 39.90  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819678  164 PVISITDKLAILPLMGRVDRERAEKLSEITANKCVHLGVEQLCIDLSGITYFDDALGEMLTNLVTMLKLLGVEAFISGIQ 243
Cdd:pfam01740   2 PEAEEIPGILILRLDGPLDFANAESLRERLLRALEEGEIKHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPS 81

                          90       100
                  ....*....|....*....|...
gi 489819678  244 PKMAQQINRVDLNLSIPAYHSLK 266
Cdd:pfam01740  82 PEVARTLEKTGLDDIIKIFPTVA 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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