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Conserved domains on  [gi|489821626|ref|WP_003725425|]
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MULTISPECIES: metalloregulator ArsR/SmtB family transcription factor [Listeria]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 16677510)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 16-91 6.77e-27

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


:

Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 94.06  E-value: 6.77e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489821626  16 VTQIFKALSDPTRVQILNLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKSRREGTTIYYMQDDNHVLELL 91
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 16-91 6.77e-27

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 94.06  E-value: 6.77e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489821626  16 VTQIFKALSDPTRVQILNLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKSRREGTTIYYMQDDNHVLELL 91
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
9-98 1.77e-26

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 93.42  E-value: 1.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821626   9 DEETLFSVTQIFKALSDPTRVQILNLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKSRREGTTIYYMQDDNHVL 88
Cdd:COG0640    3 ETKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALA 82

                         90
                 ....*....|
gi 489821626  89 ELLTQAIRHV 98
Cdd:COG0640   83 ELLEWLLELL 92
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 20-96 9.31e-20

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 75.80  E-value: 9.31e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489821626  20 FKALSDPTRVQILNLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKSRREGTTIYYMQDDN-HVLELLTQAIR 96
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAeRLLALLESLLE 78
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 19-80 7.00e-19

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 73.60  E-value: 7.00e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489821626  19 IFKALSDPTRVQILNLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKSRREGTTIYY 80
Cdd:NF033789   1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYY 62
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
30-95 8.69e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 70.70  E-value: 8.69e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489821626    30 QILNLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKSRREGTTIYYMQDDNHVLELLTQAI 95
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 25-69 1.06e-13

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 59.76  E-value: 1.06e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 489821626   25 DPTRVQILNLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLV 69
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 18-80 8.06e-07

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 43.65  E-value: 8.06e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489821626  18 QIFKALSDPTRVQILNLLQDR-EYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKSRREGTTIYY 80
Cdd:PRK10141   8 QLFKILSDETRLGIVLLLRESgELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHY 71
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 27-71 2.49e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 35.41  E-value: 2.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 489821626   27 TRVQILNLLQDR-EYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKS 71
Cdd:TIGR01884 144 EELKILEVLKATgEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQ 189
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 16-91 6.77e-27

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 94.06  E-value: 6.77e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489821626  16 VTQIFKALSDPTRVQILNLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKSRREGTTIYYMQDDNHVLELL 91
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
9-98 1.77e-26

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 93.42  E-value: 1.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821626   9 DEETLFSVTQIFKALSDPTRVQILNLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKSRREGTTIYYMQDDNHVL 88
Cdd:COG0640    3 ETKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALA 82

                         90
                 ....*....|
gi 489821626  89 ELLTQAIRHV 98
Cdd:COG0640   83 ELLEWLLELL 92
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 20-96 9.31e-20

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 75.80  E-value: 9.31e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489821626  20 FKALSDPTRVQILNLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKSRREGTTIYYMQDDN-HVLELLTQAIR 96
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAeRLLALLESLLE 78
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 19-80 7.00e-19

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 73.60  E-value: 7.00e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489821626  19 IFKALSDPTRVQILNLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKSRREGTTIYY 80
Cdd:NF033789   1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYY 62
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
30-95 8.69e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 70.70  E-value: 8.69e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489821626    30 QILNLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKSRREGTTIYYMQDDNHVLELLTQAI 95
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 25-69 1.06e-13

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 59.76  E-value: 1.06e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 489821626   25 DPTRVQILNLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLV 69
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
18-74 6.55e-13

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 59.20  E-value: 6.55e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489821626  18 QIFKALSDPTRVQILNLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKSRRE 74
Cdd:COG4189   11 EVLKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYK 67
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
19-92 5.59e-12

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 56.97  E-value: 5.59e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489821626  19 IFKALSDPTRVQILNLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKSRREGTTI-----YYMQDDNHVLELLT 92
Cdd:COG1777   10 LLDALGNPTRRRILALLSEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREGREDgrarkYYRLSAFRLEVTLT 88
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 18-75 5.40e-09

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 47.92  E-value: 5.40e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 489821626   18 QIFKALSDPTRVQIL-NLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKSRREG 75
Cdd:pfam12840   2 DVAEALADPTRLRILrALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 18-80 8.06e-07

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 43.65  E-value: 8.06e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489821626  18 QIFKALSDPTRVQILNLLQDR-EYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKSRREGTTIYY 80
Cdd:PRK10141   8 QLFKILSDETRLGIVLLLRESgELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHY 71
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
18-80 1.06e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 38.71  E-value: 1.06e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489821626  18 QIFKALSDPTRVQIL-NLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKSRREGTTIYY 80
Cdd:COG3398   89 KILAYLRRETPRRILlYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRY 152
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
26-76 3.17e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 37.95  E-value: 3.17e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489821626  26 PTRVQILNLLQDREYSVNEIARTLAFNQTTVSHQLRFLKNLRLVkSRREGT 76
Cdd:COG4742   16 EKRKNILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLI-ERDDGE 65
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 27-71 2.49e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 35.41  E-value: 2.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 489821626   27 TRVQILNLLQDR-EYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKS 71
Cdd:TIGR01884 144 EELKILEVLKATgEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQ 189
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 8-71 3.72e-03

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 34.66  E-value: 3.72e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489821626   8 LDEETLFSVTQI----FKALSDPTRVQILNLLQDR-EYSVNEIARTLAFNQTTVSHQLRFLKNLRLVKS 71
Cdd:cd09655  117 YESEEEIDFIELdlvpLLAGLSREELKILEVLKAKgEKSVKNIAKKLGKSLSTISRHLRELEKKGLVEQ 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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