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Conserved domains on  [gi|489819825|ref|WP_003723634|]
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MULTISPECIES: creatininase family protein [Listeria]

Protein Classification

creatininase family protein( domain architecture ID 10003645)

creatininase family protein similar to creatininase which catalyzes the hydrolysis of creatinine to creatine

CATH:  3.40.50.10310
EC:  3.5.2.10
PubMed:  15003455
SCOP:  4001004

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ArfB COG1402
Creatinine amidohydrolase/Fe(II)-dependent FAPy formamide hydrolase (riboflavin and F420 ...
2-236 4.05e-84

Creatinine amidohydrolase/Fe(II)-dependent FAPy formamide hydrolase (riboflavin and F420 biosynthesis) [Coenzyme transport and metabolism]; Creatinine amidohydrolase/Fe(II)-dependent FAPy formamide hydrolase (riboflavin and F420 biosynthesis) is part of the Pathway/BioSystem: Riboflavin/FAD biosynthesis


:

Pssm-ID: 441012  Cd Length: 236  Bit Score: 250.53  E-value: 4.05e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825   2 LYADENSFDIGAKITKTKPVILPIGAVEAHGPHLPLGTDNILASEYSAKIAAETDG-FVLPVLPYGQVWSLQDFPGSLTL 80
Cdd:COG1402    1 RLAELTWPEVEAALKEDDVAILPVGSTEQHGPHLPLGTDTLIAEAVAERVAERLPGvLVLPTIPYGVSPEHLGFPGTISL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825  81 SNETVTKVVVEIGESLYKQGFRLFVPVSGHLGNMAALKDAARELYAKFPDMVILHIFYPNIQKLAMDVREGKANHhtYIH 160
Cdd:COG1402   81 SPETLIAVLRDIGESLARHGFRRIVLVNGHGGNVAALKEAARELRAEHPGMLVVVLNWWRLAPPGLALSEGEETG--GGH 158
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489819825 161 ACEIETSLMLYLSPENTDMSRAIDDPPilpiDADFTPTPWQTFTKTAVLGEATLATAEKGEYLIEKTLKTCVELIK 236
Cdd:COG1402  159 AGELETSLMLALRPELVRMDRAADGPP----AGLPIGLLSRDLTPSGVLGDPTLATAEKGEALLEAAVEALVELLR 230
 
Name Accession Description Interval E-value
ArfB COG1402
Creatinine amidohydrolase/Fe(II)-dependent FAPy formamide hydrolase (riboflavin and F420 ...
2-236 4.05e-84

Creatinine amidohydrolase/Fe(II)-dependent FAPy formamide hydrolase (riboflavin and F420 biosynthesis) [Coenzyme transport and metabolism]; Creatinine amidohydrolase/Fe(II)-dependent FAPy formamide hydrolase (riboflavin and F420 biosynthesis) is part of the Pathway/BioSystem: Riboflavin/FAD biosynthesis


Pssm-ID: 441012  Cd Length: 236  Bit Score: 250.53  E-value: 4.05e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825   2 LYADENSFDIGAKITKTKPVILPIGAVEAHGPHLPLGTDNILASEYSAKIAAETDG-FVLPVLPYGQVWSLQDFPGSLTL 80
Cdd:COG1402    1 RLAELTWPEVEAALKEDDVAILPVGSTEQHGPHLPLGTDTLIAEAVAERVAERLPGvLVLPTIPYGVSPEHLGFPGTISL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825  81 SNETVTKVVVEIGESLYKQGFRLFVPVSGHLGNMAALKDAARELYAKFPDMVILHIFYPNIQKLAMDVREGKANHhtYIH 160
Cdd:COG1402   81 SPETLIAVLRDIGESLARHGFRRIVLVNGHGGNVAALKEAARELRAEHPGMLVVVLNWWRLAPPGLALSEGEETG--GGH 158
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489819825 161 ACEIETSLMLYLSPENTDMSRAIDDPPilpiDADFTPTPWQTFTKTAVLGEATLATAEKGEYLIEKTLKTCVELIK 236
Cdd:COG1402  159 AGELETSLMLALRPELVRMDRAADGPP----AGLPIGLLSRDLTPSGVLGDPTLATAEKGEALLEAAVEALVELLR 230
Creatininase pfam02633
Creatinine amidohydrolase; Creatinine amidohydrolase (EC:3.5.2.10), or creatininase, catalyzes ...
13-232 2.82e-80

Creatinine amidohydrolase; Creatinine amidohydrolase (EC:3.5.2.10), or creatininase, catalyzes the hydrolysis of creatinine to creatine.


Pssm-ID: 426892  Cd Length: 226  Bit Score: 240.61  E-value: 2.82e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825   13 AKITKTKPVILPIGAVEAHGPHLPLGTDNILASEYSAKIAAETDGFVLPVLPYGQVWSLQDFPGSLTLSNETVTKVVVEI 92
Cdd:pfam02633   2 EALKEDDVAILPVGSTEQHGPHLPLGTDTLIAEAIAERVAERAPALVLPTLPYGVSPEHRGFPGTISLSPETLIAVLRDI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825   93 GESLYKQGFRLFVPVSGHLGNMAALKDAARELYAKFPDMVILHIFYPNIQ--KLAMDVREGKANHHTYIHACEIETSLML 170
Cdd:pfam02633  82 VRSLARHGFRKIVLVNGHGGNVAALKEAARELRAEHDMAVRDGFLAVAFSwsRVGALAALLSEDEEGGGHAGEAETSLML 161
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489819825  171 YLSPENTDMSRAIDDPP---ILPIDADFTPTPWQTFTKTAVLGEATLATAEKGEYLIEKTLKTCV 232
Cdd:pfam02633 162 ALRPELVRMDRAEDGEPaplDPEGLPAPFAWDTRDLSPSGVLGDPTLATAEKGEALLEAAVDALV 226
creatininase TIGR04448
creatininase; Members of this family are creatininase (EC 3.5.2.10), an amidohydrolase that ...
9-235 2.97e-51

creatininase; Members of this family are creatininase (EC 3.5.2.10), an amidohydrolase that interconverts creatinine + H(2)O with creatine. It should not be confused with creatinase (EC 3.5.3.3), which hydrolyzes creatine to sarcosine plus urea. [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 275241  Cd Length: 246  Bit Score: 167.13  E-value: 2.97e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825    9 FDIGAKITKTKPVILPIGAVEAHGPHLPLGTDNILASEYSAKIAAETDGFVLPVLPYG---QVWS--LQDFPGSLTLSNE 83
Cdd:TIGR04448   5 PEYEEAVAEGAVIILPIGSTEQHGPHLPLGTDALLATAVAEAVAERIDGLVAPALSYGyksQPLSggGNHFPGTTSLDGA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825   84 TVTKVVVEIGESLYKQGFRLFVPVSGHLGNMA----ALKDAARELYAKFPDMVILHIFY-----PN-IQKLAMDVREGKA 153
Cdd:TIGR04448  85 TLILLVRDVVREFVRHGFRRIVLVNGHYENQWfiveGIDLALRELRYGIPDAKIMVLEYwdfvqEAtIDKLFPEGFPGWD 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825  154 nhhtYIHACEIETSLMLYLSPENTDMSRAIDDPP-------ILPIDADFTPtpwqtftKTAVLGEATLATAEKGEYLIEk 226
Cdd:TIGR04448 165 ----LEHAAVMETSLMLHLHPELVDMDRAVDDAPakfppydVYPVDPDFVP-------PSGVLSSAKGASAEKGKLLAE- 232

                  ....*....
gi 489819825  227 tlkTCVELI 235
Cdd:TIGR04448 233 ---DVVEGI 238
 
Name Accession Description Interval E-value
ArfB COG1402
Creatinine amidohydrolase/Fe(II)-dependent FAPy formamide hydrolase (riboflavin and F420 ...
2-236 4.05e-84

Creatinine amidohydrolase/Fe(II)-dependent FAPy formamide hydrolase (riboflavin and F420 biosynthesis) [Coenzyme transport and metabolism]; Creatinine amidohydrolase/Fe(II)-dependent FAPy formamide hydrolase (riboflavin and F420 biosynthesis) is part of the Pathway/BioSystem: Riboflavin/FAD biosynthesis


Pssm-ID: 441012  Cd Length: 236  Bit Score: 250.53  E-value: 4.05e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825   2 LYADENSFDIGAKITKTKPVILPIGAVEAHGPHLPLGTDNILASEYSAKIAAETDG-FVLPVLPYGQVWSLQDFPGSLTL 80
Cdd:COG1402    1 RLAELTWPEVEAALKEDDVAILPVGSTEQHGPHLPLGTDTLIAEAVAERVAERLPGvLVLPTIPYGVSPEHLGFPGTISL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825  81 SNETVTKVVVEIGESLYKQGFRLFVPVSGHLGNMAALKDAARELYAKFPDMVILHIFYPNIQKLAMDVREGKANHhtYIH 160
Cdd:COG1402   81 SPETLIAVLRDIGESLARHGFRRIVLVNGHGGNVAALKEAARELRAEHPGMLVVVLNWWRLAPPGLALSEGEETG--GGH 158
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489819825 161 ACEIETSLMLYLSPENTDMSRAIDDPPilpiDADFTPTPWQTFTKTAVLGEATLATAEKGEYLIEKTLKTCVELIK 236
Cdd:COG1402  159 AGELETSLMLALRPELVRMDRAADGPP----AGLPIGLLSRDLTPSGVLGDPTLATAEKGEALLEAAVEALVELLR 230
Creatininase pfam02633
Creatinine amidohydrolase; Creatinine amidohydrolase (EC:3.5.2.10), or creatininase, catalyzes ...
13-232 2.82e-80

Creatinine amidohydrolase; Creatinine amidohydrolase (EC:3.5.2.10), or creatininase, catalyzes the hydrolysis of creatinine to creatine.


Pssm-ID: 426892  Cd Length: 226  Bit Score: 240.61  E-value: 2.82e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825   13 AKITKTKPVILPIGAVEAHGPHLPLGTDNILASEYSAKIAAETDGFVLPVLPYGQVWSLQDFPGSLTLSNETVTKVVVEI 92
Cdd:pfam02633   2 EALKEDDVAILPVGSTEQHGPHLPLGTDTLIAEAIAERVAERAPALVLPTLPYGVSPEHRGFPGTISLSPETLIAVLRDI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825   93 GESLYKQGFRLFVPVSGHLGNMAALKDAARELYAKFPDMVILHIFYPNIQ--KLAMDVREGKANHHTYIHACEIETSLML 170
Cdd:pfam02633  82 VRSLARHGFRKIVLVNGHGGNVAALKEAARELRAEHDMAVRDGFLAVAFSwsRVGALAALLSEDEEGGGHAGEAETSLML 161
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489819825  171 YLSPENTDMSRAIDDPP---ILPIDADFTPTPWQTFTKTAVLGEATLATAEKGEYLIEKTLKTCV 232
Cdd:pfam02633 162 ALRPELVRMDRAEDGEPaplDPEGLPAPFAWDTRDLSPSGVLGDPTLATAEKGEALLEAAVDALV 226
creatininase TIGR04448
creatininase; Members of this family are creatininase (EC 3.5.2.10), an amidohydrolase that ...
9-235 2.97e-51

creatininase; Members of this family are creatininase (EC 3.5.2.10), an amidohydrolase that interconverts creatinine + H(2)O with creatine. It should not be confused with creatinase (EC 3.5.3.3), which hydrolyzes creatine to sarcosine plus urea. [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 275241  Cd Length: 246  Bit Score: 167.13  E-value: 2.97e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825    9 FDIGAKITKTKPVILPIGAVEAHGPHLPLGTDNILASEYSAKIAAETDGFVLPVLPYG---QVWS--LQDFPGSLTLSNE 83
Cdd:TIGR04448   5 PEYEEAVAEGAVIILPIGSTEQHGPHLPLGTDALLATAVAEAVAERIDGLVAPALSYGyksQPLSggGNHFPGTTSLDGA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825   84 TVTKVVVEIGESLYKQGFRLFVPVSGHLGNMA----ALKDAARELYAKFPDMVILHIFY-----PN-IQKLAMDVREGKA 153
Cdd:TIGR04448  85 TLILLVRDVVREFVRHGFRRIVLVNGHYENQWfiveGIDLALRELRYGIPDAKIMVLEYwdfvqEAtIDKLFPEGFPGWD 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825  154 nhhtYIHACEIETSLMLYLSPENTDMSRAIDDPP-------ILPIDADFTPtpwqtftKTAVLGEATLATAEKGEYLIEk 226
Cdd:TIGR04448 165 ----LEHAAVMETSLMLHLHPELVDMDRAVDDAPakfppydVYPVDPDFVP-------PSGVLSSAKGASAEKGKLLAE- 232

                  ....*....
gi 489819825  227 tlkTCVELI 235
Cdd:TIGR04448 233 ---DVVEGI 238
mycofact_creat TIGR03964
mycofactocin system creatininase family protein; Members of this protein family are ...
21-235 5.77e-33

mycofactocin system creatininase family protein; Members of this protein family are uncharacterized Actinobacterial proteins, with homology to creatinine amidohydrolase from Pseudomonas. Members occur only in the context of the mycofactocin system. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274883  Cd Length: 228  Bit Score: 119.41  E-value: 5.77e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825   21 VILPIGAVEAHGPHLPLGTDNILASEYSAKIAAETDGFVL--PVLPYGQVWSLQDFPGSLTLSNETVTKVVVEIGESLYK 98
Cdd:TIGR03964  16 LLVPLGSTEQHGPHLPLDTDTRIATAVAEGAAARLDDRVLlaPAIAYGASGEHEGFPGTVSIGTEALHLLLVEYGRSACR 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489819825   99 QGFRLfVPVSGHLGNMAALKDAARELYAKFPDMVilhiFYPNIqklamdVREGKAnhhtyiHACEIETSLMLYLSPENTD 178
Cdd:TIGR03964  96 WAGRV-VFVNGHGGNLDALRRAVALLRYEGRDVA----WWPCA------VAGADA------HAGRTETSLLLHLSPDRVR 158
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489819825  179 MSRAI--DDPPIlpidADFTPTPWQ----TFTKTAVLGEATLATAEKGEYLIEKTLKTCVELI 235
Cdd:TIGR03964 159 MDRAEagNTAPL----AELMPRLRAggvaAVSPNGVLGDPTGATAEEGARLLAEMVGRCAAAV 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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